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The map label for this gene is hupA

Identifier: 126453925

GI number: 126453925

Start: 5488

End: 5766

Strand: Direct

Name: hupA

Synonym: BURPS1106A_0004

Alternate gene names: 126453925

Gene position: 5488-5766 (Clockwise)

Preceding gene: NA

Following gene: 126454161

Centisome position: 0.14

GC content: 62.01

Gene sequence:

>279_bases
ATGAACAAACAGGAACTGATCGACGCCGTCGCCGCCCAGACGGGCGCCAGCAAGGCTCAAACCGGCGAAACGCTGGACAC
GCTCCTCGAAGTGATCAAGAAGGCTGTGTCGAAAGGCGACTCAGTTCAACTGATCGGCTTCGGCAGCTTCGGCTCGGGCA
AGCGCGCAGCGCGCACCGGCCGCAACCCCAAGACGGGCGAGACCATCAAGATCCCGGCAGCCAAGACGGTCAAGTTCACG
GCTGGCAAGGCGTTCAAGGACGCAGTGAACAAGCGCTGA

Upstream 100 bases:

>100_bases
GCGCCGTGCCGTTGCCACACACTATAGACGGCACGGTTCGCGCACGTATAATCGGCGCGTTCGCGCTGTTCGTGTCAACC
TAACCTGGAAAGGAACCTTA

Downstream 100 bases:

>100_bases
AACGAGCTGTTCGCGAACAAAAAACCCGCTGGTTTCAGCGGGTTTTTTCTTTTCGACGAGGTTTTTTTGCCACGCCGCAT
CGTCTTTTTCAATCTTTGAC

Product: DNA-binding protein HU-alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 92; Mature: 92

Protein sequence:

>92_residues
MNKQELIDAVAAQTGASKAQTGETLDTLLEVIKKAVSKGDSVQLIGFGSFGSGKRAARTGRNPKTGETIKIPAAKTVKFT
AGKAFKDAVNKR

Sequences:

>Translated_92_residues
MNKQELIDAVAAQTGASKAQTGETLDTLLEVIKKAVSKGDSVQLIGFGSFGSGKRAARTGRNPKTGETIKIPAAKTVKFT
AGKAFKDAVNKR
>Mature_92_residues
MNKQELIDAVAAQTGASKAQTGETLDTLLEVIKKAVSKGDSVQLIGFGSFGSGKRAARTGRNPKTGETIKIPAAKTVKFT
AGKAFKDAVNKR

Specific function: Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions

COG id: COG0776

COG function: function code L; Bacterial nucleoid DNA-binding protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial histone-like protein family

Homologues:

Organism=Escherichia coli, GI1786644, Length=90, Percent_Identity=53.3333333333333, Blast_Score=96, Evalue=4e-22,
Organism=Escherichia coli, GI1790433, Length=89, Percent_Identity=50.561797752809, Blast_Score=91, Evalue=1e-20,
Organism=Escherichia coli, GI1787141, Length=91, Percent_Identity=37.3626373626374, Blast_Score=68, Evalue=1e-13,
Organism=Escherichia coli, GI1788005, Length=89, Percent_Identity=37.0786516853933, Blast_Score=65, Evalue=1e-12,

Paralogues:

None

Copy number: 860 Molecules/Cell In: Growth-Phase, Minimal Media (Based on E. coli). 2040 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). [C]

Swissprot (AC and ID): DBHA_BURPS (Q9ZF89)

Other databases:

- EMBL:   AF110185
- EMBL:   BX571965
- RefSeq:   YP_106629.1
- ProteinModelPortal:   Q9ZF89
- SMR:   Q9ZF89
- GeneID:   3091972
- GenomeReviews:   BX571965_GR
- KEGG:   bps:BPSL0004
- HOGENOM:   HBG705085
- OMA:   ISAMAEK
- ProtClustDB:   CLSK930144
- BioCyc:   BPSE272560:BPSL0004-MONOMER
- InterPro:   IPR000119
- InterPro:   IPR020816
- InterPro:   IPR010992
- Gene3D:   G3DSA:4.10.520.10
- PRINTS:   PR01727
- SMART:   SM00411

Pfam domain/function: PF00216 Bac_DNA_binding; SSF47729 IHF_like_DNA_bnd

EC number: NA

Molecular weight: Translated: 9621; Mature: 9621

Theoretical pI: Translated: 10.99; Mature: 10.99

Prosite motif: PS00045 HISTONE_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKQELIDAVAAQTGASKAQTGETLDTLLEVIKKAVSKGDSVQLIGFGSFGSGKRAARTG
CCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHCC
RNPKTGETIKIPAAKTVKFTAGKAFKDAVNKR
CCCCCCCEEECCCCCEEEECCCHHHHHHHCCC
>Mature Secondary Structure
MNKQELIDAVAAQTGASKAQTGETLDTLLEVIKKAVSKGDSVQLIGFGSFGSGKRAARTG
CCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHCC
RNPKTGETIKIPAAKTVKFTAGKAFKDAVNKR
CCCCCCCEEECCCCCEEEECCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10419967