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The map label for this gene is fbp

Identifier: 126208914

GI number: 126208914

Start: 1662693

End: 1663697

Strand: Direct

Name: fbp

Synonym: APL_1450

Alternate gene names: 126208914

Gene position: 1662693-1663697 (Clockwise)

Preceding gene: 126208912

Following gene: 126208924

Centisome position: 73.1

GC content: 42.99

Gene sequence:

>1005_bases
ATGAAAACACTCGGCGAATTTATTATTGAAAAACAAGCGGAGTACCCGGAAGCGAAAGGCGAATTAAGCGGTATTTTATC
GTCTATTCGACTTGCCGCTAAAATTATTCACCGAGAAATTAACCGCGCCGGTTTAAGCCAAGATATTTTAGGCGTAGCCG
GTTCGGAGAATATTCAAGGCGAAGCGCAAATGAAATTAGACGTATTCGCTAACGAAACGATGAAAAAGGCGTTACTGGCT
CGTGAAGAAGTTGCCGGTTTTGCATCCGAAGAAGACGATAATTTTGTCGCATTTGAAAATGATCGCGCTAAAAACGCTAA
ATATATTCTGATGACCGATCCGTTGGACGGTTCTTCCAATATTGACGTAAACGTTTCGGTCGGTACGATTTTCTCTATTT
ATAAACGCGTCTCGCCGATCGGCTCGCCAGTGACGATGGAAGACTTCTTACAAGAAGGACGTAAACAAGTAGCGTCGGGG
TATGTGACTTACGGTTCATCAACGATGTTGGTATATACCACCGGTAACGGGGTAAACGGTTTCACTTACGATCCGTCGCT
CGGTTTATTTATCCTTTCTCATCCGGATATGAAAATACCGACGGAAGGTAAATACTATTCGATTAATGAAGGACAATACG
TGACATTCCCGATGGGCGTGAAAAAATTCATTAAATATTGCCAAGAAAGTGACGAAGCGACTAAACGTCCGTATTCATCA
CGTTATATCGGTTCGTTAGTATCGGATTTCCACCGCAACCTTTTAAAAGGCGGTATCTATATTTATCCGACTTCAACCGT
TTATCCGAAAGGTAAATTACGTTTATTGTATGAAGGTAATCCGATGGCATTCTTAGCCGAACAAGCCGGCGGTATGGCAA
CAGACGGTTTTAATCCGATTTTGGATATTAAACCGAGCGAACTGCATCAGCGCGTGCCGTTCTTTGTCGGTTCGACCTCA
ATGGTTAAGCAAGCGGACAAATTTATGCAGGAATGTGCGGAATAA

Upstream 100 bases:

>100_bases
TATGTGATCAATGTCACAAAATTGTTGTACCTTATTAGAGGTAACATCGGTTTATCTCTATAATATTACTTACTATTCTA
GCATAGCCCAAGGAGAAATT

Downstream 100 bases:

>100_bases
TACCGAGATAAAACAAAAAACCGAACGCTTTAAAACGTTCGGTTTTTTTATATTAAGCGGTTAATTTTGCCGCATAGTAG
ACAAAAAGGTTGGTATTTTG

Product: fructose-1,6-bisphosphatase

Products: NA

Alternate protein names: FBPase class 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MKTLGEFIIEKQAEYPEAKGELSGILSSIRLAAKIIHREINRAGLSQDILGVAGSENIQGEAQMKLDVFANETMKKALLA
REEVAGFASEEDDNFVAFENDRAKNAKYILMTDPLDGSSNIDVNVSVGTIFSIYKRVSPIGSPVTMEDFLQEGRKQVASG
YVTYGSSTMLVYTTGNGVNGFTYDPSLGLFILSHPDMKIPTEGKYYSINEGQYVTFPMGVKKFIKYCQESDEATKRPYSS
RYIGSLVSDFHRNLLKGGIYIYPTSTVYPKGKLRLLYEGNPMAFLAEQAGGMATDGFNPILDIKPSELHQRVPFFVGSTS
MVKQADKFMQECAE

Sequences:

>Translated_334_residues
MKTLGEFIIEKQAEYPEAKGELSGILSSIRLAAKIIHREINRAGLSQDILGVAGSENIQGEAQMKLDVFANETMKKALLA
REEVAGFASEEDDNFVAFENDRAKNAKYILMTDPLDGSSNIDVNVSVGTIFSIYKRVSPIGSPVTMEDFLQEGRKQVASG
YVTYGSSTMLVYTTGNGVNGFTYDPSLGLFILSHPDMKIPTEGKYYSINEGQYVTFPMGVKKFIKYCQESDEATKRPYSS
RYIGSLVSDFHRNLLKGGIYIYPTSTVYPKGKLRLLYEGNPMAFLAEQAGGMATDGFNPILDIKPSELHQRVPFFVGSTS
MVKQADKFMQECAE
>Mature_334_residues
MKTLGEFIIEKQAEYPEAKGELSGILSSIRLAAKIIHREINRAGLSQDILGVAGSENIQGEAQMKLDVFANETMKKALLA
REEVAGFASEEDDNFVAFENDRAKNAKYILMTDPLDGSSNIDVNVSVGTIFSIYKRVSPIGSPVTMEDFLQEGRKQVASG
YVTYGSSTMLVYTTGNGVNGFTYDPSLGLFILSHPDMKIPTEGKYYSINEGQYVTFPMGVKKFIKYCQESDEATKRPYSS
RYIGSLVSDFHRNLLKGGIYIYPTSTVYPKGKLRLLYEGNPMAFLAEQAGGMATDGFNPILDIKPSELHQRVPFFVGSTS
MVKQADKFMQECAE

Specific function: INVOLVED IN SEVERAL METABOLIC PATHWAYS. IN E.COLI AND YEAST IT IS NECESSARY FOR GROWTH ON SUBSTANCES SUCH AS GLYCEROL, SUCCINATE AND ACETATE. [C]

COG id: COG0158

COG function: function code G; Fructose-1,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FBPase class 1 family

Homologues:

Organism=Homo sapiens, GI22907028, Length=324, Percent_Identity=42.5925925925926, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI189083692, Length=318, Percent_Identity=44.0251572327044, Blast_Score=244, Evalue=8e-65,
Organism=Homo sapiens, GI16579888, Length=318, Percent_Identity=44.0251572327044, Blast_Score=244, Evalue=8e-65,
Organism=Escherichia coli, GI1790679, Length=331, Percent_Identity=67.6737160120846, Blast_Score=470, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI17508131, Length=327, Percent_Identity=46.177370030581, Blast_Score=303, Evalue=6e-83,
Organism=Saccharomyces cerevisiae, GI6323409, Length=331, Percent_Identity=42.5981873111783, Blast_Score=256, Evalue=3e-69,
Organism=Drosophila melanogaster, GI45550998, Length=328, Percent_Identity=46.0365853658537, Blast_Score=277, Evalue=6e-75,
Organism=Drosophila melanogaster, GI19921562, Length=328, Percent_Identity=46.0365853658537, Blast_Score=277, Evalue=8e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): F16PA_ACTP2 (A3N298)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001054139.1
- ProteinModelPortal:   A3N298
- SMR:   A3N298
- STRING:   A3N298
- GeneID:   4849228
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_1450
- eggNOG:   COG0158
- HOGENOM:   HBG731261
- OMA:   HWEAPVQ
- PhylomeDB:   A3N298
- ProtClustDB:   PRK09293
- BioCyc:   APLE416269:APL_1450-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01855
- InterPro:   IPR000146
- InterPro:   IPR020548
- PANTHER:   PTHR11556
- PRINTS:   PR00115

Pfam domain/function: PF00316 FBPase

EC number: =3.1.3.11

Molecular weight: Translated: 36937; Mature: 36937

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00124 FBPASE

Important sites: BINDING 209-209 BINDING 242-242 BINDING 272-272

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLGEFIIEKQAEYPEAKGELSGILSSIRLAAKIIHREINRAGLSQDILGVAGSENIQG
CCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCC
EAQMKLDVFANETMKKALLAREEVAGFASEEDDNFVAFENDRAKNAKYILMTDPLDGSSN
CEEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCEEEEEECCCCCCCC
IDVNVSVGTIFSIYKRVSPIGSPVTMEDFLQEGRKQVASGYVTYGSSTMLVYTTGNGVNG
EEEEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCEEEECCCEEEEEEECCCCCC
FTYDPSLGLFILSHPDMKIPTEGKYYSINEGQYVTFPMGVKKFIKYCQESDEATKRPYSS
EEECCCCCEEEEECCCCCCCCCCCEEEECCCCEEEECCCHHHHHHHHHCCCHHHCCCCHH
RYIGSLVSDFHRNLLKGGIYIYPTSTVYPKGKLRLLYEGNPMAFLAEQAGGMATDGFNPI
HHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEEECCCCEEEEEHHCCCCCCCCCCCE
LDIKPSELHQRVPFFVGSTSMVKQADKFMQECAE
EECCHHHHHHHCCEEECCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKTLGEFIIEKQAEYPEAKGELSGILSSIRLAAKIIHREINRAGLSQDILGVAGSENIQG
CCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCC
EAQMKLDVFANETMKKALLAREEVAGFASEEDDNFVAFENDRAKNAKYILMTDPLDGSSN
CEEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCEEEEEECCCCCCCC
IDVNVSVGTIFSIYKRVSPIGSPVTMEDFLQEGRKQVASGYVTYGSSTMLVYTTGNGVNG
EEEEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCEEEECCCEEEEEEECCCCCC
FTYDPSLGLFILSHPDMKIPTEGKYYSINEGQYVTFPMGVKKFIKYCQESDEATKRPYSS
EEECCCCCEEEEECCCCCCCCCCCEEEECCCCEEEECCCHHHHHHHHHCCCHHHCCCCHH
RYIGSLVSDFHRNLLKGGIYIYPTSTVYPKGKLRLLYEGNPMAFLAEQAGGMATDGFNPI
HHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEEECCCCEEEEEHHCCCCCCCCCCCE
LDIKPSELHQRVPFFVGSTSMVKQADKFMQECAE
EECCHHHHHHHCCEEECCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA