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The map label for this gene is ptxR [H]

Identifier: 126444368

GI number: 126444368

Start: 2249769

End: 2250707

Strand: Reverse

Name: ptxR [H]

Synonym: BURPS668_A2309

Alternate gene names: 126444368

Gene position: 2250707-2249769 (Counterclockwise)

Preceding gene: 126442901

Following gene: 126443570

Centisome position: 71.97

GC content: 68.69

Gene sequence:

>939_bases
TTGACAATCGAGGGCGCGATGGTGAGTTTGGATCGTTTCGACGTGTTTCGCGCGGTCGTGGAGGCCGGCTCGTTTACGGG
CGCGGCGAACGTGCTGAACCAGGCGCGCGCGGCGGTGAGCTTCCACGTCAAGCAGCTCGAGGCCGAGCTCGGCGTGACGC
TGCTCACGCGGACGACGCGGCGCGTCGAGCTGACCGAAGCGGGCGAGCGCTTCTACGAGCGTTGCCTGCGTGTGCTTGCC
GAAGCCGAAGAGGCGATCGACGATGCGCGCGCCGAGCACGGCGGCATGCAGGGCAGCTTGCGCGTGACGTCGACGGTCGA
ATACGCGCTGCGGATCGTCGCGCCCGCCTTGAGCGAATTCACGAGCGCGCATCCGGCGTTGCGCGTGCGGCTCGAGACGC
ATACGTCGCAGGCGGATCTCGTGCGCGATCGCTTCGACGTTGCGATCCGGCTCGGTCGCCTCGAGCAGTTTCGGGATCTG
CCGTACCGGGGCGTATGTATCGACACGTACGACGTGCGGCCGGTGGCGTCGCCCGCACTGCTGGCCGCGCACGGCGTTGC
GCGAATCGACTCGCCGGAGGCGCTCGCGCGCCTGCCGCAGCTCGGGCACAGTCGGCTGTCGCAGGTCGCGTCGTGGCTGC
TGCACGATCGCGACGGGCGCGAACACGTGTATCGGCCCGCGGCGAAGCCGCATCTGATCGCGGACAACGCGTCGGTGCTG
CGCGCGTTCGCGCAGCAGGGCGGTGGCGTCGCGCTGCTGCCCGAGTGGCTCGTGCGCGATGATCTGGCCAGCGGAACGTT
GATCGACGCGCTACCGGGTTACCGGTTTGCGCAACAGGGCGTCTACGCGTTGTATCCGTCGGCGCGGCACGTGCCGCAGA
AGATTCGCGCCTGGATCGATTTCATCAAGCGCTACGTTCGGCGGCGCGCGGAGGGTTGA

Upstream 100 bases:

>100_bases
GAGCGGACATGGCGGCCAACGGTGACATCGGGCGACGTAGTGTAAAGTCCGCGATCCGGGGCCGTCAGCCCGATTGCCCG
GATAGACTGATCGAAAAATT

Downstream 100 bases:

>100_bases
CGCTCGGCGCGCCGCCGGCGGGAGGCGGTGCGCAGGCCGGCACGAGCCGGCGCGATCGGGCGCACGGCTTTCCGCGTACC
CGAACCGATCCCGCTTCACG

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MTIEGAMVSLDRFDVFRAVVEAGSFTGAANVLNQARAAVSFHVKQLEAELGVTLLTRTTRRVELTEAGERFYERCLRVLA
EAEEAIDDARAEHGGMQGSLRVTSTVEYALRIVAPALSEFTSAHPALRVRLETHTSQADLVRDRFDVAIRLGRLEQFRDL
PYRGVCIDTYDVRPVASPALLAAHGVARIDSPEALARLPQLGHSRLSQVASWLLHDRDGREHVYRPAAKPHLIADNASVL
RAFAQQGGGVALLPEWLVRDDLASGTLIDALPGYRFAQQGVYALYPSARHVPQKIRAWIDFIKRYVRRRAEG

Sequences:

>Translated_312_residues
MTIEGAMVSLDRFDVFRAVVEAGSFTGAANVLNQARAAVSFHVKQLEAELGVTLLTRTTRRVELTEAGERFYERCLRVLA
EAEEAIDDARAEHGGMQGSLRVTSTVEYALRIVAPALSEFTSAHPALRVRLETHTSQADLVRDRFDVAIRLGRLEQFRDL
PYRGVCIDTYDVRPVASPALLAAHGVARIDSPEALARLPQLGHSRLSQVASWLLHDRDGREHVYRPAAKPHLIADNASVL
RAFAQQGGGVALLPEWLVRDDLASGTLIDALPGYRFAQQGVYALYPSARHVPQKIRAWIDFIKRYVRRRAEG
>Mature_311_residues
TIEGAMVSLDRFDVFRAVVEAGSFTGAANVLNQARAAVSFHVKQLEAELGVTLLTRTTRRVELTEAGERFYERCLRVLAE
AEEAIDDARAEHGGMQGSLRVTSTVEYALRIVAPALSEFTSAHPALRVRLETHTSQADLVRDRFDVAIRLGRLEQFRDLP
YRGVCIDTYDVRPVASPALLAAHGVARIDSPEALARLPQLGHSRLSQVASWLLHDRDGREHVYRPAAKPHLIADNASVLR
AFAQQGGGVALLPEWLVRDDLASGTLIDALPGYRFAQQGVYALYPSARHVPQKIRAWIDFIKRYVRRRAEG

Specific function: Transcriptional activator of the toxA (exotoxin) and regA genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786401, Length=297, Percent_Identity=30.976430976431, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1789440, Length=308, Percent_Identity=28.5714285714286, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1789639, Length=315, Percent_Identity=30.1587301587302, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI87081978, Length=303, Percent_Identity=30.6930693069307, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI145693193, Length=306, Percent_Identity=28.7581699346405, Blast_Score=104, Evalue=8e-24,
Organism=Escherichia coli, GI1787589, Length=297, Percent_Identity=31.6498316498317, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1787128, Length=317, Percent_Identity=26.4984227129338, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1789173, Length=299, Percent_Identity=29.0969899665552, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1786448, Length=289, Percent_Identity=26.643598615917, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI157672245, Length=143, Percent_Identity=33.5664335664336, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1788481, Length=305, Percent_Identity=24.9180327868852, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1788706, Length=316, Percent_Identity=26.2658227848101, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1787601, Length=124, Percent_Identity=29.8387096774194, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI145693105, Length=151, Percent_Identity=28.476821192053, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787806, Length=280, Percent_Identity=27.1428571428571, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34626; Mature: 34495

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIEGAMVSLDRFDVFRAVVEAGSFTGAANVLNQARAAVSFHVKQLEAELGVTLLTRTTR
CCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCH
RVELTEAGERFYERCLRVLAEAEEAIDDARAEHGGMQGSLRVTSTVEYALRIVAPALSEF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHH
TSAHPALRVRLETHTSQADLVRDRFDVAIRLGRLEQFRDLPYRGVCIDTYDVRPVASPAL
HCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHH
LAAHGVARIDSPEALARLPQLGHSRLSQVASWLLHDRDGREHVYRPAAKPHLIADNASVL
HHHHCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCEEECCHHHH
RAFAQQGGGVALLPEWLVRDDLASGTLIDALPGYRFAQQGVYALYPSARHVPQKIRAWID
HHHHHCCCCEEECHHHHHHHHCCCCCHHHCCCCCHHHHCCEEEECCCHHHHHHHHHHHHH
FIKRYVRRRAEG
HHHHHHHHHCCC
>Mature Secondary Structure 
TIEGAMVSLDRFDVFRAVVEAGSFTGAANVLNQARAAVSFHVKQLEAELGVTLLTRTTR
CCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCH
RVELTEAGERFYERCLRVLAEAEEAIDDARAEHGGMQGSLRVTSTVEYALRIVAPALSEF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHH
TSAHPALRVRLETHTSQADLVRDRFDVAIRLGRLEQFRDLPYRGVCIDTYDVRPVASPAL
HCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHH
LAAHGVARIDSPEALARLPQLGHSRLSQVASWLLHDRDGREHVYRPAAKPHLIADNASVL
HHHHCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCEEECCHHHH
RAFAQQGGGVALLPEWLVRDDLASGTLIDALPGYRFAQQGVYALYPSARHVPQKIRAWID
HHHHHCCCCEEECHHHHHHHHCCCCCHHHCCCCCHHHHCCEEEECCCHHHHHHHHHHHHH
FIKRYVRRRAEG
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8843437; 10984043 [H]