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The map label for this gene is mtlD

Identifier: 126209093

GI number: 126209093

Start: 1852057

End: 1853196

Strand: Reverse

Name: mtlD

Synonym: APL_1629

Alternate gene names: 126209093

Gene position: 1853196-1852057 (Counterclockwise)

Preceding gene: 126209094

Following gene: 126209092

Centisome position: 81.48

GC content: 41.49

Gene sequence:

>1140_bases
ATGAACGCATTACATTTTGGTGCAGGTAATATCGGTCGTGGTTTTATCGGTAAATTGTTGGCGGACTCGGGTGTTTTCGT
CACCTTTGCCGACATCAATCAAACGCAGATTGATCAAATTAACCAAAATAAACAATACGGCGTAAAAATCGTAGGCGATG
CGAGCCGTGTCGAAGTGGTGAAAAATATTGCGGCGATCAACTCAAAAGATGAAGAGGCAGTAATCGAACAAGTGAAAAGC
GTTGAGCTGATTACGACTGCGGTCGGTCCGAATGTTTTAGGTTTTATCGCACCGTTGTTTGCCAAAGCGTTAGCGGCACG
TTTAGAAGCGGGTAATACCCAACCGTTAAATATCATTGCCTGTGAAAATATGGTGCGTGGGACGAGTTTCTTTAAAGCAA
AAATTTTTGAAAATTTAACCGATTCTCAACAGGCGGAAATTGAAAAGTTTGTCGGTTTTGTCGATTCTGCGGTAGATAGA
ATCGTACCGCCGGCGGAATTAAACGAAGCGGATCCGTTAGAAGTGACGGTAGAAGAGTTTAGCGAATGGATTGTAGATAA
AACCCAATTCAAAGGTCAAATTCCGGATATTAAAGGTATGGAATTAACCGATAATTTAATGGCATTTGTAGAGCGTAAAC
TATTTACGTTAAATACCGGTCATTTAATTTCTGCTTATTTAGGCAAACAAGCCGGTGTGAAATGGATTAAAGAAGCGATT
GCTATCGACAGTGTGAAAGCGGCGGTAAAAGCGACCATGGAAGAAAGCGGTGCGGTATTAATTAAACGTTATAATTTTGA
CCCGCAAGCGCACGCCGCTTATATCGAAAAAATCTTAAAACGTTTTGCGAACCCGTACTTAAACGATGATGTAAACCGTG
TCGGTCGTGAGCCGATTCGTAAACTTAGCCCGAACGATCGTTTAATTAAACCGCTTTTAGGCACGTTGGAATACGGTTTA
CCGCATAAAAACCTCGTAAACGGTGTGGTAATGGCTCTACAATATCGTAATGAAGAAGACCCGCAAGCGGTCGAATTAGC
ACAATTTATTGCAGATAACGGAGTAGCTGCGGCAGTTGAGAAATATACTGGTTTAACAAACCAAGAGGTGATTGATCAAG
TTGTTGCGTTATATAACTAA

Upstream 100 bases:

>100_bases
TAAAAGGCGAATAATTCAAGTTCCCCCACGTAAGTGGGGGATTTTCGCTTACAAGCGGTCGGATTTTTCAAATATTTTAC
AAATTAAAGAGGAACATAGA

Downstream 100 bases:

>100_bases
TGCCATATTCAGATAATTTTATCGAACAATTAAGCGAAGTTCCCTCTTTACGAGGGTTCTTTGCACTTTCAGTGAATCAG
TTTGCGCAAAATATTGAACG

Product: mannitol-1-phosphate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MNALHFGAGNIGRGFIGKLLADSGVFVTFADINQTQIDQINQNKQYGVKIVGDASRVEVVKNIAAINSKDEEAVIEQVKS
VELITTAVGPNVLGFIAPLFAKALAARLEAGNTQPLNIIACENMVRGTSFFKAKIFENLTDSQQAEIEKFVGFVDSAVDR
IVPPAELNEADPLEVTVEEFSEWIVDKTQFKGQIPDIKGMELTDNLMAFVERKLFTLNTGHLISAYLGKQAGVKWIKEAI
AIDSVKAAVKATMEESGAVLIKRYNFDPQAHAAYIEKILKRFANPYLNDDVNRVGREPIRKLSPNDRLIKPLLGTLEYGL
PHKNLVNGVVMALQYRNEEDPQAVELAQFIADNGVAAAVEKYTGLTNQEVIDQVVALYN

Sequences:

>Translated_379_residues
MNALHFGAGNIGRGFIGKLLADSGVFVTFADINQTQIDQINQNKQYGVKIVGDASRVEVVKNIAAINSKDEEAVIEQVKS
VELITTAVGPNVLGFIAPLFAKALAARLEAGNTQPLNIIACENMVRGTSFFKAKIFENLTDSQQAEIEKFVGFVDSAVDR
IVPPAELNEADPLEVTVEEFSEWIVDKTQFKGQIPDIKGMELTDNLMAFVERKLFTLNTGHLISAYLGKQAGVKWIKEAI
AIDSVKAAVKATMEESGAVLIKRYNFDPQAHAAYIEKILKRFANPYLNDDVNRVGREPIRKLSPNDRLIKPLLGTLEYGL
PHKNLVNGVVMALQYRNEEDPQAVELAQFIADNGVAAAVEKYTGLTNQEVIDQVVALYN
>Mature_379_residues
MNALHFGAGNIGRGFIGKLLADSGVFVTFADINQTQIDQINQNKQYGVKIVGDASRVEVVKNIAAINSKDEEAVIEQVKS
VELITTAVGPNVLGFIAPLFAKALAARLEAGNTQPLNIIACENMVRGTSFFKAKIFENLTDSQQAEIEKFVGFVDSAVDR
IVPPAELNEADPLEVTVEEFSEWIVDKTQFKGQIPDIKGMELTDNLMAFVERKLFTLNTGHLISAYLGKQAGVKWIKEAI
AIDSVKAAVKATMEESGAVLIKRYNFDPQAHAAYIEKILKRFANPYLNDDVNRVGREPIRKLSPNDRLIKPLLGTLEYGL
PHKNLVNGVVMALQYRNEEDPQAVELAQFIADNGVAAAVEKYTGLTNQEVIDQVVALYN

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1790028, Length=379, Percent_Identity=61.7414248021108, Blast_Score=476, Evalue=1e-135,
Organism=Escherichia coli, GI1788497, Length=220, Percent_Identity=25.9090909090909, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790779, Length=268, Percent_Identity=27.2388059701493, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787823, Length=256, Percent_Identity=25.390625, Blast_Score=72, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6324401, Length=211, Percent_Identity=27.0142180094787, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320765, Length=211, Percent_Identity=27.0142180094787, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTLD_ACTP2 (A3N2S7)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001054318.1
- ProteinModelPortal:   A3N2S7
- STRING:   A3N2S7
- GeneID:   4849415
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_1629
- eggNOG:   COG0246
- HOGENOM:   HBG568825
- OMA:   FTVNTGH
- PhylomeDB:   A3N2S7
- ProtClustDB:   PRK02318
- BioCyc:   APLE416269:APL_1629-MONOMER
- HAMAP:   MF_00196
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR023028
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PRINTS:   PR00084

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C; SSF48179 6DGDH_C_like

EC number: =1.1.1.17

Molecular weight: Translated: 41648; Mature: 41648

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNALHFGAGNIGRGFIGKLLADSGVFVTFADINQTQIDQINQNKQYGVKIVGDASRVEVV
CCCEECCCCCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHCCCCCCCEEEECCHHHHHHH
KNIAAINSKDEEAVIEQVKSVELITTAVGPNVLGFIAPLFAKALAARLEAGNTQPLNIIA
HHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
CENMVRGTSFFKAKIFENLTDSQQAEIEKFVGFVDSAVDRIVPPAELNEADPLEVTVEEF
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHH
SEWIVDKTQFKGQIPDIKGMELTDNLMAFVERKLFTLNTGHLISAYLGKQAGVKWIKEAI
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
AIDSVKAAVKATMEESGAVLIKRYNFDPQAHAAYIEKILKRFANPYLNDDVNRVGREPIR
HHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
KLSPNDRLIKPLLGTLEYGLPHKNLVNGVVMALQYRNEEDPQAVELAQFIADNGVAAAVE
HCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHH
KYTGLTNQEVIDQVVALYN
HHCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MNALHFGAGNIGRGFIGKLLADSGVFVTFADINQTQIDQINQNKQYGVKIVGDASRVEVV
CCCEECCCCCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHCCCCCCCEEEECCHHHHHHH
KNIAAINSKDEEAVIEQVKSVELITTAVGPNVLGFIAPLFAKALAARLEAGNTQPLNIIA
HHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
CENMVRGTSFFKAKIFENLTDSQQAEIEKFVGFVDSAVDRIVPPAELNEADPLEVTVEEF
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHH
SEWIVDKTQFKGQIPDIKGMELTDNLMAFVERKLFTLNTGHLISAYLGKQAGVKWIKEAI
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
AIDSVKAAVKATMEESGAVLIKRYNFDPQAHAAYIEKILKRFANPYLNDDVNRVGREPIR
HHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
KLSPNDRLIKPLLGTLEYGLPHKNLVNGVVMALQYRNEEDPQAVELAQFIADNGVAAAVE
HCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHH
KYTGLTNQEVIDQVVALYN
HHCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA