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The map label for this gene is apxIC

Identifier: 126208909

GI number: 126208909

Start: 1656005

End: 1656523

Strand: Reverse

Name: apxIC

Synonym: APL_1445

Alternate gene names: 126208909

Gene position: 1656523-1656005 (Counterclockwise)

Preceding gene: 126208913

Following gene: 126208908

Centisome position: 72.83

GC content: 36.61

Gene sequence:

>519_bases
ATGAGTAAAAAAATTAATGGATTTGAGGTTTTAGGAGAGGTGGCATGGTTATGGGCAAGTTCTCCTTTACATCGAAAGTG
GCCGCTTTCTTTGTTAGCAATTAATGTGCTACCTGCGATTGAGAGTAATCAATATGTTTTGTTAAAGCGTGACGGTTTTC
CTATTGCATTTTGTAGCTGGGCAAATTTGAATTTGGAAAATGAAATTAAATACCTTGATGATGTTGCCTCGCTAGTTGCG
GATGATTGGACTTCCGGCGATCGTCGATGGTTTATAGATTGGATAGCACCGTTCGGAGACAGTGCCGCATTATACAAACA
TATGCGAGATAACTTCCCGAATGAGCTGTTTAGGGCTATTCGAGTTGATCCGGACTCTCGAGTAGGGAAAATTTCAGAAT
TTCATGGAGGAAAAATTGATAAGAAACTGGCAAGTAAAATTTTTCAACAATATCACTTTGAATTAATGAGTGAGCTAAAA
AATAAACAAAATTTTAAATTTTCATTAGTAAATAGCTAA

Upstream 100 bases:

>100_bases
ATATAAATAATCAAAAAACTTACTTTTTTTTATTTTTATCGGTAAGTATTTACAATCAAGTCAGACAAACGGCAATATTG
TTATAAATCTGGGGGGATGA

Downstream 100 bases:

>100_bases
GGAGACAACATGGCTAACTCTCAGCTCGATAGAGTCAAAGGATTGATTGATTCACTTAATCAACATACAAAAAGTGCAGC
TAAATCAGGTGCCGGCGCAT

Product: RTX-I toxin-activating lysine-acyltransferase ApxIC

Products: NA

Alternate protein names: APX-IC; Cytolysin IC; CLY-IC; HLY-IC; RTX-I toxin determinant C; Toxin RTX-I-activating protein C

Number of amino acids: Translated: 172; Mature: 171

Protein sequence:

>172_residues
MSKKINGFEVLGEVAWLWASSPLHRKWPLSLLAINVLPAIESNQYVLLKRDGFPIAFCSWANLNLENEIKYLDDVASLVA
DDWTSGDRRWFIDWIAPFGDSAALYKHMRDNFPNELFRAIRVDPDSRVGKISEFHGGKIDKKLASKIFQQYHFELMSELK
NKQNFKFSLVNS

Sequences:

>Translated_172_residues
MSKKINGFEVLGEVAWLWASSPLHRKWPLSLLAINVLPAIESNQYVLLKRDGFPIAFCSWANLNLENEIKYLDDVASLVA
DDWTSGDRRWFIDWIAPFGDSAALYKHMRDNFPNELFRAIRVDPDSRVGKISEFHGGKIDKKLASKIFQQYHFELMSELK
NKQNFKFSLVNS
>Mature_171_residues
SKKINGFEVLGEVAWLWASSPLHRKWPLSLLAINVLPAIESNQYVLLKRDGFPIAFCSWANLNLENEIKYLDDVASLVAD
DWTSGDRRWFIDWIAPFGDSAALYKHMRDNFPNELFRAIRVDPDSRVGKISEFHGGKIDKKLASKIFQQYHFELMSELKN
KQNFKFSLVNS

Specific function: Involved in fatty acylation of the protoxin, thereby converting it to the active toxin

COG id: COG2994

COG function: function code O; ACP:hemolysin acyltransferase (hemolysin-activating protein)

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RTX toxin acyltransferase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RTX1C_ACTPL (P55132)

Other databases:

- EMBL:   X68595
- EMBL:   X73117
- EMBL:   U05042
- EMBL:   U04954
- PIR:   I39644
- GO:   GO:0005737
- GO:   GO:0019835
- InterPro:   IPR003996
- PRINTS:   PR01489

Pfam domain/function: PF02794 HlyC

EC number: NA

Molecular weight: Translated: 19895; Mature: 19764

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: NA

Important sites: ACT_SITE 24-24

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKINGFEVLGEVAWLWASSPLHRKWPLSLLAINVLPAIESNQYVLLKRDGFPIAFCSW
CCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHEEHHHCCCCCCCEEEEEECCCCEEEEEE
ANLNLENEIKYLDDVASLVADDWTSGDRRWFIDWIAPFGDSAALYKHMRDNFPNELFRAI
CCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCHHHHHHHH
RVDPDSRVGKISEFHGGKIDKKLASKIFQQYHFELMSELKNKQNFKFSLVNS
CCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECC
>Mature Secondary Structure 
SKKINGFEVLGEVAWLWASSPLHRKWPLSLLAINVLPAIESNQYVLLKRDGFPIAFCSW
CCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHEEHHHCCCCCCCEEEEEECCCCEEEEEE
ANLNLENEIKYLDDVASLVADDWTSGDRRWFIDWIAPFGDSAALYKHMRDNFPNELFRAI
CCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCHHHHHHHH
RVDPDSRVGKISEFHGGKIDKKLASKIFQQYHFELMSELKNKQNFKFSLVNS
CCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8181764; 8359891