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The map label for this gene is xth [H]

Identifier: 126452249

GI number: 126452249

Start: 176281

End: 177051

Strand: Direct

Name: xth [H]

Synonym: BURPS1106A_0186

Alternate gene names: 126452249

Gene position: 176281-177051 (Clockwise)

Preceding gene: 126453377

Following gene: 126452647

Centisome position: 4.42

GC content: 62.39

Gene sequence:

>771_bases
ATGCTGCGTGTCATCACCGCGAATCTGAACGGCATCCGCTCAGCGGCGAAGAAGGGCTTTTTCGAATGGCTCGGCGAGCA
GAACGCCGATTGCGTCTGCGTGCAGGAAATCAAGGTGTCGGCGGACGATCTGCCCGCCGAGTTCGTCGAGCCGCACGGCT
TGCGAAGCTATTTCCATCATGCGCAGAAGAAGGGCTACAGCGGCGCGGGCCTCTACTCGCGCCGCGAGCCCGACGACGTG
ATCATCGGTTACGGCAGCAGCGAATTCGATGCGGAGGGCCGTTACGTCGAGGCGCGCTTCGGCAAGCTGTCGGTCGTGTC
GGTGTACGTGCCGTCCGGCTCGAGCGGCGACGAGCGCCAGCAGGCGAAGTACCGCTTCATGGACGAGTTCATGCCGCACC
TTGCCGAGCTGAAGGCGAAGCGCGAGGTGATCCTGTGCGGCGACGTGAACATCGTCCACAAGGAAATCGACATCAAGAAC
TGGAAGAGCAACCAGAAGAACTCCGGCTGCCTGCCCGAGGAGCGCGCGTGGCTCACGAAGCTGTTCGATGACGTCGGCTA
TGTCGACGTGTTCCGAACGCTCGATCCGCGGCCCGAGCAGTACACGTGGTGGAGCAACCGCGGTCAGGCGTATGCGAAGA
ACGTCGGGTGGCGGATCGACTACCAGATCGCGACGCCGGGTGTGGCCGGCACGGCGAAGAACACGTCGATCTTCCGTGAC
ATCAAGTTCAGCGATCACGCGCCGCTCACGGTCGATTACGACTACAAGTGA

Upstream 100 bases:

>100_bases
GAGCTGACCGCGATGAAGCTCGAATACCCGCCCGCGAAGCCCGAGCTCGCCGGCATCCAGATCCAATAAACCGCAACGAA
TTCACTGGACGGAACTCACC

Downstream 100 bases:

>100_bases
CGTGGCGTGGCGTGGCGTGGCGGACGGCCGTGCCGGTGCGCGTTCGTCGGCGCGGCCGGGCGATCGCCGCGGGCGACGCG
TGATAGAAAACGGACCGCGT

Product: exodeoxyribonuclease III

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MLRVITANLNGIRSAAKKGFFEWLGEQNADCVCVQEIKVSADDLPAEFVEPHGLRSYFHHAQKKGYSGAGLYSRREPDDV
IIGYGSSEFDAEGRYVEARFGKLSVVSVYVPSGSSGDERQQAKYRFMDEFMPHLAELKAKREVILCGDVNIVHKEIDIKN
WKSNQKNSGCLPEERAWLTKLFDDVGYVDVFRTLDPRPEQYTWWSNRGQAYAKNVGWRIDYQIATPGVAGTAKNTSIFRD
IKFSDHAPLTVDYDYK

Sequences:

>Translated_256_residues
MLRVITANLNGIRSAAKKGFFEWLGEQNADCVCVQEIKVSADDLPAEFVEPHGLRSYFHHAQKKGYSGAGLYSRREPDDV
IIGYGSSEFDAEGRYVEARFGKLSVVSVYVPSGSSGDERQQAKYRFMDEFMPHLAELKAKREVILCGDVNIVHKEIDIKN
WKSNQKNSGCLPEERAWLTKLFDDVGYVDVFRTLDPRPEQYTWWSNRGQAYAKNVGWRIDYQIATPGVAGTAKNTSIFRD
IKFSDHAPLTVDYDYK
>Mature_256_residues
MLRVITANLNGIRSAAKKGFFEWLGEQNADCVCVQEIKVSADDLPAEFVEPHGLRSYFHHAQKKGYSGAGLYSRREPDDV
IIGYGSSEFDAEGRYVEARFGKLSVVSVYVPSGSSGDERQQAKYRFMDEFMPHLAELKAKREVILCGDVNIVHKEIDIKN
WKSNQKNSGCLPEERAWLTKLFDDVGYVDVFRTLDPRPEQYTWWSNRGQAYAKNVGWRIDYQIATPGVAGTAKNTSIFRD
IKFSDHAPLTVDYDYK

Specific function: Major Apurinic-Apyrimidinic Endonuclease Of E.Coli. It Removes The Damaged DNA At Cytosines And Guanines By Cleaving On The 3' Side Of The Ap Site By A Beta-Elimination Reaction. It Exhibits 3'-5'-Exonuclease, 3'-Phosphomonoesterase, 3'-Repair Diesterase

COG id: COG0708

COG function: function code L; Exonuclease III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA repair enzymes AP/ExoA family [H]

Homologues:

Organism=Homo sapiens, GI18375505, Length=253, Percent_Identity=37.9446640316205, Blast_Score=179, Evalue=2e-45,
Organism=Homo sapiens, GI18375503, Length=253, Percent_Identity=37.9446640316205, Blast_Score=179, Evalue=2e-45,
Organism=Homo sapiens, GI18375501, Length=253, Percent_Identity=37.9446640316205, Blast_Score=179, Evalue=2e-45,
Organism=Escherichia coli, GI1788046, Length=267, Percent_Identity=30.7116104868914, Blast_Score=107, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71989536, Length=257, Percent_Identity=30.7392996108949, Blast_Score=139, Evalue=1e-33,
Organism=Drosophila melanogaster, GI221330655, Length=251, Percent_Identity=34.2629482071713, Blast_Score=147, Evalue=8e-36,
Organism=Drosophila melanogaster, GI17136678, Length=251, Percent_Identity=34.2629482071713, Blast_Score=146, Evalue=1e-35,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000097
- InterPro:   IPR020847
- InterPro:   IPR020848
- InterPro:   IPR005135
- InterPro:   IPR004808 [H]

Pfam domain/function: PF03372 Exo_endo_phos [H]

EC number: =3.1.11.2 [H]

Molecular weight: Translated: 29108; Mature: 29108

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRVITANLNGIRSAAKKGFFEWLGEQNADCVCVQEIKVSADDLPAEFVEPHGLRSYFHH
CEEEEEECCHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHCCCCHHHHHHHH
AQKKGYSGAGLYSRREPDDVIIGYGSSEFDAEGRYVEARFGKLSVVSVYVPSGSSGDERQ
HHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCEEEEECCCEEEEEEEECCCCCCCHHH
QAKYRFMDEFMPHLAELKAKREVILCGDVNIVHKEIDIKNWKSNQKNSGCLPEERAWLTK
HHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHH
LFDDVGYVDVFRTLDPRPEQYTWWSNRGQAYAKNVGWRIDYQIATPGVAGTAKNTSIFRD
HHHHCCHHHHHHHCCCCCCCEEEECCCCCEEHHCCCEEEEEEEECCCCCCCCCCCEEEEE
IKFSDHAPLTVDYDYK
CCCCCCCCEEEECCCC
>Mature Secondary Structure
MLRVITANLNGIRSAAKKGFFEWLGEQNADCVCVQEIKVSADDLPAEFVEPHGLRSYFHH
CEEEEEECCHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHCCCCHHHHHHHH
AQKKGYSGAGLYSRREPDDVIIGYGSSEFDAEGRYVEARFGKLSVVSVYVPSGSSGDERQ
HHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCEEEEECCCEEEEEEEECCCCCCCHHH
QAKYRFMDEFMPHLAELKAKREVILCGDVNIVHKEIDIKNWKSNQKNSGCLPEERAWLTK
HHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHH
LFDDVGYVDVFRTLDPRPEQYTWWSNRGQAYAKNVGWRIDYQIATPGVAGTAKNTSIFRD
HHHHCCHHHHHHHCCCCCCCEEEECCCCCEEHHCCCEEEEEEEECCCCCCCCCCCEEEEE
IKFSDHAPLTVDYDYK
CCCCCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]