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The map label for this gene is yvaG [H]

Identifier: 126445246

GI number: 126445246

Start: 1028414

End: 1029208

Strand: Reverse

Name: yvaG [H]

Synonym: BURPS668_A1069

Alternate gene names: 126445246

Gene position: 1029208-1028414 (Counterclockwise)

Preceding gene: 126444581

Following gene: 126442724

Centisome position: 32.91

GC content: 69.06

Gene sequence:

>795_bases
ATGCACATCGACCTCACCGGCAAGACCGCCCTCGTGACCGCCTCGACCGCCGGCATCGGCCTCGCGATCGCCGAGGGACT
CGCGCGCGCCGGCGCGCAGTTGTTCATCAACGGCCGCAGCGACGCGTCCGTCAAGGCGGCGCTCGCGCACCTGCGCGTCA
CCGCGCCCGGCGCGCACGCGCAAGGCGTCGTCGCCGATCTGTCGGACGCTGACGGCGCGCGGCGCGTGATCGACGCCGCG
CCGTCGGCCGACATCCTCGTCAACAACGCGGGCATCTACGGCCCGAAGCCGTTCTTCGACATCGACGACGCCGAATGGGA
ACATTTCTTCCAGGTGAACGTGATGTCGGGCGTGCGGCTCGCGCGCCATTATCTGAAGGGGATGCTCGAGCGCGACTGGG
GGCGCGTCGTCTTCATCTCGTCGGAATCGGCGCTCAATGTCCCGGCCGACATGATCCATTACGGCTTCACGAAAACCGCG
CAATTGTCGATCTCGCGCGGGCTCGCCAAGCTCGCGGCCGGCAGCCGCGTGACGGTGAACGCGGTGCTGCCCGGCCCGAC
GATGTCCGACGGCGTGAAGGCGATGCTCAAGGCGACGGCCGACGCCGAACACACGAGCATCGAGCAGGCGGGCGTCGATT
TCGTGCGCACGCACCGCTCGAGCTCGATCATCCAGCGGCCGGCGACTTGCGACGAAGTCGCGAACCTCGTCGTCTACGTG
TGCTCGCCGCAGGCGTCGGCGACGACGGGCGCGGCGTTGCGCGTCGACGGCGGCGTCGTAGACACGATCGCCTGA

Upstream 100 bases:

>100_bases
CTCGCCCGACTGCCGACTTCGCGGCTTTCGTCTAAGCTAGTCGCTCGCGTCCGCCGCCGCCGCGCGGCGGATCGTTCTCT
CCTTTTTGCGGAGTCTGCCC

Downstream 100 bases:

>100_bases
CGAACCGAACGGCCGGCGCGTTCGGCGCCGGCTCATCCCGCCTGGCTCGAACGAGCCACAAGAGCCGCAAGGGCCGCAAG
GGCCGCAAGGGCCTCAAGAA

Product: D-beta-hydroxybutyrate dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MHIDLTGKTALVTASTAGIGLAIAEGLARAGAQLFINGRSDASVKAALAHLRVTAPGAHAQGVVADLSDADGARRVIDAA
PSADILVNNAGIYGPKPFFDIDDAEWEHFFQVNVMSGVRLARHYLKGMLERDWGRVVFISSESALNVPADMIHYGFTKTA
QLSISRGLAKLAAGSRVTVNAVLPGPTMSDGVKAMLKATADAEHTSIEQAGVDFVRTHRSSSIIQRPATCDEVANLVVYV
CSPQASATTGAALRVDGGVVDTIA

Sequences:

>Translated_264_residues
MHIDLTGKTALVTASTAGIGLAIAEGLARAGAQLFINGRSDASVKAALAHLRVTAPGAHAQGVVADLSDADGARRVIDAA
PSADILVNNAGIYGPKPFFDIDDAEWEHFFQVNVMSGVRLARHYLKGMLERDWGRVVFISSESALNVPADMIHYGFTKTA
QLSISRGLAKLAAGSRVTVNAVLPGPTMSDGVKAMLKATADAEHTSIEQAGVDFVRTHRSSSIIQRPATCDEVANLVVYV
CSPQASATTGAALRVDGGVVDTIA
>Mature_264_residues
MHIDLTGKTALVTASTAGIGLAIAEGLARAGAQLFINGRSDASVKAALAHLRVTAPGAHAQGVVADLSDADGARRVIDAA
PSADILVNNAGIYGPKPFFDIDDAEWEHFFQVNVMSGVRLARHYLKGMLERDWGRVVFISSESALNVPADMIHYGFTKTA
QLSISRGLAKLAAGSRVTVNAVLPGPTMSDGVKAMLKATADAEHTSIEQAGVDFVRTHRSSSIIQRPATCDEVANLVVYV
CSPQASATTGAALRVDGGVVDTIA

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=262, Percent_Identity=31.2977099236641, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI5031737, Length=259, Percent_Identity=31.6602316602317, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI33667109, Length=242, Percent_Identity=30.5785123966942, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI7705925, Length=259, Percent_Identity=25.0965250965251, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI126723191, Length=186, Percent_Identity=32.7956989247312, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI66933014, Length=255, Percent_Identity=24.7058823529412, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI126723750, Length=265, Percent_Identity=28.3018867924528, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI31542939, Length=194, Percent_Identity=32.9896907216495, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI19923817, Length=261, Percent_Identity=24.5210727969349, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1787335, Length=265, Percent_Identity=29.4339622641509, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI87082100, Length=265, Percent_Identity=30.188679245283, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1787905, Length=268, Percent_Identity=29.8507462686567, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1788459, Length=259, Percent_Identity=29.3436293436293, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790717, Length=266, Percent_Identity=27.0676691729323, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI2367365, Length=258, Percent_Identity=29.8449612403101, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1786812, Length=257, Percent_Identity=29.5719844357977, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI87082160, Length=267, Percent_Identity=26.9662921348315, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1789208, Length=272, Percent_Identity=26.1029411764706, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI2367175, Length=260, Percent_Identity=28.4615384615385, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17561402, Length=265, Percent_Identity=29.4339622641509, Blast_Score=103, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17560676, Length=264, Percent_Identity=28.7878787878788, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI71994604, Length=261, Percent_Identity=30.6513409961686, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71994600, Length=256, Percent_Identity=29.296875, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI115534694, Length=265, Percent_Identity=29.0566037735849, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17555706, Length=267, Percent_Identity=26.2172284644195, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI72000259, Length=265, Percent_Identity=27.9245283018868, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI193204405, Length=265, Percent_Identity=27.9245283018868, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17531453, Length=272, Percent_Identity=28.3088235294118, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25147288, Length=259, Percent_Identity=26.6409266409266, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17564282, Length=190, Percent_Identity=30.5263157894737, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17568967, Length=269, Percent_Identity=23.7918215613383, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562990, Length=265, Percent_Identity=28.6792452830189, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193203115, Length=170, Percent_Identity=30, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17562910, Length=265, Percent_Identity=25.2830188679245, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI23397609, Length=258, Percent_Identity=32.1705426356589, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21355319, Length=263, Percent_Identity=30.0380228136882, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24644339, Length=260, Percent_Identity=26.1538461538462, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI28571526, Length=255, Percent_Identity=28.6274509803922, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21357041, Length=258, Percent_Identity=29.0697674418605, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24643142, Length=184, Percent_Identity=30.9782608695652, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24639444, Length=263, Percent_Identity=26.9961977186312, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 27533; Mature: 27533

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIDLTGKTALVTASTAGIGLAIAEGLARAGAQLFINGRSDASVKAALAHLRVTAPGAHA
CEEECCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHEEEECCCCCC
QGVVADLSDADGARRVIDAAPSADILVNNAGIYGPKPFFDIDDAEWEHFFQVNVMSGVRL
CCEEEECCCCCCHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHH
ARHYLKGMLERDWGRVVFISSESALNVPADMIHYGFTKTAQLSISRGLAKLAAGSRVTVN
HHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHCCCCCEEHHHHHHHHHHHCCCEEEEE
AVLPGPTMSDGVKAMLKATADAEHTSIEQAGVDFVRTHRSSSIIQRPATCDEVANLVVYV
EEECCCCHHHHHHHHHHHHCCCCHHHHHHHCHHHHHHCCCHHHHCCCCCHHHHCCEEEEE
CSPQASATTGAALRVDGGVVDTIA
ECCCCCCCCCEEEEECCCEEECCC
>Mature Secondary Structure
MHIDLTGKTALVTASTAGIGLAIAEGLARAGAQLFINGRSDASVKAALAHLRVTAPGAHA
CEEECCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHEEEECCCCCC
QGVVADLSDADGARRVIDAAPSADILVNNAGIYGPKPFFDIDDAEWEHFFQVNVMSGVRL
CCEEEECCCCCCHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHH
ARHYLKGMLERDWGRVVFISSESALNVPADMIHYGFTKTAQLSISRGLAKLAAGSRVTVN
HHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHCCCCCEEHHHHHHHHHHHCCCEEEEE
AVLPGPTMSDGVKAMLKATADAEHTSIEQAGVDFVRTHRSSSIIQRPATCDEVANLVVYV
EEECCCCHHHHHHHHHHHHCCCCHHHHHHHCHHHHHHCCCHHHHCCCCCHHHHCCEEEEE
CSPQASATTGAALRVDGGVVDTIA
ECCCCCCCCCEEEEECCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]