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The map label for this gene is cat [H]

Identifier: 126445028

GI number: 126445028

Start: 2245390

End: 2246721

Strand: Reverse

Name: cat [H]

Synonym: BURPS668_A2303

Alternate gene names: 126445028

Gene position: 2246721-2245390 (Counterclockwise)

Preceding gene: 126443557

Following gene: 126444020

Centisome position: 71.84

GC content: 65.54

Gene sequence:

>1332_bases
ATGCGAAACGATCGGGATGCGCGGGAGATCTACGCGGGAAAACTGACGTCGCCGCAGCGGGCGGTGTCGCAAGTGCGCAG
CGGTTCGGCGATCGCGCTCGGCATGGCGATGTCGCAGCCGCCCGCGCTGCTCGCCGCGCTTGCCGAGCGCGCGCAGGCCG
GCGACGTCGACGCGCTGCGTGTGTATTACTTTCATGCGGAGGCGTTTCTGCGCGAGACGCTGCTGCGCTATTCGCTGATG
GGGCGAATCCTGCCGCACTGCATGTTCATGGGGCCGCCCGAGCGCGAGCTCGTGAAGCTCGGCGAAGCGGACGGCGGGCG
CAAGGTCGTGTTCTTCGTGCCGAACTCGTTCAGCCAGTCGCCGCGGCTGTTCGCCGAACACGTCGACGTCGACACGATGC
TCGTGATGGTCTCGCCGATGGATCGCAACGGCTACTTCACGTTCGGCACGAACAACGATTACACGAGCTCGGTCGCGCGC
GCCGCGCGCCGGCTGCTCGTCGAGGTGAACCCGAACATGCCGCGCGTGTTCGGCAACTCGCTGCTGCACGTGTCCGAAGT
GGACGCGATCGTCGAATCGGACCAACCGTTGCCGGAACTGATCCCGAAGCCCGGCGGCGAGCTCGATCGCGTGATCGGCG
AACAGATCGCGGAACTCGTGACGGAGGGCGCGTGTCTGCAAATGGGGATCGGCGCGTTGCCCAATGCGGTATGCGGCGCG
CTCGTCGGCCATCGGCATCTCGGCATCCATACCGAGCTGCTGACGCCGGGGCTCGTCGAGCTGATTCGCCGCGGGGTCGT
CGACAACAGCCGCAAGACGCTCGATCGCGGCAAGTCGGTATTCACGTTCGCGATGGGCGATCGCGCGATGTACGACTTCA
TTCACGACAACCCGGCGCTCGAGAGCCATCCTGTCGACTACGTGAACGATCCGTGCAACATCGCGCGCAACGACAACATG
ATCTCCGTGAACTCGACGATCGAGATGGATCTGACGGGCGCATGCAATTCGGAGCATGTCAACGGGCACCAATACAGCGC
GTCCGGCGGGCAGCTCGACTTCGTGCGCGGCGCGTATGCATCGCGCGGCGGCAAGTCGATCCTCGCGTTCCATTCGACCG
CGGCGGGCGCAACGGTGTCGAAGATCGTTCCGCAATTGACGGGCCCCGTCACGACGCCGCGCACCGATACGCATCTCGTC
GTGACCGAATACGGTGTCGCGAACCTGAAGGGCCTGTCGTCGACCGAACGGGCGCGCGCGCTGATCCGGCTCGCGCACCC
CGATTTTCGCGACGCGCTGAGCGTGCACGCACGCCGGCTACACTTGATCTGA

Upstream 100 bases:

>100_bases
CATCGTGATGTCTTTCGAACGCACGATGCTGATCTATAAGCGCGGGCATTCGCCGGAAGCCGGCGCCAATTACTGAGACC
GAACGACGGGGAGGTTGGGG

Downstream 100 bases:

>100_bases
ATGGAGGATCGCATGGCGAGCACGATTGCCGACTACCTCGCGCGGACGCTGGCCGCCGCCGGCGTCACGAAGATCTGGGG
CGTGACGGGCGACAGCCTGA

Product: 4-hydroxybutyrate coenzyme A transferase

Products: propionate; succinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MRNDRDAREIYAGKLTSPQRAVSQVRSGSAIALGMAMSQPPALLAALAERAQAGDVDALRVYYFHAEAFLRETLLRYSLM
GRILPHCMFMGPPERELVKLGEADGGRKVVFFVPNSFSQSPRLFAEHVDVDTMLVMVSPMDRNGYFTFGTNNDYTSSVAR
AARRLLVEVNPNMPRVFGNSLLHVSEVDAIVESDQPLPELIPKPGGELDRVIGEQIAELVTEGACLQMGIGALPNAVCGA
LVGHRHLGIHTELLTPGLVELIRRGVVDNSRKTLDRGKSVFTFAMGDRAMYDFIHDNPALESHPVDYVNDPCNIARNDNM
ISVNSTIEMDLTGACNSEHVNGHQYSASGGQLDFVRGAYASRGGKSILAFHSTAAGATVSKIVPQLTGPVTTPRTDTHLV
VTEYGVANLKGLSSTERARALIRLAHPDFRDALSVHARRLHLI

Sequences:

>Translated_443_residues
MRNDRDAREIYAGKLTSPQRAVSQVRSGSAIALGMAMSQPPALLAALAERAQAGDVDALRVYYFHAEAFLRETLLRYSLM
GRILPHCMFMGPPERELVKLGEADGGRKVVFFVPNSFSQSPRLFAEHVDVDTMLVMVSPMDRNGYFTFGTNNDYTSSVAR
AARRLLVEVNPNMPRVFGNSLLHVSEVDAIVESDQPLPELIPKPGGELDRVIGEQIAELVTEGACLQMGIGALPNAVCGA
LVGHRHLGIHTELLTPGLVELIRRGVVDNSRKTLDRGKSVFTFAMGDRAMYDFIHDNPALESHPVDYVNDPCNIARNDNM
ISVNSTIEMDLTGACNSEHVNGHQYSASGGQLDFVRGAYASRGGKSILAFHSTAAGATVSKIVPQLTGPVTTPRTDTHLV
VTEYGVANLKGLSSTERARALIRLAHPDFRDALSVHARRLHLI
>Mature_443_residues
MRNDRDAREIYAGKLTSPQRAVSQVRSGSAIALGMAMSQPPALLAALAERAQAGDVDALRVYYFHAEAFLRETLLRYSLM
GRILPHCMFMGPPERELVKLGEADGGRKVVFFVPNSFSQSPRLFAEHVDVDTMLVMVSPMDRNGYFTFGTNNDYTSSVAR
AARRLLVEVNPNMPRVFGNSLLHVSEVDAIVESDQPLPELIPKPGGELDRVIGEQIAELVTEGACLQMGIGALPNAVCGA
LVGHRHLGIHTELLTPGLVELIRRGVVDNSRKTLDRGKSVFTFAMGDRAMYDFIHDNPALESHPVDYVNDPCNIARNDNM
ISVNSTIEMDLTGACNSEHVNGHQYSASGGQLDFVRGAYASRGGKSILAFHSTAAGATVSKIVPQLTGPVTTPRTDTHLV
VTEYGVANLKGLSSTERARALIRLAHPDFRDALSVHARRLHLI

Specific function: Unknown

COG id: COG0427

COG function: function code C; Acetyl-CoA hydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetyl-CoA hydrolase/transferase family [H]

Homologues:

Organism=Escherichia coli, GI1789287, Length=270, Percent_Identity=28.8888888888889, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17538151, Length=440, Percent_Identity=36.5909090909091, Blast_Score=249, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI32563853, Length=442, Percent_Identity=35.5203619909502, Blast_Score=248, Evalue=6e-66,
Organism=Saccharomyces cerevisiae, GI6319456, Length=280, Percent_Identity=31.7857142857143, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21358615, Length=429, Percent_Identity=37.0629370629371, Blast_Score=267, Evalue=9e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003702 [H]

Pfam domain/function: PF02550 AcetylCoA_hydro [H]

EC number: NA

Molecular weight: Translated: 48235; Mature: 48235

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNDRDAREIYAGKLTSPQRAVSQVRSGSAIALGMAMSQPPALLAALAERAQAGDVDALR
CCCCCCHHHHHHCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCEEE
VYYFHAEAFLRETLLRYSLMGRILPHCMFMGPPERELVKLGEADGGRKVVFFVPNSFSQS
EEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEEECCCCCCCC
PRLFAEHVDVDTMLVMVSPMDRNGYFTFGTNNDYTSSVARAARRLLVEVNPNMPRVFGNS
CHHHHHHCCCEEEEEEEECCCCCCEEEECCCCCHHHHHHHHHHHEEEEECCCCCHHHCCC
LLHVSEVDAIVESDQPLPELIPKPGGELDRVIGEQIAELVTEGACLQMGIGALPNAVCGA
EEEHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCHHHHHH
LVGHRHLGIHTELLTPGLVELIRRGVVDNSRKTLDRGKSVFTFAMGDRAMYDFIHDNPAL
HHCCCCCCEEHHHCCHHHHHHHHHHCCCCCHHHHHCCCCEEEEECCCHHHHHHHCCCCCC
ESHPVDYVNDPCNIARNDNMISVNSTIEMDLTGACNSEHVNGHQYSASGGQLDFVRGAYA
CCCCCCCCCCCCCCCCCCCEEEECCEEEEEECCCCCCCCCCCCEECCCCCCEEHHHHHHH
SRGGKSILAFHSTAAGATVSKIVPQLTGPVTTPRTDTHLVVTEYGVANLKGLSSTERARA
CCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHCCCCCHHHHHHH
LIRLAHPDFRDALSVHARRLHLI
HHHHCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRNDRDAREIYAGKLTSPQRAVSQVRSGSAIALGMAMSQPPALLAALAERAQAGDVDALR
CCCCCCHHHHHHCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCEEE
VYYFHAEAFLRETLLRYSLMGRILPHCMFMGPPERELVKLGEADGGRKVVFFVPNSFSQS
EEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEEECCCCCCCC
PRLFAEHVDVDTMLVMVSPMDRNGYFTFGTNNDYTSSVARAARRLLVEVNPNMPRVFGNS
CHHHHHHCCCEEEEEEEECCCCCCEEEECCCCCHHHHHHHHHHHEEEEECCCCCHHHCCC
LLHVSEVDAIVESDQPLPELIPKPGGELDRVIGEQIAELVTEGACLQMGIGALPNAVCGA
EEEHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCHHHHHH
LVGHRHLGIHTELLTPGLVELIRRGVVDNSRKTLDRGKSVFTFAMGDRAMYDFIHDNPAL
HHCCCCCCEEHHHCCHHHHHHHHHHCCCCCHHHHHCCCCEEEEECCCHHHHHHHCCCCCC
ESHPVDYVNDPCNIARNDNMISVNSTIEMDLTGACNSEHVNGHQYSASGGQLDFVRGAYA
CCCCCCCCCCCCCCCCCCCEEEECCEEEEEECCCCCCCCCCCCEECCCCCCEEHHHHHHH
SRGGKSILAFHSTAAGATVSKIVPQLTGPVTTPRTDTHLVVTEYGVANLKGLSSTERARA
CCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHCCCCCHHHHHHH
LIRLAHPDFRDALSVHARRLHLI
HHHHCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: propionyl-CoA; succinate [C]

Specific reaction: propionyl-CoA + succinate = propionate + succinyl-CoA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550525 [H]