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The map label for this gene is accC [H]

Identifier: 126445266

GI number: 126445266

Start: 330511

End: 331956

Strand: Reverse

Name: accC [H]

Synonym: BURPS668_A0364

Alternate gene names: 126445266

Gene position: 331956-330511 (Counterclockwise)

Preceding gene: 126443114

Following gene: 126445025

Centisome position: 10.61

GC content: 71.78

Gene sequence:

>1446_bases
ATGAACGACCTCGATTCGACCCACGCTTCGTTTTACCGGCCGTCCCGGATCGGCACGGTGCTCGTCGCCAATCGCGGCGA
GATCGCGGTGCGCGTGATTCGCGCCGCGCACGAGCTCGGGATGCGCGCGGTCGCCGCGGTCAGCGACGCGGACCGCGACA
GCCTCGCCGCGCGGATGGCCGACGAAGCGGTGCACATCGGCCCGTCGCACGCGGCGAAGAGCTATCTGGATCCGGCCGCG
ATGCTCGCCGCCGCGCGGCAATGCGGCGCCGACGCGATTCATCCGGGCTACGGCTTTCTGTCGGAGAACGCGGACTTCGC
CGCGCAGGTCGAAGCCGCCGGCCTGATCTTCGTCGGTCCGCCCGCGCGCGTGATCGCGACGATGGGCGACAAGGCCCGCG
CGCGCGAAACCGCGCGGCGCGCCGGCGTGCCGACGGTGCCGGGCAGCGAAGGCGTCGTCGCGTCGCTCGACGGCGCGCGC
GAGGTGGCCGCGCGCATCGGCTACCCGGTGATGATCAAGGCGGCCGCGGGCGGCGGCGGGCGCGGTATCCGCGTCGCGCA
CGACGCCGCGCAGCTCGCCGCGCAGCTACCGCTCGCGCAGCGCGAGGCACAGGCCGCGTTCGGCGACGGCGGCGTCTATC
TCGAACGCTTCATCGCGCGCGCGCGGCACATCGAAGTGCAGATCCTGGGCGACGGCGAGAACGTTATTCATCTGTTCGAA
CGCGAATGCTCGCTGCAGCGGCGGCGCCAGAAGATTCTCGAGGAAGCGCCGTCTCCGTCGCTCACGCCCGCGCTGCGCGA
TGCGCTGTGCGCATCGGCGACGCGTCTCGCGCGGCAGGTAGGCTATCGCGGCGCGGGCACGCTCGAGTATCTGTTCGACG
ACGCGCGCGGCGAGTTCTACTTCATCGAGATGAACACGCGCATCCAGGTCGAGCATCCGGTGACGGAGGCGATCACGGGC
GTCGATCTCGTGCGCGAGATGCTGCGCATCGCGGACGGCGAGCCGCTGCGCTTCGCGCAGGGCGACATCGCGCTGCACGG
CGCCGCGCTCGAATGCCGGATCAACGCGGAAGACCCGCTGCAGGATTTCCGGCCCAACCCCGGCCGCATCGATGCGCTCG
TCTGGCCCGCGGGCCCCGGCGTTCGAATCGATTCGCTGCTCTATCCGGGCTACACGGTGCCGCCGTTCTACGATTCGCTG
CTCGCGAAGCTGATCGTGCACGACGAAAGCCGGCCGGCCGCGCTCGCGCGCGCGGCGCGCGCGCTGCGCGAGCTGCGCAT
CGACGGCGTGAAGACCACCGCGCCGCTGCATCGCGCGCTGCTCGACGACGCCGACGTGCGCGCGGGCCGCTATCACACGA
ACTATCTGGAGGCCTGGATGCGCGACTGGCTCGCGCGGCTCGACGCCCGCGCGAGCGCGCCGCGTGGCCTGGGAGAGGCA
GCATGA

Upstream 100 bases:

>100_bases
TCGAGACGGCGGCCGCGGGCCGCGTCGTCGAGATTCTGGTCGACGACGGCGAGCCCGTCGACGCGGGCCAGGTGCTGATG
CGCACGGAGGAGTGAGCGCG

Downstream 100 bases:

>100_bases
CGATCCGATACACATTCGGCGGCGACGAGTTCATCTTCGTCGAGATCAGCGAATCGATGTCGCTCGACGCGTTCTTCAAG
GGCACCGCGATCACGCGCGA

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A 1; ACC 1 [H]

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MNDLDSTHASFYRPSRIGTVLVANRGEIAVRVIRAAHELGMRAVAAVSDADRDSLAARMADEAVHIGPSHAAKSYLDPAA
MLAAARQCGADAIHPGYGFLSENADFAAQVEAAGLIFVGPPARVIATMGDKARARETARRAGVPTVPGSEGVVASLDGAR
EVAARIGYPVMIKAAAGGGGRGIRVAHDAAQLAAQLPLAQREAQAAFGDGGVYLERFIARARHIEVQILGDGENVIHLFE
RECSLQRRRQKILEEAPSPSLTPALRDALCASATRLARQVGYRGAGTLEYLFDDARGEFYFIEMNTRIQVEHPVTEAITG
VDLVREMLRIADGEPLRFAQGDIALHGAALECRINAEDPLQDFRPNPGRIDALVWPAGPGVRIDSLLYPGYTVPPFYDSL
LAKLIVHDESRPAALARAARALRELRIDGVKTTAPLHRALLDDADVRAGRYHTNYLEAWMRDWLARLDARASAPRGLGEA
A

Sequences:

>Translated_481_residues
MNDLDSTHASFYRPSRIGTVLVANRGEIAVRVIRAAHELGMRAVAAVSDADRDSLAARMADEAVHIGPSHAAKSYLDPAA
MLAAARQCGADAIHPGYGFLSENADFAAQVEAAGLIFVGPPARVIATMGDKARARETARRAGVPTVPGSEGVVASLDGAR
EVAARIGYPVMIKAAAGGGGRGIRVAHDAAQLAAQLPLAQREAQAAFGDGGVYLERFIARARHIEVQILGDGENVIHLFE
RECSLQRRRQKILEEAPSPSLTPALRDALCASATRLARQVGYRGAGTLEYLFDDARGEFYFIEMNTRIQVEHPVTEAITG
VDLVREMLRIADGEPLRFAQGDIALHGAALECRINAEDPLQDFRPNPGRIDALVWPAGPGVRIDSLLYPGYTVPPFYDSL
LAKLIVHDESRPAALARAARALRELRIDGVKTTAPLHRALLDDADVRAGRYHTNYLEAWMRDWLARLDARASAPRGLGEA
A
>Mature_481_residues
MNDLDSTHASFYRPSRIGTVLVANRGEIAVRVIRAAHELGMRAVAAVSDADRDSLAARMADEAVHIGPSHAAKSYLDPAA
MLAAARQCGADAIHPGYGFLSENADFAAQVEAAGLIFVGPPARVIATMGDKARARETARRAGVPTVPGSEGVVASLDGAR
EVAARIGYPVMIKAAAGGGGRGIRVAHDAAQLAAQLPLAQREAQAAFGDGGVYLERFIARARHIEVQILGDGENVIHLFE
RECSLQRRRQKILEEAPSPSLTPALRDALCASATRLARQVGYRGAGTLEYLFDDARGEFYFIEMNTRIQVEHPVTEAITG
VDLVREMLRIADGEPLRFAQGDIALHGAALECRINAEDPLQDFRPNPGRIDALVWPAGPGVRIDSLLYPGYTVPPFYDSL
LAKLIVHDESRPAALARAARALRELRIDGVKTTAPLHRALLDDADVRAGRYHTNYLEAWMRDWLARLDARASAPRGLGEA
A

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=440, Percent_Identity=47.7272727272727, Blast_Score=388, Evalue=1e-108,
Organism=Homo sapiens, GI65506442, Length=440, Percent_Identity=47.7272727272727, Blast_Score=388, Evalue=1e-108,
Organism=Homo sapiens, GI295821183, Length=440, Percent_Identity=47.7272727272727, Blast_Score=388, Evalue=1e-108,
Organism=Homo sapiens, GI116805327, Length=468, Percent_Identity=44.8717948717949, Blast_Score=386, Evalue=1e-107,
Organism=Homo sapiens, GI106049528, Length=452, Percent_Identity=45.7964601769911, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI106049295, Length=452, Percent_Identity=45.7964601769911, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI106049292, Length=452, Percent_Identity=45.7964601769911, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI38679974, Length=503, Percent_Identity=32.0079522862823, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI38679977, Length=503, Percent_Identity=32.0079522862823, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI38679967, Length=503, Percent_Identity=32.0079522862823, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI38679960, Length=503, Percent_Identity=32.0079522862823, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI38679971, Length=503, Percent_Identity=32.0079522862823, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI134142062, Length=521, Percent_Identity=31.4779270633397, Blast_Score=211, Evalue=1e-54,
Organism=Escherichia coli, GI1789654, Length=443, Percent_Identity=52.8216704288939, Blast_Score=451, Evalue=1e-128,
Organism=Escherichia coli, GI1786216, Length=244, Percent_Identity=24.5901639344262, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17567343, Length=448, Percent_Identity=46.6517857142857, Blast_Score=384, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI71987519, Length=468, Percent_Identity=45.7264957264957, Blast_Score=380, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17562816, Length=448, Percent_Identity=46.6517857142857, Blast_Score=370, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI71997168, Length=511, Percent_Identity=29.7455968688845, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71997163, Length=511, Percent_Identity=29.7455968688845, Blast_Score=199, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI133931226, Length=486, Percent_Identity=29.0123456790123, Blast_Score=194, Evalue=6e-50,
Organism=Saccharomyces cerevisiae, GI6319685, Length=442, Percent_Identity=43.2126696832579, Blast_Score=375, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6319695, Length=446, Percent_Identity=45.067264573991, Blast_Score=355, Evalue=1e-98,
Organism=Saccharomyces cerevisiae, GI6321376, Length=446, Percent_Identity=44.8430493273543, Blast_Score=347, Evalue=3e-96,
Organism=Saccharomyces cerevisiae, GI6324343, Length=510, Percent_Identity=30.5882352941176, Blast_Score=210, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6323863, Length=464, Percent_Identity=31.4655172413793, Blast_Score=208, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24652212, Length=452, Percent_Identity=46.4601769911504, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652210, Length=452, Percent_Identity=46.4601769911504, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652214, Length=452, Percent_Identity=46.4601769911504, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI19921944, Length=452, Percent_Identity=46.4601769911504, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652216, Length=452, Percent_Identity=46.4601769911504, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI281363050, Length=452, Percent_Identity=46.4601769911504, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652224, Length=452, Percent_Identity=46.4601769911504, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652222, Length=452, Percent_Identity=46.4601769911504, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652220, Length=452, Percent_Identity=46.4601769911504, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652218, Length=452, Percent_Identity=46.4601769911504, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24651757, Length=443, Percent_Identity=42.8893905191874, Blast_Score=353, Evalue=1e-97,
Organism=Drosophila melanogaster, GI24651759, Length=405, Percent_Identity=41.4814814814815, Blast_Score=310, Evalue=1e-84,
Organism=Drosophila melanogaster, GI24586458, Length=502, Percent_Identity=31.0756972111554, Blast_Score=211, Evalue=9e-55,
Organism=Drosophila melanogaster, GI161076409, Length=502, Percent_Identity=31.0756972111554, Blast_Score=211, Evalue=1e-54,
Organism=Drosophila melanogaster, GI161076407, Length=502, Percent_Identity=31.0756972111554, Blast_Score=211, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24586460, Length=502, Percent_Identity=31.0756972111554, Blast_Score=211, Evalue=1e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 51783; Mature: 51783

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDLDSTHASFYRPSRIGTVLVANRGEIAVRVIRAAHELGMRAVAAVSDADRDSLAARMA
CCCCCCCHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
DEAVHIGPSHAAKSYLDPAAMLAAARQCGADAIHPGYGFLSENADFAAQVEAAGLIFVGP
HHHEECCCHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCEEEECC
PARVIATMGDKARARETARRAGVPTVPGSEGVVASLDGAREVAARIGYPVMIKAAAGGGG
CHHHEEECCCHHHHHHHHHHCCCCCCCCCCCCEEECCHHHHHHHHCCCCEEEEEECCCCC
RGIRVAHDAAQLAAQLPLAQREAQAAFGDGGVYLERFIARARHIEVQILGDGENVIHLFE
CCEEEHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEEEECCCHHHHHHH
RECSLQRRRQKILEEAPSPSLTPALRDALCASATRLARQVGYRGAGTLEYLFDDARGEFY
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCEE
FIEMNTRIQVEHPVTEAITGVDLVREMLRIADGEPLRFAQGDIALHGAALECRINAEDPL
EEEECCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEECEEEEEEECCCCCH
QDFRPNPGRIDALVWPAGPGVRIDSLLYPGYTVPPFYDSLLAKLIVHDESRPAALARAAR
HHCCCCCCCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHH
ALRELRIDGVKTTAPLHRALLDDADVRAGRYHTNYLEAWMRDWLARLDARASAPRGLGEA
HHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
A
C
>Mature Secondary Structure
MNDLDSTHASFYRPSRIGTVLVANRGEIAVRVIRAAHELGMRAVAAVSDADRDSLAARMA
CCCCCCCHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
DEAVHIGPSHAAKSYLDPAAMLAAARQCGADAIHPGYGFLSENADFAAQVEAAGLIFVGP
HHHEECCCHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCEEEECC
PARVIATMGDKARARETARRAGVPTVPGSEGVVASLDGAREVAARIGYPVMIKAAAGGGG
CHHHEEECCCHHHHHHHHHHCCCCCCCCCCCCEEECCHHHHHHHHCCCCEEEEEECCCCC
RGIRVAHDAAQLAAQLPLAQREAQAAFGDGGVYLERFIARARHIEVQILGDGENVIHLFE
CCEEEHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEEEECCCHHHHHHH
RECSLQRRRQKILEEAPSPSLTPALRDALCASATRLARQVGYRGAGTLEYLFDDARGEFY
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCEE
FIEMNTRIQVEHPVTEAITGVDLVREMLRIADGEPLRFAQGDIALHGAALECRINAEDPL
EEEECCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEECEEEEEEECCCCCH
QDFRPNPGRIDALVWPAGPGVRIDSLLYPGYTVPPFYDSLLAKLIVHDESRPAALARAAR
HHCCCCCCCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHH
ALRELRIDGVKTTAPLHRALLDDADVRAGRYHTNYLEAWMRDWLARLDARASAPRGLGEA
HHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7592499; 8969508; 9384377 [H]