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The map label for this gene is kdsA

Identifier: 126209042

GI number: 126209042

Start: 1804277

End: 1805137

Strand: Reverse

Name: kdsA

Synonym: APL_1578

Alternate gene names: 126209042

Gene position: 1805137-1804277 (Counterclockwise)

Preceding gene: 126209043

Following gene: 126209041

Centisome position: 79.36

GC content: 41.7

Gene sequence:

>861_bases
ATGACAATTTTAAATAAAATCGTAAAAGTTGGCAATATTGAAGTGGCGAATGACAAGCCGTTTACTTTATTCGGTGGTAT
GAACGTATTAGAAAGCCGTGATATGGCAATGCGTGTCTGTGAACAATACGTAGAAGTGACCAACAAACTGGGTGTGCCTT
ATGTATTTAAAGCCTCTTTCGATAAAGCGAATCGCTCGTCAATTCACTCTTACCGAGGACCGGGTATGGAAGAAGGTTTA
AAAATCTTCCAAGAATTAAAAGATACGTTCGGTGTGAGCATTATTACTGACGTACACGAAATTTATCAATGTAAACCGGT
AGCGGAAGTGGTGGATATTATCCAGTTACCGGCATTCTTAGCTCGCCAAACAGATTTAGTCGAAGCAATGGCACGTACCG
GTGTGGTGATTAACGTGAAAAAACCACAATTTTTAAGCCCGGGTCAAATGGGTAATATCGTAGAAAAAATTGCAGAATGC
GGTAACGAAAACGTAATTCTTTGTGACCGTGGTACTAACTTCGGCTACGATAATTTAGTGGTGGATATGCTCGGCTTTAA
CATTATGAAAAAAGTATCAAAAGGCTGTCCGGTCATTTTTGACGTGACTCACTCACTACAATGCCGTGACCCGTTCGGTG
CAGCATCAGGCGGTCGCCGTGATCAAGTAACCGAATTGGCTCGCAGCGGTATGGCAATTGGTTTAGCCGGTTTATTCCTT
GAAGCGCATCCGGATCCGAACAGTGCGAAATGTGACGGTCCGTCAGCCCTACCGTTATCAAAATTAGAAGCATTCGTTAG
CCAAATGAAAGCGATTGATGATTTAGTTAAATCATTTGAAGAAATTGATACATCAAGATAA

Upstream 100 bases:

>100_bases
ACATAAAACAAAATTTCTCAATTTTTTAGATTCAATATTAAAAGAAATATAATTAAAGAACTTTAATTTTAGATTTACTT
TACTAAGTGGAATTAAAATC

Downstream 100 bases:

>100_bases
GAAATACTTCCCCTCTTAATTAGAGGGGATTTTTATGAGGTTTTTATGAAGTTTACTATTATTATCCCGGCTCGTTATGC
TTCGACTCGCTTACCTAGAA

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MTILNKIVKVGNIEVANDKPFTLFGGMNVLESRDMAMRVCEQYVEVTNKLGVPYVFKASFDKANRSSIHSYRGPGMEEGL
KIFQELKDTFGVSIITDVHEIYQCKPVAEVVDIIQLPAFLARQTDLVEAMARTGVVINVKKPQFLSPGQMGNIVEKIAEC
GNENVILCDRGTNFGYDNLVVDMLGFNIMKKVSKGCPVIFDVTHSLQCRDPFGAASGGRRDQVTELARSGMAIGLAGLFL
EAHPDPNSAKCDGPSALPLSKLEAFVSQMKAIDDLVKSFEEIDTSR

Sequences:

>Translated_286_residues
MTILNKIVKVGNIEVANDKPFTLFGGMNVLESRDMAMRVCEQYVEVTNKLGVPYVFKASFDKANRSSIHSYRGPGMEEGL
KIFQELKDTFGVSIITDVHEIYQCKPVAEVVDIIQLPAFLARQTDLVEAMARTGVVINVKKPQFLSPGQMGNIVEKIAEC
GNENVILCDRGTNFGYDNLVVDMLGFNIMKKVSKGCPVIFDVTHSLQCRDPFGAASGGRRDQVTELARSGMAIGLAGLFL
EAHPDPNSAKCDGPSALPLSKLEAFVSQMKAIDDLVKSFEEIDTSR
>Mature_285_residues
TILNKIVKVGNIEVANDKPFTLFGGMNVLESRDMAMRVCEQYVEVTNKLGVPYVFKASFDKANRSSIHSYRGPGMEEGLK
IFQELKDTFGVSIITDVHEIYQCKPVAEVVDIIQLPAFLARQTDLVEAMARTGVVINVKKPQFLSPGQMGNIVEKIAECG
NENVILCDRGTNFGYDNLVVDMLGFNIMKKVSKGCPVIFDVTHSLQCRDPFGAASGGRRDQVTELARSGMAIGLAGLFLE
AHPDPNSAKCDGPSALPLSKLEAFVSQMKAIDDLVKSFEEIDTSR

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family

Homologues:

Organism=Escherichia coli, GI1787466, Length=282, Percent_Identity=81.5602836879433, Blast_Score=489, Evalue=1e-140,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): KDSA_ACTPL (O68662)

Other databases:

- EMBL:   AF053723
- ProteinModelPortal:   O68662
- SMR:   O68662
- BRENDA:   2.5.1.55
- GO:   GO:0005737
- HAMAP:   MF_00056
- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR21057:SF2
- TIGRFAMs:   TIGR01362

Pfam domain/function: PF00793 DAHP_synth_1

EC number: =2.5.1.55

Molecular weight: Translated: 31344; Mature: 31212

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILNKIVKVGNIEVANDKPFTLFGGMNVLESRDMAMRVCEQYVEVTNKLGVPYVFKASF
CCHHHHHHHHCCEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
DKANRSSIHSYRGPGMEEGLKIFQELKDTFGVSIITDVHEIYQCKPVAEVVDIIQLPAFL
CCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHH
ARQTDLVEAMARTGVVINVKKPQFLSPGQMGNIVEKIAECGNENVILCDRGTNFGYDNLV
HHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHH
VDMLGFNIMKKVSKGCPVIFDVTHSLQCRDPFGAASGGRRDQVTELARSGMAIGLAGLFL
HHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHEE
EAHPDPNSAKCDGPSALPLSKLEAFVSQMKAIDDLVKSFEEIDTSR
ECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TILNKIVKVGNIEVANDKPFTLFGGMNVLESRDMAMRVCEQYVEVTNKLGVPYVFKASF
CHHHHHHHHCCEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
DKANRSSIHSYRGPGMEEGLKIFQELKDTFGVSIITDVHEIYQCKPVAEVVDIIQLPAFL
CCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHH
ARQTDLVEAMARTGVVINVKKPQFLSPGQMGNIVEKIAECGNENVILCDRGTNFGYDNLV
HHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHH
VDMLGFNIMKKVSKGCPVIFDVTHSLQCRDPFGAASGGRRDQVTELARSGMAIGLAGLFL
HHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHEE
EAHPDPNSAKCDGPSALPLSKLEAFVSQMKAIDDLVKSFEEIDTSR
ECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA