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The map label for this gene is ilvA [H]

Identifier: 126208919

GI number: 126208919

Start: 1668513

End: 1670039

Strand: Reverse

Name: ilvA [H]

Synonym: APL_1455

Alternate gene names: 126208919

Gene position: 1670039-1668513 (Counterclockwise)

Preceding gene: 126208920

Following gene: 126208918

Centisome position: 73.43

GC content: 43.55

Gene sequence:

>1527_bases
ATGAGCAATCCGACAATTCAATCCGGCACCGATTATCTGCGTGTAATCCTCAGTTCAAATATCTACGACCTAGCGCAAGT
TACCCCGCTTCAAAAAATGGAAAAACTCTCCGAGCGTTTAGGCAACCAAATTCTTATCAAACGTGAAGATCGCCAACCGG
TACATAGTTTCAAACTGCGTGGTGCATTTGCCATGATTTCCAATCTCTCGGCAAGCCAAAAAGCCGCCGGTGTGATTACC
GCTTCGGCAGGAAACCACGCTCAAGGCGTGGCGCTTTCATCAAAACACTTAGGACTTCGTGCATTAATCGTTATGCCGCA
AAATACGCCGGCAATTAAAGTCGATGCGGTGCGAGGGTTCGGTGGAGAAGTCTTACTATTCGGTGCCAATTTTGATGAGG
CGAAAGCCAAAGCATTAGAACTTTCTACAGAGTTGGGGATGACTTTCGTACCACCGTTCGATCACCCGATGGTGATTGCC
GGACAAGGTACGATCGGTATGGAATTAGTACAGCAAAGATCAGATTTAGATTATGTATTCGTACCGGTCGGTGGCGGCGG
TTTAGCCGCCGGTATTGCGGTATTAATTAAGCAAATTCTACCGAATGTAAAAGTGATTGGCGTTGAATCAAAAGATTCCG
CTTGTTTGCAACATGCCTTAAAAGTCGGCAAACCGGATAACTTGGAACGTGTCGGCTTATTCGCAGACGGTATTGCGGTA
AAAAGAATCGGTGACGAAACTTTCCGTTTATGCCAGAAATATATCGATGAAGTGGTACTGGTCGATAACGATCAGATTTG
TGCGGCAATGAAAGATATTTTTGAAAACGTACGTGCGATTGCAGAACCTTCCGGTGCGACTTCATTAGCCGGCTTAAAAA
AATATGTGAAAGAACACCAACTTGAAGGCAAAAACTTAGCTTGTGTGCTTTCCGGTGCGAACTTGAATTTCCATACGTTA
CGTTATGTTTCGGAACGTTGTGAAATCGGCGAAAAACATGAAGCCTTATTAGCGGTAACCATTCCGGAACAAAAAGGCAG
TTTTTTAAAATTCTGTGAGATTTTAGGCAATAGAGCGGTCACCGAATTTAACTATCGACACGCAGATGACAATAAAGCGT
GTATTTTCGTTGGGGTTCGTATTACCGGCAATGCGGAAAAAGCGGATATCATTCGCGATCTACAACAGCACAATTATAAC
GTAGTGGATCTTTCGGATGATGACATTGCTAAAACGCATATTCGTTATATGGTCGGCGGTCGTCCTAACAGCATTAGCAG
CGAGCAACTTTATAGCTTCGAATTCCCTGAGCAAAAAGGCGCATTATTAAAATTCCTCCAAACACTGACCGATTGGGATA
TTTCATTATTCCATTATCGTGCGCACGGGGCGGATTACGGCGATATTCTCGCTGCGTTTACTTTAGATGAAAGCGATAAG
CATCGCCTTAATCAGCATTTGGATCAACTTGGTTATCGTTATCAAAACGTAACGGATAGCCTTGCATATCAATACTTTTT
AAAATAA

Upstream 100 bases:

>100_bases
AGCGTTATCGCTTGTGCCTTTTTAGTTTTTTTTCAAACAATAACCTGACGTACCCTTCAATACGCCGATATAAAAGTATA
ATAAAATACAGAGCAGTGTT

Downstream 100 bases:

>100_bases
ATCGCAGGAATTATTGGTTAAATCGGCTGTCTAATCGGCAGTTTTCACTCTTCTTTTTTAAGGATCTAACAATGGCAGAA
CGTAAATATTTCGGTACGGA

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 508; Mature: 507

Protein sequence:

>508_residues
MSNPTIQSGTDYLRVILSSNIYDLAQVTPLQKMEKLSERLGNQILIKREDRQPVHSFKLRGAFAMISNLSASQKAAGVIT
ASAGNHAQGVALSSKHLGLRALIVMPQNTPAIKVDAVRGFGGEVLLFGANFDEAKAKALELSTELGMTFVPPFDHPMVIA
GQGTIGMELVQQRSDLDYVFVPVGGGGLAAGIAVLIKQILPNVKVIGVESKDSACLQHALKVGKPDNLERVGLFADGIAV
KRIGDETFRLCQKYIDEVVLVDNDQICAAMKDIFENVRAIAEPSGATSLAGLKKYVKEHQLEGKNLACVLSGANLNFHTL
RYVSERCEIGEKHEALLAVTIPEQKGSFLKFCEILGNRAVTEFNYRHADDNKACIFVGVRITGNAEKADIIRDLQQHNYN
VVDLSDDDIAKTHIRYMVGGRPNSISSEQLYSFEFPEQKGALLKFLQTLTDWDISLFHYRAHGADYGDILAAFTLDESDK
HRLNQHLDQLGYRYQNVTDSLAYQYFLK

Sequences:

>Translated_508_residues
MSNPTIQSGTDYLRVILSSNIYDLAQVTPLQKMEKLSERLGNQILIKREDRQPVHSFKLRGAFAMISNLSASQKAAGVIT
ASAGNHAQGVALSSKHLGLRALIVMPQNTPAIKVDAVRGFGGEVLLFGANFDEAKAKALELSTELGMTFVPPFDHPMVIA
GQGTIGMELVQQRSDLDYVFVPVGGGGLAAGIAVLIKQILPNVKVIGVESKDSACLQHALKVGKPDNLERVGLFADGIAV
KRIGDETFRLCQKYIDEVVLVDNDQICAAMKDIFENVRAIAEPSGATSLAGLKKYVKEHQLEGKNLACVLSGANLNFHTL
RYVSERCEIGEKHEALLAVTIPEQKGSFLKFCEILGNRAVTEFNYRHADDNKACIFVGVRITGNAEKADIIRDLQQHNYN
VVDLSDDDIAKTHIRYMVGGRPNSISSEQLYSFEFPEQKGALLKFLQTLTDWDISLFHYRAHGADYGDILAAFTLDESDK
HRLNQHLDQLGYRYQNVTDSLAYQYFLK
>Mature_507_residues
SNPTIQSGTDYLRVILSSNIYDLAQVTPLQKMEKLSERLGNQILIKREDRQPVHSFKLRGAFAMISNLSASQKAAGVITA
SAGNHAQGVALSSKHLGLRALIVMPQNTPAIKVDAVRGFGGEVLLFGANFDEAKAKALELSTELGMTFVPPFDHPMVIAG
QGTIGMELVQQRSDLDYVFVPVGGGGLAAGIAVLIKQILPNVKVIGVESKDSACLQHALKVGKPDNLERVGLFADGIAVK
RIGDETFRLCQKYIDEVVLVDNDQICAAMKDIFENVRAIAEPSGATSLAGLKKYVKEHQLEGKNLACVLSGANLNFHTLR
YVSERCEIGEKHEALLAVTIPEQKGSFLKFCEILGNRAVTEFNYRHADDNKACIFVGVRITGNAEKADIIRDLQQHNYNV
VDLSDDDIAKTHIRYMVGGRPNSISSEQLYSFEFPEQKGALLKFLQTLTDWDISLFHYRAHGADYGDILAAFTLDESDKH
RLNQHLDQLGYRYQNVTDSLAYQYFLK

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=305, Percent_Identity=32.4590163934426, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI33469958, Length=320, Percent_Identity=26.5625, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI19923959, Length=271, Percent_Identity=29.520295202952, Blast_Score=92, Evalue=2e-18,
Organism=Escherichia coli, GI1790207, Length=501, Percent_Identity=67.2654690618762, Blast_Score=672, Evalue=0.0,
Organism=Escherichia coli, GI1789505, Length=297, Percent_Identity=38.047138047138, Blast_Score=187, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI71991565, Length=307, Percent_Identity=34.2019543973941, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17537387, Length=333, Percent_Identity=32.7327327327327, Blast_Score=141, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI17508781, Length=287, Percent_Identity=28.5714285714286, Blast_Score=125, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6320930, Length=515, Percent_Identity=47.1844660194175, Blast_Score=457, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6322631, Length=307, Percent_Identity=35.1791530944625, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6319788, Length=298, Percent_Identity=26.1744966442953, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI21355833, Length=389, Percent_Identity=30.8483290488432, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24645328, Length=311, Percent_Identity=29.2604501607717, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 55985; Mature: 55854

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPTIQSGTDYLRVILSSNIYDLAQVTPLQKMEKLSERLGNQILIKREDRQPVHSFKLR
CCCCCCCCCHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHH
GAFAMISNLSASQKAAGVITASAGNHAQGVALSSKHLGLRALIVMPQNTPAIKVDAVRGF
HHHHHHHCCCCCCCCCEEEEECCCCCCCCEEECCCCCCEEEEEEECCCCCEEEEEEECCC
GGEVLLFGANFDEAKAKALELSTELGMTFVPPFDHPMVIAGQGTIGMELVQQRSDLDYVF
CCCEEEEECCCCHHHHHHHHHHHHCCCEECCCCCCCEEEECCCCHHHHHHHHCCCCCEEE
VPVGGGGLAAGIAVLIKQILPNVKVIGVESKDSACLQHALKVGKPDNLERVGLFADGIAV
EEECCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCCCEEEEEECCEEE
KRIGDETFRLCQKYIDEVVLVDNDQICAAMKDIFENVRAIAEPSGATSLAGLKKYVKEHQ
ECCCHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
LEGKNLACVLSGANLNFHTLRYVSERCEIGEKHEALLAVTIPEQKGSFLKFCEILGNRAV
CCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHCCCCE
TEFNYRHADDNKACIFVGVRITGNAEKADIIRDLQQHNYNVVDLSDDDIAKTHIRYMVGG
EECCCEECCCCCEEEEEEEEEECCCHHHHHHHHHHHCCCEEEECCCCCHHHHHEEEEECC
RPNSISSEQLYSFEFPEQKGALLKFLQTLTDWDISLFHYRAHGADYGDILAAFTLDESDK
CCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCEEEEEEEECCCCHHHEEEEEECCCCHH
HRLNQHLDQLGYRYQNVTDSLAYQYFLK
HHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNPTIQSGTDYLRVILSSNIYDLAQVTPLQKMEKLSERLGNQILIKREDRQPVHSFKLR
CCCCCCCCHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHH
GAFAMISNLSASQKAAGVITASAGNHAQGVALSSKHLGLRALIVMPQNTPAIKVDAVRGF
HHHHHHHCCCCCCCCCEEEEECCCCCCCCEEECCCCCCEEEEEEECCCCCEEEEEEECCC
GGEVLLFGANFDEAKAKALELSTELGMTFVPPFDHPMVIAGQGTIGMELVQQRSDLDYVF
CCCEEEEECCCCHHHHHHHHHHHHCCCEECCCCCCCEEEECCCCHHHHHHHHCCCCCEEE
VPVGGGGLAAGIAVLIKQILPNVKVIGVESKDSACLQHALKVGKPDNLERVGLFADGIAV
EEECCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCCCEEEEEECCEEE
KRIGDETFRLCQKYIDEVVLVDNDQICAAMKDIFENVRAIAEPSGATSLAGLKKYVKEHQ
ECCCHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
LEGKNLACVLSGANLNFHTLRYVSERCEIGEKHEALLAVTIPEQKGSFLKFCEILGNRAV
CCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHCCCCE
TEFNYRHADDNKACIFVGVRITGNAEKADIIRDLQQHNYNVVDLSDDDIAKTHIRYMVGG
EECCCEECCCCCEEEEEEEEEECCCHHHHHHHHHHHCCCEEEECCCCCHHHHHEEEEECC
RPNSISSEQLYSFEFPEQKGALLKFLQTLTDWDISLFHYRAHGADYGDILAAFTLDESDK
CCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCEEEEEEEECCCCHHHEEEEEECCCCHH
HRLNQHLDQLGYRYQNVTDSLAYQYFLK
HHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]