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The map label for this gene is rspB [H]

Identifier: 126447385

GI number: 126447385

Start: 1588328

End: 1589359

Strand: Direct

Name: rspB [H]

Synonym: BMA10247_A1649

Alternate gene names: 126447385

Gene position: 1588328-1589359 (Clockwise)

Preceding gene: 126447832

Following gene: 126447101

Centisome position: 67.51

GC content: 69.67

Gene sequence:

>1032_bases
ATGCTGAGCGTCGTCGTCGACCAGCCGCATAGCATGGGCGTGCGCGAAATGCCCACGCCCGAGCCCGCCGCGGGCGAAGT
GCGCGTGCGCGTGCGCTATGCGGGCATCTGCGGATCGGATCTGCACATCTTCCACGGCAAGAACCCGTTCGTCTCGTATC
CGCGCGTCATCGGGCACGAGTTCGTCGGGCGAATCGAATCGGTCGGCGCGGGCGTCGACGCGTCGCGCATCGGCGAGATC
GTCGCAGTCGACCCGGTCATCAGTTGCGGGCGCTGCCACGCATGCGCGATCGGCCGGCGCAACGTGTGCCGCAGCCTGAC
CGTGCTCGGCGTGCATCGCGACGGCGGCTTCAGCGAGTACGCCTGCGTGCCCGCCGCGAACGCCCACCGGATTGCGCCCG
AGATCGCCGACACGTGCGCTGCGATCGTCGAGCCGTTCGCGGTCGCCGCGAACGCGACCGCGCGCACCGGCGTGCTGCCG
TCCGACGTCGCGCTGATCTACGGCGCGGGCACCGTCGGCCTCACGCTGCTGCAAGTGCTCAAGCACGTCTACGGCATTCG
CGCGTTCATCGCCGATCGCCTCGACGAGCGTCTCGCGCTCGCGCGCAAGTGCGGCGCGGCGGCCGACGAAGTCATCCACG
CGGCGACGGAAACGGTGCCGGACGCGCTCGAGCGACGCGGCGTCGACGGCGGCCCGACGCTGATCTTCGACGCGGTGTGC
CATCCGTCGATCCTCGAGGAGGCGGTGCGGCTCGCGGCGCCCGCCGCGCGCATCGGTGTGCTCGGCTTCTCGTCGGAGCC
GTCGTCGATCGTGCAGGCCGAGCTGACGAAGAAGGAATTGACGCTGTGCGCGTCGCGCCTGAACTGCGCGATGTTCCCGC
AGGTCATCGAATGGATCGCCGACGGGCGCGTGCATCCGGAGCACATCGTCACGCACACGCTCGATTTTCGCGATGTCGCG
CGCGCGTTCGAGCTCGCCGAGCGCAACCCGCGCGAAAGCTGCAAGATCCTGCTGGATTTCGCCGCGCATTGA

Upstream 100 bases:

>100_bases
CGCCTACCTGCCCGTCGCCCGCCTGCGCGACGGCTCGATGTGGAACTGGTGATCGCGCGCCGCCCCACCGTCTAGACGAA
ACACGAAGGAGAATCAGGAC

Downstream 100 bases:

>100_bases
CCGACGGGAGGCGGGCGGCGGCGCTCGGCGCGGCGCGCCGGATGCCGCTTCGAGGTGGATTCCGATGCGCACCGGATGCC
TGCCGGATGCGCGGGCCGGC

Product: putative dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MLSVVVDQPHSMGVREMPTPEPAAGEVRVRVRYAGICGSDLHIFHGKNPFVSYPRVIGHEFVGRIESVGAGVDASRIGEI
VAVDPVISCGRCHACAIGRRNVCRSLTVLGVHRDGGFSEYACVPAANAHRIAPEIADTCAAIVEPFAVAANATARTGVLP
SDVALIYGAGTVGLTLLQVLKHVYGIRAFIADRLDERLALARKCGAAADEVIHAATETVPDALERRGVDGGPTLIFDAVC
HPSILEEAVRLAAPAARIGVLGFSSEPSSIVQAELTKKELTLCASRLNCAMFPQVIEWIADGRVHPEHIVTHTLDFRDVA
RAFELAERNPRESCKILLDFAAH

Sequences:

>Translated_343_residues
MLSVVVDQPHSMGVREMPTPEPAAGEVRVRVRYAGICGSDLHIFHGKNPFVSYPRVIGHEFVGRIESVGAGVDASRIGEI
VAVDPVISCGRCHACAIGRRNVCRSLTVLGVHRDGGFSEYACVPAANAHRIAPEIADTCAAIVEPFAVAANATARTGVLP
SDVALIYGAGTVGLTLLQVLKHVYGIRAFIADRLDERLALARKCGAAADEVIHAATETVPDALERRGVDGGPTLIFDAVC
HPSILEEAVRLAAPAARIGVLGFSSEPSSIVQAELTKKELTLCASRLNCAMFPQVIEWIADGRVHPEHIVTHTLDFRDVA
RAFELAERNPRESCKILLDFAAH
>Mature_343_residues
MLSVVVDQPHSMGVREMPTPEPAAGEVRVRVRYAGICGSDLHIFHGKNPFVSYPRVIGHEFVGRIESVGAGVDASRIGEI
VAVDPVISCGRCHACAIGRRNVCRSLTVLGVHRDGGFSEYACVPAANAHRIAPEIADTCAAIVEPFAVAANATARTGVLP
SDVALIYGAGTVGLTLLQVLKHVYGIRAFIADRLDERLALARKCGAAADEVIHAATETVPDALERRGVDGGPTLIFDAVC
HPSILEEAVRLAAPAARIGVLGFSSEPSSIVQAELTKKELTLCASRLNCAMFPQVIEWIADGRVHPEHIVTHTLDFRDVA
RAFELAERNPRESCKILLDFAAH

Specific function: Not known; probable catabolic enzyme [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=335, Percent_Identity=26.865671641791, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI71565154, Length=349, Percent_Identity=23.4957020057307, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI71743840, Length=373, Percent_Identity=24.3967828418231, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI262073058, Length=373, Percent_Identity=24.3967828418231, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI156523966, Length=360, Percent_Identity=24.4444444444444, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI4501939, Length=349, Percent_Identity=24.3553008595989, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI4501929, Length=359, Percent_Identity=22.2841225626741, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4501933, Length=261, Percent_Identity=26.4367816091954, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI34577061, Length=371, Percent_Identity=22.911051212938, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1787863, Length=342, Percent_Identity=52.6315789473684, Blast_Score=377, Evalue=1e-106,
Organism=Escherichia coli, GI226510992, Length=347, Percent_Identity=31.1239193083574, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1788073, Length=339, Percent_Identity=29.4985250737463, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1790045, Length=332, Percent_Identity=28.9156626506024, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1788407, Length=340, Percent_Identity=30.2941176470588, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1790718, Length=322, Percent_Identity=25.776397515528, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1786825, Length=396, Percent_Identity=26.7676767676768, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87082125, Length=352, Percent_Identity=24.1477272727273, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788075, Length=331, Percent_Identity=24.1691842900302, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI87081918, Length=312, Percent_Identity=26.6025641025641, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1786552, Length=342, Percent_Identity=25.7309941520468, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1786518, Length=88, Percent_Identity=37.5, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI87082401, Length=97, Percent_Identity=36.0824742268041, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=339, Percent_Identity=27.4336283185841, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17562878, Length=211, Percent_Identity=31.7535545023697, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI71988145, Length=160, Percent_Identity=32.5, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17562584, Length=339, Percent_Identity=23.0088495575221, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562582, Length=153, Percent_Identity=32.6797385620915, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI25146526, Length=368, Percent_Identity=22.2826086956522, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71997431, Length=370, Percent_Identity=22.1621621621622, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6323099, Length=349, Percent_Identity=22.9226361031519, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6322619, Length=348, Percent_Identity=22.1264367816092, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319955, Length=348, Percent_Identity=21.8390804597701, Blast_Score=93, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6319621, Length=171, Percent_Identity=32.7485380116959, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6319257, Length=362, Percent_Identity=26.5193370165746, Blast_Score=89, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6323729, Length=250, Percent_Identity=28, Blast_Score=89, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6319258, Length=219, Percent_Identity=30.5936073059361, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320033, Length=358, Percent_Identity=25.4189944134078, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324486, Length=125, Percent_Identity=34.4, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323961, Length=150, Percent_Identity=30.6666666666667, Blast_Score=79, Evalue=8e-16,
Organism=Drosophila melanogaster, GI17137530, Length=351, Percent_Identity=26.4957264957265, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI17737897, Length=360, Percent_Identity=26.3888888888889, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI221457811, Length=328, Percent_Identity=24.0853658536585, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI45550770, Length=328, Percent_Identity=24.0853658536585, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI45551930, Length=328, Percent_Identity=24.0853658536585, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI17737895, Length=364, Percent_Identity=21.7032967032967, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 36641; Mature: 36641

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSVVVDQPHSMGVREMPTPEPAAGEVRVRVRYAGICGSDLHIFHGKNPFVSYPRVIGHE
CCEEEECCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCEEEEECCCCCCCCHHHHHHH
FVGRIESVGAGVDASRIGEIVAVDPVISCGRCHACAIGRRNVCRSLTVLGVHRDGGFSEY
HHHHHHHHCCCCCHHHCCCEEEECCHHCCCCCHHHHCCHHHHHHHEEEEEEECCCCCCCE
ACVPAANAHRIAPEIADTCAAIVEPFAVAANATARTGVLPSDVALIYGAGTVGLTLLQVL
EECCCCCCHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECHHHHHHHHHHH
KHVYGIRAFIADRLDERLALARKCGAAADEVIHAATETVPDALERRGVDGGPTLIFDAVC
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHC
HPSILEEAVRLAAPAARIGVLGFSSEPSSIVQAELTKKELTLCASRLNCAMFPQVIEWIA
CHHHHHHHHHHHCCHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DGRVHPEHIVTHTLDFRDVARAFELAERNPRESCKILLDFAAH
CCCCCHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MLSVVVDQPHSMGVREMPTPEPAAGEVRVRVRYAGICGSDLHIFHGKNPFVSYPRVIGHE
CCEEEECCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCEEEEECCCCCCCCHHHHHHH
FVGRIESVGAGVDASRIGEIVAVDPVISCGRCHACAIGRRNVCRSLTVLGVHRDGGFSEY
HHHHHHHHCCCCCHHHCCCEEEECCHHCCCCCHHHHCCHHHHHHHEEEEEEECCCCCCCE
ACVPAANAHRIAPEIADTCAAIVEPFAVAANATARTGVLPSDVALIYGAGTVGLTLLQVL
EECCCCCCHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECHHHHHHHHHHH
KHVYGIRAFIADRLDERLALARKCGAAADEVIHAATETVPDALERRGVDGGPTLIFDAVC
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHC
HPSILEEAVRLAAPAARIGVLGFSSEPSSIVQAELTKKELTLCASRLNCAMFPQVIEWIA
CHHHHHHHHHHHCCHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DGRVHPEHIVTHTLDFRDVARAFELAERNPRESCKILLDFAAH
CCCCCHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7545940; 9097039; 9278503 [H]