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The map label for this gene is tauD [C]

Identifier: 126451902

GI number: 126451902

Start: 2527826

End: 2528704

Strand: Reverse

Name: tauD [C]

Synonym: BURPS1106A_2573

Alternate gene names: 126451902

Gene position: 2528704-2527826 (Counterclockwise)

Preceding gene: 126453344

Following gene: 126451545

Centisome position: 63.4

GC content: 69.4

Gene sequence:

>879_bases
ATGCAAACACTGGAGATTCGGCCGCTGAGCGGGACCATCGGCGCGCAGGTGCGCAACCGCACGCTCGCCGACGTCGTCGA
GAGCGGGCGCGCCGACGAGATCCGGCAGGCGCTGCTGCGATACAAGGTGCTGTTCTTCACGAACCAGCCGGAGCTGAGCG
TCGAGACCCAGATCGCGTTCGGCAGGCTGTTCGGCGAACTGGAGACGAATTTTCCGTCGTTTACCGCGAAGCCCGACGGC
CAGCCCGAGGTCACGGTGTTCGACGGCGCGGTGTCGACCGGCCGCGCGTCGATCTGGCATACGGACCTCAGCATCGCGAA
GACGCCGAGCGCGATGGGCATCCTGTGCGTGAAGGAGACGCCCGACAGCGGCGGCGACACGATGTGGGCCGACCTCGAGG
CCGCGTACGCGGCGTTGTCGCCGGGCATGCAGGCGTTTCTCGAAGGGCAGCGCGCGGTGCACGACATGATGACCCCGCAG
TACGCGCAGCGCCCCGGCGCGTTCCAGACGCGGGGCCGCTCCGACATGGACCTGTCCGAGGTGTTCGGCGCCGAGCATCC
GGTCGTGCGCGTGCATCCGGAGACGGGGCGCAAGTGCCTGTTCGTCAATCCGTTCCTCACGTCCCACCTCGTGGGCTTTC
ATTCGGCCGAGAGCGCGACGATCCTCAACTACCTGTACGCGCTGATGGAGCGGCCGCAGTACGTGGTGCGCTGGCACTGG
TCGCGCGGCGACGTCGCGCTCTGGGACAACCGCTGCACGATGCACACGGCCGTCGACGACTACGGCGCGGGGCGTCGCTT
CGCGCGGCGCGTGTGCGTGCGCGGGGACGTGCCCTACGGCGTCGGCGAACGCACGCCGGCCACGGCCGCCGTCGCGTGA

Upstream 100 bases:

>100_bases
CACTTCGAGTCCGCCGCCGCGAGCGGCGACGACGGGCGGGCGGATCGTTCGGCCGATCGCCCGGCCGACCACGCGGTTCA
TACGACAAGGAGCTGACGAG

Downstream 100 bases:

>100_bases
GGCGCGGGCGGCAGACACGCTCGCCGCGGATCGCCCGCGGCGGACCATTCAATTTAGCGCGAGTCCGATATGTCAAATCA
GTTGATTCAATCCGGCGTCG

Product: dioxygenase, TauD/TfdA

Products: Aminoacetaldehyde; CO2; H+; Sulfite; Succinate [C]

Alternate protein names: NA

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MQTLEIRPLSGTIGAQVRNRTLADVVESGRADEIRQALLRYKVLFFTNQPELSVETQIAFGRLFGELETNFPSFTAKPDG
QPEVTVFDGAVSTGRASIWHTDLSIAKTPSAMGILCVKETPDSGGDTMWADLEAAYAALSPGMQAFLEGQRAVHDMMTPQ
YAQRPGAFQTRGRSDMDLSEVFGAEHPVVRVHPETGRKCLFVNPFLTSHLVGFHSAESATILNYLYALMERPQYVVRWHW
SRGDVALWDNRCTMHTAVDDYGAGRRFARRVCVRGDVPYGVGERTPATAAVA

Sequences:

>Translated_292_residues
MQTLEIRPLSGTIGAQVRNRTLADVVESGRADEIRQALLRYKVLFFTNQPELSVETQIAFGRLFGELETNFPSFTAKPDG
QPEVTVFDGAVSTGRASIWHTDLSIAKTPSAMGILCVKETPDSGGDTMWADLEAAYAALSPGMQAFLEGQRAVHDMMTPQ
YAQRPGAFQTRGRSDMDLSEVFGAEHPVVRVHPETGRKCLFVNPFLTSHLVGFHSAESATILNYLYALMERPQYVVRWHW
SRGDVALWDNRCTMHTAVDDYGAGRRFARRVCVRGDVPYGVGERTPATAAVA
>Mature_292_residues
MQTLEIRPLSGTIGAQVRNRTLADVVESGRADEIRQALLRYKVLFFTNQPELSVETQIAFGRLFGELETNFPSFTAKPDG
QPEVTVFDGAVSTGRASIWHTDLSIAKTPSAMGILCVKETPDSGGDTMWADLEAAYAALSPGMQAFLEGQRAVHDMMTPQ
YAQRPGAFQTRGRSDMDLSEVFGAEHPVVRVHPETGRKCLFVNPFLTSHLVGFHSAESATILNYLYALMERPQYVVRWHW
SRGDVALWDNRCTMHTAVDDYGAGRRFARRVCVRGDVPYGVGERTPATAAVA

Specific function: Catalyzes The Conversion Of Taurine And Alpha Ketoglutarate To Sulfite, Aminoacetaldehyde And Succinate. Required For The Utilization Of Taurine (2-Aminoethanesulfonic Acid) As An Alternative Sulfur Source. Pentane-Sulfonic Acid, 3- (N-Morpholino)Propanes

COG id: COG2175

COG function: function code Q; Probable taurine catabolism dioxygenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tfdA dioxygenase family [H]

Homologues:

Organism=Escherichia coli, GI1786565, Length=281, Percent_Identity=35.5871886120996, Blast_Score=171, Evalue=7e-44,
Organism=Saccharomyces cerevisiae, GI6322971, Length=295, Percent_Identity=30.1694915254237, Blast_Score=125, Evalue=9e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003819 [H]

Pfam domain/function: PF02668 TauD [H]

EC number: 1.14.11.17 [C]

Molecular weight: Translated: 32271; Mature: 32271

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTLEIRPLSGTIGAQVRNRTLADVVESGRADEIRQALLRYKVLFFTNQPELSVETQIAF
CCCEEEEECCCCHHHHHHCCHHHHHHHCCCHHHHHHHHHHEEEEEEECCCCCEEEHHHHH
GRLFGELETNFPSFTAKPDGQPEVTVFDGAVSTGRASIWHTDLSIAKTPSAMGILCVKET
HHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEECCCCCCCCCCCEEEEEEECC
PDSGGDTMWADLEAAYAALSPGMQAFLEGQRAVHDMMTPQYAQRPGAFQTRGRSDMDLSE
CCCCCCCEEHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCHHH
VFGAEHPVVRVHPETGRKCLFVNPFLTSHLVGFHSAESATILNYLYALMERPQYVVRWHW
HCCCCCCEEEECCCCCCEEEEECHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEEEE
SRGDVALWDNRCTMHTAVDDYGAGRRFARRVCVRGDVPYGVGERTPATAAVA
CCCCEEEECCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQTLEIRPLSGTIGAQVRNRTLADVVESGRADEIRQALLRYKVLFFTNQPELSVETQIAF
CCCEEEEECCCCHHHHHHCCHHHHHHHCCCHHHHHHHHHHEEEEEEECCCCCEEEHHHHH
GRLFGELETNFPSFTAKPDGQPEVTVFDGAVSTGRASIWHTDLSIAKTPSAMGILCVKET
HHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEECCCCCCCCCCCEEEEEEECC
PDSGGDTMWADLEAAYAALSPGMQAFLEGQRAVHDMMTPQYAQRPGAFQTRGRSDMDLSE
CCCCCCCEEHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCHHH
VFGAEHPVVRVHPETGRKCLFVNPFLTSHLVGFHSAESATILNYLYALMERPQYVVRWHW
HCCCCCCEEEECCCCCCEEEEECHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEEEE
SRGDVALWDNRCTMHTAVDDYGAGRRFARRVCVRGDVPYGVGERTPATAAVA
CCCCEEEECCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Ascorbate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-Oxoglutarate; O2; Taurine [C]

Specific reaction: 2-Oxoglutarate + O2 + Taurine --> Aminoacetaldehyde + CO2 + H+ + Sulfite + Succinate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]