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The map label for this gene is dmsA [H]

Identifier: 126209138

GI number: 126209138

Start: 1900092

End: 1902509

Strand: Direct

Name: dmsA [H]

Synonym: APL_1674

Alternate gene names: 126209138

Gene position: 1900092-1902509 (Clockwise)

Preceding gene: 126209137

Following gene: 126209139

Centisome position: 83.54

GC content: 39.08

Gene sequence:

>2418_bases
ATGTCAATTACAAGACGTGGATTCCTAAAAGGAACATCAGCAAGTATGACCGCATTAGCGGCATCCGGCGGTATCGCTCT
CCCTTTTGTTGCTAAAGCTGAAACAAAAGATAATGTTGCCGGACAAGCACAAGATGAAAAAGTAGTTTGGAGTGCCTGTA
CAGTAAACTGTGGTAGCCGTTGTCCATTGAGAATGCATGTAAAAGATAATCAAATTTTATATGTGGAAACGGATAATACC
GGTACGGAAACCTATAATCTTGATCATCAAGTTCGTGCTTGTTTACGTGGGCGTTCAATGCGCCGTCGTGTTTATAATCC
TGATCGTTTGAAATATCCGATGAAACGTGTAGGTAAGCGTGGCGAGGGTAAATTTAAACGTATTTCTTGGGATGAAGCAT
TAACGGAAATTGCACAATCATTACGTAAAAATATTGAGAAATACGGTAATGAAAGTATTTATCTCAACTATGGTACGGGA
ACATTAGGTGGAACCGTAACAAAATCTTGGCCGCCGGGTTCAACTTTAGTTGCACGTTTGATGAATTGTATCGGTGGTTA
TTTAAATCATTATGGCGACTATAGTACCGCTCAAATTGCAGTAGGTTTAGATTACACCTATGGTGGTGGCTGGGCATTAG
GCAATGGCTTAGCTGATATTGAAAACACAAAACTTATCGTACTATTCGGTAATAATCCAGCGGAAACTCGCATGAGTGGA
GGTGGTTTAACCTATTGTTTTGAGCAGGCTAAAGAAAAATCAAATGCCAAAGTTATCATCATTGATCCACGTTATACGGA
TACAGGAGTGGGTAAAGAGGATGAATGGATTCCTATTCGCCCTAGTACTGATGCAGCGTTAGTATCTGCACTTGCTTATG
TATTAATCACCGAAAATATGGTCGATCAGGCGTTTTTAGATAAATATTGTGTTGGCTATGATGAAAAAACATTACCTGCT
GATGCACCTAAAAATGGTCATTATAAAGCCTATATTTTAGGTCAAGGCGATGATGGCATTGCTAAAACACCTGAATGGGC
TTCTAAAATTACCGGTATTCCTGTTGAGCGTATTATCAAATTAGCCCGTGAAATTGGTCAAACAAAACCTGCTTATATTT
CACAAGGCTGGGGACCACAACGCCGTAGTAATGGCGAGTTAATTTCTCGTGCGATTGCGATGTTACCGATTTTAACCGGC
AATGTAGGGATTAGTGGCGGTAATACAGGTGCAAGAGAAAGTGCTTATGGAATACCGTTTGTAAGAATGCCAACTTTAAC
CAACCCGGTGCAAGCAAGTATCCCAATGTTCTTATGGACGGATGCGATTCTTCGTGGTCCAGAGATGACCGCAACCACAG
ACGGCATTCAAGGTGTTGAAAAATTATCCGCACCAATTAAAGTAATTTGGAATTATGCAAGTAACTGTTTGATTAACCAA
CATGCAGAAATTAACCGCACTCATGAAATTCTACAAGATGAGTCTAAATGTGAATTGATCATTACCATTGATAACCATAT
GACTTCAACTGCGAAATATAGTGATATTTTGTTACCGGATTGTATGACTTCAGAACAGATGGATTTCTGTTTAGATGCTT
ATGTTGCCAATATGAACTATGTTATTTTTGCTGATCAAGTGGTTAAACCTTCATTTGAGTGTCGTAATATCTACGATATG
TTAAGTGATTTGGCTGAAAAATTAGGTGTAAAAGAACAATTTACGGAAGGCAGAACCCAAGAACAATGGTTACGCCATAT
TTATGAGCAATCTCGCCAAAAATTACCTGAGCTTCCAACGTTTGAAGAATTTAGACAACAAGGTATTTTCAAAAAAGTCG
ATCCAAAAGGTTTCTTTATCGCTTATAAAGATTTCAGAGAAAACCCTGAAGCGAATCCATTAAAAACACCGTCAGGTAAA
ATTGAAATCTATTCATCTCGTTTAGCGGAAATTGCACGTACTTGGAAATTGGAAAAAGATGAAGTGATTCATCCGTTACC
AATTCATACCGATAGCTTTGAGCATTACGGCGACCCATTAATGCAAAAATATCCGTTACAACTTTCCGGTTTCCATTATA
AAGCGCGTACTCACTCAACTTACGGTAATGTTGATGTGATTAAAGAAGCTAATCCTCAAGAGATTTGGATTAATCCGATT
GATGCACAAACGAGAGGAATTCAAAACGGGGAATTGGTTCGTATCTTTAATGATCGTGGGGAAGTGCGTATTAATGCTAA
GGTTACACCTCGTATTATTCCGGGTGTTGTAGCATTGAGTGAAGGGGCTTGGTATGCACCGGATAAAAATGGTGTGGATT
ATTCAGGTTGTATTAATGTGCTTACTACCCAACGCCCATCTCCACTAGCGAAAGGCAATCCGCAACATTCTAACTTAGTG
CAAATTGAGAAATTATAG

Upstream 100 bases:

>100_bases
TCCCCAATTTCCGTACAAATTTTCTTATCATCTTTACAGAGTAACTATAGAATCAAATTATACCCTTATTTAGTTATGTT
TAATTTTGTTTGGAGTGAAT

Downstream 100 bases:

>100_bases
AGGTGAGCTATGGAACAATATGGTTTTTATTTCGATTCTGAACGTTGCACAGGTTGTAAAACTTGCGAATTAGCGTGCAA
GGATTATAAAGATTTAGGTA

Product: anaerobic dimethyl sulfoxide reductase chain A precursor

Products: Reduced form of N-Oxide compounds [C]

Alternate protein names: DMSO reductase [H]

Number of amino acids: Translated: 805; Mature: 804

Protein sequence:

>805_residues
MSITRRGFLKGTSASMTALAASGGIALPFVAKAETKDNVAGQAQDEKVVWSACTVNCGSRCPLRMHVKDNQILYVETDNT
GTETYNLDHQVRACLRGRSMRRRVYNPDRLKYPMKRVGKRGEGKFKRISWDEALTEIAQSLRKNIEKYGNESIYLNYGTG
TLGGTVTKSWPPGSTLVARLMNCIGGYLNHYGDYSTAQIAVGLDYTYGGGWALGNGLADIENTKLIVLFGNNPAETRMSG
GGLTYCFEQAKEKSNAKVIIIDPRYTDTGVGKEDEWIPIRPSTDAALVSALAYVLITENMVDQAFLDKYCVGYDEKTLPA
DAPKNGHYKAYILGQGDDGIAKTPEWASKITGIPVERIIKLAREIGQTKPAYISQGWGPQRRSNGELISRAIAMLPILTG
NVGISGGNTGARESAYGIPFVRMPTLTNPVQASIPMFLWTDAILRGPEMTATTDGIQGVEKLSAPIKVIWNYASNCLINQ
HAEINRTHEILQDESKCELIITIDNHMTSTAKYSDILLPDCMTSEQMDFCLDAYVANMNYVIFADQVVKPSFECRNIYDM
LSDLAEKLGVKEQFTEGRTQEQWLRHIYEQSRQKLPELPTFEEFRQQGIFKKVDPKGFFIAYKDFRENPEANPLKTPSGK
IEIYSSRLAEIARTWKLEKDEVIHPLPIHTDSFEHYGDPLMQKYPLQLSGFHYKARTHSTYGNVDVIKEANPQEIWINPI
DAQTRGIQNGELVRIFNDRGEVRINAKVTPRIIPGVVALSEGAWYAPDKNGVDYSGCINVLTTQRPSPLAKGNPQHSNLV
QIEKL

Sequences:

>Translated_805_residues
MSITRRGFLKGTSASMTALAASGGIALPFVAKAETKDNVAGQAQDEKVVWSACTVNCGSRCPLRMHVKDNQILYVETDNT
GTETYNLDHQVRACLRGRSMRRRVYNPDRLKYPMKRVGKRGEGKFKRISWDEALTEIAQSLRKNIEKYGNESIYLNYGTG
TLGGTVTKSWPPGSTLVARLMNCIGGYLNHYGDYSTAQIAVGLDYTYGGGWALGNGLADIENTKLIVLFGNNPAETRMSG
GGLTYCFEQAKEKSNAKVIIIDPRYTDTGVGKEDEWIPIRPSTDAALVSALAYVLITENMVDQAFLDKYCVGYDEKTLPA
DAPKNGHYKAYILGQGDDGIAKTPEWASKITGIPVERIIKLAREIGQTKPAYISQGWGPQRRSNGELISRAIAMLPILTG
NVGISGGNTGARESAYGIPFVRMPTLTNPVQASIPMFLWTDAILRGPEMTATTDGIQGVEKLSAPIKVIWNYASNCLINQ
HAEINRTHEILQDESKCELIITIDNHMTSTAKYSDILLPDCMTSEQMDFCLDAYVANMNYVIFADQVVKPSFECRNIYDM
LSDLAEKLGVKEQFTEGRTQEQWLRHIYEQSRQKLPELPTFEEFRQQGIFKKVDPKGFFIAYKDFRENPEANPLKTPSGK
IEIYSSRLAEIARTWKLEKDEVIHPLPIHTDSFEHYGDPLMQKYPLQLSGFHYKARTHSTYGNVDVIKEANPQEIWINPI
DAQTRGIQNGELVRIFNDRGEVRINAKVTPRIIPGVVALSEGAWYAPDKNGVDYSGCINVLTTQRPSPLAKGNPQHSNLV
QIEKL
>Mature_804_residues
SITRRGFLKGTSASMTALAASGGIALPFVAKAETKDNVAGQAQDEKVVWSACTVNCGSRCPLRMHVKDNQILYVETDNTG
TETYNLDHQVRACLRGRSMRRRVYNPDRLKYPMKRVGKRGEGKFKRISWDEALTEIAQSLRKNIEKYGNESIYLNYGTGT
LGGTVTKSWPPGSTLVARLMNCIGGYLNHYGDYSTAQIAVGLDYTYGGGWALGNGLADIENTKLIVLFGNNPAETRMSGG
GLTYCFEQAKEKSNAKVIIIDPRYTDTGVGKEDEWIPIRPSTDAALVSALAYVLITENMVDQAFLDKYCVGYDEKTLPAD
APKNGHYKAYILGQGDDGIAKTPEWASKITGIPVERIIKLAREIGQTKPAYISQGWGPQRRSNGELISRAIAMLPILTGN
VGISGGNTGARESAYGIPFVRMPTLTNPVQASIPMFLWTDAILRGPEMTATTDGIQGVEKLSAPIKVIWNYASNCLINQH
AEINRTHEILQDESKCELIITIDNHMTSTAKYSDILLPDCMTSEQMDFCLDAYVANMNYVIFADQVVKPSFECRNIYDML
SDLAEKLGVKEQFTEGRTQEQWLRHIYEQSRQKLPELPTFEEFRQQGIFKKVDPKGFFIAYKDFRENPEANPLKTPSGKI
EIYSSRLAEIARTWKLEKDEVIHPLPIHTDSFEHYGDPLMQKYPLQLSGFHYKARTHSTYGNVDVIKEANPQEIWINPID
AQTRGIQNGELVRIFNDRGEVRINAKVTPRIIPGVVALSEGAWYAPDKNGVDYSGCINVLTTQRPSPLAKGNPQHSNLVQ
IEKL

Specific function: Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081797, Length=803, Percent_Identity=73.4744707347447, Blast_Score=1251, Evalue=0.0,
Organism=Escherichia coli, GI1787870, Length=809, Percent_Identity=65.512978986403, Blast_Score=1123, Evalue=0.0,
Organism=Escherichia coli, GI171474008, Length=807, Percent_Identity=61.090458488228, Blast_Score=1033, Evalue=0.0,
Organism=Escherichia coli, GI1787231, Length=768, Percent_Identity=32.5520833333333, Blast_Score=318, Evalue=8e-88,
Organism=Escherichia coli, GI145693196, Length=759, Percent_Identity=32.4110671936759, Blast_Score=308, Evalue=8e-85,
Organism=Escherichia coli, GI87081994, Length=861, Percent_Identity=29.9651567944251, Blast_Score=291, Evalue=2e-79,
Organism=Escherichia coli, GI3868721, Length=789, Percent_Identity=24.7148288973384, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI3868720, Length=470, Percent_Identity=25.7446808510638, Blast_Score=115, Evalue=2e-26,
Organism=Escherichia coli, GI3868719, Length=472, Percent_Identity=24.364406779661, Blast_Score=96, Evalue=1e-20,
Organism=Escherichia coli, GI1788534, Length=881, Percent_Identity=22.8149829738933, Blast_Score=95, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011888
- InterPro:   IPR009010
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.8.99.- [C]

Molecular weight: Translated: 89732; Mature: 89601

Theoretical pI: Translated: 7.49; Mature: 7.49

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1 ; PS00932 MOLYBDOPTERIN_PROK_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSITRRGFLKGTSASMTALAASGGIALPFVAKAETKDNVAGQAQDEKVVWSACTVNCGSR
CCCCCCCCCCCCCCCHHEEECCCCEEEEEEEECCCCCCCCCCCCCCEEEEEEEEECCCCC
CPLRMHVKDNQILYVETDNTGTETYNLDHQVRACLRGRSMRRRVYNPDRLKYPMKRVGKR
CCEEEEECCCEEEEEEECCCCCEEECCHHHHHHHHHCHHHHHHCCCCHHHCCHHHHCCCC
GEGKFKRISWDEALTEIAQSLRKNIEKYGNESIYLNYGTGTLGGTVTKSWPPGSTLVARL
CCCCEEEECHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEECCCCCCHHHHHHH
MNCIGGYLNHYGDYSTAQIAVGLDYTYGGGWALGNGLADIENTKLIVLFGNNPAETRMSG
HHHHHHHHHHCCCCCCEEEEEEEEEECCCCEECCCCCCCCCCCEEEEEECCCCHHHEECC
GGLTYCFEQAKEKSNAKVIIIDPRYTDTGVGKEDEWIPIRPSTDAALVSALAYVLITENM
CCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHH
VDQAFLDKYCVGYDEKTLPADAPKNGHYKAYILGQGDDGIAKTPEWASKITGIPVERIIK
HHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHCCCCHHHHHH
LAREIGQTKPAYISQGWGPQRRSNGELISRAIAMLPILTGNVGISGGNTGARESAYGIPF
HHHHHCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHEECCEECCCCCCCCCCCCCCCCE
VRMPTLTNPVQASIPMFLWTDAILRGPEMTATTDGIQGVEKLSAPIKVIWNYASNCLINQ
EECCCCCCCHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCEECC
HAEINRTHEILQDESKCELIITIDNHMTSTAKYSDILLPDCMTSEQMDFCLDAYVANMNY
CCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHCCCE
VIFADQVVKPSFECRNIYDMLSDLAEKLGVKEQFTEGRTQEQWLRHIYEQSRQKLPELPT
EEEECCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCC
FEEFRQQGIFKKVDPKGFFIAYKDFRENPEANPLKTPSGKIEIYSSRLAEIARTWKLEKD
HHHHHHCCCCEECCCCEEEEEEHHHCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHCCCHH
EVIHPLPIHTDSFEHYGDPLMQKYPLQLSGFHYKARTHSTYGNVDVIKEANPQEIWINPI
CCCCCCCCCCCCHHHHCCHHHHHCCCEECCEEEEEECCCCCCCEEEEECCCCCEEEEECC
DAQTRGIQNGELVRIFNDRGEVRINAKVTPRIIPGVVALSEGAWYAPDKNGVDYSGCINV
CHHHCCCCCCCEEEEECCCCCEEEEEEECCCCCCCEEEECCCCEECCCCCCCCHHHHHHH
LTTQRPSPLAKGNPQHSNLVQIEKL
EECCCCCCCCCCCCCCCCCEEEECC
>Mature Secondary Structure 
SITRRGFLKGTSASMTALAASGGIALPFVAKAETKDNVAGQAQDEKVVWSACTVNCGSR
CCCCCCCCCCCCCCHHEEECCCCEEEEEEEECCCCCCCCCCCCCCEEEEEEEEECCCCC
CPLRMHVKDNQILYVETDNTGTETYNLDHQVRACLRGRSMRRRVYNPDRLKYPMKRVGKR
CCEEEEECCCEEEEEEECCCCCEEECCHHHHHHHHHCHHHHHHCCCCHHHCCHHHHCCCC
GEGKFKRISWDEALTEIAQSLRKNIEKYGNESIYLNYGTGTLGGTVTKSWPPGSTLVARL
CCCCEEEECHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEECCCCCCHHHHHHH
MNCIGGYLNHYGDYSTAQIAVGLDYTYGGGWALGNGLADIENTKLIVLFGNNPAETRMSG
HHHHHHHHHHCCCCCCEEEEEEEEEECCCCEECCCCCCCCCCCEEEEEECCCCHHHEECC
GGLTYCFEQAKEKSNAKVIIIDPRYTDTGVGKEDEWIPIRPSTDAALVSALAYVLITENM
CCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHH
VDQAFLDKYCVGYDEKTLPADAPKNGHYKAYILGQGDDGIAKTPEWASKITGIPVERIIK
HHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHCCCCHHHHHH
LAREIGQTKPAYISQGWGPQRRSNGELISRAIAMLPILTGNVGISGGNTGARESAYGIPF
HHHHHCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHEECCEECCCCCCCCCCCCCCCCE
VRMPTLTNPVQASIPMFLWTDAILRGPEMTATTDGIQGVEKLSAPIKVIWNYASNCLINQ
EECCCCCCCHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCEECC
HAEINRTHEILQDESKCELIITIDNHMTSTAKYSDILLPDCMTSEQMDFCLDAYVANMNY
CCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHCCCE
VIFADQVVKPSFECRNIYDMLSDLAEKLGVKEQFTEGRTQEQWLRHIYEQSRQKLPELPT
EEEECCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCC
FEEFRQQGIFKKVDPKGFFIAYKDFRENPEANPLKTPSGKIEIYSSRLAEIARTWKLEKD
HHHHHHCCCCEECCCCEEEEEEHHHCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHCCCHH
EVIHPLPIHTDSFEHYGDPLMQKYPLQLSGFHYKARTHSTYGNVDVIKEANPQEIWINPI
CCCCCCCCCCCCHHHHCCHHHHHCCCEECCEEEEEECCCCCCCEEEEECCCCCEEEEECC
DAQTRGIQNGELVRIFNDRGEVRINAKVTPRIIPGVVALSEGAWYAPDKNGVDYSGCINV
CHHHCCCCCCCEEEEECCCCCEEEEEEECCCCCCCEEEECCCCEECCCCCCCCHHHHHHH
LTTQRPSPLAKGNPQHSNLVQIEKL
EECCCCCCCCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: May Bind 4Fe-4S Cluster. [C]

Metal ions: Fe; Mo [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-Oxide; Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

Specific reaction: Reduces Various N-Oxide And Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800; 8635740 [H]