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The map label for this gene is fklB [H]

Identifier: 126209169

GI number: 126209169

Start: 1937132

End: 1937761

Strand: Reverse

Name: fklB [H]

Synonym: APL_1705

Alternate gene names: 126209169

Gene position: 1937761-1937132 (Counterclockwise)

Preceding gene: 126209174

Following gene: 162329624

Centisome position: 85.2

GC content: 47.62

Gene sequence:

>630_bases
ATGGCATTAGATTTCAATGCGGTAGCTTTAGAAACAACGGAAGCAAAGGGCGGTTACGGAATCGGTTTACAAATCGGTCA
GCAATTATTAAGTAGCGGTATGGAAGTGGATGCGGAAGCGGTTGCTCGCGGTATTAATGACGTATTAAATCAAAACCCGC
CGGCGATTGATCTTAACGATGTGACCAAAGCGCTACAAGAGTTAGGCGCACGCGCGGAAGCGGCGCAAGCGGAAGCGTTT
AAAGCGATTGAAGCGGATAACAAAGCGTTCTTAGAAGAAAACAAGAAAGCAAAAGGCGTTGTGGTGACAGAATCGGGTTT
ACAATATGAAGTCTTAACCGAAGGTACGGGCGCAAAACCGACGGCGGCAAGTTCCGTTCGTGTACACTATACCGGTTCTT
TAATTGACGGTACGGTATTCGATAGCTCGGTAAAACGCGGTACTCCGGCGGAATTCCCGGTCGGCGGCGTGATCAAAGGT
TGGACGGAAGCGTTACAATTAATGACCATCGGTTCAAAATGGCGTTTAACCATCCCGCAAGAGTTAGCATACGGCGAGCG
TGGCGCAGGCGCATCAATTCCTCCGTTTGCCACCTTAATTTTTGAAGTGGAATTATTAGATATTCTTTAA

Upstream 100 bases:

>100_bases
TTCTATCTTAACGCTATTTTCTGAGCCGTTTAGGGTTGTATTCTTAAAATTCATCCCCATAAATGGAAACGTCTTTACAC
CATCATAAAAGGAAACAAAA

Downstream 100 bases:

>100_bases
TTCTGATTCAAACCATCTATCTAGCCTCCGTATTCGGAGGCTTTTTTATCGCCGGAAACAATATACCGCTTAATAAGTTC
GATAAAAAAGCGGTCGAATT

Product: FKBP-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: FKBP22; PPIase; Rotamase [H]

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MALDFNAVALETTEAKGGYGIGLQIGQQLLSSGMEVDAEAVARGINDVLNQNPPAIDLNDVTKALQELGARAEAAQAEAF
KAIEADNKAFLEENKKAKGVVVTESGLQYEVLTEGTGAKPTAASSVRVHYTGSLIDGTVFDSSVKRGTPAEFPVGGVIKG
WTEALQLMTIGSKWRLTIPQELAYGERGAGASIPPFATLIFEVELLDIL

Sequences:

>Translated_209_residues
MALDFNAVALETTEAKGGYGIGLQIGQQLLSSGMEVDAEAVARGINDVLNQNPPAIDLNDVTKALQELGARAEAAQAEAF
KAIEADNKAFLEENKKAKGVVVTESGLQYEVLTEGTGAKPTAASSVRVHYTGSLIDGTVFDSSVKRGTPAEFPVGGVIKG
WTEALQLMTIGSKWRLTIPQELAYGERGAGASIPPFATLIFEVELLDIL
>Mature_208_residues
ALDFNAVALETTEAKGGYGIGLQIGQQLLSSGMEVDAEAVARGINDVLNQNPPAIDLNDVTKALQELGARAEAAQAEAFK
AIEADNKAFLEENKKAKGVVVTESGLQYEVLTEGTGAKPTAASSVRVHYTGSLIDGTVFDSSVKRGTPAEFPVGGVIKGW
TEALQLMTIGSKWRLTIPQELAYGERGAGASIPPFATLIFEVELLDIL

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cytoplasm. Periplasm. Note=According to PubMed:7610040 it is periplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=106, Percent_Identity=44.3396226415094, Blast_Score=87, Evalue=8e-18,
Organism=Homo sapiens, GI4503725, Length=106, Percent_Identity=44.3396226415094, Blast_Score=87, Evalue=8e-18,
Organism=Homo sapiens, GI206725530, Length=92, Percent_Identity=52.1739130434783, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI17149844, Length=92, Percent_Identity=52.1739130434783, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI17149842, Length=92, Percent_Identity=52.1739130434783, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI4503729, Length=101, Percent_Identity=45.5445544554455, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI4503727, Length=99, Percent_Identity=48.4848484848485, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI4758380, Length=106, Percent_Identity=42.4528301886792, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI192448443, Length=99, Percent_Identity=42.4242424242424, Blast_Score=78, Evalue=5e-15,
Organism=Homo sapiens, GI33469985, Length=135, Percent_Identity=36.2962962962963, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI7706131, Length=108, Percent_Identity=39.8148148148148, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI8923659, Length=117, Percent_Identity=38.4615384615385, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI87082390, Length=201, Percent_Identity=61.1940298507463, Blast_Score=244, Evalue=2e-66,
Organism=Escherichia coli, GI1789745, Length=211, Percent_Identity=36.0189573459716, Blast_Score=123, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI71993519, Length=106, Percent_Identity=44.3396226415094, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17540882, Length=97, Percent_Identity=45.360824742268, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17561782, Length=100, Percent_Identity=46, Blast_Score=81, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6320727, Length=108, Percent_Identity=49.0740740740741, Blast_Score=99, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6324194, Length=110, Percent_Identity=45.4545454545455, Blast_Score=92, Evalue=4e-20,
Organism=Drosophila melanogaster, GI281363946, Length=113, Percent_Identity=46.0176991150442, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17352457, Length=113, Percent_Identity=46.0176991150442, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24583150, Length=106, Percent_Identity=45.2830188679245, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24655568, Length=106, Percent_Identity=42.4528301886792, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21356629, Length=98, Percent_Identity=44.8979591836735, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24647110, Length=94, Percent_Identity=43.6170212765958, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 22021; Mature: 21890

Theoretical pI: Translated: 4.30; Mature: 4.30

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALDFNAVALETTEAKGGYGIGLQIGQQLLSSGMEVDAEAVARGINDVLNQNPPAIDLND
CCCCCCEEEEEECCCCCCEEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEECHHH
VTKALQELGARAEAAQAEAFKAIEADNKAFLEENKKAKGVVVTESGLQYEVLTEGTGAKP
HHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEEECCCCEEEEEECCCCCCC
TAASSVRVHYTGSLIDGTVFDSSVKRGTPAEFPVGGVIKGWTEALQLMTIGSKWRLTIPQ
CCCCEEEEEEECCEECCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECHH
ELAYGERGAGASIPPFATLIFEVELLDIL
HHCCCCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ALDFNAVALETTEAKGGYGIGLQIGQQLLSSGMEVDAEAVARGINDVLNQNPPAIDLND
CCCCCEEEEEECCCCCCEEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEECHHH
VTKALQELGARAEAAQAEAFKAIEADNKAFLEENKKAKGVVVTESGLQYEVLTEGTGAKP
HHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEEECCCCEEEEEECCCCCCC
TAASSVRVHYTGSLIDGTVFDSSVKRGTPAEFPVGGVIKGWTEALQLMTIGSKWRLTIPQ
CCCCEEEEEEECCEECCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECHH
ELAYGERGAGASIPPFATLIFEVELLDIL
HHCCCCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 8703024; 9298646 [H]