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The map label for this gene is argM [C]

Identifier: 126444673

GI number: 126444673

Start: 693048

End: 694466

Strand: Reverse

Name: argM [C]

Synonym: BURPS668_A0727

Alternate gene names: 126444673

Gene position: 694466-693048 (Counterclockwise)

Preceding gene: 126443713

Following gene: 126445558

Centisome position: 22.21

GC content: 67.3

Gene sequence:

>1419_bases
ATGAGCTACCGACCGAACAACGAATCCGCATGGATTCAACCCGCCGCGCCCGCGCACCGCACGAGCGCCGAATACCGCGC
GCTCGACGCCGCGCACCACCTCCACCCGTTCTCGGACATGGGCTCGCTCAATCGCGCGGGCAGCCGCGTGATCGTGAAGG
CCGAAGGCGTCCACCTGTGGGATTCCGACGGCAACAGGATCATCGACGGCATGGCCGGGCTCTGGTGCGTGAACGTCGGC
TACGGCCGCGACGAGCTGATCGAGGCCGGCAGCCGCCAGTTGCGCGAGCTGCCGTTCTACAACACCTTCTTCAAGACCAC
CCATCCGCCCGTCATCGAGCTGTCCGCGCTGCTCGCGCAGATCGCGCCGCCCGCGTTCAACCGCTTCTTCTATTGCAACA
GCGGCTCCGAGGGCAACGACACGGTGCTGCGCATCGCGCATCAGTACTGGCGCGCGCAGAACCGCCCGCAGAAGAAGTTC
GTCATTTCGCGCCGAAACGGCTACCACGGCTCGACGATCGCGGGCGCGACGCTCGGCGGCATGCGCTACATGCACGAGCA
GATGCCCTCGAAGGTCGAGCACATCGTCCACATCGATCAGCCCTATTACTTCGGCGAAGCGCGCGAGGGGCAGACGCCCG
AGGCGTTCGGCCTCGAGCGCGCGCGACAGCTCGAAGCGAAGATTCTCGAGCTCGGCGCGCAGAACGTCGCGGCGTTCATC
GGCGAGCCGTTCCAGGGCGCGGGCGGCGTGATCTTTCCGCCGTCGACGTACTGGCCGGAGATCGAGCGGATCTGCCGCCA
GTACGACGTGCTGCTCGTCGCCGACGAAGTGATCGGCGGCTTCGGGCGCACCGGCGAATGGTTCGCGCACCAGCACTTCG
GCTTCGCGCCCGACCTGATGACGCTCGCCAAGGGCCTGACGAGCGGTTACGTGCCGATGGGCGCGGTCGCGCTGTCGGAC
CGGATCGCCGACGCGCTGATCGCGCACGGCGAGTTCAACCACGGGATGACGTACTCCGGGCATCCGGTCGCGGCGGCGGT
GGCCGTCGCGAATCTGAAGGTGCTGCGCGACGAGCGGATCGTCGAGCGCGTGAAGACCGATACCGGCCCCTACTTCCAGC
AGCGGTTGCGCGAAACGTTCGCGAACCATCCGATCGTCGGCGACATCGCCGGCGCGGGGCTCGTCGCCGGCATCCAGCTC
GCGCGCGAGCCGCGCACGCGCAAGCGCTTCGAGAACGGCGGCGAAGTCGGCACGATCTGCCGCGACTACTGCTTCAACGG
CAACCTGATCATGCGCGCGACGGGCGACCGGATGCTGCTGTCGCCGCCGCTCGTGATCTCGAAACCGCAGATCGACGAGA
TCGTCGAGAAGGCGAAGCGTGCGATCGATGCGACGGCGCAGCAACTGGGTCTTTCCTAA

Upstream 100 bases:

>100_bases
AATACGAAGCGTTCTTCCGCGTGATCAGCTCGTGGGAACGCAAGCATCTGCTGCTGCACGTCTGAACGCGCATGCAGCCG
CATCCATCCAGGAGGACACG

Downstream 100 bases:

>100_bases
CGGCATTGCCAATCGGGCAGGCGGCGCGCGGGCGCCGCGCGCCCACCTTCATCATCAGGGGAACAACATGAGTGTGAGCC
ATCTTCGTCATGCGGTCGCG

Product: putative aminotransferase

Products: L-glutamate; N2-succinylglutamic-semialdehyde [C]

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MSYRPNNESAWIQPAAPAHRTSAEYRALDAAHHLHPFSDMGSLNRAGSRVIVKAEGVHLWDSDGNRIIDGMAGLWCVNVG
YGRDELIEAGSRQLRELPFYNTFFKTTHPPVIELSALLAQIAPPAFNRFFYCNSGSEGNDTVLRIAHQYWRAQNRPQKKF
VISRRNGYHGSTIAGATLGGMRYMHEQMPSKVEHIVHIDQPYYFGEAREGQTPEAFGLERARQLEAKILELGAQNVAAFI
GEPFQGAGGVIFPPSTYWPEIERICRQYDVLLVADEVIGGFGRTGEWFAHQHFGFAPDLMTLAKGLTSGYVPMGAVALSD
RIADALIAHGEFNHGMTYSGHPVAAAVAVANLKVLRDERIVERVKTDTGPYFQQRLRETFANHPIVGDIAGAGLVAGIQL
AREPRTRKRFENGGEVGTICRDYCFNGNLIMRATGDRMLLSPPLVISKPQIDEIVEKAKRAIDATAQQLGLS

Sequences:

>Translated_472_residues
MSYRPNNESAWIQPAAPAHRTSAEYRALDAAHHLHPFSDMGSLNRAGSRVIVKAEGVHLWDSDGNRIIDGMAGLWCVNVG
YGRDELIEAGSRQLRELPFYNTFFKTTHPPVIELSALLAQIAPPAFNRFFYCNSGSEGNDTVLRIAHQYWRAQNRPQKKF
VISRRNGYHGSTIAGATLGGMRYMHEQMPSKVEHIVHIDQPYYFGEAREGQTPEAFGLERARQLEAKILELGAQNVAAFI
GEPFQGAGGVIFPPSTYWPEIERICRQYDVLLVADEVIGGFGRTGEWFAHQHFGFAPDLMTLAKGLTSGYVPMGAVALSD
RIADALIAHGEFNHGMTYSGHPVAAAVAVANLKVLRDERIVERVKTDTGPYFQQRLRETFANHPIVGDIAGAGLVAGIQL
AREPRTRKRFENGGEVGTICRDYCFNGNLIMRATGDRMLLSPPLVISKPQIDEIVEKAKRAIDATAQQLGLS
>Mature_471_residues
SYRPNNESAWIQPAAPAHRTSAEYRALDAAHHLHPFSDMGSLNRAGSRVIVKAEGVHLWDSDGNRIIDGMAGLWCVNVGY
GRDELIEAGSRQLRELPFYNTFFKTTHPPVIELSALLAQIAPPAFNRFFYCNSGSEGNDTVLRIAHQYWRAQNRPQKKFV
ISRRNGYHGSTIAGATLGGMRYMHEQMPSKVEHIVHIDQPYYFGEAREGQTPEAFGLERARQLEAKILELGAQNVAAFIG
EPFQGAGGVIFPPSTYWPEIERICRQYDVLLVADEVIGGFGRTGEWFAHQHFGFAPDLMTLAKGLTSGYVPMGAVALSDR
IADALIAHGEFNHGMTYSGHPVAAAVAVANLKVLRDERIVERVKTDTGPYFQQRLRETFANHPIVGDIAGAGLVAGIQLA
REPRTRKRFENGGEVGTICRDYCFNGNLIMRATGDRMLLSPPLVISKPQIDEIVEKAKRAIDATAQQLGLS

Specific function: Catalyzes The Transmination Of N(2)-Succinylornithine And Alpha-Ketoglutarate Into N(2)-Succinylglutamate Semialdehyde And Glutamate. Can Also Act As A Acetylornithine Aminotransferase. [C]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI24119277, Length=360, Percent_Identity=29.1666666666667, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI37574042, Length=370, Percent_Identity=29.7297297297297, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI226442705, Length=367, Percent_Identity=29.9727520435967, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI13994255, Length=423, Percent_Identity=27.8959810874704, Blast_Score=142, Evalue=9e-34,
Organism=Homo sapiens, GI226442709, Length=323, Percent_Identity=30.6501547987616, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI4557809, Length=444, Percent_Identity=26.3513513513513, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI284507298, Length=228, Percent_Identity=32.8947368421053, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI188536080, Length=286, Percent_Identity=26.5734265734266, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI38679950, Length=286, Percent_Identity=26.5734265734266, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI38679946, Length=286, Percent_Identity=26.5734265734266, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1788044, Length=415, Percent_Identity=26.9879518072289, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1786991, Length=447, Percent_Identity=28.8590604026846, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI1789759, Length=415, Percent_Identity=27.710843373494, Blast_Score=155, Evalue=6e-39,
Organism=Escherichia coli, GI145693181, Length=411, Percent_Identity=25.7907542579075, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1789016, Length=421, Percent_Identity=26.3657957244656, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1787560, Length=370, Percent_Identity=29.7297297297297, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1786349, Length=310, Percent_Identity=25.4838709677419, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71992977, Length=427, Percent_Identity=28.3372365339578, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI25144271, Length=423, Percent_Identity=27.4231678486998, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI32564660, Length=450, Percent_Identity=29.3333333333333, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI25144274, Length=235, Percent_Identity=33.1914893617021, Blast_Score=134, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6323470, Length=460, Percent_Identity=26.5217391304348, Blast_Score=167, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6324386, Length=366, Percent_Identity=30.6010928961749, Blast_Score=139, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6324432, Length=433, Percent_Identity=25.4041570438799, Blast_Score=130, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6321456, Length=364, Percent_Identity=23.3516483516484, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI161085790, Length=426, Percent_Identity=28.8732394366197, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI28574759, Length=430, Percent_Identity=29.3023255813954, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI21356575, Length=371, Percent_Identity=29.9191374663073, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI21357415, Length=475, Percent_Identity=26.7368421052632, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI281366494, Length=342, Percent_Identity=23.6842105263158, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24667139, Length=342, Percent_Identity=23.6842105263158, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24667143, Length=342, Percent_Identity=23.6842105263158, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.- [C]

Molecular weight: Translated: 52183; Mature: 52052

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYRPNNESAWIQPAAPAHRTSAEYRALDAAHHLHPFSDMGSLNRAGSRVIVKAEGVHLW
CCCCCCCCCCEEECCCCCHHCCHHHHHHHHHHHCCCCHHHCCHHCCCCEEEEEECCEEEE
DSDGNRIIDGMAGLWCVNVGYGRDELIEAGSRQLRELPFYNTFFKTTHPPVIELSALLAQ
CCCCCEEHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHH
IAPPAFNRFFYCNSGSEGNDTVLRIAHQYWRAQNRPQKKFVISRRNGYHGSTIAGATLGG
HCCCHHCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCHHEEEECCCCCCCCCCCHHHHHH
MRYMHEQMPSKVEHIVHIDQPYYFGEAREGQTPEAFGLERARQLEAKILELGAQNVAAFI
HHHHHHHHHHHHHHHEECCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEPFQGAGGVIFPPSTYWPEIERICRQYDVLLVADEVIGGFGRTGEWFAHQHFGFAPDLM
CCCCCCCCCEEECCCCCCHHHHHHHHHHCEEEEEHHHHCCCCCCCHHHHHHCCCCCHHHH
TLAKGLTSGYVPMGAVALSDRIADALIAHGEFNHGMTYSGHPVAAAVAVANLKVLRDERI
HHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VERVKTDTGPYFQQRLRETFANHPIVGDIAGAGLVAGIQLAREPRTRKRFENGGEVGTIC
HHHHHCCCCHHHHHHHHHHHCCCCCEEHHHCCHHHHHHHHHCCCHHHHHHHCCCCHHHHH
RDYCFNGNLIMRATGDRMLLSPPLVISKPQIDEIVEKAKRAIDATAQQLGLS
HHHHCCCCEEEEECCCEEEECCCCEECCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SYRPNNESAWIQPAAPAHRTSAEYRALDAAHHLHPFSDMGSLNRAGSRVIVKAEGVHLW
CCCCCCCCCEEECCCCCHHCCHHHHHHHHHHHCCCCHHHCCHHCCCCEEEEEECCEEEE
DSDGNRIIDGMAGLWCVNVGYGRDELIEAGSRQLRELPFYNTFFKTTHPPVIELSALLAQ
CCCCCEEHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHH
IAPPAFNRFFYCNSGSEGNDTVLRIAHQYWRAQNRPQKKFVISRRNGYHGSTIAGATLGG
HCCCHHCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCHHEEEECCCCCCCCCCCHHHHHH
MRYMHEQMPSKVEHIVHIDQPYYFGEAREGQTPEAFGLERARQLEAKILELGAQNVAAFI
HHHHHHHHHHHHHHHEECCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEPFQGAGGVIFPPSTYWPEIERICRQYDVLLVADEVIGGFGRTGEWFAHQHFGFAPDLM
CCCCCCCCCEEECCCCCCHHHHHHHHHHCEEEEEHHHHCCCCCCCHHHHHHCCCCCHHHH
TLAKGLTSGYVPMGAVALSDRIADALIAHGEFNHGMTYSGHPVAAAVAVANLKVLRDERI
HHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VERVKTDTGPYFQQRLRETFANHPIVGDIAGAGLVAGIQLAREPRTRKRFENGGEVGTIC
HHHHHCCCCHHHHHHHHHHHCCCCCEEHHHCCHHHHHHHHHCCCHHHHHHHCCCCHHHHH
RDYCFNGNLIMRATGDRMLLSPPLVISKPQIDEIVEKAKRAIDATAQQLGLS
HHHHCCCCEEEEECCCEEEECCCCEECCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-alpha-acetylornithine; 2-oxoglutarate [C]

Specific reaction: N-alpha-acetylornithine + 2-oxoglutarate = N-acetylglutamate semialdehyde + L-glutamate N2-succinylornithine + 2-oxoglutarate = N2-succinylglutamic-semialdehyde + L-glutamate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8796346; 9163424 [H]