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The map label for this gene is mmr [H]

Identifier: 126443791

GI number: 126443791

Start: 527785

End: 529329

Strand: Reverse

Name: mmr [H]

Synonym: BURPS668_A0562

Alternate gene names: 126443791

Gene position: 529329-527785 (Counterclockwise)

Preceding gene: 126445279

Following gene: 126444546

Centisome position: 16.93

GC content: 73.59

Gene sequence:

>1545_bases
ATGGACACGCACCTTCCCCACCCCACCCTTTCCCGCGCCGCGCTCGTGCGGATCGTGTCGACCGTCAGCGCGGGCTTCGT
GATCACGCAGCTCGACGTGACGATCGTCAACGTCGCGCTCGCGCGCATCGGCATCGATCTGCATACGAGCGTCGCGGGCC
TGCAATGGATCGTCGACGCCTACACGCTCGCGCTCGCGGGCCTGATGCTGTCGGCCGGCGCGCTCGGCGACCGGTTCGGC
GCGCGCCGGCTGTTCGCCGCCGGGCTCGCGCTCTTCGCCGTCGCATCGTTCGTCTGCGGCATCGCCGCGAACGCGGCGAC
GCTCATCGCCGCGCGCGCGCTGCAAGGGCTCGCGGCGGCCGCGATGCTCCCGAACTCGCTCGCGCTGCTCAACCATGCGT
GCGCGCACGATCCACGGCTGCGGGCGCGCGCGGTCGGCTGGTGGACCGCGTCGGGCGCGATCTCGATCGCGGCGGGCCCG
GTGATCGGCGGCGTGCTGATCGCGCAGTTCGGCTGGCGCAGCATCTTCTTCGTCAACCTGCCGCTGTGCGCGGCGGGCCT
CGCCGCGACGCGCCTGTGGATCGACAGCGACGACACGCGCGCGGCGGCCGCTTCGTCGGCCTCGTCCGCTTCGTCCGCCT
CGTCCGCTTCATCCGCCGCCGACGGCGCGCACCATTCGCACCCGGCGGCGGACCGGCGCGCATCCGGCCCGAATGCCTGC
GCCCCCGCGCCCAAGCGCGCCGCCGGCGCCGGAACACGCGGCCTCGACCTGCCCGGCCAGTGCCTCGCCGTCGTCGCGCT
CACGCTCTTCACCGGCGCGGTGATCGACTGGCGTCCGGCGCTCGTCGCGATCGCGCTCGCGGCGGGCGCCGCGTTCGTGT
TCGTCGAATCGCGCAGCGCGCACCCGATGATGCCGCTCGCGCTGTTCAGGCGGCGCACGTTCAGCGTCGCCGTGCTGTTC
GGTGTCTGCATGAATCTGTCGTACTACGGGATCATCTTCGTGCTGAGCCTGTATTTGCAGCGCGTGCGCCACGACACGCC
GCTCGAGGCGGGGCTCGCGTTCCTGCCGCTCACGGGGGGCTTCCTGCTGTCGAACGTCGCGAGCGGCTGGGCGACCGCGC
ACTACGGCCCGCGCCGGCCGATGATCGCCGGCGCGCTGATCGGCGCGACCGGTTTCGCGCTGCTGAGCGCGGTGCGTGCC
GATACGCCGATCGCGATGCTCGTCGTGCCGTTCCTGCTGATTCCGGGCGGCATGGGGCTCGCGGTGCCCGCGATGACGAC
GACGGTGCTCGCCTCGGTCGAACGCGCGCGCGCCGCGACCGCGTCGGCCGTGCTCAATACCGCGCGGCAAGCGGGCGGCG
CGATCGGCGTCGCCGCGTTCGGCGCGCTCGCGAGCGGCGCGCGGCCGCCGGACATCGTGTCGGGATTGCACGCGTCGGCG
TACGTATCGGCCGCGCTCTTCGTGTTCGCCTCGGCGATGGCGGCCTTCGTGCACGGCGCGCCGCAGCCGGCGGCGGGCAA
GCCGGCGAACGCGAACGCACGCTGA

Upstream 100 bases:

>100_bases
GCAAGCCGCCGCCGAAAGGGCGCGGCCGCCCGTGCGCGCCGCATCGACATTTCAGCAGACCCCGTAACGTCGCCGTCCCG
CGCCGCCCTACGATGCGTGC

Downstream 100 bases:

>100_bases
CGCGGCGCGAACCCGCCGCGCGCGCGTCATGTCATGAGCGAGGACGCGGGTGCAAAAGCGAAAAAACGCCCGCGGAAAAG
GAAACCATCGGGCAACGGGA

Product: major facilitator superfamily permease

Products: NA

Alternate protein names: MMR peptide [H]

Number of amino acids: Translated: 514; Mature: 514

Protein sequence:

>514_residues
MDTHLPHPTLSRAALVRIVSTVSAGFVITQLDVTIVNVALARIGIDLHTSVAGLQWIVDAYTLALAGLMLSAGALGDRFG
ARRLFAAGLALFAVASFVCGIAANAATLIAARALQGLAAAAMLPNSLALLNHACAHDPRLRARAVGWWTASGAISIAAGP
VIGGVLIAQFGWRSIFFVNLPLCAAGLAATRLWIDSDDTRAAAASSASSASSASSASSAADGAHHSHPAADRRASGPNAC
APAPKRAAGAGTRGLDLPGQCLAVVALTLFTGAVIDWRPALVAIALAAGAAFVFVESRSAHPMMPLALFRRRTFSVAVLF
GVCMNLSYYGIIFVLSLYLQRVRHDTPLEAGLAFLPLTGGFLLSNVASGWATAHYGPRRPMIAGALIGATGFALLSAVRA
DTPIAMLVVPFLLIPGGMGLAVPAMTTTVLASVERARAATASAVLNTARQAGGAIGVAAFGALASGARPPDIVSGLHASA
YVSAALFVFASAMAAFVHGAPQPAAGKPANANAR

Sequences:

>Translated_514_residues
MDTHLPHPTLSRAALVRIVSTVSAGFVITQLDVTIVNVALARIGIDLHTSVAGLQWIVDAYTLALAGLMLSAGALGDRFG
ARRLFAAGLALFAVASFVCGIAANAATLIAARALQGLAAAAMLPNSLALLNHACAHDPRLRARAVGWWTASGAISIAAGP
VIGGVLIAQFGWRSIFFVNLPLCAAGLAATRLWIDSDDTRAAAASSASSASSASSASSAADGAHHSHPAADRRASGPNAC
APAPKRAAGAGTRGLDLPGQCLAVVALTLFTGAVIDWRPALVAIALAAGAAFVFVESRSAHPMMPLALFRRRTFSVAVLF
GVCMNLSYYGIIFVLSLYLQRVRHDTPLEAGLAFLPLTGGFLLSNVASGWATAHYGPRRPMIAGALIGATGFALLSAVRA
DTPIAMLVVPFLLIPGGMGLAVPAMTTTVLASVERARAATASAVLNTARQAGGAIGVAAFGALASGARPPDIVSGLHASA
YVSAALFVFASAMAAFVHGAPQPAAGKPANANAR
>Mature_514_residues
MDTHLPHPTLSRAALVRIVSTVSAGFVITQLDVTIVNVALARIGIDLHTSVAGLQWIVDAYTLALAGLMLSAGALGDRFG
ARRLFAAGLALFAVASFVCGIAANAATLIAARALQGLAAAAMLPNSLALLNHACAHDPRLRARAVGWWTASGAISIAAGP
VIGGVLIAQFGWRSIFFVNLPLCAAGLAATRLWIDSDDTRAAAASSASSASSASSASSAADGAHHSHPAADRRASGPNAC
APAPKRAAGAGTRGLDLPGQCLAVVALTLFTGAVIDWRPALVAIALAAGAAFVFVESRSAHPMMPLALFRRRTFSVAVLF
GVCMNLSYYGIIFVLSLYLQRVRHDTPLEAGLAFLPLTGGFLLSNVASGWATAHYGPRRPMIAGALIGATGFALLSAVRA
DTPIAMLVVPFLLIPGGMGLAVPAMTTTVLASVERARAATASAVLNTARQAGGAIGVAAFGALASGARPPDIVSGLHASA
YVSAALFVFASAMAAFVHGAPQPAAGKPANANAR

Specific function: Resistance to the epoxide antibiotic methylenomycin A; probably by mediating its efflux [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI87081983, Length=452, Percent_Identity=27.6548672566372, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1790195, Length=483, Percent_Identity=25.4658385093168, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1788710, Length=446, Percent_Identity=23.7668161434978, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1789042, Length=173, Percent_Identity=31.2138728323699, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788392, Length=171, Percent_Identity=30.9941520467836, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790146, Length=177, Percent_Identity=31.0734463276836, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324954, Length=267, Percent_Identity=26.2172284644195, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 52065; Mature: 52065

Theoretical pI: Translated: 11.10; Mature: 11.10

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTHLPHPTLSRAALVRIVSTVSAGFVITQLDVTIVNVALARIGIDLHTSVAGLQWIVDA
CCCCCCCCHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
YTLALAGLMLSAGALGDRFGARRLFAAGLALFAVASFVCGIAANAATLIAARALQGLAAA
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMLPNSLALLNHACAHDPRLRARAVGWWTASGAISIAAGPVIGGVLIAQFGWRSIFFVNL
HHCCCHHHHHHHHHCCCCCHHHEEEEEEECCCCEEEECCHHHHHHHHHHHCCCEEEEEEC
PLCAAGLAATRLWIDSDDTRAAAASSASSASSASSASSAADGAHHSHPAADRRASGPNAC
HHHHHHHHHHEEEECCCCCHHHHHCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCC
APAPKRAAGAGTRGLDLPGQCLAVVALTLFTGAVIDWRPALVAIALAAGAAFVFVESRSA
CCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHCCEEEEEECCCC
HPMMPLALFRRRTFSVAVLFGVCMNLSYYGIIFVLSLYLQRVRHDTPLEAGLAFLPLTGG
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHCEEEEECCCH
FLLSNVASGWATAHYGPRRPMIAGALIGATGFALLSAVRADTPIAMLVVPFLLIPGGMGL
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCH
AVPAMTTTVLASVERARAATASAVLNTARQAGGAIGVAAFGALASGARPPDIVSGLHASA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHH
YVSAALFVFASAMAAFVHGAPQPAAGKPANANAR
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDTHLPHPTLSRAALVRIVSTVSAGFVITQLDVTIVNVALARIGIDLHTSVAGLQWIVDA
CCCCCCCCHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
YTLALAGLMLSAGALGDRFGARRLFAAGLALFAVASFVCGIAANAATLIAARALQGLAAA
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMLPNSLALLNHACAHDPRLRARAVGWWTASGAISIAAGPVIGGVLIAQFGWRSIFFVNL
HHCCCHHHHHHHHHCCCCCHHHEEEEEEECCCCEEEECCHHHHHHHHHHHCCCEEEEEEC
PLCAAGLAATRLWIDSDDTRAAAASSASSASSASSASSAADGAHHSHPAADRRASGPNAC
HHHHHHHHHHEEEECCCCCHHHHHCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCC
APAPKRAAGAGTRGLDLPGQCLAVVALTLFTGAVIDWRPALVAIALAAGAAFVFVESRSA
CCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHCCEEEEEECCCC
HPMMPLALFRRRTFSVAVLFGVCMNLSYYGIIFVLSLYLQRVRHDTPLEAGLAFLPLTGG
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHCEEEEECCCH
FLLSNVASGWATAHYGPRRPMIAGALIGATGFALLSAVRADTPIAMLVVPFLLIPGGMGL
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCH
AVPAMTTTVLASVERARAATASAVLNTARQAGGAIGVAAFGALASGARPPDIVSGLHASA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHH
YVSAALFVFASAMAAFVHGAPQPAAGKPANANAR
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2828187; 12000953 [H]