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The map label for this gene is menA [H]

Identifier: 126208925

GI number: 126208925

Start: 1674525

End: 1675433

Strand: Direct

Name: menA [H]

Synonym: APL_1461

Alternate gene names: 126208925

Gene position: 1674525-1675433 (Clockwise)

Preceding gene: 126208924

Following gene: 126208927

Centisome position: 73.62

GC content: 40.04

Gene sequence:

>909_bases
ATGGATAAACATTCCGCTTTTTCAATTTGGTTTACTACCGCTCGCCCAAGAACATTGCCTTTAGCGTTAGCCTCTATTAT
CGTCGGCTCGGCATTGGCATATTGGGCAGGGCATTTCGATATAATCACTACGTTACTTGCTTTTATTACCACTATTTTAT
TACAAGTGCTGTCTAATTTCGCTAACGATTATGGCGATCACGTCAAAGGCTCCGACACGAAAGAGCGTATCGGGCCGTTA
CGAGCGATTCAGCACGGGGCAATTACCGGCGGGCAATTAAGAAATGCGGTTATTTTACTCAGCATTTTATCCTTTATTGC
CGGCGTAGGGCTGACGGTTTACGCTTATCAATCTATTCAAGATGTCGTAGTGTTTATCAGTTTAGGTGTTATTTCGATTA
TAGCGGCAATTACTTATACGGTTGGCAAAAAAGCCTATGGTTATTTAGGATTAGGTGATTTATTCGTACTGATCTTTTTT
GGATTTGTCGCGGTTATCGGCACATTCTATTTACAAGCGCATAGTATTCCGGCAATGATTTTTATTCCGGCGTTCGGTTG
CGGCTTATTATCGGTGGCGGTATTAAATATCAATAACCTACGTGATATTAACCAAGACAAACAAGCCGGTAAAAATACTC
TGATTGTCCGTATCGGTAGTCAAAACGGACGGATTTATCATGTCGTATTATTAGGATTAGCGGTCATTTCTTATCTGATT
TTTGCCATCAGTGAATTTCAACATTGGTACAGCTACTTATTTTTACTTGCCGTCCCGTTACTTGCTAAACACGGTTCATT
TGTTTATCGTCACCAAGATCCGATTGAATTACGCCCGATTTTAGGACAAATGGCAGGATTAGCACTAATTACTAACCTTT
TATTTAGCTTAGGAATTTTTTTAGGTTAG

Upstream 100 bases:

>100_bases
CGAGTCAATATCAGCTCTATCTACCGAGTGAGCAGCGGCTTTTAGAAGAAGTTCAGAAAGAGATTCAACAGTTCAAACAA
AAACAGGAAGAAAACGATTA

Downstream 100 bases:

>100_bases
GGTAAATTTAGGGTAAAAAAGACCGCTTGTTTGAGAGTGATTAGTCGCAAACAAGCGGGCTTTTTTGATTAAAATATTTC
AAATGCTAAAGGATGAACCG

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MDKHSAFSIWFTTARPRTLPLALASIIVGSALAYWAGHFDIITTLLAFITTILLQVLSNFANDYGDHVKGSDTKERIGPL
RAIQHGAITGGQLRNAVILLSILSFIAGVGLTVYAYQSIQDVVVFISLGVISIIAAITYTVGKKAYGYLGLGDLFVLIFF
GFVAVIGTFYLQAHSIPAMIFIPAFGCGLLSVAVLNINNLRDINQDKQAGKNTLIVRIGSQNGRIYHVVLLGLAVISYLI
FAISEFQHWYSYLFLLAVPLLAKHGSFVYRHQDPIELRPILGQMAGLALITNLLFSLGIFLG

Sequences:

>Translated_302_residues
MDKHSAFSIWFTTARPRTLPLALASIIVGSALAYWAGHFDIITTLLAFITTILLQVLSNFANDYGDHVKGSDTKERIGPL
RAIQHGAITGGQLRNAVILLSILSFIAGVGLTVYAYQSIQDVVVFISLGVISIIAAITYTVGKKAYGYLGLGDLFVLIFF
GFVAVIGTFYLQAHSIPAMIFIPAFGCGLLSVAVLNINNLRDINQDKQAGKNTLIVRIGSQNGRIYHVVLLGLAVISYLI
FAISEFQHWYSYLFLLAVPLLAKHGSFVYRHQDPIELRPILGQMAGLALITNLLFSLGIFLG
>Mature_302_residues
MDKHSAFSIWFTTARPRTLPLALASIIVGSALAYWAGHFDIITTLLAFITTILLQVLSNFANDYGDHVKGSDTKERIGPL
RAIQHGAITGGQLRNAVILLSILSFIAGVGLTVYAYQSIQDVVVFISLGVISIIAAITYTVGKKAYGYLGLGDLFVLIFF
GFVAVIGTFYLQAHSIPAMIFIPAFGCGLLSVAVLNINNLRDINQDKQAGKNTLIVRIGSQNGRIYHVVLLGLAVISYLI
FAISEFQHWYSYLFLLAVPLLAKHGSFVYRHQDPIELRPILGQMAGLALITNLLFSLGIFLG

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=290, Percent_Identity=27.9310344827586, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1790365, Length=293, Percent_Identity=54.6075085324232, Blast_Score=324, Evalue=4e-90,
Organism=Drosophila melanogaster, GI17737429, Length=276, Percent_Identity=29.3478260869565, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 32904; Mature: 32904

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKHSAFSIWFTTARPRTLPLALASIIVGSALAYWAGHFDIITTLLAFITTILLQVLSNF
CCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ANDYGDHVKGSDTKERIGPLRAIQHGAITGGQLRNAVILLSILSFIAGVGLTVYAYQSIQ
HHHHCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
DVVVFISLGVISIIAAITYTVGKKAYGYLGLGDLFVLIFFGFVAVIGTFYLQAHSIPAMI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
FIPAFGCGLLSVAVLNINNLRDINQDKQAGKNTLIVRIGSQNGRIYHVVLLGLAVISYLI
EHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHH
FAISEFQHWYSYLFLLAVPLLAKHGSFVYRHQDPIELRPILGQMAGLALITNLLFSLGIF
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LG
CC
>Mature Secondary Structure
MDKHSAFSIWFTTARPRTLPLALASIIVGSALAYWAGHFDIITTLLAFITTILLQVLSNF
CCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ANDYGDHVKGSDTKERIGPLRAIQHGAITGGQLRNAVILLSILSFIAGVGLTVYAYQSIQ
HHHHCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
DVVVFISLGVISIIAAITYTVGKKAYGYLGLGDLFVLIFFGFVAVIGTFYLQAHSIPAMI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
FIPAFGCGLLSVAVLNINNLRDINQDKQAGKNTLIVRIGSQNGRIYHVVLLGLAVISYLI
EHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHH
FAISEFQHWYSYLFLLAVPLLAKHGSFVYRHQDPIELRPILGQMAGLALITNLLFSLGIF
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LG
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]