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The map label for this gene is mltA [H]

Identifier: 126447439

GI number: 126447439

Start: 1838260

End: 1839537

Strand: Reverse

Name: mltA [H]

Synonym: BMA10247_A1906

Alternate gene names: 126447439

Gene position: 1839537-1838260 (Counterclockwise)

Preceding gene: 126446754

Following gene: 262192876

Centisome position: 78.19

GC content: 68.78

Gene sequence:

>1278_bases
TTGTCGTGCCGGCTGGGCTGCTTCTTCTTGCCCGAAGCCGTCCAGACGACGATGAAGACGAGCAGGGCGAGCGCCAGCAA
CGATTCCAGCGCGAAGATGAGCATCGGGTATTGGTCGAGCAGATCGGACATGGCGGTTTCCATCAACAACGGACATTGTA
TGGGTTTTAGCCGGCGGCTTGCCGGGTGGGCGGCGGCTGTCGCGGCCGCGGCGCTTCTCGCCGCATGTGTCGGCTCGCCG
GTGCGGCAGGGGGCACGGCCCGCGGGTGCCGCGATCGTACCAGGACAGATCGCGGCGGCGCGACTCACGCCCGTCGCGTG
GCAGCAGGTGCCCGGCTGGCAGGACGACAGCCTGATCGGCGCGACGATCGCGCTGCGCCAGAACTGCGCGCGCCTCGCGC
GGCAGGCGAACTGGCAGCGCGCGTGCGCGGCCGCCATGCGGCTCGACGATCTCGATGTCGGCAGCGCCCGCACCTTCTTC
GAAACGTACTTCACGCCGTTCCAGTTCGCGAACAACGACGGCACGCTCGACGGCCTCGTGACGGGTTATTACGAGCCGCT
GCTGCACGGCTCGCGCGTGCGTCGCGGCCCGTATCAGTACGCGCTCTACCGCTGGCCGGCCGGCTACCGCGCGGGCGCGT
CGATGCCGGCGCGCGCGCAGCTCATGCGCTCGGGCGCGCTGAGCGGCAACGAGCTCGTTTGGGTCGACGATCCGATCGAA
GCGTTCTTTCTGCAGGTGCAGGGTTCCGGCCGCGTCGTTCTCGACGACGGCACGGTGATGCGCGTCGGCTACGGCGGCAC
GAACAACCAGCCGTACCGCTCGATCGGCAAGTGGCTGCTCGATCATGGCGAACTCGGCGCCGGGCAGGCGACGATGCAGG
GAATCAAGGCATGGGCGCGCGCGAATCCGTCGCGGGTCGACGCGCTGCTCGACACGAATCCGCGTTTCGTGTTCTTCCGT
GAGATGCCTTCACAGGAGGACGTGCCGCACGGCGGCGCGGACGGGCCGGTCGGCGCGCTCGGCGTGCCGCTCACGCCGGA
GCGCTCGATTGCGGTCGACCCTTCGTCGATCCCGCTCGGCACGCCGGTGTTCCTGCAGACGACGCGCCCGATGACGAATG
CGCCGCTCAATCGCCTCGTGTTCGCGCAGGATGTCGGAACGGCGATCAAGGGCGGCGTGCGGGCCGACTATTTCTGGGGG
CTCGGCGACGACGCGGGCGATCAGGCGGGGCGGATGAAGCAGAACGGACGGATGTGGCTGCTGTTTCCGAATTCGTGA

Upstream 100 bases:

>100_bases
CGTCGACGAATTCGCGCTGCACATGCCGCGCACGCTGCACTGAGCGCGGCGTCGCGGGGGTGCGGGGCGCGGAGGATAGG
GGCGCTGTCAGCGCTGGGGC

Downstream 100 bases:

>100_bases
TCCTGTGATCTCGTGATCGCGGCCGTGTGCGCGCGCGGCGAGCGTCAGGAGCCCTGCCCGCGGGCGTGATTGCATGAGCG
TTGTGTTTGAGTGGCAGACT

Product: putative membrane-bound lytic murein transglycosylase A

Products: Muramic Acid Residue [C]

Alternate protein names: Mlt38; Murein hydrolase A [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MSCRLGCFFLPEAVQTTMKTSRASASNDSSAKMSIGYWSSRSDMAVSINNGHCMGFSRRLAGWAAAVAAAALLAACVGSP
VRQGARPAGAAIVPGQIAAARLTPVAWQQVPGWQDDSLIGATIALRQNCARLARQANWQRACAAAMRLDDLDVGSARTFF
ETYFTPFQFANNDGTLDGLVTGYYEPLLHGSRVRRGPYQYALYRWPAGYRAGASMPARAQLMRSGALSGNELVWVDDPIE
AFFLQVQGSGRVVLDDGTVMRVGYGGTNNQPYRSIGKWLLDHGELGAGQATMQGIKAWARANPSRVDALLDTNPRFVFFR
EMPSQEDVPHGGADGPVGALGVPLTPERSIAVDPSSIPLGTPVFLQTTRPMTNAPLNRLVFAQDVGTAIKGGVRADYFWG
LGDDAGDQAGRMKQNGRMWLLFPNS

Sequences:

>Translated_425_residues
MSCRLGCFFLPEAVQTTMKTSRASASNDSSAKMSIGYWSSRSDMAVSINNGHCMGFSRRLAGWAAAVAAAALLAACVGSP
VRQGARPAGAAIVPGQIAAARLTPVAWQQVPGWQDDSLIGATIALRQNCARLARQANWQRACAAAMRLDDLDVGSARTFF
ETYFTPFQFANNDGTLDGLVTGYYEPLLHGSRVRRGPYQYALYRWPAGYRAGASMPARAQLMRSGALSGNELVWVDDPIE
AFFLQVQGSGRVVLDDGTVMRVGYGGTNNQPYRSIGKWLLDHGELGAGQATMQGIKAWARANPSRVDALLDTNPRFVFFR
EMPSQEDVPHGGADGPVGALGVPLTPERSIAVDPSSIPLGTPVFLQTTRPMTNAPLNRLVFAQDVGTAIKGGVRADYFWG
LGDDAGDQAGRMKQNGRMWLLFPNS
>Mature_424_residues
SCRLGCFFLPEAVQTTMKTSRASASNDSSAKMSIGYWSSRSDMAVSINNGHCMGFSRRLAGWAAAVAAAALLAACVGSPV
RQGARPAGAAIVPGQIAAARLTPVAWQQVPGWQDDSLIGATIALRQNCARLARQANWQRACAAAMRLDDLDVGSARTFFE
TYFTPFQFANNDGTLDGLVTGYYEPLLHGSRVRRGPYQYALYRWPAGYRAGASMPARAQLMRSGALSGNELVWVDDPIEA
FFLQVQGSGRVVLDDGTVMRVGYGGTNNQPYRSIGKWLLDHGELGAGQATMQGIKAWARANPSRVDALLDTNPRFVFFRE
MPSQEDVPHGGADGPVGALGVPLTPERSIAVDPSSIPLGTPVFLQTTRPMTNAPLNRLVFAQDVGTAIKGGVRADYFWGL
GDDAGDQAGRMKQNGRMWLLFPNS

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=372, Percent_Identity=31.7204301075269, Blast_Score=136, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 45684; Mature: 45553

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSCRLGCFFLPEAVQTTMKTSRASASNDSSAKMSIGYWSSRSDMAVSINNGHCMGFSRRL
CCCCEEEEECCHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEEEECCCEEECHHHHH
AGWAAAVAAAALLAACVGSPVRQGARPAGAAIVPGQIAAARLTPVAWQQVPGWQDDSLIG
HHHHHHHHHHHHHHHHHCCHHHHCCCCCCCEECCCCHHHHHCCCHHHHHCCCCCCCCHHH
ATIALRQNCARLARQANWQRACAAAMRLDDLDVGSARTFFETYFTPFQFANNDGTLDGLV
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCCEEEECCCCCCHHHH
TGYYEPLLHGSRVRRGPYQYALYRWPAGYRAGASMPARAQLMRSGALSGNELVWVDDPIE
HHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCE
AFFLQVQGSGRVVLDDGTVMRVGYGGTNNQPYRSIGKWLLDHGELGAGQATMQGIKAWAR
EEEEEECCCCEEEEECCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
ANPSRVDALLDTNPRFVFFREMPSQEDVPHGGADGPVGALGVPLTPERSIAVDPSSIPLG
CCHHHHHHEECCCCCEEEEECCCCCCCCCCCCCCCCCCEECCCCCCCCCEEECCCCCCCC
TPVFLQTTRPMTNAPLNRLVFAQDVGTAIKGGVRADYFWGLGDDAGDQAGRMKQNGRMWL
CCEEEEECCCCCCCCHHHEEEHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHCCCCEEE
LFPNS
EECCC
>Mature Secondary Structure 
SCRLGCFFLPEAVQTTMKTSRASASNDSSAKMSIGYWSSRSDMAVSINNGHCMGFSRRL
CCCEEEEECCHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEEEECCCEEECHHHHH
AGWAAAVAAAALLAACVGSPVRQGARPAGAAIVPGQIAAARLTPVAWQQVPGWQDDSLIG
HHHHHHHHHHHHHHHHHCCHHHHCCCCCCCEECCCCHHHHHCCCHHHHHCCCCCCCCHHH
ATIALRQNCARLARQANWQRACAAAMRLDDLDVGSARTFFETYFTPFQFANNDGTLDGLV
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCCEEEECCCCCCHHHH
TGYYEPLLHGSRVRRGPYQYALYRWPAGYRAGASMPARAQLMRSGALSGNELVWVDDPIE
HHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCE
AFFLQVQGSGRVVLDDGTVMRVGYGGTNNQPYRSIGKWLLDHGELGAGQATMQGIKAWAR
EEEEEECCCCEEEEECCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
ANPSRVDALLDTNPRFVFFREMPSQEDVPHGGADGPVGALGVPLTPERSIAVDPSSIPLG
CCHHHHHHEECCCCCEEEEECCCCCCCCCCCCCCCCCCEECCCCCCCCCEEECCCCCCCC
TPVFLQTTRPMTNAPLNRLVFAQDVGTAIKGGVRADYFWGLGDDAGDQAGRMKQNGRMWL
CCEEEEECCCCCCCCHHHEEEHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHCCCCEEE
LFPNS
EECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]