Click here to switch to the map view.

The map label for this gene is hisC [H]

Identifier: 126209475

GI number: 126209475

Start: 2248616

End: 2249668

Strand: Direct

Name: hisC [H]

Synonym: APL_2021

Alternate gene names: 126209475

Gene position: 2248616-2249668 (Clockwise)

Preceding gene: 126209474

Following gene: 126209476

Centisome position: 98.86

GC content: 46.82

Gene sequence:

>1053_bases
ATGCAAATCTCAAAACTCTCTCGAAAAAATGTACAAGCCCTCACTCCATACCAATCTGCACGCCGTTTAGGGGGCAATGG
GGATGTGTGGCTGAATGCGAATGAATACCCGACTTCACCAAGCTTTGATTTACTTAATCGCACTTTTAACCGCTATCCGG
AAGCCCAGCCAGCCGCTGTGGTGAATGGTTACGCTCAATACGCAGGTGTAAAACCTGAAAATGTGATCGTTACCCGTGGC
GGCGATGAAAGCATTGAGTTGATTATCCGAGCTTTCTGCGAGCCAAGCGACAGCGTGCTTTACTGCCCACCGACTTACGG
AATGTACAGCGTATCGGCGGAAACTTTTGGTGTCGCACTCAAAACCGTCCCTTTAACCGCTGATTTTCAGCTTAATTTGC
CTGAAATCGAACGCAATTTGGACGGTGTGAAAGTGGTGTTTGTGTGCAGCCCAAACAACCCAACAGGCACGCTAGTCAAG
CGGTCGGATTTGCTCAAACTTTTGCAAATTACTGCAGGGCGAGCGATTGTGGTGGTGGACGAAGCCTATATCGAATTTTG
CCCCGAAGCGACAATGGTTAGCGAATTAGCTAACTTCCCACATTTGGCGATTATCCGCACGCTTTCCAAAGCCTTTGCCC
TAGCGGGCTTGCGTTGCGGTTTTACCCTTGCTAATGAAGAATTAATCGGTGTTCTGCAAAAAGTGATTGCCCCTTATCCG
CTCCCTGTACCCGTTTCCGACATTGCCGCTCAAGCCTTGTCCGAAAAAGGGATAAACGAGATGAAACAACGTGTAGCAAA
TGTGTTAGAAAACCGTATGTGGTTAATCGAACAGCTTAAAACTATTCCAAGCGTGGTAAACATTTTCGATACTGAAGCCA
ATTATGTTCTCGTCAAATTCCAAGACGGACAACAAGTGTTTAAAGCGCTGTGGGAAAAAGGCATTATCTTGCGTGATCAA
CACAAAGCCTTGGGATTGCAGAATTGTATTCGGATCAGTGTTGGTACAAGATCGGAGTTGGAGAGAACGGTGGAAGCAAT
TAGAAATGCCTAG

Upstream 100 bases:

>100_bases
ATCCCAGCCCCGCTGGGGCTGAAAATTAGAAGATAAAGAGCCACAGAGTGGCTCGGATTAAGTAACCCCATACGACTCGT
ATGGGGAGGAAGGAAAATAT

Downstream 100 bases:

>100_bases
CACGAGCCGTGCTAGGTTCCACAATCCCAGCCACGCTGTGGCTGTTAATTAGATAATATAAGAGCCACAGCGTAGCTCAG
ATTAAGTAGCCCCATACAGC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 2 [H]

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MQISKLSRKNVQALTPYQSARRLGGNGDVWLNANEYPTSPSFDLLNRTFNRYPEAQPAAVVNGYAQYAGVKPENVIVTRG
GDESIELIIRAFCEPSDSVLYCPPTYGMYSVSAETFGVALKTVPLTADFQLNLPEIERNLDGVKVVFVCSPNNPTGTLVK
RSDLLKLLQITAGRAIVVVDEAYIEFCPEATMVSELANFPHLAIIRTLSKAFALAGLRCGFTLANEELIGVLQKVIAPYP
LPVPVSDIAAQALSEKGINEMKQRVANVLENRMWLIEQLKTIPSVVNIFDTEANYVLVKFQDGQQVFKALWEKGIILRDQ
HKALGLQNCIRISVGTRSELERTVEAIRNA

Sequences:

>Translated_350_residues
MQISKLSRKNVQALTPYQSARRLGGNGDVWLNANEYPTSPSFDLLNRTFNRYPEAQPAAVVNGYAQYAGVKPENVIVTRG
GDESIELIIRAFCEPSDSVLYCPPTYGMYSVSAETFGVALKTVPLTADFQLNLPEIERNLDGVKVVFVCSPNNPTGTLVK
RSDLLKLLQITAGRAIVVVDEAYIEFCPEATMVSELANFPHLAIIRTLSKAFALAGLRCGFTLANEELIGVLQKVIAPYP
LPVPVSDIAAQALSEKGINEMKQRVANVLENRMWLIEQLKTIPSVVNIFDTEANYVLVKFQDGQQVFKALWEKGIILRDQ
HKALGLQNCIRISVGTRSELERTVEAIRNA
>Mature_350_residues
MQISKLSRKNVQALTPYQSARRLGGNGDVWLNANEYPTSPSFDLLNRTFNRYPEAQPAAVVNGYAQYAGVKPENVIVTRG
GDESIELIIRAFCEPSDSVLYCPPTYGMYSVSAETFGVALKTVPLTADFQLNLPEIERNLDGVKVVFVCSPNNPTGTLVK
RSDLLKLLQITAGRAIVVVDEAYIEFCPEATMVSELANFPHLAIIRTLSKAFALAGLRCGFTLANEELIGVLQKVIAPYP
LPVPVSDIAAQALSEKGINEMKQRVANVLENRMWLIEQLKTIPSVVNIFDTEANYVLVKFQDGQQVFKALWEKGIILRDQ
HKALGLQNCIRISVGTRSELERTVEAIRNA

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=347, Percent_Identity=64.8414985590778, Blast_Score=478, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6322075, Length=368, Percent_Identity=33.1521739130435, Blast_Score=176, Evalue=6e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 38672; Mature: 38672

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQISKLSRKNVQALTPYQSARRLGGNGDVWLNANEYPTSPSFDLLNRTFNRYPEAQPAAV
CCCCHHHHCCCCEECCHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCCCCCHHH
VNGYAQYAGVKPENVIVTRGGDESIELIIRAFCEPSDSVLYCPPTYGMYSVSAETFGVAL
HHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCEEECCCCCCEEEECHHHHEEEE
KTVPLTADFQLNLPEIERNLDGVKVVFVCSPNNPTGTLVKRSDLLKLLQITAGRAIVVVD
EEEEEEECEEECCHHHHCCCCCEEEEEEECCCCCCCCEEEHHHHHHHHHHCCCCEEEEEE
EAYIEFCPEATMVSELANFPHLAIIRTLSKAFALAGLRCGFTLANEELIGVLQKVIAPYP
HHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHCCCC
LPVPVSDIAAQALSEKGINEMKQRVANVLENRMWLIEQLKTIPSVVNIFDTEANYVLVKF
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEE
QDGQQVFKALWEKGIILRDQHKALGLQNCIRISVGTRSELERTVEAIRNA
CCHHHHHHHHHHCCCEEECCHHHCCCCHHEEEECCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MQISKLSRKNVQALTPYQSARRLGGNGDVWLNANEYPTSPSFDLLNRTFNRYPEAQPAAV
CCCCHHHHCCCCEECCHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCCCCCHHH
VNGYAQYAGVKPENVIVTRGGDESIELIIRAFCEPSDSVLYCPPTYGMYSVSAETFGVAL
HHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCEEECCCCCCEEEECHHHHEEEE
KTVPLTADFQLNLPEIERNLDGVKVVFVCSPNNPTGTLVKRSDLLKLLQITAGRAIVVVD
EEEEEEECEEECCHHHHCCCCCEEEEEEECCCCCCCCEEEHHHHHHHHHHCCCCEEEEEE
EAYIEFCPEATMVSELANFPHLAIIRTLSKAFALAGLRCGFTLANEELIGVLQKVIAPYP
HHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHCCCC
LPVPVSDIAAQALSEKGINEMKQRVANVLENRMWLIEQLKTIPSVVNIFDTEANYVLVKF
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEE
QDGQQVFKALWEKGIILRDQHKALGLQNCIRISVGTRSELERTVEAIRNA
CCHHHHHHHHHHCCCEEECCHHHCCCCHHEEEECCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA