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The map label for this gene is tcpE [H]

Identifier: 126446654

GI number: 126446654

Start: 613138

End: 614214

Strand: Direct

Name: tcpE [H]

Synonym: BMA10247_A0662

Alternate gene names: 126446654

Gene position: 613138-614214 (Clockwise)

Preceding gene: 126447382

Following gene: 126447519

Centisome position: 26.06

GC content: 69.08

Gene sequence:

>1077_bases
ATGGCACTTGAGCTGAACCGCCGCTGGGCGAAGCTCTGCCTGAACGCCGACGAGCGGCTGCGCGTCTACCGGAAGATCGC
GAAGATGCTCGGCAACGGGCTGCCGTTGCTGAAGGTGCTCGAGGAGCTCGAGTGGCGTGCGTCGCGCGAAGGCCGCAAGC
CGCGCGAGCCGCTCGCGATCGTGCTGTCCGACTGGCGCCTCGCGGTGCAGAACGGCGGGATGCTGTCCGAGGCGATGGAC
GCGTGGGTGCCCGCCACCGAGCAGATGATCGTCGCGGCGGGCGAGCAGGCCGGGCGCATCGAGGACGCGCTCGCGTCGGT
GGCCGACATCGTGCAGTCGAGCCGCAAGATCCGCCGCGCCGTCACGGGCGGCGTCGCGTATCCGGTCGGGCTCGTCGTGA
TGGTGATCGGCTATCTGTACCTGTTCGGCACGCACGTGATCCCGAAATTCGCGCTGATCGCCGATCCGGCGCACTGGCGC
GGCGCCGCGCGCTCGCTGTATCTGATGTCGCTGTTCGTGCAGGGCTGGATGCTCGTCGTCGTCGCGGCGCTCGCGGCGGC
GCTCGTCGCGCTCGCGTGGTCGCTGCCGCGCTGGCGCGGGCCGCTGCGCATCTACGCGGACCGCGTGCCGCCTTATTCGA
TCTACCGGCTCATCGCGGGCAGCGGCTTTCTGATCGCGTTCTCGGCGCTGCAGGCGTCGGGCGTCACCGTCGAGAAGGCG
CTGCTGAAGATCGGCTCGGTCGCGGGGCCGTGGCTGCGCGAGCGAATCGACGACACGCTCGTCGGCGTGAAGTCGGGCCT
GAACGCCGGCGAGGCGCTGCTCAACGCCGGCTATCAGTTTCCGTCGCGCGAGATCGTCGAGGATCTGTGCATCTATGCCG
AATACGGCGGCTTCGACGCCGCGCTCAAGATGCTCGCCGACGAATGGCTCGAGGAGGGCGTCGCGCGGATCACCGCGCAG
ATGCGCGTGCTCAACGGCGTCGCGATCGTCGTGCTCGCGCTGCTGATCGGCTGGCTCGTGACGGGCTTCTTCGGCATCCA
GCAGGAAATCGCCGCAATGACGCGCGCGATGCATTGA

Upstream 100 bases:

>100_bases
GCGGGGCTCGTCGATCCGCGCGGCGTCGAGCGCGTGGTCGGCGCGCTCGCGCCGGTGACGGGCGACGCGCGACAGCAGCT
GTCGCTCGTCGGATTCAGCT

Downstream 100 bases:

>100_bases
CGTCGCGCATTTTCAATTCAGGAGAAACCAGCATGAAACCACTCGCCGCCCATCCCGCCTATCGACACGAGCCGGCGTTC
TGCCGGCGCCACCGCCGCGA

Product: type IV pilus biogenesis protein

Products: NA

Alternate protein names: TCP pilus biosynthesis protein tcpE [H]

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MALELNRRWAKLCLNADERLRVYRKIAKMLGNGLPLLKVLEELEWRASREGRKPREPLAIVLSDWRLAVQNGGMLSEAMD
AWVPATEQMIVAAGEQAGRIEDALASVADIVQSSRKIRRAVTGGVAYPVGLVVMVIGYLYLFGTHVIPKFALIADPAHWR
GAARSLYLMSLFVQGWMLVVVAALAAALVALAWSLPRWRGPLRIYADRVPPYSIYRLIAGSGFLIAFSALQASGVTVEKA
LLKIGSVAGPWLRERIDDTLVGVKSGLNAGEALLNAGYQFPSREIVEDLCIYAEYGGFDAALKMLADEWLEEGVARITAQ
MRVLNGVAIVVLALLIGWLVTGFFGIQQEIAAMTRAMH

Sequences:

>Translated_358_residues
MALELNRRWAKLCLNADERLRVYRKIAKMLGNGLPLLKVLEELEWRASREGRKPREPLAIVLSDWRLAVQNGGMLSEAMD
AWVPATEQMIVAAGEQAGRIEDALASVADIVQSSRKIRRAVTGGVAYPVGLVVMVIGYLYLFGTHVIPKFALIADPAHWR
GAARSLYLMSLFVQGWMLVVVAALAAALVALAWSLPRWRGPLRIYADRVPPYSIYRLIAGSGFLIAFSALQASGVTVEKA
LLKIGSVAGPWLRERIDDTLVGVKSGLNAGEALLNAGYQFPSREIVEDLCIYAEYGGFDAALKMLADEWLEEGVARITAQ
MRVLNGVAIVVLALLIGWLVTGFFGIQQEIAAMTRAMH
>Mature_357_residues
ALELNRRWAKLCLNADERLRVYRKIAKMLGNGLPLLKVLEELEWRASREGRKPREPLAIVLSDWRLAVQNGGMLSEAMDA
WVPATEQMIVAAGEQAGRIEDALASVADIVQSSRKIRRAVTGGVAYPVGLVVMVIGYLYLFGTHVIPKFALIADPAHWRG
AARSLYLMSLFVQGWMLVVVAALAAALVALAWSLPRWRGPLRIYADRVPPYSIYRLIAGSGFLIAFSALQASGVTVEKAL
LKIGSVAGPWLRERIDDTLVGVKSGLNAGEALLNAGYQFPSREIVEDLCIYAEYGGFDAALKMLADEWLEEGVARITAQM
RVLNGVAIVVLALLIGWLVTGFFGIQQEIAAMTRAMH

Specific function: Probably involved in cholera toxin receptor (GM1) interaction in order to bring the cells within close proximity of the ganglioside for efficient toxin delivery [H]

COG id: COG1459

COG function: function code NU; Type II secretory pathway, component PulF

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GSP F family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018076
- InterPro:   IPR001992 [H]

Pfam domain/function: PF00482 GSPII_F [H]

EC number: NA

Molecular weight: Translated: 39229; Mature: 39098

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALELNRRWAKLCLNADERLRVYRKIAKMLGNGLPLLKVLEELEWRASREGRKPREPLAI
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHH
VLSDWRLAVQNGGMLSEAMDAWVPATEQMIVAAGEQAGRIEDALASVADIVQSSRKIRRA
HHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VTGGVAYPVGLVVMVIGYLYLFGTHVIPKFALIADPAHWRGAARSLYLMSLFVQGWMLVV
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
VAALAAALVALAWSLPRWRGPLRIYADRVPPYSIYRLIAGSGFLIAFSALQASGVTVEKA
HHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHCCCHHHHHHHHHHCCCHHHHH
LLKIGSVAGPWLRERIDDTLVGVKSGLNAGEALLNAGYQFPSREIVEDLCIYAEYGGFDA
HHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHH
ALKMLADEWLEEGVARITAQMRVLNGVAIVVLALLIGWLVTGFFGIQQEIAAMTRAMH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ALELNRRWAKLCLNADERLRVYRKIAKMLGNGLPLLKVLEELEWRASREGRKPREPLAI
CCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHH
VLSDWRLAVQNGGMLSEAMDAWVPATEQMIVAAGEQAGRIEDALASVADIVQSSRKIRRA
HHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VTGGVAYPVGLVVMVIGYLYLFGTHVIPKFALIADPAHWRGAARSLYLMSLFVQGWMLVV
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
VAALAAALVALAWSLPRWRGPLRIYADRVPPYSIYRLIAGSGFLIAFSALQASGVTVEKA
HHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHCCCHHHHHHHHHHCCCHHHHH
LLKIGSVAGPWLRERIDDTLVGVKSGLNAGEALLNAGYQFPSREIVEDLCIYAEYGGFDA
HHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHH
ALKMLADEWLEEGVARITAQMRVLNGVAIVVLALLIGWLVTGFFGIQQEIAAMTRAMH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11179381 [H]