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The map label for this gene is kipI [H]

Identifier: 126445025

GI number: 126445025

Start: 329639

End: 330514

Strand: Reverse

Name: kipI [H]

Synonym: BURPS668_A0363

Alternate gene names: 126445025

Gene position: 330514-329639 (Counterclockwise)

Preceding gene: 126445266

Following gene: 126443806

Centisome position: 10.57

GC content: 65.18

Gene sequence:

>876_bases
ATGACGATCCGATACACATTCGGCGGCGACGAGTTCATCTTCGTCGAGATCAGCGAATCGATGTCGCTCGACGCGTTCTT
CAAGGGCACCGCGATCACGCGCGAGCTGCGGCGGCGCAACGTGCCGGGCGTCACCGAGATCTGCCCGGCGAATGCGTCCT
ATCAGGTTCGCTACGATCCCGACGTGATCGAGCCGGACACGCTGCTCGCGCTGCTGAAGACGATCGAGGCCGAAGTCGGC
GAAGCGGCGCTGAACATCGATACGCGCATCGTCGAGGTGCCCGTGCTCTACAACGATCCGTGGACGCACGAAACGCTGAT
GCGCTTTCGCGAGCGGCATCAGGCGCCCGAATCCACCGATCTCGAATACGCGGCGCGCGTCAACGGCAAGCGCGATATCG
ACGAGTTCATCGCCGCGCACGCGGGCTCGCCGTGGTTCGTGTCGATGGTCGGCTTCGTCGCCGGGCTGCCGTTCATGTAT
CAGATGGTCGAGCGCGAGCGGCAGCTCCAGGTGCCGAAATACCTGCGCCCGCGCACCGACACGCCGAAGCTCACCGTCGG
CCACGGCGGCTGCTTCGGCTGCATCTATTCGGTGCGCGGCGCGGGCGGCTATCAGATGTTCGGCGTGACGCCCGCGCCGA
TCTTCGATCCCGCGCAGCGGCTCGATTACCTGCGCGATTTCATGGTGTTCTTCCGCCCCGGCGACATCGTGAAGTTCAAG
CCGATCGATCGCGCCGAATACGACGCGGCCGTCGCCGCCGTCGAAGCCGGCACGTTCACGCTGCGCGTGAAGCCGGTTCG
GTTCGCGCTCGAGGCGTTCCTGCGCGATCCGCACGCGTACAACCGTTCTCTCGTCGAGGTGCTGGATGCCAACTGA

Upstream 100 bases:

>100_bases
CGGGCCGCTATCACACGAACTATCTGGAGGCCTGGATGCGCGACTGGCTCGCGCGGCTCGACGCCCGCGCGAGCGCGCCG
CGTGGCCTGGGAGAGGCAGC

Downstream 100 bases:

>100_bases
TACGCTCAACGCGATCGAGGTCGTGAAGCCGGGCCTCGCGACGTCCGTGCAGGACGCCGGCCGCCACGGCTACTATCACG
TCGGCATCCCGCCGTCCGGC

Product: allophanate hydrolase subunit 1

Products: NA

Alternate protein names: Sporulation inhibitor kipI [H]

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MTIRYTFGGDEFIFVEISESMSLDAFFKGTAITRELRRRNVPGVTEICPANASYQVRYDPDVIEPDTLLALLKTIEAEVG
EAALNIDTRIVEVPVLYNDPWTHETLMRFRERHQAPESTDLEYAARVNGKRDIDEFIAAHAGSPWFVSMVGFVAGLPFMY
QMVERERQLQVPKYLRPRTDTPKLTVGHGGCFGCIYSVRGAGGYQMFGVTPAPIFDPAQRLDYLRDFMVFFRPGDIVKFK
PIDRAEYDAAVAAVEAGTFTLRVKPVRFALEAFLRDPHAYNRSLVEVLDAN

Sequences:

>Translated_291_residues
MTIRYTFGGDEFIFVEISESMSLDAFFKGTAITRELRRRNVPGVTEICPANASYQVRYDPDVIEPDTLLALLKTIEAEVG
EAALNIDTRIVEVPVLYNDPWTHETLMRFRERHQAPESTDLEYAARVNGKRDIDEFIAAHAGSPWFVSMVGFVAGLPFMY
QMVERERQLQVPKYLRPRTDTPKLTVGHGGCFGCIYSVRGAGGYQMFGVTPAPIFDPAQRLDYLRDFMVFFRPGDIVKFK
PIDRAEYDAAVAAVEAGTFTLRVKPVRFALEAFLRDPHAYNRSLVEVLDAN
>Mature_290_residues
TIRYTFGGDEFIFVEISESMSLDAFFKGTAITRELRRRNVPGVTEICPANASYQVRYDPDVIEPDTLLALLKTIEAEVGE
AALNIDTRIVEVPVLYNDPWTHETLMRFRERHQAPESTDLEYAARVNGKRDIDEFIAAHAGSPWFVSMVGFVAGLPFMYQ
MVERERQLQVPKYLRPRTDTPKLTVGHGGCFGCIYSVRGAGGYQMFGVTPAPIFDPAQRLDYLRDFMVFFRPGDIVKFKP
IDRAEYDAAVAAVEAGTFTLRVKPVRFALEAFLRDPHAYNRSLVEVLDAN

Specific function: Is a potent inhibitor of the autophosphorylation reaction of kinase A and its reverse reaction, but does not inhibit phosphate transfer to the Spo0F response regulator once kinase A is phosphorylated. KipI is an inhibitor of the catalytic domain of kinase

COG id: COG2049

COG function: function code E; Allophanate hydrolase subunit 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786929, Length=206, Percent_Identity=27.6699029126214, Blast_Score=69, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319685, Length=287, Percent_Identity=23.6933797909408, Blast_Score=79, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003833
- InterPro:   IPR020899
- InterPro:   IPR010016
- InterPro:   IPR002130 [H]

Pfam domain/function: PF02682 AHS1 [H]

EC number: NA

Molecular weight: Translated: 32934; Mature: 32803

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIRYTFGGDEFIFVEISESMSLDAFFKGTAITRELRRRNVPGVTEICPANASYQVRYDP
CEEEEEECCCEEEEEEECCCCCCHHHHCCHHHHHHHHHCCCCCHHHCCCCCCCEEEEECC
DVIEPDTLLALLKTIEAEVGEAALNIDTRIVEVPVLYNDPWTHETLMRFRERHQAPESTD
CCCCHHHHHHHHHHHHHHHCHHHEECCEEEEEEEEEECCCCCHHHHHHHHHHHCCCCCCC
LEYAARVNGKRDIDEFIAAHAGSPWFVSMVGFVAGLPFMYQMVERERQLQVPKYLRPRTD
CHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHCCCCC
TPKLTVGHGGCFGCIYSVRGAGGYQMFGVTPAPIFDPAQRLDYLRDFMVFFRPGDIVKFK
CCEEEECCCCHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEC
PIDRAEYDAAVAAVEAGTFTLRVKPVRFALEAFLRDPHAYNRSLVEVLDAN
CCCCHHHHHHHEEEECCEEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
TIRYTFGGDEFIFVEISESMSLDAFFKGTAITRELRRRNVPGVTEICPANASYQVRYDP
EEEEEECCCEEEEEEECCCCCCHHHHCCHHHHHHHHHCCCCCHHHCCCCCCCEEEEECC
DVIEPDTLLALLKTIEAEVGEAALNIDTRIVEVPVLYNDPWTHETLMRFRERHQAPESTD
CCCCHHHHHHHHHHHHHHHCHHHEECCEEEEEEEEEECCCCCHHHHHHHHHHHCCCCCCC
LEYAARVNGKRDIDEFIAAHAGSPWFVSMVGFVAGLPFMYQMVERERQLQVPKYLRPRTD
CHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHCCCCC
TPKLTVGHGGCFGCIYSVRGAGGYQMFGVTPAPIFDPAQRLDYLRDFMVFFRPGDIVKFK
CCEEEECCCCHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEC
PIDRAEYDAAVAAVEAGTFTLRVKPVRFALEAFLRDPHAYNRSLVEVLDAN
CCCCHHHHHHHEEEECCEEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 10568751 [H]