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The map label for this gene is fucK [H]

Identifier: 126209149

GI number: 126209149

Start: 1915853

End: 1917286

Strand: Direct

Name: fucK [H]

Synonym: APL_1685

Alternate gene names: 126209149

Gene position: 1915853-1917286 (Clockwise)

Preceding gene: 126209148

Following gene: 126209150

Centisome position: 84.23

GC content: 44.7

Gene sequence:

>1434_bases
ATGTCTATTGCCCTTATTTTTGACTGCGGTGCGACGAATTTACGTACGATTGCCATTGATCAAAGCGGGAAAATTCTCGC
GATGCAACACCTTGCCAATAATACCCAAGCAGGGGAAGAAAACCCTGATTATCACATTTGGGATATTGAAGAAATTTGGC
AAAAATTGATGACTTGTGCAAAAAGCACCCTTTCACAACTTTCAGCGCAACAACGCCAATCTATCGTAGGGATTTCCGTG
ACGACCTTTGGCGTGGACGGTACGATTTTTGATAAAGCAGGCAACCAACTTTATCCGATTATTTCTTGGAAATGTCCGCG
TACGTTACCGATTATGGCGGAACTTGCCGATAAACTTGACGTAGAAGCACTTTATCAGCGTAACGGTGTAGGACATTACA
GTTTTAACACTTTATTTAAATTGTTATGGTTGAAACAACATAAACCTGAACTTTATGCTCAGGCGGACAGTTTCTTATTT
ATCTCTTCTATTTTGACCTATCGCCTAACCGGAGTACAAAGTACCGACCGCACTATGGCGGGAACTTCTATGATGACCAA
TATCGAAAATGATGATTGGGATAAAGAGGTTCTCTCATTATTAGGCTTAACCGAAGCGCATTTCCCGCCGATGAAAAGTG
CCGGCGAAGTGATAGGTACATTAACAACGGATCTCGCCGAACAACTCGGTTTAAGCGATCAAATTCTGGTGATTTCTTGC
GGTCATGATACGCAATTCGCCATTTTCGGTTCCGGAGCCGGTTATAACCAACCGGTATTAAGTTCGGGAACGTGGGAAAT
TTTAATGTCGCGTTGCCAACAAGCTAAACCTAAATGGAAATTTGTTGAGCAAGGTTTGACGATTGAATTTGACAGTCAAT
CCGGCGGTTTCAACCCCGGCGTGCAATGGGTTGCGTCCGGTGTGATGGAATGGTTGGGCAAACGTTTCTTTGCCGATGTA
GTCGGTCAAGATAATTATTACGGCACAATGATCTCCGAAGCACAATCGGTGTCGGCAGGTGCAAACGGTGTGAAATTAGT
CGGTAATTTTGACGGGACGACGGCAGAAAGCGGATCGATTACTGGTTTATCAATGCACACCAGTCGCGGTGAAATTTACC
GTGCCGGATTGGAATATATGGCGTATCGCTTAAAAGCCGGTTTAGCCGTTCTAGAACAAGTCGGACAATTTAATGCGGAA
AGTTTAATTTGTGTCGGCGGCGGTTCTAAAAACACCCTTTGGAATCAAATTCGTGCCGATGTGTTAAATCGACCGCTGGA
TGTGGTGGATTTCCCTGAGAGTACCGTGTTGGGTGCGGCAATGTTCACTTTTGCCGGTGCGGGGGTCTTCTCATCGCCGG
AACAAGCGCAACAGGCAATGAAACCGAATGTACAACGAGTAGAACCATCAACTAACAGTCAGTTTTATCAATAA

Upstream 100 bases:

>100_bases
ACTTCGGTCCATTATATAAATAAAAAAATATCTTCCCTCTCCCTCTACGGGAGAGGGGTTTTACCCACTTTAGAACGGAA
GTAAAGGGAGAATAATATTT

Downstream 100 bases:

>100_bases
TCATTAAGTTACGAATCCCTATCTATATTAGCTGCAAGCGATCGAATTTCTTGCCGGCTTTGTGAAGTGCTGCCCAAAAA
CGACCGCTTGGTGAAAATTT

Product: L-fuculokinase

Products: NA

Alternate protein names: L-fuculose kinase [H]

Number of amino acids: Translated: 477; Mature: 476

Protein sequence:

>477_residues
MSIALIFDCGATNLRTIAIDQSGKILAMQHLANNTQAGEENPDYHIWDIEEIWQKLMTCAKSTLSQLSAQQRQSIVGISV
TTFGVDGTIFDKAGNQLYPIISWKCPRTLPIMAELADKLDVEALYQRNGVGHYSFNTLFKLLWLKQHKPELYAQADSFLF
ISSILTYRLTGVQSTDRTMAGTSMMTNIENDDWDKEVLSLLGLTEAHFPPMKSAGEVIGTLTTDLAEQLGLSDQILVISC
GHDTQFAIFGSGAGYNQPVLSSGTWEILMSRCQQAKPKWKFVEQGLTIEFDSQSGGFNPGVQWVASGVMEWLGKRFFADV
VGQDNYYGTMISEAQSVSAGANGVKLVGNFDGTTAESGSITGLSMHTSRGEIYRAGLEYMAYRLKAGLAVLEQVGQFNAE
SLICVGGGSKNTLWNQIRADVLNRPLDVVDFPESTVLGAAMFTFAGAGVFSSPEQAQQAMKPNVQRVEPSTNSQFYQ

Sequences:

>Translated_477_residues
MSIALIFDCGATNLRTIAIDQSGKILAMQHLANNTQAGEENPDYHIWDIEEIWQKLMTCAKSTLSQLSAQQRQSIVGISV
TTFGVDGTIFDKAGNQLYPIISWKCPRTLPIMAELADKLDVEALYQRNGVGHYSFNTLFKLLWLKQHKPELYAQADSFLF
ISSILTYRLTGVQSTDRTMAGTSMMTNIENDDWDKEVLSLLGLTEAHFPPMKSAGEVIGTLTTDLAEQLGLSDQILVISC
GHDTQFAIFGSGAGYNQPVLSSGTWEILMSRCQQAKPKWKFVEQGLTIEFDSQSGGFNPGVQWVASGVMEWLGKRFFADV
VGQDNYYGTMISEAQSVSAGANGVKLVGNFDGTTAESGSITGLSMHTSRGEIYRAGLEYMAYRLKAGLAVLEQVGQFNAE
SLICVGGGSKNTLWNQIRADVLNRPLDVVDFPESTVLGAAMFTFAGAGVFSSPEQAQQAMKPNVQRVEPSTNSQFYQ
>Mature_476_residues
SIALIFDCGATNLRTIAIDQSGKILAMQHLANNTQAGEENPDYHIWDIEEIWQKLMTCAKSTLSQLSAQQRQSIVGISVT
TFGVDGTIFDKAGNQLYPIISWKCPRTLPIMAELADKLDVEALYQRNGVGHYSFNTLFKLLWLKQHKPELYAQADSFLFI
SSILTYRLTGVQSTDRTMAGTSMMTNIENDDWDKEVLSLLGLTEAHFPPMKSAGEVIGTLTTDLAEQLGLSDQILVISCG
HDTQFAIFGSGAGYNQPVLSSGTWEILMSRCQQAKPKWKFVEQGLTIEFDSQSGGFNPGVQWVASGVMEWLGKRFFADVV
GQDNYYGTMISEAQSVSAGANGVKLVGNFDGTTAESGSITGLSMHTSRGEIYRAGLEYMAYRLKAGLAVLEQVGQFNAES
LICVGGGSKNTLWNQIRADVLNRPLDVVDFPESTVLGAAMFTFAGAGVFSSPEQAQQAMKPNVQRVEPSTNSQFYQ

Specific function: Fucose metabolism; second step. [C]

COG id: COG1070

COG function: function code G; Sugar (pentulose and hexulose) kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI42794763, Length=454, Percent_Identity=24.6696035242291, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI41393575, Length=450, Percent_Identity=24.6666666666667, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI189409120, Length=454, Percent_Identity=24.8898678414097, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI4504007, Length=454, Percent_Identity=24.8898678414097, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789168, Length=475, Percent_Identity=45.0526315789474, Blast_Score=417, Evalue=1e-118,
Organism=Escherichia coli, GI1787789, Length=469, Percent_Identity=24.5202558635394, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1790338, Length=406, Percent_Identity=27.3399014778325, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1789987, Length=487, Percent_Identity=23.4086242299795, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790005, Length=489, Percent_Identity=23.9263803680982, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1790361, Length=495, Percent_Identity=23.8383838383838, Blast_Score=89, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17535599, Length=407, Percent_Identity=24.3243243243243, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24657106, Length=523, Percent_Identity=24.0917782026769, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24657102, Length=523, Percent_Identity=24.0917782026769, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21356323, Length=382, Percent_Identity=25.9162303664921, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR013450 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.51 [H]

Molecular weight: Translated: 52187; Mature: 52055

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00933 FGGY_KINASES_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIALIFDCGATNLRTIAIDQSGKILAMQHLANNTQAGEENPDYHIWDIEEIWQKLMTCA
CEEEEEEECCCCCEEEEEECCCCCEEEEHHHHCCCCCCCCCCCEEEECHHHHHHHHHHHH
KSTLSQLSAQQRQSIVGISVTTFGVDGTIFDKAGNQLYPIISWKCPRTLPIMAELADKLD
HHHHHHHHHHHHHCEEEEEEEEECCCCEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHH
VEALYQRNGVGHYSFNTLFKLLWLKQHKPELYAQADSFLFISSILTYRLTGVQSTDRTMA
HHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHH
GTSMMTNIENDDWDKEVLSLLGLTEAHFPPMKSAGEVIGTLTTDLAEQLGLSDQILVISC
CCHHHCCCCCCCHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEC
GHDTQFAIFGSGAGYNQPVLSSGTWEILMSRCQQAKPKWKFVEQGLTIEFDSQSGGFNPG
CCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCEEEECCCCCCCCHH
VQWVASGVMEWLGKRFFADVVGQDNYYGTMISEAQSVSAGANGVKLVGNFDGTTAESGSI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCE
TGLSMHTSRGEIYRAGLEYMAYRLKAGLAVLEQVGQFNAESLICVGGGSKNTLWNQIRAD
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHH
VLNRPLDVVDFPESTVLGAAMFTFAGAGVFSSPEQAQQAMKPNVQRVEPSTNSQFYQ
HHCCCCCEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCEEECCCCCCCCCC
>Mature Secondary Structure 
SIALIFDCGATNLRTIAIDQSGKILAMQHLANNTQAGEENPDYHIWDIEEIWQKLMTCA
EEEEEEECCCCCEEEEEECCCCCEEEEHHHHCCCCCCCCCCCEEEECHHHHHHHHHHHH
KSTLSQLSAQQRQSIVGISVTTFGVDGTIFDKAGNQLYPIISWKCPRTLPIMAELADKLD
HHHHHHHHHHHHHCEEEEEEEEECCCCEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHH
VEALYQRNGVGHYSFNTLFKLLWLKQHKPELYAQADSFLFISSILTYRLTGVQSTDRTMA
HHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHH
GTSMMTNIENDDWDKEVLSLLGLTEAHFPPMKSAGEVIGTLTTDLAEQLGLSDQILVISC
CCHHHCCCCCCCHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEC
GHDTQFAIFGSGAGYNQPVLSSGTWEILMSRCQQAKPKWKFVEQGLTIEFDSQSGGFNPG
CCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCEEEECCCCCCCCHH
VQWVASGVMEWLGKRFFADVVGQDNYYGTMISEAQSVSAGANGVKLVGNFDGTTAESGSI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCE
TGLSMHTSRGEIYRAGLEYMAYRLKAGLAVLEQVGQFNAESLICVGGGSKNTLWNQIRAD
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHH
VLNRPLDVVDFPESTVLGAAMFTFAGAGVFSSPEQAQQAMKPNVQRVEPSTNSQFYQ
HHCCCCCEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]