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The map label for this gene is ilvR [H]

Identifier: 126453441

GI number: 126453441

Start: 1004330

End: 1005325

Strand: Direct

Name: ilvR [H]

Synonym: BURPS1106A_1028

Alternate gene names: 126453441

Gene position: 1004330-1005325 (Clockwise)

Preceding gene: 126455401

Following gene: 126454600

Centisome position: 25.18

GC content: 74.3

Gene sequence:

>996_bases
TTGACCCCCGATTTGCGCCAATGGCGCTATTTCGTCGCCGTGGCCGACGAGCGGCACTTCGGCCGCGCCGCCGAGCGGCT
CTCGATGACGCAGCCGCCGCTGTCGCAGGCGATCCGCGCGCTCGAGGACGCGCTCGGCGTCGCGCTGTTCGCGCGCACGA
AGCGCTCGGTCGAGCTGACCGCGGTCGGCGCGGCGCTGCTGCCCGACGTGCGGCGGCTGATCGCCGCGGCCGACGCGTTG
CCGCCGCTCGCGCAGAGCCTCGCGCGCGGCGAGGCGGGCTCGCTCGCGCTCGCGTTCGTGTCGACGGCCGACTATGGGCT
GCTACCGCAACTGCTGCGCGAGTTCGGCGCGCGCTATCCGCACGTGCGGCTGCAACTGGCCGAGGCGACGAGCGACGTGC
AGATCGAGGAGCTTGTGGCCGGCCGCATCGACGCGGGGCTCGTGATCCCGCCCGTGCCGCCGCGGCACGCGGCGTCGCTG
TCATACCTGCCGGTGCTGCGCGAGCCGCTCGTCGTCGCGATGCCGGCCGAAGCCGCCGAAGTCGCCGAAGTCGCCGATGC
CGCGGCGGATGCGCCCGTGCGCATCGCCGACATCGCGTCGCTGCCGCTCGTGATCTTTCCGCGTCGTTTGGCGCCCGGCT
TTTATGACATCATTACGGGCTGCTACGGCGCGGCGGGCGTCACGCCGCGCATCGGCCAGGAGGCGATCCAGATGCAGACG
ATCGTGAGCCTCGTGTCCGCGGGCATGGGTGTCGCGCTCGTGCCGCAATCGCTGCGTAACCTGCGGCGCACGGGGGTCGT
CTACCGCGCGCTCGCCGATCCGGCGCCCGTCGTCGAGACGGGCCTCGTGTGGCGCACGGACGACGTGAGCCCGGTGCTCG
CGGGCTTCATCGACGTGGTGCGCGGCGCGGCGCGGCGCGCTTCGCCTTCGCGGCCGGGCTCGACGCCGGACGCGGCGGGT
GCGGCGGGTGCGGGCCGGCGCGCGTCGCGGCCGTGA

Upstream 100 bases:

>100_bases
AGAATGCAGTTTCTGTTAGAGAATGTCCAATATATTATTCATCGTCTATTAGGTCGATGTGCATATCAATCGACCGGTCG
ACGACGATACGGAGCCTGAT

Downstream 100 bases:

>100_bases
ACGTTCGCGCGGCGCGCGCGTCGAATCGCGGTCGCGACGCGTTCGCGCGGCGGCGCCCGACGCGGTCACGCATGCCGCAT
CGATTCAGAACCTTCAACGC

Product: isoleucine biosynthesis transcriptional activator IlvR

Products: NA

Alternate protein names: Isoleucine biosynthesis transcriptional activator [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MTPDLRQWRYFVAVADERHFGRAAERLSMTQPPLSQAIRALEDALGVALFARTKRSVELTAVGAALLPDVRRLIAAADAL
PPLAQSLARGEAGSLALAFVSTADYGLLPQLLREFGARYPHVRLQLAEATSDVQIEELVAGRIDAGLVIPPVPPRHAASL
SYLPVLREPLVVAMPAEAAEVAEVADAAADAPVRIADIASLPLVIFPRRLAPGFYDIITGCYGAAGVTPRIGQEAIQMQT
IVSLVSAGMGVALVPQSLRNLRRTGVVYRALADPAPVVETGLVWRTDDVSPVLAGFIDVVRGAARRASPSRPGSTPDAAG
AAGAGRRASRP

Sequences:

>Translated_331_residues
MTPDLRQWRYFVAVADERHFGRAAERLSMTQPPLSQAIRALEDALGVALFARTKRSVELTAVGAALLPDVRRLIAAADAL
PPLAQSLARGEAGSLALAFVSTADYGLLPQLLREFGARYPHVRLQLAEATSDVQIEELVAGRIDAGLVIPPVPPRHAASL
SYLPVLREPLVVAMPAEAAEVAEVADAAADAPVRIADIASLPLVIFPRRLAPGFYDIITGCYGAAGVTPRIGQEAIQMQT
IVSLVSAGMGVALVPQSLRNLRRTGVVYRALADPAPVVETGLVWRTDDVSPVLAGFIDVVRGAARRASPSRPGSTPDAAG
AAGAGRRASRP
>Mature_330_residues
TPDLRQWRYFVAVADERHFGRAAERLSMTQPPLSQAIRALEDALGVALFARTKRSVELTAVGAALLPDVRRLIAAADALP
PLAQSLARGEAGSLALAFVSTADYGLLPQLLREFGARYPHVRLQLAEATSDVQIEELVAGRIDAGLVIPPVPPRHAASLS
YLPVLREPLVVAMPAEAAEVAEVADAAADAPVRIADIASLPLVIFPRRLAPGFYDIITGCYGAAGVTPRIGQEAIQMQTI
VSLVSAGMGVALVPQSLRNLRRTGVVYRALADPAPVVETGLVWRTDDVSPVLAGFIDVVRGAARRASPSRPGSTPDAAGA
AGAGRRASRP

Specific function: Positively regulates the expression of the ilvD gene while negatively autoregulating its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=298, Percent_Identity=38.255033557047, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI1788887, Length=300, Percent_Identity=33, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI2367136, Length=295, Percent_Identity=32.2033898305085, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1790399, Length=288, Percent_Identity=29.5138888888889, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI145693105, Length=173, Percent_Identity=31.2138728323699, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI157672245, Length=250, Percent_Identity=30, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1788748, Length=258, Percent_Identity=27.906976744186, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1787806, Length=301, Percent_Identity=25.2491694352159, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787530, Length=253, Percent_Identity=28.0632411067194, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790208, Length=261, Percent_Identity=28.735632183908, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787589, Length=137, Percent_Identity=36.4963503649635, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI87081904, Length=146, Percent_Identity=33.5616438356164, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1788297, Length=259, Percent_Identity=25.0965250965251, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1786713, Length=121, Percent_Identity=35.5371900826446, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789204, Length=144, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI48994962, Length=71, Percent_Identity=46.4788732394366, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34858; Mature: 34726

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPDLRQWRYFVAVADERHFGRAAERLSMTQPPLSQAIRALEDALGVALFARTKRSVELT
CCCCHHHHEEEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEE
AVGAALLPDVRRLIAAADALPPLAQSLARGEAGSLALAFVSTADYGLLPQLLREFGARYP
HHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCC
HVRLQLAEATSDVQIEELVAGRIDAGLVIPPVPPRHAASLSYLPVLREPLVVAMPAEAAE
EEEEEEECCCCCCHHHHHHHHHCCCCEEECCCCCCHHCCCHHHHHHHCCEEEECCCHHHH
VAEVADAAADAPVRIADIASLPLVIFPRRLAPGFYDIITGCYGAAGVTPRIGQEAIQMQT
HHHHHHHHCCCCEEHHHHHCCCHHEECHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHH
IVSLVSAGMGVALVPQSLRNLRRTGVVYRALADPAPVVETGLVWRTDDVSPVLAGFIDVV
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCEEECCCCHHHHHHHHHHH
RGAARRASPSRPGSTPDAAGAAGAGRRASRP
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TPDLRQWRYFVAVADERHFGRAAERLSMTQPPLSQAIRALEDALGVALFARTKRSVELT
CCCHHHHEEEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEE
AVGAALLPDVRRLIAAADALPPLAQSLARGEAGSLALAFVSTADYGLLPQLLREFGARYP
HHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCC
HVRLQLAEATSDVQIEELVAGRIDAGLVIPPVPPRHAASLSYLPVLREPLVVAMPAEAAE
EEEEEEECCCCCCHHHHHHHHHCCCCEEECCCCCCHHCCCHHHHHHHCCEEEECCCHHHH
VAEVADAAADAPVRIADIASLPLVIFPRRLAPGFYDIITGCYGAAGVTPRIGQEAIQMQT
HHHHHHHHCCCCEEHHHHHCCCHHEECHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHH
IVSLVSAGMGVALVPQSLRNLRRTGVVYRALADPAPVVETGLVWRTDDVSPVLAGFIDVV
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCEEECCCCHHHHHHHHHHH
RGAARRASPSRPGSTPDAAGAAGAGRRASRP
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8113165; 11259647 [H]