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The map label for this gene is tdh

Identifier: 126445944

GI number: 126445944

Start: 6074

End: 7105

Strand: Direct

Name: tdh

Synonym: BMA10247_A0007

Alternate gene names: 126445944

Gene position: 6074-7105 (Clockwise)

Preceding gene: 126447669

Following gene: 126447550

Centisome position: 0.26

GC content: 64.34

Gene sequence:

>1032_bases
ATGAAAGCGCTGGCGAAACTCGAACGCGGGCCGGGCCTCACGCTCACCCGTGTGAAAAAGCCGGAGGTCGGCCACAACGA
CGTCCTCATCAAGATCCGCCGCACCGCAATCTGCGGCACCGACATCCATATCTGGAAGTGGGACGACTGGGCGCAGAAGA
CGATTCCGGTGCCGATGCACGTCGGCCACGAGTACGTCGGCGAGATCGTCGAGATGGGCCAGGAAGTGCGCGGCTTCTCG
ATCGGCGATCGCGTATCCGGCGAAGGCCACATCACGTGCGGCTTCTGTCGGAACTGCCGCGCGGGGCGGCGCCATTTGTG
CCGCAACACGGTGGGCGTCGGCGTGAATCGCGAAGGCGCGTTCGCCGAGTACCTCGCGATTCCCGCGTTCAACGCGTTCA
AGATTCCGCCCGAGATCTCCGACGATCTCGCCGCGATCTTCGATCCGTTCGGCAACGCGACGCACACCGCGCTGTCGTTC
AACCTCGTCGGCGAGGACGTGCTGATCACGGGTGCGGGGCCGATCGGCGTGATGGCGGTGGCGATCGCGAAGCACGTCGG
CGCGCGCAACGTCGTCATCACCGACATCAACGACTATCGCCTCGAACTCGCGCGCAAGATGGGCGCGACACGCGCGGTGA
ACGTGTCGCGCGAATCGCTGCGCGACGTGATGGCCGACCTGCACATGACGGAGGGCTTCGACGTCGGGCTCGAGATGTCC
GGCGTGCCGAGCGCGTTCACGTCGCTGCTCGAATCGATGAATCACGGCGGCAAGGTCGCGCTGCTCGGCATTCCGCCCGC
GCAGACCGCGATCGACTGGAACCAGGTGATCTTCAAGGGCCTCGAGATCAAGGGCATCTATGGGCGCGAGATGTTCGAGA
CGTGGTACAAGATGGTCGCGATGCTGCAAAGCGGGCTCGATCTTTCGCCGATCATCACGCACCGCTTCGCCGTGGACGAC
TACGAGAAAGGTTTCGCTGCGATGCTGTCGGGCGAAAGCGGCAAGGTGATTCTCGACTGGGCCGACGCGTGA

Upstream 100 bases:

>100_bases
GCAGATGAGCGCCGCGCATACGCGCGAGCAGATCGATCGCGCGGTCGACGCGTTCGTGCGCGTCGGCAAGACGCTCGGCG
TCATTTGACGGGAGTTCGCG

Downstream 100 bases:

>100_bases
CGTCGGGCGTGCGATCCGGCGCAATGCCGGGTTGTACGTCACACGTTGCGATACGGACTGCGAACGTTCAACCGCCATCC
GCATCGCATACGGCACAGCC

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MKALAKLERGPGLTLTRVKKPEVGHNDVLIKIRRTAICGTDIHIWKWDDWAQKTIPVPMHVGHEYVGEIVEMGQEVRGFS
IGDRVSGEGHITCGFCRNCRAGRRHLCRNTVGVGVNREGAFAEYLAIPAFNAFKIPPEISDDLAAIFDPFGNATHTALSF
NLVGEDVLITGAGPIGVMAVAIAKHVGARNVVITDINDYRLELARKMGATRAVNVSRESLRDVMADLHMTEGFDVGLEMS
GVPSAFTSLLESMNHGGKVALLGIPPAQTAIDWNQVIFKGLEIKGIYGREMFETWYKMVAMLQSGLDLSPIITHRFAVDD
YEKGFAAMLSGESGKVILDWADA

Sequences:

>Translated_343_residues
MKALAKLERGPGLTLTRVKKPEVGHNDVLIKIRRTAICGTDIHIWKWDDWAQKTIPVPMHVGHEYVGEIVEMGQEVRGFS
IGDRVSGEGHITCGFCRNCRAGRRHLCRNTVGVGVNREGAFAEYLAIPAFNAFKIPPEISDDLAAIFDPFGNATHTALSF
NLVGEDVLITGAGPIGVMAVAIAKHVGARNVVITDINDYRLELARKMGATRAVNVSRESLRDVMADLHMTEGFDVGLEMS
GVPSAFTSLLESMNHGGKVALLGIPPAQTAIDWNQVIFKGLEIKGIYGREMFETWYKMVAMLQSGLDLSPIITHRFAVDD
YEKGFAAMLSGESGKVILDWADA
>Mature_343_residues
MKALAKLERGPGLTLTRVKKPEVGHNDVLIKIRRTAICGTDIHIWKWDDWAQKTIPVPMHVGHEYVGEIVEMGQEVRGFS
IGDRVSGEGHITCGFCRNCRAGRRHLCRNTVGVGVNREGAFAEYLAIPAFNAFKIPPEISDDLAAIFDPFGNATHTALSF
NLVGEDVLITGAGPIGVMAVAIAKHVGARNVVITDINDYRLELARKMGATRAVNVSRESLRDVMADLHMTEGFDVGLEMS
GVPSAFTSLLESMNHGGKVALLGIPPAQTAIDWNQVIFKGLEIKGIYGREMFETWYKMVAMLQSGLDLSPIITHRFAVDD
YEKGFAAMLSGESGKVILDWADA

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family

Homologues:

Organism=Homo sapiens, GI156627571, Length=341, Percent_Identity=27.2727272727273, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI4501929, Length=348, Percent_Identity=24.7126436781609, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI34577061, Length=346, Percent_Identity=25.4335260115607, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI71743840, Length=348, Percent_Identity=26.7241379310345, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI262073058, Length=348, Percent_Identity=26.7241379310345, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI156523966, Length=352, Percent_Identity=26.1363636363636, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI4501939, Length=346, Percent_Identity=26.0115606936416, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI71565154, Length=379, Percent_Identity=24.2744063324538, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI1790045, Length=340, Percent_Identity=77.0588235294118, Blast_Score=566, Evalue=1e-163,
Organism=Escherichia coli, GI1788075, Length=370, Percent_Identity=30.5405405405405, Blast_Score=147, Evalue=9e-37,
Organism=Escherichia coli, GI87082125, Length=355, Percent_Identity=31.5492957746479, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1788073, Length=332, Percent_Identity=26.8072289156627, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1787863, Length=323, Percent_Identity=28.7925696594427, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI226510992, Length=250, Percent_Identity=32, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1788407, Length=333, Percent_Identity=27.9279279279279, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1786825, Length=382, Percent_Identity=27.4869109947644, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI87081918, Length=267, Percent_Identity=30.3370786516854, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1790718, Length=308, Percent_Identity=25.3246753246753, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI1786552, Length=380, Percent_Identity=27.6315789473684, Blast_Score=98, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17562876, Length=334, Percent_Identity=30.2395209580838, Blast_Score=164, Evalue=9e-41,
Organism=Caenorhabditis elegans, GI17562878, Length=341, Percent_Identity=30.4985337243402, Blast_Score=144, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI71988145, Length=200, Percent_Identity=32, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17562584, Length=297, Percent_Identity=28.6195286195286, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17562582, Length=284, Percent_Identity=27.112676056338, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI25146526, Length=371, Percent_Identity=25.3369272237197, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71997431, Length=357, Percent_Identity=25.4901960784314, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17565904, Length=340, Percent_Identity=24.1176470588235, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323099, Length=327, Percent_Identity=29.6636085626911, Blast_Score=132, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6322619, Length=322, Percent_Identity=27.639751552795, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6319955, Length=322, Percent_Identity=27.3291925465839, Blast_Score=125, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6319258, Length=372, Percent_Identity=25.5376344086022, Blast_Score=113, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6319257, Length=294, Percent_Identity=27.2108843537415, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6319621, Length=340, Percent_Identity=28.5294117647059, Blast_Score=93, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6320033, Length=352, Percent_Identity=26.1363636363636, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6324486, Length=304, Percent_Identity=31.25, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=320, Percent_Identity=29.375, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323729, Length=301, Percent_Identity=28.2392026578073, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319949, Length=342, Percent_Identity=26.3157894736842, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323980, Length=275, Percent_Identity=28.7272727272727, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17737897, Length=330, Percent_Identity=26.0606060606061, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17137530, Length=322, Percent_Identity=25.776397515528, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI17737895, Length=353, Percent_Identity=28.0453257790368, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI221457811, Length=182, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45551930, Length=182, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45550770, Length=182, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TDH_BURM7 (A3MAC8)

Other databases:

- EMBL:   CP000547
- RefSeq:   YP_001077214.1
- ProteinModelPortal:   A3MAC8
- SMR:   A3MAC8
- GeneID:   4890740
- GenomeReviews:   CP000547_GR
- KEGG:   bmn:BMA10247_A0007
- TIGR:   BMA10247_A0007
- HOGENOM:   HBG753318
- OMA:   MVDAPKP
- ProtClustDB:   PRK05396
- BioCyc:   BMAL320389:BMA10247_A0007-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00627
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR11695
- TIGRFAMs:   TIGR00692

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N; SSF50129 GroES_like

EC number: =1.1.1.103

Molecular weight: Translated: 37462; Mature: 37462

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALAKLERGPGLTLTRVKKPEVGHNDVLIKIRRTAICGTDIHIWKWDDWAQKTIPVPMH
CCHHHHHHCCCCCEEEEECCCCCCCCCEEEEEEEEEEECCCEEEEECCCHHHCCCCCCHH
VGHEYVGEIVEMGQEVRGFSIGDRVSGEGHITCGFCRNCRAGRRHLCRNTVGVGVNREGA
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEHHHHCCHHHHHHHHHHHHCCCCCCCCC
FAEYLAIPAFNAFKIPPEISDDLAAIFDPFGNATHTALSFNLVGEDVLITGAGPIGVMAV
HHHHHCCCCCCCEECCCCCCHHHHHHHCCCCCCEEEEEEEEEECCEEEEECCCHHHHHHH
AIAKHVGARNVVITDINDYRLELARKMGATRAVNVSRESLRDVMADLHMTEGFDVGLEMS
HHHHHCCCCEEEEECCHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHCCCCCCCCEECC
GVPSAFTSLLESMNHGGKVALLGIPPAQTAIDWNQVIFKGLEIKGIYGREMFETWYKMVA
CCCHHHHHHHHHHCCCCEEEEEECCCCCHHCCHHHHHHCCCEEEEECCHHHHHHHHHHHH
MLQSGLDLSPIITHRFAVDDYEKGFAAMLSGESGKVILDWADA
HHHCCCCCCHHHHHEEECCCHHCCCEEEECCCCCEEEEEECCC
>Mature Secondary Structure
MKALAKLERGPGLTLTRVKKPEVGHNDVLIKIRRTAICGTDIHIWKWDDWAQKTIPVPMH
CCHHHHHHCCCCCEEEEECCCCCCCCCEEEEEEEEEEECCCEEEEECCCHHHCCCCCCHH
VGHEYVGEIVEMGQEVRGFSIGDRVSGEGHITCGFCRNCRAGRRHLCRNTVGVGVNREGA
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEHHHHCCHHHHHHHHHHHHCCCCCCCCC
FAEYLAIPAFNAFKIPPEISDDLAAIFDPFGNATHTALSFNLVGEDVLITGAGPIGVMAV
HHHHHCCCCCCCEECCCCCCHHHHHHHCCCCCCEEEEEEEEEECCEEEEECCCHHHHHHH
AIAKHVGARNVVITDINDYRLELARKMGATRAVNVSRESLRDVMADLHMTEGFDVGLEMS
HHHHHCCCCEEEEECCHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHCCCCCCCCEECC
GVPSAFTSLLESMNHGGKVALLGIPPAQTAIDWNQVIFKGLEIKGIYGREMFETWYKMVA
CCCHHHHHHHHHHCCCCEEEEEECCCCCHHCCHHHHHHCCCEEEEECCHHHHHHHHHHHH
MLQSGLDLSPIITHRFAVDDYEKGFAAMLSGESGKVILDWADA
HHHCCCCCCHHHHHEEECCCHHCCCEEEECCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA