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The map label for this gene is ureC

Identifier: 126209080

GI number: 126209080

Start: 1841163

End: 1842881

Strand: Reverse

Name: ureC

Synonym: APL_1616

Alternate gene names: 126209080

Gene position: 1842881-1841163 (Counterclockwise)

Preceding gene: 126209081

Following gene: 126209079

Centisome position: 81.02

GC content: 48.81

Gene sequence:

>1719_bases
ATGGCATTAACAATCCCACGCAGCCAGTATGTAGCGACTTACGGCCCGACAGTCGGTGATAAAGTCCGTTTAGGCGACAC
CGATTTATGGGCGACAATTGAACAAGATTTTTTAACTAAAGGTGATGAGTGTAAATTCGGTGGCGGTAAATCGGTGCGTG
ACGGTATGGCACAATCAAGCACCTCTACCCGTGATAATCCGAACGTATTGGATTTTGCTCTCACTAACGTGATGATTATC
GACGCAAAATTAGGCATTATCAAAGCGGATATCGGGATTCGTGACGGACGCATTGTCGGTATCGGTCAGGCGGGTAATCC
GGATACGATGGATAACGTCACGCCAAATATGATTATCGGCGCAAGCACCGAAGTACATAACGGCGCACATTTAATTGCGA
CCGCTGGCGGTATTGATACGCATATTCACTGGATTTGTCCGCAACAAGCACAACACGCTATCGAAAACGGCATTACTACG
ATGATCGGCGGTGGTTCAGGCCCGGCGGACGGCACGCATGCCACCACCTGTACACCGGGTAAATTTAATATCGAAAGAAT
GTTCCAAGCTTGCGAAGCGTTACCGGTCAATATCGGCTTTTTCGGCAAAGGTAACTGTTCTATGCTCGAACCGCTTAAAG
AACAAGTGGTTGCCGGTGCGTTAGGCTTAAAAATCCACGAAGACTGGGGGGCAACACCGGCAGTGATTGACGCAGCGTTA
AAAGTAGCGGACGAAATGGACGTGCAAGTAGCGATTCACACCGATACGCTCAACGAAAGTGGTTTCTTAGAAGACACGAT
GAAAGCGATTAACGGACGTGTGATTCACACTTTCCACACCGAAGGTGCCGGCGGCGGTCACGCACCGGATATTATTAAAG
CGGCGATGTACCCGAACGTATTGCCGGCTTCCACCAATCCAACCCGCCCATTTACTGTGAACACAATTGACGAGCATTTG
GATATGCTAATGGTTTGTCACCACTTAGATAAACGAGTGCCGGAAGATGTCGCATTTGCCGACAGCCGTATCCGTCCCGA
AACCATTGCGGCGGAAGACATTCTGCACGATATGGGCGTGTTCTCGATTATGAGTTCAGATTCACAAGCAATGGGACGTG
TCGGCGAAGTAGTGACTCGTACGTGGCAAACGGCAGATAAAATGAAAGCGCAGCGTGGCGCATTGGGCGATGAAGGTAAC
GACAACTTCCGTATTAAACGCTATATTGCGAAATACACGATTAATCCGGCAATTGCTCACGGTATCAGCCAATACGTCGG
CTCGCTTGAAGTGGGTAAACTAGCCGACATCGTATTGTGGAAGCCGCAATTCTTCGGCGTAAAACCGGAATTTGTGATGA
AAAAAGGCTTTATCAGCTTTGCTAAAATGGGTGACCCGAACGCTTCAATCCCAACGCCACAACCGGTATTCTACCGCCCA
ATGTTTGGGGCGAATGCGAAAGCGAATACCGAAAGTGCGGTTTATTTCGTTTCACAAGCGAGCGTGGATGCGAACATCAA
AGCCCAATACGGCATTCAGAAAGAAACCCTCGCGGTAAAAGGTTGTCGTGACGTAGGTAAAAAAGACCTTGTTCACAACA
ATGCAACGCCTGAAATTACCGTAGATCCGGAACGCTACGAAGTACGTGTGGACGGCGAGCATATTACTTGCGAACCTGCT
ACCAAAGTGCCACTTGCACAGCGTTATTTCTTGTTCTAG

Upstream 100 bases:

>100_bases
CCCGGCGAAGCGAAAGAAGTGGAACTGGTTGAGTTTGGTGGTAATAAAGTGATTTACGGTTTCCATAATGAAATCGACGG
CAAATTATAGGGGGCAGAAA

Downstream 100 bases:

>100_bases
CAAAATCTCCCCAGCCCCTCTTTACAAAAGAGGGGTATAGTTGGGGGGAAGCATTAAGATCTTCATTCTTCATTAAAATC
AGTTCCCCTCTTTTGTAAAG

Product: urease subunit alpha

Products: NA

Alternate protein names: Urea amidohydrolase subunit alpha

Number of amino acids: Translated: 572; Mature: 571

Protein sequence:

>572_residues
MALTIPRSQYVATYGPTVGDKVRLGDTDLWATIEQDFLTKGDECKFGGGKSVRDGMAQSSTSTRDNPNVLDFALTNVMII
DAKLGIIKADIGIRDGRIVGIGQAGNPDTMDNVTPNMIIGASTEVHNGAHLIATAGGIDTHIHWICPQQAQHAIENGITT
MIGGGSGPADGTHATTCTPGKFNIERMFQACEALPVNIGFFGKGNCSMLEPLKEQVVAGALGLKIHEDWGATPAVIDAAL
KVADEMDVQVAIHTDTLNESGFLEDTMKAINGRVIHTFHTEGAGGGHAPDIIKAAMYPNVLPASTNPTRPFTVNTIDEHL
DMLMVCHHLDKRVPEDVAFADSRIRPETIAAEDILHDMGVFSIMSSDSQAMGRVGEVVTRTWQTADKMKAQRGALGDEGN
DNFRIKRYIAKYTINPAIAHGISQYVGSLEVGKLADIVLWKPQFFGVKPEFVMKKGFISFAKMGDPNASIPTPQPVFYRP
MFGANAKANTESAVYFVSQASVDANIKAQYGIQKETLAVKGCRDVGKKDLVHNNATPEITVDPERYEVRVDGEHITCEPA
TKVPLAQRYFLF

Sequences:

>Translated_572_residues
MALTIPRSQYVATYGPTVGDKVRLGDTDLWATIEQDFLTKGDECKFGGGKSVRDGMAQSSTSTRDNPNVLDFALTNVMII
DAKLGIIKADIGIRDGRIVGIGQAGNPDTMDNVTPNMIIGASTEVHNGAHLIATAGGIDTHIHWICPQQAQHAIENGITT
MIGGGSGPADGTHATTCTPGKFNIERMFQACEALPVNIGFFGKGNCSMLEPLKEQVVAGALGLKIHEDWGATPAVIDAAL
KVADEMDVQVAIHTDTLNESGFLEDTMKAINGRVIHTFHTEGAGGGHAPDIIKAAMYPNVLPASTNPTRPFTVNTIDEHL
DMLMVCHHLDKRVPEDVAFADSRIRPETIAAEDILHDMGVFSIMSSDSQAMGRVGEVVTRTWQTADKMKAQRGALGDEGN
DNFRIKRYIAKYTINPAIAHGISQYVGSLEVGKLADIVLWKPQFFGVKPEFVMKKGFISFAKMGDPNASIPTPQPVFYRP
MFGANAKANTESAVYFVSQASVDANIKAQYGIQKETLAVKGCRDVGKKDLVHNNATPEITVDPERYEVRVDGEHITCEPA
TKVPLAQRYFLF
>Mature_571_residues
ALTIPRSQYVATYGPTVGDKVRLGDTDLWATIEQDFLTKGDECKFGGGKSVRDGMAQSSTSTRDNPNVLDFALTNVMIID
AKLGIIKADIGIRDGRIVGIGQAGNPDTMDNVTPNMIIGASTEVHNGAHLIATAGGIDTHIHWICPQQAQHAIENGITTM
IGGGSGPADGTHATTCTPGKFNIERMFQACEALPVNIGFFGKGNCSMLEPLKEQVVAGALGLKIHEDWGATPAVIDAALK
VADEMDVQVAIHTDTLNESGFLEDTMKAINGRVIHTFHTEGAGGGHAPDIIKAAMYPNVLPASTNPTRPFTVNTIDEHLD
MLMVCHHLDKRVPEDVAFADSRIRPETIAAEDILHDMGVFSIMSSDSQAMGRVGEVVTRTWQTADKMKAQRGALGDEGND
NFRIKRYIAKYTINPAIAHGISQYVGSLEVGKLADIVLWKPQFFGVKPEFVMKKGFISFAKMGDPNASIPTPQPVFYRPM
FGANAKANTESAVYFVSQASVDANIKAQYGIQKETLAVKGCRDVGKKDLVHNNATPEITVDPERYEVRVDGEHITCEPAT
KVPLAQRYFLF

Specific function: Unknown

COG id: COG0804

COG function: function code E; Urea amidohydrolase (urease) alpha subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 urease domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): URE1_ACTP2 (A3N2R4)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001054305.1
- ProteinModelPortal:   A3N2R4
- SMR:   A3N2R4
- STRING:   A3N2R4
- GeneID:   4850391
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_1616
- eggNOG:   COG0804
- HOGENOM:   HBG357507
- OMA:   MPYTINT
- ProtClustDB:   PRK13207
- BioCyc:   APLE416269:APL_1616-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01953
- InterPro:   IPR006680
- InterPro:   IPR011059
- InterPro:   IPR011612
- InterPro:   IPR005848
- InterPro:   IPR017951
- InterPro:   IPR017950
- PRINTS:   PR01752
- TIGRFAMs:   TIGR01792

Pfam domain/function: PF01979 Amidohydro_1; PF00449 Urease_alpha; SSF51338 Metalo_hydrolase

EC number: =3.5.1.5

Molecular weight: Translated: 61836; Mature: 61705

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS01120 UREASE_1; PS00145 UREASE_2; PS51368 UREASE_3; PS00024 HEMOPEXIN

Important sites: ACT_SITE 327-327 BINDING 226-226

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALTIPRSQYVATYGPTVGDKVRLGDTDLWATIEQDFLTKGDECKFGGGKSVRDGMAQSS
CEEECCCCCEEEECCCCCCCEEEECCCHHHEEEHHHHCCCCCCCCCCCCCHHHHHHHHCC
TSTRDNPNVLDFALTNVMIIDAKLGIIKADIGIRDGRIVGIGQAGNPDTMDNVTPNMIIG
CCCCCCCCEEEEEEEEEEEEEECCCEEEECCCCCCCEEEEECCCCCCCCCCCCCCCEEEE
ASTEVHNGAHLIATAGGIDTHIHWICPQQAQHAIENGITTMIGGGSGPADGTHATTCTPG
CCCCCCCCEEEEEECCCCCCEEEEECCHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCC
KFNIERMFQACEALPVNIGFFGKGNCSMLEPLKEQVVAGALGLKIHEDWGATPAVIDAAL
CCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHH
KVADEMDVQVAIHTDTLNESGFLEDTMKAINGRVIHTFHTEGAGGGHAPDIIKAAMYPNV
HHHCCCCEEEEEEECCCCCCCCHHHHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHCCCC
LPASTNPTRPFTVNTIDEHLDMLMVCHHLDKRVPEDVAFADSRIRPETIAAEDILHDMGV
CCCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHH
FSIMSSDSQAMGRVGEVVTRTWQTADKMKAQRGALGDEGNDNFRIKRYIAKYTINPAIAH
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEHHHCCCHHHHH
GISQYVGSLEVGKLADIVLWKPQFFGVKPEFVMKKGFISFAKMGDPNASIPTPQPVFYRP
HHHHHHCCCCCCCEEEEEEECCHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECC
MFGANAKANTESAVYFVSQASVDANIKAQYGIQKETLAVKGCRDVGKKDLVHNNATPEIT
CCCCCCCCCCCCEEEEEEECCCCCCEEEECCCCHHHEEEHHHHHCCHHHHHCCCCCCCEE
VDPERYEVRVDGEHITCEPATKVPLAQRYFLF
ECCCEEEEEECCCEEEECCCCCCCCCHHHCCC
>Mature Secondary Structure 
ALTIPRSQYVATYGPTVGDKVRLGDTDLWATIEQDFLTKGDECKFGGGKSVRDGMAQSS
EEECCCCCEEEECCCCCCCEEEECCCHHHEEEHHHHCCCCCCCCCCCCCHHHHHHHHCC
TSTRDNPNVLDFALTNVMIIDAKLGIIKADIGIRDGRIVGIGQAGNPDTMDNVTPNMIIG
CCCCCCCCEEEEEEEEEEEEEECCCEEEECCCCCCCEEEEECCCCCCCCCCCCCCCEEEE
ASTEVHNGAHLIATAGGIDTHIHWICPQQAQHAIENGITTMIGGGSGPADGTHATTCTPG
CCCCCCCCEEEEEECCCCCCEEEEECCHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCC
KFNIERMFQACEALPVNIGFFGKGNCSMLEPLKEQVVAGALGLKIHEDWGATPAVIDAAL
CCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHH
KVADEMDVQVAIHTDTLNESGFLEDTMKAINGRVIHTFHTEGAGGGHAPDIIKAAMYPNV
HHHCCCCEEEEEEECCCCCCCCHHHHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHCCCC
LPASTNPTRPFTVNTIDEHLDMLMVCHHLDKRVPEDVAFADSRIRPETIAAEDILHDMGV
CCCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHH
FSIMSSDSQAMGRVGEVVTRTWQTADKMKAQRGALGDEGNDNFRIKRYIAKYTINPAIAH
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEHHHCCCHHHHH
GISQYVGSLEVGKLADIVLWKPQFFGVKPEFVMKKGFISFAKMGDPNASIPTPQPVFYRP
HHHHHHCCCCCCCEEEEEEECCHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECC
MFGANAKANTESAVYFVSQASVDANIKAQYGIQKETLAVKGCRDVGKKDLVHNNATPEIT
CCCCCCCCCCCCEEEEEEECCCCCCEEEECCCCHHHEEEHHHHHCCHHHHHCCCCCCCEE
VDPERYEVRVDGEHITCEPATKVPLAQRYFLF
ECCCEEEEEECCCEEEECCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA