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The map label for this gene is accC [H]

Identifier: 126209327

GI number: 126209327

Start: 2095087

End: 2096430

Strand: Direct

Name: accC [H]

Synonym: APL_1865

Alternate gene names: 126209327

Gene position: 2095087-2096430 (Clockwise)

Preceding gene: 126209326

Following gene: 126209329

Centisome position: 92.11

GC content: 44.57

Gene sequence:

>1344_bases
ATGTTAGAAAAAGTTGTCATTGCCAACCGCGGCGAGATCGCATTACGTATTTTACGTGCCTGTAAAGAGCTTGGTATCAA
GACGGTTGCGGTTCACTCGACTGCCGACCGTGAACTAAAACACGTACTTTTAGCGGACGAAACGATTTGTATCGGCCCGG
CACCTTCAGTAAAAAGTTACTTAAACATTCCAATGATTATTGCCGCTGCGGAAGTGACTAACGCAGACGCAATCCACCCG
GGTTACGGTTTCTTATCTGAAAATGCGGACTTTGCCGAACAAGTAGAAAACTCAGGCTTTACTTTTATTGGCCCTACTGC
GGACGTGATTCGTTTAATGGGCGATAAAGTATCGGCAATCAATGCAATGAAAAAAGCGGGCGTCCCTTGCGTACCGGGTT
CCGACGGTCCGGTAGGCAACGATCCGGCAAAAAACAAAGAAATTGCAAAACGTATCGGTTATCCGGTGATTATTAAAGCG
TCCGGCGGCGGCGGCGGTCGTGGTATGCGTGTGGTATACAACGAGAAAGATCTCGAAGAATCTATCGCAATGACCAAAGC
GGAAGCGAAAGCAGCATTTAATAACGATATGGTATATATGGAAAAATATTTAGAAAATCCACGCCATATTGAAATCCAAG
TATTAGCGGATACACACGGTAATGCGGTTTATTTAGCGGAACGTGACTGTTCAATGCAACGCCGTCACCAAAAAGTGGTG
GAAGAAGCACCAGCACCGGGCATTACCCCTGAATTACGTAAATTCATCGGTGAGCGTTGTGCGAATGCGTGTCGTGAAAT
CGGCTATCGTGGCGCAGGTACATTCGAATTCTTATTTGAAAACGGCGAATTCTATTTCATCGAAATGAATACCCGTTTAC
AAGTAGAGCATCCGGTTACGGAAATGATCACCGGTGTGGACTTAGTAAAAGAGCAATTACGTGTGGCGGCTGGTCTTCCG
ATTTCAATCAAACAAGAAGACATCAAAGTGAAAGGTCACGCAATGGAATGCCGTATCAATGCAGAAGATCCGAATGCCTT
CTTACCTTCACCGGGTAAAATCACACGTTTACACGTGCCGGGCGGTTTAGGCGTACGTTGGGATTCTCACATTTATACCG
GTTATACCGTACCACCGCATTATGATTCAATGATCGGTAAATTGATTACTTTTGCAGAAGATCGTGATATTGCAATCCGT
CGTATGCAAAATGCCTTATCAGAAACGATTGTGGAAGGTATCAAAACCAATATTCCATTACACAATCTGATTATGGAAGA
CGAAAACTTCCGTAAAGGTGGCACAAATATCCACTACCTCGAGAAAAAGCTCGGTCTTAAATAA

Upstream 100 bases:

>100_bases
TCTGTTTTCTCTCGAATTTTGTAAAAGAATCAGCAAAATTAACCGCTTGCAACTGTTTCCGGGTGTTCCGTTCTTTCCTT
GACAAAAGGGGAAAACTCCA

Downstream 100 bases:

>100_bases
GCAACAAGCGGTAAGATTTTCAGTAAATCTTACCGCTTTCTTTTAGCTTTTAAGCCATTGTCGAATAAAATCCGCAATCT
GATCAATATCATTAATATCT

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MLEKVVIANRGEIALRILRACKELGIKTVAVHSTADRELKHVLLADETICIGPAPSVKSYLNIPMIIAAAEVTNADAIHP
GYGFLSENADFAEQVENSGFTFIGPTADVIRLMGDKVSAINAMKKAGVPCVPGSDGPVGNDPAKNKEIAKRIGYPVIIKA
SGGGGGRGMRVVYNEKDLEESIAMTKAEAKAAFNNDMVYMEKYLENPRHIEIQVLADTHGNAVYLAERDCSMQRRHQKVV
EEAPAPGITPELRKFIGERCANACREIGYRGAGTFEFLFENGEFYFIEMNTRLQVEHPVTEMITGVDLVKEQLRVAAGLP
ISIKQEDIKVKGHAMECRINAEDPNAFLPSPGKITRLHVPGGLGVRWDSHIYTGYTVPPHYDSMIGKLITFAEDRDIAIR
RMQNALSETIVEGIKTNIPLHNLIMEDENFRKGGTNIHYLEKKLGLK

Sequences:

>Translated_447_residues
MLEKVVIANRGEIALRILRACKELGIKTVAVHSTADRELKHVLLADETICIGPAPSVKSYLNIPMIIAAAEVTNADAIHP
GYGFLSENADFAEQVENSGFTFIGPTADVIRLMGDKVSAINAMKKAGVPCVPGSDGPVGNDPAKNKEIAKRIGYPVIIKA
SGGGGGRGMRVVYNEKDLEESIAMTKAEAKAAFNNDMVYMEKYLENPRHIEIQVLADTHGNAVYLAERDCSMQRRHQKVV
EEAPAPGITPELRKFIGERCANACREIGYRGAGTFEFLFENGEFYFIEMNTRLQVEHPVTEMITGVDLVKEQLRVAAGLP
ISIKQEDIKVKGHAMECRINAEDPNAFLPSPGKITRLHVPGGLGVRWDSHIYTGYTVPPHYDSMIGKLITFAEDRDIAIR
RMQNALSETIVEGIKTNIPLHNLIMEDENFRKGGTNIHYLEKKLGLK
>Mature_447_residues
MLEKVVIANRGEIALRILRACKELGIKTVAVHSTADRELKHVLLADETICIGPAPSVKSYLNIPMIIAAAEVTNADAIHP
GYGFLSENADFAEQVENSGFTFIGPTADVIRLMGDKVSAINAMKKAGVPCVPGSDGPVGNDPAKNKEIAKRIGYPVIIKA
SGGGGGRGMRVVYNEKDLEESIAMTKAEAKAAFNNDMVYMEKYLENPRHIEIQVLADTHGNAVYLAERDCSMQRRHQKVV
EEAPAPGITPELRKFIGERCANACREIGYRGAGTFEFLFENGEFYFIEMNTRLQVEHPVTEMITGVDLVKEQLRVAAGLP
ISIKQEDIKVKGHAMECRINAEDPNAFLPSPGKITRLHVPGGLGVRWDSHIYTGYTVPPHYDSMIGKLITFAEDRDIAIR
RMQNALSETIVEGIKTNIPLHNLIMEDENFRKGGTNIHYLEKKLGLK

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=420, Percent_Identity=51.9047619047619, Blast_Score=430, Evalue=1e-120,
Organism=Homo sapiens, GI189095269, Length=446, Percent_Identity=49.1031390134529, Blast_Score=426, Evalue=1e-119,
Organism=Homo sapiens, GI65506442, Length=446, Percent_Identity=49.1031390134529, Blast_Score=426, Evalue=1e-119,
Organism=Homo sapiens, GI295821183, Length=446, Percent_Identity=49.1031390134529, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI106049528, Length=449, Percent_Identity=46.7706013363029, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI106049295, Length=449, Percent_Identity=46.7706013363029, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI106049292, Length=449, Percent_Identity=46.7706013363029, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI38679974, Length=509, Percent_Identity=29.6660117878193, Blast_Score=238, Evalue=6e-63,
Organism=Homo sapiens, GI38679971, Length=509, Percent_Identity=29.6660117878193, Blast_Score=238, Evalue=6e-63,
Organism=Homo sapiens, GI38679960, Length=509, Percent_Identity=29.6660117878193, Blast_Score=238, Evalue=6e-63,
Organism=Homo sapiens, GI38679977, Length=509, Percent_Identity=29.6660117878193, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI38679967, Length=509, Percent_Identity=29.6660117878193, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI134142062, Length=505, Percent_Identity=30.0990099009901, Blast_Score=228, Evalue=1e-59,
Organism=Escherichia coli, GI1789654, Length=447, Percent_Identity=82.3266219239374, Blast_Score=754, Evalue=0.0,
Organism=Escherichia coli, GI1786216, Length=240, Percent_Identity=25, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=48.0812641083521, Blast_Score=419, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI71987519, Length=442, Percent_Identity=47.0588235294118, Blast_Score=391, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17562816, Length=448, Percent_Identity=45.3125, Blast_Score=366, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI71997163, Length=512, Percent_Identity=28.515625, Blast_Score=206, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI133931226, Length=495, Percent_Identity=29.8989898989899, Blast_Score=205, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI71997168, Length=512, Percent_Identity=28.515625, Blast_Score=205, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6319685, Length=443, Percent_Identity=41.9864559819413, Blast_Score=355, Evalue=1e-98,
Organism=Saccharomyces cerevisiae, GI6319695, Length=439, Percent_Identity=45.3302961275626, Blast_Score=344, Evalue=2e-95,
Organism=Saccharomyces cerevisiae, GI6321376, Length=439, Percent_Identity=46.4692482915718, Blast_Score=338, Evalue=9e-94,
Organism=Saccharomyces cerevisiae, GI6324343, Length=510, Percent_Identity=31.5686274509804, Blast_Score=238, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6323863, Length=453, Percent_Identity=34.2163355408389, Blast_Score=234, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24652212, Length=448, Percent_Identity=48.4375, Blast_Score=396, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652210, Length=448, Percent_Identity=48.4375, Blast_Score=396, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652214, Length=448, Percent_Identity=48.4375, Blast_Score=396, Evalue=1e-110,
Organism=Drosophila melanogaster, GI19921944, Length=448, Percent_Identity=48.4375, Blast_Score=396, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652216, Length=448, Percent_Identity=48.4375, Blast_Score=396, Evalue=1e-110,
Organism=Drosophila melanogaster, GI281363050, Length=448, Percent_Identity=48.8839285714286, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652224, Length=448, Percent_Identity=48.8839285714286, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652222, Length=448, Percent_Identity=48.8839285714286, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652220, Length=448, Percent_Identity=48.8839285714286, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652218, Length=448, Percent_Identity=48.8839285714286, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24651757, Length=421, Percent_Identity=46.3182897862233, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24651759, Length=382, Percent_Identity=46.3350785340314, Blast_Score=347, Evalue=1e-95,
Organism=Drosophila melanogaster, GI161076409, Length=498, Percent_Identity=28.714859437751, Blast_Score=211, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24586458, Length=498, Percent_Identity=28.714859437751, Blast_Score=211, Evalue=1e-54,
Organism=Drosophila melanogaster, GI161076407, Length=498, Percent_Identity=28.714859437751, Blast_Score=211, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24586460, Length=498, Percent_Identity=28.714859437751, Blast_Score=211, Evalue=1e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49234; Mature: 49234

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEKVVIANRGEIALRILRACKELGIKTVAVHSTADRELKHVLLADETICIGPAPSVKSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHEECCEEEECCCCCHHHH
LNIPMIIAAAEVTNADAIHPGYGFLSENADFAEQVENSGFTFIGPTADVIRLMGDKVSAI
CCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEECCHHHHHHHHCCHHHHH
NAMKKAGVPCVPGSDGPVGNDPAKNKEIAKRIGYPVIIKASGGGGGRGMRVVYNEKDLEE
HHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCCCEEEEECCHHHHH
SIAMTKAEAKAAFNNDMVYMEKYLENPRHIEIQVLADTHGNAVYLAERDCSMQRRHQKVV
HHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEEEECCCCEEEEECCCCHHHHHHHHHH
EEAPAPGITPELRKFIGERCANACREIGYRGAGTFEFLFENGEFYFIEMNTRLQVEHPVT
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
EMITGVDLVKEQLRVAAGLPISIKQEDIKVKGHAMECRINAEDPNAFLPSPGKITRLHVP
HHHHHHHHHHHHHHHHCCCCEEEECCCEEEECEEEEEEEECCCCCCCCCCCCCEEEEECC
GGLGVRWDSHIYTGYTVPPHYDSMIGKLITFAEDRDIAIRRMQNALSETIVEGIKTNIPL
CCCCCEECCEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCH
HNLIMEDENFRKGGTNIHYLEKKLGLK
HHEEECCCCCCCCCCEEEEHHHHHCCC
>Mature Secondary Structure
MLEKVVIANRGEIALRILRACKELGIKTVAVHSTADRELKHVLLADETICIGPAPSVKSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHEECCEEEECCCCCHHHH
LNIPMIIAAAEVTNADAIHPGYGFLSENADFAEQVENSGFTFIGPTADVIRLMGDKVSAI
CCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEECCHHHHHHHHCCHHHHH
NAMKKAGVPCVPGSDGPVGNDPAKNKEIAKRIGYPVIIKASGGGGGRGMRVVYNEKDLEE
HHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCCCEEEEECCHHHHH
SIAMTKAEAKAAFNNDMVYMEKYLENPRHIEIQVLADTHGNAVYLAERDCSMQRRHQKVV
HHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEEEECCCCEEEEECCCCHHHHHHHHHH
EEAPAPGITPELRKFIGERCANACREIGYRGAGTFEFLFENGEFYFIEMNTRLQVEHPVT
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
EMITGVDLVKEQLRVAAGLPISIKQEDIKVKGHAMECRINAEDPNAFLPSPGKITRLHVP
HHHHHHHHHHHHHHHHCCCCEEEECCCEEEECEEEEEEEECCCCCCCCCCCCCEEEEECC
GGLGVRWDSHIYTGYTVPPHYDSMIGKLITFAEDRDIAIRRMQNALSETIVEGIKTNIPL
CCCCCEECCEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCH
HNLIMEDENFRKGGTNIHYLEKKLGLK
HHEEECCCCCCCCCCEEEEHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]