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The map label for this gene is kbl [C]

Identifier: 126447669

GI number: 126447669

Start: 4862

End: 6061

Strand: Direct

Name: kbl [C]

Synonym: BMA10247_A0006

Alternate gene names: 126447669

Gene position: 4862-6061 (Clockwise)

Preceding gene: 126447264

Following gene: 126445944

Centisome position: 0.21

GC content: 67.08

Gene sequence:

>1200_bases
ATGCGTGATGCCTATCTCGCTCATCTACGCGGCACCCTCGAGCAGATTCGCGCGGACGGTTTCTACAAGACCGAACGCGA
GATCGCGAGCCCTCAGGCGGCCGACATCCGGCTGGCCGGCGGCACGCACGTGCTGAATTTTTGCGCGAACAACTACCTGG
GGCTCGCGGACGATTCGCGCCTCATCGCCGCCGCACAGGCGGCGCTCGAGCAGGACGGGTTCGGGATGGCCTCGGTGCGC
TTCATCTGCGGCACGCAGACCGTGCACAAGCAGCTCGAGGCAGCGTTGTCCGCGTTCCTGAAGACCGACGATTGCATTCT
GTATTCGAGCTGCTTCGACGCGAACGGCGGCCTGTTCGAGACGCTGCTCGACGAAAACGACGCGATCATCAGCGACGAGC
TGAATCACGCGAGCATCATCGACGGCATTCGTCTGTCGAAGGCCAGGCGCTTTCGCTACAAGAACAACGACCTCGCCGAT
CTCGAGGCGAAGCTGCGCGAAGCCGACGCGGCGGGCGCGCGCTTCAAGCTGATCGCGACCGACGGCGTATTCTCGATGGA
CGGCATCATCGCGAACCTGAAGGGCGTGTGCGATCTGGCCGACCGCTACGGCGCGCTCGTGATGGTCGACGATTCGCACG
CCGTCGGCTTCATCGGCGAGCACGGGCGCGGCACCCCGGAGTATTGCGGCGTCGAGGGCCGCGTCGACATCGTCACGGGC
ACGCTCGGCAAGGCGCTGGGCGGCGCGTCGGGCGGTTACGTGGCCGCGCGGCGCGAGATCGTCGAGCTGCTGCGGCAGCG
CTCGCGCCCCTATCTGTTCTCGAACACGCTGACGCCGAGCATCGCGGCCGCATCGCTGAAAGTGCTCGAACTGCTCGCGA
GCGACGAGGGCGCGTGCCTGCGCGAGCGCGTGCGCGCGAACGGCGCGCATTTCCGCGAGAAGATGAGCGCGGCGGGCTTC
GCGCTCGTGCCGGGCGAGCATCCGATCATTCCGGTGATGCTCGGCGACGCGCAGGTCGCATCGAAGATGGCCGATGCGCT
GCTCGCCGAGGGCGTCTATGTGATCGGCTTTTCGTTTCCGGTCGTGCCGCGCGGCCGCGCGCGCATCCGCACGCAGATGA
GCGCCGCGCATACGCGCGAGCAGATCGATCGCGCGGTCGACGCGTTCGTGCGCGTCGGCAAGACGCTCGGCGTCATTTGA

Upstream 100 bases:

>100_bases
TGAACCCGACGGCCGACTATAACAGTAGCAAGCTGCCTTGCCGCCGCCACGAGCGCGGACGAGCGCCGAGCCTTGCAGCC
CATATCAGGAGCTTATTGCG

Downstream 100 bases:

>100_bases
CGGGAGTTCGCGATGAAAGCGCTGGCGAAACTCGAACGCGGGCCGGGCCTCACGCTCACCCGTGTGAAAAAGCCGGAGGT
CGGCCACAACGACGTCCTCA

Product: 2-amino-3-ketobutyrate coenzyme A ligase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MRDAYLAHLRGTLEQIRADGFYKTEREIASPQAADIRLAGGTHVLNFCANNYLGLADDSRLIAAAQAALEQDGFGMASVR
FICGTQTVHKQLEAALSAFLKTDDCILYSSCFDANGGLFETLLDENDAIISDELNHASIIDGIRLSKARRFRYKNNDLAD
LEAKLREADAAGARFKLIATDGVFSMDGIIANLKGVCDLADRYGALVMVDDSHAVGFIGEHGRGTPEYCGVEGRVDIVTG
TLGKALGGASGGYVAARREIVELLRQRSRPYLFSNTLTPSIAAASLKVLELLASDEGACLRERVRANGAHFREKMSAAGF
ALVPGEHPIIPVMLGDAQVASKMADALLAEGVYVIGFSFPVVPRGRARIRTQMSAAHTREQIDRAVDAFVRVGKTLGVI

Sequences:

>Translated_399_residues
MRDAYLAHLRGTLEQIRADGFYKTEREIASPQAADIRLAGGTHVLNFCANNYLGLADDSRLIAAAQAALEQDGFGMASVR
FICGTQTVHKQLEAALSAFLKTDDCILYSSCFDANGGLFETLLDENDAIISDELNHASIIDGIRLSKARRFRYKNNDLAD
LEAKLREADAAGARFKLIATDGVFSMDGIIANLKGVCDLADRYGALVMVDDSHAVGFIGEHGRGTPEYCGVEGRVDIVTG
TLGKALGGASGGYVAARREIVELLRQRSRPYLFSNTLTPSIAAASLKVLELLASDEGACLRERVRANGAHFREKMSAAGF
ALVPGEHPIIPVMLGDAQVASKMADALLAEGVYVIGFSFPVVPRGRARIRTQMSAAHTREQIDRAVDAFVRVGKTLGVI
>Mature_399_residues
MRDAYLAHLRGTLEQIRADGFYKTEREIASPQAADIRLAGGTHVLNFCANNYLGLADDSRLIAAAQAALEQDGFGMASVR
FICGTQTVHKQLEAALSAFLKTDDCILYSSCFDANGGLFETLLDENDAIISDELNHASIIDGIRLSKARRFRYKNNDLAD
LEAKLREADAAGARFKLIATDGVFSMDGIIANLKGVCDLADRYGALVMVDDSHAVGFIGEHGRGTPEYCGVEGRVDIVTG
TLGKALGGASGGYVAARREIVELLRQRSRPYLFSNTLTPSIAAASLKVLELLASDEGACLRERVRANGAHFREKMSAAGF
ALVPGEHPIIPVMLGDAQVASKMADALLAEGVYVIGFSFPVVPRGRARIRTQMSAAHTREQIDRAVDAFVRVGKTLGVI

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=392, Percent_Identity=56.1224489795918, Blast_Score=435, Evalue=1e-122,
Organism=Homo sapiens, GI284448556, Length=418, Percent_Identity=52.6315789473684, Blast_Score=426, Evalue=1e-119,
Organism=Homo sapiens, GI83977440, Length=355, Percent_Identity=35.4929577464789, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI83977444, Length=355, Percent_Identity=35.4929577464789, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI83977442, Length=355, Percent_Identity=35.4929577464789, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI4502025, Length=355, Percent_Identity=33.8028169014084, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI40316939, Length=355, Percent_Identity=33.8028169014084, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI119220554, Length=369, Percent_Identity=32.520325203252, Blast_Score=188, Evalue=6e-48,
Organism=Homo sapiens, GI4758668, Length=367, Percent_Identity=31.3351498637602, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI5454084, Length=287, Percent_Identity=29.9651567944251, Blast_Score=122, Evalue=8e-28,
Organism=Escherichia coli, GI1790046, Length=399, Percent_Identity=69.6741854636591, Blast_Score=564, Evalue=1e-162,
Organism=Escherichia coli, GI1786993, Length=346, Percent_Identity=32.9479768786127, Blast_Score=178, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI71994529, Length=395, Percent_Identity=55.4430379746835, Blast_Score=445, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI32566772, Length=373, Percent_Identity=29.7587131367292, Blast_Score=187, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI17560914, Length=366, Percent_Identity=31.6939890710383, Blast_Score=184, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17560912, Length=366, Percent_Identity=31.6939890710383, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI71982617, Length=392, Percent_Identity=25.5102040816327, Blast_Score=101, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI71982625, Length=392, Percent_Identity=25.5102040816327, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320438, Length=370, Percent_Identity=32.7027027027027, Blast_Score=209, Evalue=9e-55,
Organism=Saccharomyces cerevisiae, GI6320267, Length=370, Percent_Identity=30.2702702702703, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6323954, Length=268, Percent_Identity=28.3582089552239, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24662918, Length=399, Percent_Identity=55.8897243107769, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI17137420, Length=353, Percent_Identity=32.8611898016997, Blast_Score=203, Evalue=1e-52,
Organism=Drosophila melanogaster, GI17136286, Length=372, Percent_Identity=31.4516129032258, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24653280, Length=378, Percent_Identity=24.8677248677249, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24653276, Length=378, Percent_Identity=24.8677248677249, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24653278, Length=378, Percent_Identity=24.8677248677249, Blast_Score=102, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011282
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 42894; Mature: 42894

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDAYLAHLRGTLEQIRADGFYKTEREIASPQAADIRLAGGTHVLNFCANNYLGLADDSR
CCCHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCEEEECCCHHHHHHHHCCCCCCCCCCH
LIAAAQAALEQDGFGMASVRFICGTQTVHKQLEAALSAFLKTDDCILYSSCFDANGGLFE
HHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHH
TLLDENDAIISDELNHASIIDGIRLSKARRFRYKNNDLADLEAKLREADAAGARFKLIAT
HHHCCCCCEECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEEE
DGVFSMDGIIANLKGVCDLADRYGALVMVDDSHAVGFIGEHGRGTPEYCGVEGRVDIVTG
CCCEEHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEECCCCCCCCCCCCCCEEEEEEC
TLGKALGGASGGYVAARREIVELLRQRSRPYLFSNTLTPSIAAASLKVLELLASDEGACL
HHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCHHH
RERVRANGAHFREKMSAAGFALVPGEHPIIPVMLGDAQVASKMADALLAEGVYVIGFSFP
HHHHHCCCHHHHHHHHHCCEEECCCCCCEEEEEECCHHHHHHHHHHHHHCCEEEEEEECC
VVPRGRARIRTQMSAAHTREQIDRAVDAFVRVGKTLGVI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRDAYLAHLRGTLEQIRADGFYKTEREIASPQAADIRLAGGTHVLNFCANNYLGLADDSR
CCCHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCEEEECCCHHHHHHHHCCCCCCCCCCH
LIAAAQAALEQDGFGMASVRFICGTQTVHKQLEAALSAFLKTDDCILYSSCFDANGGLFE
HHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHH
TLLDENDAIISDELNHASIIDGIRLSKARRFRYKNNDLADLEAKLREADAAGARFKLIAT
HHHCCCCCEECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEEE
DGVFSMDGIIANLKGVCDLADRYGALVMVDDSHAVGFIGEHGRGTPEYCGVEGRVDIVTG
CCCEEHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEECCCCCCCCCCCCCCEEEEEEC
TLGKALGGASGGYVAARREIVELLRQRSRPYLFSNTLTPSIAAASLKVLELLASDEGACL
HHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCHHH
RERVRANGAHFREKMSAAGFALVPGEHPIIPVMLGDAQVASKMADALLAEGVYVIGFSFP
HHHHHCCCHHHHHHHHHCCEEECCCCCCEEEEEECCHHHHHHHHHHHHHCCEEEEEEECC
VVPRGRARIRTQMSAAHTREQIDRAVDAFVRVGKTLGVI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]