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The map label for this gene is carA [H]

Identifier: 126452643

GI number: 126452643

Start: 1460146

End: 1461291

Strand: Direct

Name: carA [H]

Synonym: BURPS1106A_1505

Alternate gene names: 126452643

Gene position: 1460146-1461291 (Clockwise)

Preceding gene: 126453869

Following gene: 126455333

Centisome position: 36.61

GC content: 67.19

Gene sequence:

>1146_bases
GTGTTGCCGTCTTTTTCTCCCGCTTTGCTCGCACTCGCCGACGGCACGGTCTTTCGTGGTTATTCGATCGGCGCGGCCGG
CCATACGATCGGCGAAGTCGTGTTCAACACCGCGATCACCGGCTATCAGGAAATCCTGACGGATCCGAGCTATGCGCGCC
AGATCGTCACGCTGACCTATCCGCACATCGGCAACGTCGGCGTGAATGCCGAGGACGTCGAAGCGACGAAAGTCCATGCC
GCCGGCCTCATCGTGCGCGATTTGCCCGCGCTCGCGTCGAACTTCCGGATGGCGCGCACGCTCGGCGATTACCTGCGCGA
CGAAGGCGTCGTCGCGATCGCGGGCATCGACACCCGCAAGCTGACCCGCATTCTGCGCGAGAAGGGCGCGCAGAACGGCT
GCATCCTGACGGGCTCCGACGACGAAACGAAGGCGCTCGCGCTCGCGCGCTCGTTCCCGGGCCTCGCGGGGATGGACCTC
GCGAAGGTCGTCTCGACGACCAAGCCGTTCGAGTGGAAGCAGACGGAATGGCGCCTCGGCAGCGGCTACGGGATGCAGGA
GACGCCGCGCTACCGCGTCGTCGCGTTCGATTTCGGCGTGAAATACAACATCCTGCGCATGCTCGCCGAGCGCGGCTGCC
ACGTGAGCGTGCTGCCCGCGCAATCGAGCGCGGCCGACGCGCTCGCGCTCAATCCGGACGGCATCTTCCTGTCGAACGGC
CCGGGCGATCCGCAGCCGTGCGACTACGCGATCGCCGCGACCCGGGAGTTCATCGAGCGCGGCGTGCCGACCTTCGGCAT
CTGCCTCGGCCACCAGATCATGGGCCTCGCGCTCGGCGCGAAGACGCTCAAGATGAAGACGGGCCATCACGGCGCGAACC
ATCCGGTGAAGGATCTCGCGAACGGCCGTGTCGTGATCACGTCGCAGAACCACGGTTTCGCGGTCGACGCCGATTCGCTG
CCCGCGAACGCGCGCGCGACGCACGTGTCGCTGTTCGACGGCACGCTGCAGGGCTTCGAGCTGACCGACAAGCCCGCGTT
CTGCTTCCAGGGGCACCCGGAGGCGTCGCCCGGCCCGCACGACATCGGCTATCTGTTCGACCGCTTCACCGCGCTGATGG
ACGCGGCGAAGGCGCGCAGCGCCTGA

Upstream 100 bases:

>100_bases
CGCGCGAAAGCGCCCACGCGCGCGTGATGCGTCACGCGGCCCGCGAGCGCGCGGCAGGATAGACAGGTCGGCGGCAAGGG
TGTCCCCCAAGGAGCCCCCC

Downstream 100 bases:

>100_bases
ACCCGTCGCATCGATCAAGGAGTCTCGCATCATGTTCGGTCACGCACTCGGCATCACGGATCTCTGGACCTATGTGTTCG
GCGTGGTGTTCATCATTCTG

Product: carbamoyl phosphate synthase small subunit

Products: NA

Alternate protein names: Carbamoyl-phosphate synthetase glutamine chain [H]

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MLPSFSPALLALADGTVFRGYSIGAAGHTIGEVVFNTAITGYQEILTDPSYARQIVTLTYPHIGNVGVNAEDVEATKVHA
AGLIVRDLPALASNFRMARTLGDYLRDEGVVAIAGIDTRKLTRILREKGAQNGCILTGSDDETKALALARSFPGLAGMDL
AKVVSTTKPFEWKQTEWRLGSGYGMQETPRYRVVAFDFGVKYNILRMLAERGCHVSVLPAQSSAADALALNPDGIFLSNG
PGDPQPCDYAIAATREFIERGVPTFGICLGHQIMGLALGAKTLKMKTGHHGANHPVKDLANGRVVITSQNHGFAVDADSL
PANARATHVSLFDGTLQGFELTDKPAFCFQGHPEASPGPHDIGYLFDRFTALMDAAKARSA

Sequences:

>Translated_381_residues
MLPSFSPALLALADGTVFRGYSIGAAGHTIGEVVFNTAITGYQEILTDPSYARQIVTLTYPHIGNVGVNAEDVEATKVHA
AGLIVRDLPALASNFRMARTLGDYLRDEGVVAIAGIDTRKLTRILREKGAQNGCILTGSDDETKALALARSFPGLAGMDL
AKVVSTTKPFEWKQTEWRLGSGYGMQETPRYRVVAFDFGVKYNILRMLAERGCHVSVLPAQSSAADALALNPDGIFLSNG
PGDPQPCDYAIAATREFIERGVPTFGICLGHQIMGLALGAKTLKMKTGHHGANHPVKDLANGRVVITSQNHGFAVDADSL
PANARATHVSLFDGTLQGFELTDKPAFCFQGHPEASPGPHDIGYLFDRFTALMDAAKARSA
>Mature_381_residues
MLPSFSPALLALADGTVFRGYSIGAAGHTIGEVVFNTAITGYQEILTDPSYARQIVTLTYPHIGNVGVNAEDVEATKVHA
AGLIVRDLPALASNFRMARTLGDYLRDEGVVAIAGIDTRKLTRILREKGAQNGCILTGSDDETKALALARSFPGLAGMDL
AKVVSTTKPFEWKQTEWRLGSGYGMQETPRYRVVAFDFGVKYNILRMLAERGCHVSVLPAQSSAADALALNPDGIFLSNG
PGDPQPCDYAIAATREFIERGVPTFGICLGHQIMGLALGAKTLKMKTGHHGANHPVKDLANGRVVITSQNHGFAVDADSL
PANARATHVSLFDGTLQGFELTDKPAFCFQGHPEASPGPHDIGYLFDRFTALMDAAKARSA

Specific function: Arginine biosynthesis. Pyrimidine biosynthesis; first step. [C]

COG id: COG0505

COG function: function code EF; Carbamoylphosphate synthase small subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=384, Percent_Identity=38.8020833333333, Blast_Score=242, Evalue=3e-64,
Organism=Homo sapiens, GI169790915, Length=385, Percent_Identity=37.1428571428571, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI21361331, Length=385, Percent_Identity=37.1428571428571, Blast_Score=223, Evalue=2e-58,
Organism=Escherichia coli, GI1786215, Length=371, Percent_Identity=64.1509433962264, Blast_Score=500, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI193204318, Length=384, Percent_Identity=39.3229166666667, Blast_Score=246, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6322331, Length=388, Percent_Identity=37.3711340206186, Blast_Score=240, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6324878, Length=377, Percent_Identity=38.1962864721485, Blast_Score=237, Evalue=2e-63,
Organism=Drosophila melanogaster, GI45555749, Length=379, Percent_Identity=39.8416886543536, Blast_Score=238, Evalue=5e-63,
Organism=Drosophila melanogaster, GI24642586, Length=379, Percent_Identity=39.8416886543536, Blast_Score=238, Evalue=7e-63,

Paralogues:

None

Copy number: 620 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2599 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001317
- InterPro:   IPR006274
- InterPro:   IPR002474
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF00988 CPSase_sm_chain; PF00117 GATase [H]

EC number: =6.3.5.5 [H]

Molecular weight: Translated: 40698; Mature: 40698

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPSFSPALLALADGTVFRGYSIGAAGHTIGEVVFNTAITGYQEILTDPSYARQIVTLTY
CCCCCCCCEEEEECCCEEECEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHCEEEEEEC
PHIGNVGVNAEDVEATKVHAAGLIVRDLPALASNFRMARTLGDYLRDEGVVAIAGIDTRK
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHH
LTRILREKGAQNGCILTGSDDETKALALARSFPGLAGMDLAKVVSTTKPFEWKQTEWRLG
HHHHHHHCCCCCCEEEECCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCEEEC
SGYGMQETPRYRVVAFDFGVKYNILRMLAERGCHVSVLPAQSSAADALALNPDGIFLSNG
CCCCCCCCCCEEEEEEECCCHHHHHHHHHHCCCEEEEECCCCCCCCEEEECCCCEEEECC
PGDPQPCDYAIAATREFIERGVPTFGICLGHQIMGLALGAKTLKMKTGHHGANHPVKDLA
CCCCCCCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHC
NGRVVITSQNHGFAVDADSLPANARATHVSLFDGTLQGFELTDKPAFCFQGHPEASPGPH
CCEEEEEECCCCEEEECCCCCCCCCEEEEEEECCCCCCCEECCCCCEEECCCCCCCCCCC
DIGYLFDRFTALMDAAKARSA
HHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLPSFSPALLALADGTVFRGYSIGAAGHTIGEVVFNTAITGYQEILTDPSYARQIVTLTY
CCCCCCCCEEEEECCCEEECEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHCEEEEEEC
PHIGNVGVNAEDVEATKVHAAGLIVRDLPALASNFRMARTLGDYLRDEGVVAIAGIDTRK
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHH
LTRILREKGAQNGCILTGSDDETKALALARSFPGLAGMDLAKVVSTTKPFEWKQTEWRLG
HHHHHHHCCCCCCEEEECCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCEEEC
SGYGMQETPRYRVVAFDFGVKYNILRMLAERGCHVSVLPAQSSAADALALNPDGIFLSNG
CCCCCCCCCCEEEEEEECCCHHHHHHHHHHCCCEEEEECCCCCCCCEEEECCCCEEEECC
PGDPQPCDYAIAATREFIERGVPTFGICLGHQIMGLALGAKTLKMKTGHHGANHPVKDLA
CCCCCCCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHC
NGRVVITSQNHGFAVDADSLPANARATHVSLFDGTLQGFELTDKPAFCFQGHPEASPGPH
CCEEEEEECCCCEEEECCCCCCCCCEEEEEEECCCCCCCEECCCCCEEECCCCCCCCCCC
DIGYLFDRFTALMDAAKARSA
HHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]