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The map label for this gene is cpxA [H]

Identifier: 126209049

GI number: 126209049

Start: 1812387

End: 1813037

Strand: Direct

Name: cpxA [H]

Synonym: APL_1585

Alternate gene names: 126209049

Gene position: 1812387-1813037 (Clockwise)

Preceding gene: 126209048

Following gene: 126209053

Centisome position: 79.68

GC content: 38.56

Gene sequence:

>651_bases
ATGATTAGCGTAAAAAATGTGAGTAAAGATTACTATACTCGAAGCGGTAAAAAAACCGTATTGCAAGATATTAATTTTGA
GCTGAAAAAAGGCGAGAAAATCGGTATTTTAGGGCGTAACGGTGCAGGGAAATCAACGCTAATCCGTTTGTTAAGTGGTG
TTGAGCCGCCAACATCAGGTACTATCGAACGTAATATGTCGATATCTTGGCCGCTCGCTTTCAGCGGGGCGTTCCAAGGC
AGTTTAACCGGTATGGATAATTTACGCTTTATTTGCCGTATATATAATGCGGATATTGAATACGTTAAAGCCTTTACCGA
AGAATTTTCCGAATTGGGTGATTATTTATATGAGCCGGTTAAGAAATATTCCTCCGGTATGAAAGCCCGACTTGCCTTTG
CTTTGTCACTTTCGGTAGAGTTTGATTGCTACTTAATTGATGAAGTGATTGCTGTGGGCGATTCCCGTTTTGCGGCAAAA
TGTAAACATGAATTATTTGAAAAGCGCAAAGATCGTTCGATTATTTTGGTTTCACATAGCCCGTCTGCAATGAAAGAATA
TTGCGATAATGCAATGGTATTGGATAAAGGGATTATGTATAAATTTGAGAATATGGACGAGGCTTACAAGTTCTATAATT
CAACGCTTTAA

Upstream 100 bases:

>100_bases
TCACATATGAAAGTATAAGCTATCTCGTAATATGTGATGTAGCCATGTTACTTTTTGGGCTCATTATGGTAAAAAACTTC
AGTAAAGGAATCGAACCGCA

Downstream 100 bases:

>100_bases
AGTCCCACATATCCCCCCTCTTTAGCAAAGAGGGGCTGGGGGAGATTTGACAGAATAAATTAGCGAAGAAATATGCTAAT
TAACGCTTTTATAAATATAA

Product: ATP-binding protein

Products: ADP; phosphate; maltose [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MISVKNVSKDYYTRSGKKTVLQDINFELKKGEKIGILGRNGAGKSTLIRLLSGVEPPTSGTIERNMSISWPLAFSGAFQG
SLTGMDNLRFICRIYNADIEYVKAFTEEFSELGDYLYEPVKKYSSGMKARLAFALSLSVEFDCYLIDEVIAVGDSRFAAK
CKHELFEKRKDRSIILVSHSPSAMKEYCDNAMVLDKGIMYKFENMDEAYKFYNSTL

Sequences:

>Translated_216_residues
MISVKNVSKDYYTRSGKKTVLQDINFELKKGEKIGILGRNGAGKSTLIRLLSGVEPPTSGTIERNMSISWPLAFSGAFQG
SLTGMDNLRFICRIYNADIEYVKAFTEEFSELGDYLYEPVKKYSSGMKARLAFALSLSVEFDCYLIDEVIAVGDSRFAAK
CKHELFEKRKDRSIILVSHSPSAMKEYCDNAMVLDKGIMYKFENMDEAYKFYNSTL
>Mature_216_residues
MISVKNVSKDYYTRSGKKTVLQDINFELKKGEKIGILGRNGAGKSTLIRLLSGVEPPTSGTIERNMSISWPLAFSGAFQG
SLTGMDNLRFICRIYNADIEYVKAFTEEFSELGDYLYEPVKKYSSGMKARLAFALSLSVEFDCYLIDEVIAVGDSRFAAK
CKHELFEKRKDRSIILVSHSPSAMKEYCDNAMVLDKGIMYKFENMDEAYKFYNSTL

Specific function: Putative ATP-binding protein, and an energy-coupling component of capsule polysaccharide export apparatus [H]

COG id: COG1134

COG function: function code GM; ABC-type polysaccharide/polyol phosphate transport system, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI27436953, Length=202, Percent_Identity=27.7227722772277, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI27477115, Length=205, Percent_Identity=27.3170731707317, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI27262624, Length=237, Percent_Identity=28.6919831223629, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI27262626, Length=237, Percent_Identity=28.6919831223629, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI153792144, Length=218, Percent_Identity=27.0642201834862, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI6005701, Length=201, Percent_Identity=26.865671641791, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1790467, Length=225, Percent_Identity=27.5555555555556, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI1788761, Length=230, Percent_Identity=25.2173913043478, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1789751, Length=217, Percent_Identity=27.6497695852535, Blast_Score=74, Evalue=5e-15,
Organism=Escherichia coli, GI1789891, Length=224, Percent_Identity=24.1071428571429, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1787547, Length=226, Percent_Identity=26.5486725663717, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787758, Length=215, Percent_Identity=25.5813953488372, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI2367384, Length=157, Percent_Identity=32.484076433121, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1787029, Length=220, Percent_Identity=25.9090909090909, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788165, Length=203, Percent_Identity=28.0788177339901, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1786398, Length=245, Percent_Identity=25.7142857142857, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI87081782, Length=163, Percent_Identity=31.2883435582822, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71992290, Length=238, Percent_Identity=26.0504201680672, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17510237, Length=210, Percent_Identity=26.1904761904762, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI28573573, Length=214, Percent_Identity=28.9719626168224, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI28573571, Length=214, Percent_Identity=28.9719626168224, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI62484234, Length=193, Percent_Identity=31.0880829015544, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 24432; Mature: 24432

Theoretical pI: Translated: 8.27; Mature: 8.27

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISVKNVSKDYYTRSGKKTVLQDINFELKKGEKIGILGRNGAGKSTLIRLLSGVEPPTSG
CCCCCCCCHHHHHCCCCHHHHHHCCCEECCCCEEEEEECCCCCHHHHHHHHHCCCCCCCC
TIERNMSISWPLAFSGAFQGSLTGMDNLRFICRIYNADIEYVKAFTEEFSELGDYLYEPV
CEECCCEEECCEEECCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
KKYSSGMKARLAFALSLSVEFDCYLIDEVIAVGDSRFAAKCKHELFEKRKDRSIILVSHS
HHHHCCHHEEEEEEEEEEEEECCEEHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEECC
PSAMKEYCDNAMVLDKGIMYKFENMDEAYKFYNSTL
CHHHHHHCCCCEEECCCCEEEECCHHHHHHHHHCCC
>Mature Secondary Structure
MISVKNVSKDYYTRSGKKTVLQDINFELKKGEKIGILGRNGAGKSTLIRLLSGVEPPTSG
CCCCCCCCHHHHHCCCCHHHHHHCCCEECCCCEEEEEECCCCCHHHHHHHHHCCCCCCCC
TIERNMSISWPLAFSGAFQGSLTGMDNLRFICRIYNADIEYVKAFTEEFSELGDYLYEPV
CEECCCEEECCEEECCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
KKYSSGMKARLAFALSLSVEFDCYLIDEVIAVGDSRFAAKCKHELFEKRKDRSIILVSHS
HHHHCCHHEEEEEEEEEEEEECCEEHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEECC
PSAMKEYCDNAMVLDKGIMYKFENMDEAYKFYNSTL
CHHHHHHCCCCEEECCCCEEEECCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; maltose [Periplasm]; H2O [C]

Specific reaction: ATP + maltose [Periplasm] + H2O = ADP + phosphate + maltose [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 3284653; 2082145 [H]