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The map label for this gene is paaF [H]

Identifier: 126453807

GI number: 126453807

Start: 1295525

End: 1296316

Strand: Reverse

Name: paaF [H]

Synonym: BURPS1106A_1325

Alternate gene names: 126453807

Gene position: 1296316-1295525 (Counterclockwise)

Preceding gene: 126455071

Following gene: 126453226

Centisome position: 32.5

GC content: 70.71

Gene sequence:

>792_bases
ATGAGCGCAGAACTGCTCGCGTCGCGCCCGCCGGAGAGCGAATCGACGCTCGTCCTCACGCTGTCCAACCCCGGCGCGCG
CAACGCGCTGCACCCCGACATGTACGCCGCCGGCCTCGAGGCGCTGAATACGGCGGAGCGCGATCCGTCGATCCGCGCGG
TCGTGCTGACGGGCGCGGACCGCTTCTTCTGCGCGGGCGGCAACCTGAACCGGCTGCTCGACAACCGCGCGAAGGCGCCG
TCCGTGCAGGCGGCGAGCATCGATCTGCTCGGCGAATGGATCACCGCGATCAATACGGTGACGAAGCCCGTGATCGCGGC
GGTCGAAGGCGCCGCCGCGGGGGCCGGCTTCTCGCTCGCGCTCGCATGCGATCTGCTCGTCGCCGCCGACGACGCGAAGT
TCGTGATGTCGTATGCGCGCGTCGCGCTCACGCCCGACGGCGGCGGCTCGTGGTTCCTCGCGCGGGCGCTGCCCCGCGCG
CTCGCGGCCGAGATCCTGTTCGAGGGCAAGCCGGCTGCCGCGACGCGCCTGCATCAGCTCGGCGTCGTGAATCGCCTGAC
GAAGCCGGGCACCACGCGCGACGAGGCGATCGCCTGGGCCGACCAGCTCGGCACGATGTCGCCGAACGCGCTTGCGCGCA
TCAAGTCGCTGATCGCCGACGCGCAGACGCAACCGCTCGCCGCGCATCTCGCCGCGGAACGCGATCACTTCGTCGCATCG
CTGCATCATGCGGACGCGCTCGAAGGCATCACCGCGTTCCTCGACAAGCGCGCCCCCATCTACAAACGCTGA

Upstream 100 bases:

>100_bases
ACGGCTTCAAAACATGCCGGCCGGGACGATGCCCGATCGTGCGACGCATCGGCGCGACGCATCGTTTCCCGACGCCATCG
AATCCAAGGAGACTCACTGC

Downstream 100 bases:

>100_bases
CGCCCGCCCATGTCCTATCAATTGCCGAAACGCCGCCGCATCTATCTGATGCGCCACGGCGACGTCACCTACTTCGATGC
GAGCGGCCGCCCTTTCGACC

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MSAELLASRPPESESTLVLTLSNPGARNALHPDMYAAGLEALNTAERDPSIRAVVLTGADRFFCAGGNLNRLLDNRAKAP
SVQAASIDLLGEWITAINTVTKPVIAAVEGAAAGAGFSLALACDLLVAADDAKFVMSYARVALTPDGGGSWFLARALPRA
LAAEILFEGKPAAATRLHQLGVVNRLTKPGTTRDEAIAWADQLGTMSPNALARIKSLIADAQTQPLAAHLAAERDHFVAS
LHHADALEGITAFLDKRAPIYKR

Sequences:

>Translated_263_residues
MSAELLASRPPESESTLVLTLSNPGARNALHPDMYAAGLEALNTAERDPSIRAVVLTGADRFFCAGGNLNRLLDNRAKAP
SVQAASIDLLGEWITAINTVTKPVIAAVEGAAAGAGFSLALACDLLVAADDAKFVMSYARVALTPDGGGSWFLARALPRA
LAAEILFEGKPAAATRLHQLGVVNRLTKPGTTRDEAIAWADQLGTMSPNALARIKSLIADAQTQPLAAHLAAERDHFVAS
LHHADALEGITAFLDKRAPIYKR
>Mature_262_residues
SAELLASRPPESESTLVLTLSNPGARNALHPDMYAAGLEALNTAERDPSIRAVVLTGADRFFCAGGNLNRLLDNRAKAPS
VQAASIDLLGEWITAINTVTKPVIAAVEGAAAGAGFSLALACDLLVAADDAKFVMSYARVALTPDGGGSWFLARALPRAL
AAEILFEGKPAAATRLHQLGVVNRLTKPGTTRDEAIAWADQLGTMSPNALARIKSLIADAQTQPLAAHLAAERDHFVASL
HHADALEGITAFLDKRAPIYKR

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=259, Percent_Identity=31.2741312741313, Blast_Score=121, Evalue=5e-28,
Organism=Homo sapiens, GI31542718, Length=244, Percent_Identity=27.8688524590164, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI4502327, Length=257, Percent_Identity=28.4046692607004, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI260274832, Length=249, Percent_Identity=25.7028112449799, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI45643119, Length=249, Percent_Identity=25.7028112449799, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI260275230, Length=249, Percent_Identity=25.7028112449799, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI221136756, Length=207, Percent_Identity=28.0193236714976, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI221136753, Length=207, Percent_Identity=28.0193236714976, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI221307494, Length=207, Percent_Identity=28.0193236714976, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI116235487, Length=207, Percent_Identity=29.4685990338164, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI4757966, Length=206, Percent_Identity=26.6990291262136, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI51538581, Length=206, Percent_Identity=26.6990291262136, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI25453481, Length=206, Percent_Identity=26.6990291262136, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI51538573, Length=206, Percent_Identity=26.6990291262136, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI70995211, Length=239, Percent_Identity=29.2887029288703, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI4757968, Length=206, Percent_Identity=26.6990291262136, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI49355787, Length=206, Percent_Identity=26.6990291262136, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI37594471, Length=143, Percent_Identity=31.4685314685315, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI37594469, Length=143, Percent_Identity=31.4685314685315, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1787659, Length=260, Percent_Identity=34.6153846153846, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1787660, Length=250, Percent_Identity=37.6, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI221142681, Length=253, Percent_Identity=34.3873517786561, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1788597, Length=247, Percent_Identity=29.9595141700405, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87082183, Length=231, Percent_Identity=25.1082251082251, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788682, Length=172, Percent_Identity=29.6511627906977, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17554946, Length=251, Percent_Identity=30.6772908366534, Blast_Score=120, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI25145438, Length=254, Percent_Identity=31.1023622047244, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17540714, Length=180, Percent_Identity=32.2222222222222, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17540306, Length=256, Percent_Identity=26.953125, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17535521, Length=247, Percent_Identity=23.8866396761134, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17560910, Length=159, Percent_Identity=30.188679245283, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17549921, Length=253, Percent_Identity=26.0869565217391, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17558304, Length=168, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17536985, Length=259, Percent_Identity=22.7799227799228, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17508951, Length=234, Percent_Identity=26.0683760683761, Blast_Score=64, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI25144276, Length=244, Percent_Identity=25.8196721311475, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI20129971, Length=246, Percent_Identity=31.7073170731707, Blast_Score=121, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24653477, Length=246, Percent_Identity=31.7073170731707, Blast_Score=121, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24653139, Length=250, Percent_Identity=32, Blast_Score=117, Evalue=6e-27,
Organism=Drosophila melanogaster, GI19922422, Length=252, Percent_Identity=27.3809523809524, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24654903, Length=243, Percent_Identity=24.2798353909465, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19920382, Length=208, Percent_Identity=27.8846153846154, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 27635; Mature: 27504

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAELLASRPPESESTLVLTLSNPGARNALHPDMYAAGLEALNTAERDPSIRAVVLTGAD
CCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCC
RFFCAGGNLNRLLDNRAKAPSVQAASIDLLGEWITAINTVTKPVIAAVEGAAAGAGFSLA
EEEEECCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
LACDLLVAADDAKFVMSYARVALTPDGGGSWFLARALPRALAAEILFEGKPAAATRLHQL
HHHHHHHCCCCHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
GVVNRLTKPGTTRDEAIAWADQLGTMSPNALARIKSLIADAQTQPLAAHLAAERDHFVAS
HHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
LHHADALEGITAFLDKRAPIYKR
HHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SAELLASRPPESESTLVLTLSNPGARNALHPDMYAAGLEALNTAERDPSIRAVVLTGAD
CCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCC
RFFCAGGNLNRLLDNRAKAPSVQAASIDLLGEWITAINTVTKPVIAAVEGAAAGAGFSLA
EEEEECCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
LACDLLVAADDAKFVMSYARVALTPDGGGSWFLARALPRALAAEILFEGKPAAATRLHQL
HHHHHHHCCCCHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
GVVNRLTKPGTTRDEAIAWADQLGTMSPNALARIKSLIADAQTQPLAAHLAAERDHFVAS
HHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
LHHADALEGITAFLDKRAPIYKR
HHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]