Click here to switch to the map view.

The map label for this gene is icd [H]

Identifier: 126453346

GI number: 126453346

Start: 940131

End: 941390

Strand: Direct

Name: icd [H]

Synonym: BURPS1106A_0960

Alternate gene names: 126453346

Gene position: 940131-941390 (Clockwise)

Preceding gene: 126453124

Following gene: 126453660

Centisome position: 23.57

GC content: 62.06

Gene sequence:

>1260_bases
ATGCCGTATCAGCACATCAAGGTTCCGGAAGGCGGTGACAAGATCACCGTCAACAAGGATTTCTCGCTCAACGTTTCCGA
TCAGCCGATCATCCCTTACATCGAGGGCGACGGCACGGGCTTCGACATCACGCCGGTGATGATCAAGGTCGTCGACGCGG
CGGTCGAGAAGGCGTACGGCGGCAAGAAGAAGATTCACTGGATGGAGATCTACGCCGGCGAGAAGGCGACGAAGGTCTAC
GGCCCGGACGTGTGGCTGCCGGAAGAGACGCTGCAGGTGCTGAAGGAATACGTCGTGTCGATCAAGGGGCCGCTCACGAC
CCCGGTCGGCGGCGGCATCCGCTCGCTGAACGTCGCGCTGCGTCAGGAGCTCGACCTGTACGTCTGCCTGCGCCCGATCC
AGTACTTCAAGGGCGTGCCTTCGCCCGTGCGCGAGCCGGAGAAGACCAACATGGTCATCTTCCGCGAGAACTCGGAAGAC
ATCTACGCCGGCATCGAATGGGCGGCCGAATCCGAGCAGGCGAAGAAGGTCATCAAGTTCCTGCAGGAAGAGATGGGCGT
GAAGAAGATCCGCTTCCCGCAGACCTCGGGCATCGGCATCAAGCCCGTGTCGAAGGAAGGCACCGAGCGCCTCGTGCGCA
AGGCGATCCAGTACGCGATCGACAACGACCGCAAGTCGGTCACGCTCGTCCACAAGGGCAACATCATGAAGTTCACGGAA
GGTGCGTTCCGTGACGCCGGCTATGCGCTCGCGCAGAAGGAATTCGGCGCCGAGCTGATCGACGGCGGCCCGTGGATGAA
GTTCAAGAACCCGAAGACGGGCAACGAGATCGTGGTCAAGGATTCGATCGCCGACGCGTTCCTGCAGCAGATCCTGCTGC
GCCCGGCCGAATACGACGTGATCGCGACGCTGAACCTGAACGGCGACTACATCTCGGACGCGCTCGCCGCGCAAGTCGGC
GGCATCGGCATCGCGCCGGGCGCGAACCTGTCGGATTCGGTCGCGATGTTCGAAGCGACGCACGGCACGGCGCCGAAGTA
CGCGGGCAAGGATTACGTGAACCCGGGTTCGGAAATCCTGTCGGCCGAAATGATGCTGCGCCACCTCGGCTGGACCGAAG
CGGCCGACGTGATCATTTCCGCGATGGAGAAGTCGATCAAGCAGAAGCGCGTCACGTACGACTTCGCGCGCCTGATGGAA
GGCGCGACGCAAGTGTCGTGCTCGGGCTTCGGTCAGGTGCTGATCGAAAACATGGAGTAA

Upstream 100 bases:

>100_bases
ATAGCGGCTCGCCGTTGCGGACGCAGGGCCGGCGCCGCGCGCGCCCGACCGCGCACCACCACAGATACCCACCAGCCCAG
CCATATCACTGGAGTCGATC

Downstream 100 bases:

>100_bases
GCGCATCGGCATAGCCGATGTCGAGCGACACCCCGGCGGGCCGCGTGGCCGCCGGGGTGTTTCATTTTGGTGCCGCGCGT
GCGCGCGTTGTCCGCACGCG

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MPYQHIKVPEGGDKITVNKDFSLNVSDQPIIPYIEGDGTGFDITPVMIKVVDAAVEKAYGGKKKIHWMEIYAGEKATKVY
GPDVWLPEETLQVLKEYVVSIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPIQYFKGVPSPVREPEKTNMVIFRENSED
IYAGIEWAAESEQAKKVIKFLQEEMGVKKIRFPQTSGIGIKPVSKEGTERLVRKAIQYAIDNDRKSVTLVHKGNIMKFTE
GAFRDAGYALAQKEFGAELIDGGPWMKFKNPKTGNEIVVKDSIADAFLQQILLRPAEYDVIATLNLNGDYISDALAAQVG
GIGIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHLGWTEAADVIISAMEKSIKQKRVTYDFARLME
GATQVSCSGFGQVLIENME

Sequences:

>Translated_419_residues
MPYQHIKVPEGGDKITVNKDFSLNVSDQPIIPYIEGDGTGFDITPVMIKVVDAAVEKAYGGKKKIHWMEIYAGEKATKVY
GPDVWLPEETLQVLKEYVVSIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPIQYFKGVPSPVREPEKTNMVIFRENSED
IYAGIEWAAESEQAKKVIKFLQEEMGVKKIRFPQTSGIGIKPVSKEGTERLVRKAIQYAIDNDRKSVTLVHKGNIMKFTE
GAFRDAGYALAQKEFGAELIDGGPWMKFKNPKTGNEIVVKDSIADAFLQQILLRPAEYDVIATLNLNGDYISDALAAQVG
GIGIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHLGWTEAADVIISAMEKSIKQKRVTYDFARLME
GATQVSCSGFGQVLIENME
>Mature_418_residues
PYQHIKVPEGGDKITVNKDFSLNVSDQPIIPYIEGDGTGFDITPVMIKVVDAAVEKAYGGKKKIHWMEIYAGEKATKVYG
PDVWLPEETLQVLKEYVVSIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPIQYFKGVPSPVREPEKTNMVIFRENSEDI
YAGIEWAAESEQAKKVIKFLQEEMGVKKIRFPQTSGIGIKPVSKEGTERLVRKAIQYAIDNDRKSVTLVHKGNIMKFTEG
AFRDAGYALAQKEFGAELIDGGPWMKFKNPKTGNEIVVKDSIADAFLQQILLRPAEYDVIATLNLNGDYISDALAAQVGG
IGIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHLGWTEAADVIISAMEKSIKQKRVTYDFARLMEG
ATQVSCSGFGQVLIENME

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=398, Percent_Identity=31.4070351758794, Blast_Score=175, Evalue=9e-44,
Organism=Homo sapiens, GI28178821, Length=298, Percent_Identity=31.2080536912752, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI28178816, Length=298, Percent_Identity=31.2080536912752, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI28178838, Length=281, Percent_Identity=29.1814946619217, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI4758582, Length=279, Percent_Identity=29.0322580645161, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI28178819, Length=184, Percent_Identity=34.2391304347826, Blast_Score=86, Evalue=6e-17,
Organism=Escherichia coli, GI1787381, Length=413, Percent_Identity=75.3026634382567, Blast_Score=651, Evalue=0.0,
Organism=Escherichia coli, GI1788101, Length=377, Percent_Identity=27.5862068965517, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI87081683, Length=402, Percent_Identity=23.8805970149254, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71986051, Length=377, Percent_Identity=31.2997347480106, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI25144293, Length=305, Percent_Identity=31.1475409836066, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17505779, Length=301, Percent_Identity=31.2292358803987, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17550882, Length=297, Percent_Identity=26.9360269360269, Blast_Score=97, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324709, Length=364, Percent_Identity=29.1208791208791, Blast_Score=150, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6322097, Length=365, Percent_Identity=28.7671232876712, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6324291, Length=370, Percent_Identity=30, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6319830, Length=390, Percent_Identity=24.3589743589744, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24643270, Length=383, Percent_Identity=33.420365535248, Blast_Score=184, Evalue=8e-47,
Organism=Drosophila melanogaster, GI24643268, Length=383, Percent_Identity=33.420365535248, Blast_Score=184, Evalue=8e-47,
Organism=Drosophila melanogaster, GI24661184, Length=390, Percent_Identity=30.7692307692308, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI161078635, Length=273, Percent_Identity=30.7692307692308, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI161078637, Length=273, Percent_Identity=30.7692307692308, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI161078639, Length=273, Percent_Identity=30.4029304029304, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI161078633, Length=273, Percent_Identity=30.7692307692308, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24650122, Length=273, Percent_Identity=30.7692307692308, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI20130355, Length=388, Percent_Identity=25, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI281362242, Length=339, Percent_Identity=27.7286135693215, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24648872, Length=339, Percent_Identity=27.7286135693215, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 46147; Mature: 46015

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYQHIKVPEGGDKITVNKDFSLNVSDQPIIPYIEGDGTGFDITPVMIKVVDAAVEKAYG
CCCCEEECCCCCCEEEEECCEEECCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCC
GKKKIHWMEIYAGEKATKVYGPDVWLPEETLQVLKEYVVSIKGPLTTPVGGGIRSLNVAL
CCCCEEEEEEECCCCCCEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
RQELDLYVCLRPIQYFKGVPSPVREPEKTNMVIFRENSEDIYAGIEWAAESEQAKKVIKF
HHCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCEEECEEHHCCHHHHHHHHHH
LQEEMGVKKIRFPQTSGIGIKPVSKEGTERLVRKAIQYAIDNDRKSVTLVHKGNIMKFTE
HHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECC
GAFRDAGYALAQKEFGAELIDGGPWMKFKNPKTGNEIVVKDSIADAFLQQILLRPAEYDV
CHHHHCCHHHHHHHHCCCEECCCCCEEECCCCCCCEEEEECHHHHHHHHHHHCCCCCCCE
IATLNLNGDYISDALAAQVGGIGIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEIL
EEEEECCCHHHHHHHHHHHCCEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHH
SAEMMLRHLGWTEAADVIISAMEKSIKQKRVTYDFARLMEGATQVSCSGFGQVLIENME
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHCCCC
>Mature Secondary Structure 
PYQHIKVPEGGDKITVNKDFSLNVSDQPIIPYIEGDGTGFDITPVMIKVVDAAVEKAYG
CCCEEECCCCCCEEEEECCEEECCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCC
GKKKIHWMEIYAGEKATKVYGPDVWLPEETLQVLKEYVVSIKGPLTTPVGGGIRSLNVAL
CCCCEEEEEEECCCCCCEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
RQELDLYVCLRPIQYFKGVPSPVREPEKTNMVIFRENSEDIYAGIEWAAESEQAKKVIKF
HHCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCEEECEEHHCCHHHHHHHHHH
LQEEMGVKKIRFPQTSGIGIKPVSKEGTERLVRKAIQYAIDNDRKSVTLVHKGNIMKFTE
HHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECC
GAFRDAGYALAQKEFGAELIDGGPWMKFKNPKTGNEIVVKDSIADAFLQQILLRPAEYDV
CHHHHCCHHHHHHHHCCCEECCCCCEEECCCCCCCEEEEECHHHHHHHHHHHCCCCCCCE
IATLNLNGDYISDALAAQVGGIGIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEIL
EEEEECCCHHHHHHHHHHHCCEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHH
SAEMMLRHLGWTEAADVIISAMEKSIKQKRVTYDFARLMEGATQVSCSGFGQVLIENME
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10361714; 10556719; 12704232 [H]