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The map label for this gene is truD [H]

Identifier: 126209386

GI number: 126209386

Start: 2162989

End: 2164002

Strand: Direct

Name: truD [H]

Synonym: APL_1926

Alternate gene names: 126209386

Gene position: 2162989-2164002 (Clockwise)

Preceding gene: 126209384

Following gene: 126209387

Centisome position: 95.1

GC content: 44.58

Gene sequence:

>1014_bases
ATGCAATTAAATTATCTCTTAGGGCAACCGCAACAAGCGGGCAGATTAAAGGCGGAATTTGCCGATTTCATCGTGCGTGA
AGAATTGGGTTATCCGCTTAGCGGCGAAGGCGAATTTGTGGCGGTAAAAATCCGTAAAACCAATGCGAACACATTGTTTG
TCGGCGAACGACTGGCAAAATTTGCCGGTATCTCCGAACGAAATATGAGCTACGCCGGTCTTAAAGATCGTCATGCGGTA
ACCGAACAATGGTTTTGTTTACACTTAGCCGGCAAAGAAACGCCTGATTTTACGCAATTTGAATGCGAGGGCGTAGAGGT
GTTGGAAGTTACTCGCCATAATCGTAAGATCCGAGTCGGAAGCCTTGCCGGAAATCATTTTGAATTGTTATTGCGCGATG
TGAATGAATCGGAAGAACTGAACCAACGTTTAAACCGTTTACAAGCGGTCGGATTTCCGAATTATTTTACCGAGCAGCGT
TTTGGCAGAGACGGCCACAATTTAACGCAATCATTGCGTTGGGCAAACGGCGAAATAGCGGTTAAAGATCGTAAAAAACG
TAGTTTTTATTTATCGGCGGCACGTAGTGAAGTGTTTAACTTAGTGGTTTCGCAACGTATTGCCGATCATTTAACCCAAA
CCGTATTAGCCGGCGATTATGTGCAGTTAGCCGGTTCAAACAGTTTTTTTATGGTGGAAGAAAAGGAAGTTGCCGAAACG
CAACAGCGTTTAGCATCGGGCGACGTGTTACTAACCGCCCCCTTAATCGGCGAAAAATCGTTAGAATTAACCGCTTGCGA
GCAAGAAAAAGCGATAATTGCGCAACATTCGACGTTAGTCGAGTTGATGAAAAAAGAACGTATGGCAAACGCACGCCGTG
CGATGTTGTGTAAACCGCAAGATTTTTCGTGGCGATTTGAAGCCGAGGGCTTACGACTTCGTTTCTTTTTAGATTCGGGA
AGCTATGCTACCGCATTAGTGCGAGAATTAATTCAATTAACGGAACAAGAATAA

Upstream 100 bases:

>100_bases
GCTTTTAAAGTGAGCGATAACTGTTAAAATAGCAAGATAGGATTCAATAGGCAGGAAAGTACTTTAGTGTACTTTTTTTA
TGCCTGAACAAGGACATTCA

Downstream 100 bases:

>100_bases
TGAATATCTTAATCAGTAATGATGACGGCTATCACGCACAGGGCATTCAAACACTTGCCGAAACGTTGCGCGATGCAGGA
CATTCGGTGACGGTAATTGC

Product: tRNA pseudouridine synthase D

Products: NA

Alternate protein names: tRNA pseudouridylate synthase D; tRNA-uridine isomerase D [H]

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MQLNYLLGQPQQAGRLKAEFADFIVREELGYPLSGEGEFVAVKIRKTNANTLFVGERLAKFAGISERNMSYAGLKDRHAV
TEQWFCLHLAGKETPDFTQFECEGVEVLEVTRHNRKIRVGSLAGNHFELLLRDVNESEELNQRLNRLQAVGFPNYFTEQR
FGRDGHNLTQSLRWANGEIAVKDRKKRSFYLSAARSEVFNLVVSQRIADHLTQTVLAGDYVQLAGSNSFFMVEEKEVAET
QQRLASGDVLLTAPLIGEKSLELTACEQEKAIIAQHSTLVELMKKERMANARRAMLCKPQDFSWRFEAEGLRLRFFLDSG
SYATALVRELIQLTEQE

Sequences:

>Translated_337_residues
MQLNYLLGQPQQAGRLKAEFADFIVREELGYPLSGEGEFVAVKIRKTNANTLFVGERLAKFAGISERNMSYAGLKDRHAV
TEQWFCLHLAGKETPDFTQFECEGVEVLEVTRHNRKIRVGSLAGNHFELLLRDVNESEELNQRLNRLQAVGFPNYFTEQR
FGRDGHNLTQSLRWANGEIAVKDRKKRSFYLSAARSEVFNLVVSQRIADHLTQTVLAGDYVQLAGSNSFFMVEEKEVAET
QQRLASGDVLLTAPLIGEKSLELTACEQEKAIIAQHSTLVELMKKERMANARRAMLCKPQDFSWRFEAEGLRLRFFLDSG
SYATALVRELIQLTEQE
>Mature_337_residues
MQLNYLLGQPQQAGRLKAEFADFIVREELGYPLSGEGEFVAVKIRKTNANTLFVGERLAKFAGISERNMSYAGLKDRHAV
TEQWFCLHLAGKETPDFTQFECEGVEVLEVTRHNRKIRVGSLAGNHFELLLRDVNESEELNQRLNRLQAVGFPNYFTEQR
FGRDGHNLTQSLRWANGEIAVKDRKKRSFYLSAARSEVFNLVVSQRIADHLTQTVLAGDYVQLAGSNSFFMVEEKEVAET
QQRLASGDVLLTAPLIGEKSLELTACEQEKAIIAQHSTLVELMKKERMANARRAMLCKPQDFSWRFEAEGLRLRFFLDSG
SYATALVRELIQLTEQE

Specific function: Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs [H]

COG id: COG0585

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRUD domain [H]

Homologues:

Organism=Escherichia coli, GI1789102, Length=335, Percent_Identity=46.2686567164179, Blast_Score=298, Evalue=4e-82,
Organism=Caenorhabditis elegans, GI17557232, Length=121, Percent_Identity=33.0578512396694, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020103
- InterPro:   IPR001656
- InterPro:   IPR020119
- InterPro:   IPR011760 [H]

Pfam domain/function: PF01142 TruD [H]

EC number: NA

Molecular weight: Translated: 38328; Mature: 38328

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS50984 TRUD ; PS01268 UPF0024

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLNYLLGQPQQAGRLKAEFADFIVREELGYPLSGEGEFVAVKIRKTNANTLFVGERLAK
CCCCCCCCCCCHHCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCEEEHHHHHHH
FAGISERNMSYAGLKDRHAVTEQWFCLHLAGKETPDFTQFECEGVEVLEVTRHNRKIRVG
HCCCCCCCCCCCCCCHHHHHHHCEEEEEECCCCCCCCCEEECCCEEEEEEECCCCEEEEE
SLAGNHFELLLRDVNESEELNQRLNRLQAVGFPNYFTEQRFGRDGHNLTQSLRWANGEIA
ECCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHCCCCEEE
VKDRKKRSFYLSAARSEVFNLVVSQRIADHLTQTVLAGDYVQLAGSNSFFMVEEKEVAET
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEHHHHHHH
QQRLASGDVLLTAPLIGEKSLELTACEQEKAIIAQHSTLVELMKKERMANARRAMLCKPQ
HHHHHCCCEEEEECCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCC
DFSWRFEAEGLRLRFFLDSGSYATALVRELIQLTEQE
CCCEEEECCCEEEEEEECCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQLNYLLGQPQQAGRLKAEFADFIVREELGYPLSGEGEFVAVKIRKTNANTLFVGERLAK
CCCCCCCCCCCHHCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCEEEHHHHHHH
FAGISERNMSYAGLKDRHAVTEQWFCLHLAGKETPDFTQFECEGVEVLEVTRHNRKIRVG
HCCCCCCCCCCCCCCHHHHHHHCEEEEEECCCCCCCCCEEECCCEEEEEEECCCCEEEEE
SLAGNHFELLLRDVNESEELNQRLNRLQAVGFPNYFTEQRFGRDGHNLTQSLRWANGEIA
ECCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHCCCCEEE
VKDRKKRSFYLSAARSEVFNLVVSQRIADHLTQTVLAGDYVQLAGSNSFFMVEEKEVAET
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEHHHHHHH
QQRLASGDVLLTAPLIGEKSLELTACEQEKAIIAQHSTLVELMKKERMANARRAMLCKPQ
HHHHHCCCEEEEECCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCC
DFSWRFEAEGLRLRFFLDSGSYATALVRELIQLTEQE
CCCEEEECCCEEEEEEECCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]