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The map label for this gene is fabH

Identifier: 126208848

GI number: 126208848

Start: 1584980

End: 1585930

Strand: Reverse

Name: fabH

Synonym: APL_1384

Alternate gene names: 126208848

Gene position: 1585930-1584980 (Counterclockwise)

Preceding gene: 126208849

Following gene: 126208847

Centisome position: 69.73

GC content: 44.69

Gene sequence:

>951_bases
ATGTACAGCAAAATTCTAGCAACGGGTAGTTATTTACCCGCTCAAATTCGTACTAATGCTGATTTAGAAAAAATGGTCGA
TACTAGCGATGAGTGGATTTTTACTCGTTCCGGTATGAAAGAGCGTCGTATTGCCGCCGCAGATGAAACGGTTGCGACAA
TGGGCGCGCAAGCGGCTAAAAATGCACTGGAAATAGCGAATATCGATCACAATGAAATTGATCTGATTGTTGTGGGAACT
ACAACCAACTCTCACGCCTATCCGAGTGCGGCTTGCCAAATTCAAGGTATGTTAGATATCCAAGATGCGATTGCGTTTGA
CGTTGCCGCCGCTTGTACCGGTTTTGTGTATGCGTTGAGTGTTGCCGATCAGTTTATACGTAGCGGAAAAATAAAAAAAG
CGTTGGTCATCGGTTCGGATTTAAATTCTCGTGCATTAGATGAAACCGATCGCAGTACCGTGGTGTTATTCGGTGATGGA
GCCGGTGCGGTTATTCTTGAAGCAAGTGAAGAGCAGGGTATTATTTCGACTCATTTACATTCGTCTTCCGATACTGAATA
TATGCTTGCTTTACCGGCACAAAAGCGTGGTGATGAAAAATCCGGCTTTATTCAAATGCAAGGAAACGCCACCTTTAAAT
TGGCGGTAGGTCAGCTTTCAAGTGTGGTGGAAGAAACCCTTGAAGCCAATAACTTACAAAAATCGGATTTAGATTGGCTA
GTTCCTCACCAAGCGAATATTCGTATTATTGCCGCAACAGCGAAGAAACTCGAAATGGATATGTCGCAAGTGGTATTGAC
CGTTGAGAAATACGGTAATAACAGTGCTGCAACCGTGCCTGTTGCATTAGATGAAGCGGTGCGTGACGGACGTATTCAAC
GCGGTCAATTATTGCTGCTTGAAGCCTTTGGCGGCGGCTGGACTTGGGGTTCCGCTCTTGTTCGTTTTTAA

Upstream 100 bases:

>100_bases
ATGCGATAGATCACGCAATCGGGCAGATTCGGAGCGGAATTCCTGATAAAATTTCACAAGGTTTAAACAGATTACATCAA
AATTTATAGAGAATCGAAAT

Downstream 100 bases:

>100_bases
CCAATCTCGTTTCTAACAAGCGGTCAAAAAAGATAGAATTTTTACAAATGTCAGAAAAACAAACTTTTGCAGATAAAAAA
CGTAAAACGGTAGAACAAGC

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MYSKILATGSYLPAQIRTNADLEKMVDTSDEWIFTRSGMKERRIAAADETVATMGAQAAKNALEIANIDHNEIDLIVVGT
TTNSHAYPSAACQIQGMLDIQDAIAFDVAAACTGFVYALSVADQFIRSGKIKKALVIGSDLNSRALDETDRSTVVLFGDG
AGAVILEASEEQGIISTHLHSSSDTEYMLALPAQKRGDEKSGFIQMQGNATFKLAVGQLSSVVEETLEANNLQKSDLDWL
VPHQANIRIIAATAKKLEMDMSQVVLTVEKYGNNSAATVPVALDEAVRDGRIQRGQLLLLEAFGGGWTWGSALVRF

Sequences:

>Translated_316_residues
MYSKILATGSYLPAQIRTNADLEKMVDTSDEWIFTRSGMKERRIAAADETVATMGAQAAKNALEIANIDHNEIDLIVVGT
TTNSHAYPSAACQIQGMLDIQDAIAFDVAAACTGFVYALSVADQFIRSGKIKKALVIGSDLNSRALDETDRSTVVLFGDG
AGAVILEASEEQGIISTHLHSSSDTEYMLALPAQKRGDEKSGFIQMQGNATFKLAVGQLSSVVEETLEANNLQKSDLDWL
VPHQANIRIIAATAKKLEMDMSQVVLTVEKYGNNSAATVPVALDEAVRDGRIQRGQLLLLEAFGGGWTWGSALVRF
>Mature_316_residues
MYSKILATGSYLPAQIRTNADLEKMVDTSDEWIFTRSGMKERRIAAADETVATMGAQAAKNALEIANIDHNEIDLIVVGT
TTNSHAYPSAACQIQGMLDIQDAIAFDVAAACTGFVYALSVADQFIRSGKIKKALVIGSDLNSRALDETDRSTVVLFGDG
AGAVILEASEEQGIISTHLHSSSDTEYMLALPAQKRGDEKSGFIQMQGNATFKLAVGQLSSVVEETLEANNLQKSDLDWL
VPHQANIRIIAATAKKLEMDMSQVVLTVEKYGNNSAATVPVALDEAVRDGRIQRGQLLLLEAFGGGWTWGSALVRF

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=317, Percent_Identity=64.9842271293375, Blast_Score=433, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_ACTP2 (A3N232)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001054073.1
- ProteinModelPortal:   A3N232
- SMR:   A3N232
- STRING:   A3N232
- GeneID:   4848572
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_1384
- eggNOG:   COG0332
- HOGENOM:   HBG649927
- OMA:   YLPAQVR
- PhylomeDB:   A3N232
- ProtClustDB:   PRK09352
- BioCyc:   APLE416269:APL_1384-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.41

Molecular weight: Translated: 34014; Mature: 34014

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: NA

Important sites: ACT_SITE 112-112 ACT_SITE 243-243 ACT_SITE 273-273

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSKILATGSYLPAQIRTNADLEKMVDTSDEWIFTRSGMKERRIAAADETVATMGAQAAK
CCCCEEECCCCCCEEEECCCCHHHHHCCCCCEEEECCCCCHHHHHHCCHHHHHHCHHHHH
NALEIANIDHNEIDLIVVGTTTNSHAYPSAACQIQGMLDIQDAIAFDVAAACTGFVYALS
CHHEEECCCCCCEEEEEEEECCCCCCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHH
VADQFIRSGKIKKALVIGSDLNSRALDETDRSTVVLFGDGAGAVILEASEEQGIISTHLH
HHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCEEEEEEC
SSSDTEYMLALPAQKRGDEKSGFIQMQGNATFKLAVGQLSSVVEETLEANNLQKSDLDWL
CCCCCEEEEEECCHHCCCCCCCEEEECCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCEE
VPHQANIRIIAATAKKLEMDMSQVVLTVEKYGNNSAATVPVALDEAVRDGRIQRGQLLLL
CCCCCCEEEEEEEHHHHHHCHHHHEEEEECCCCCCCEEEEEEHHHHHHCCCCCCCCEEEE
EAFGGGWTWGSALVRF
EECCCCEEHHHHHHCC
>Mature Secondary Structure
MYSKILATGSYLPAQIRTNADLEKMVDTSDEWIFTRSGMKERRIAAADETVATMGAQAAK
CCCCEEECCCCCCEEEECCCCHHHHHCCCCCEEEECCCCCHHHHHHCCHHHHHHCHHHHH
NALEIANIDHNEIDLIVVGTTTNSHAYPSAACQIQGMLDIQDAIAFDVAAACTGFVYALS
CHHEEECCCCCCEEEEEEEECCCCCCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHH
VADQFIRSGKIKKALVIGSDLNSRALDETDRSTVVLFGDGAGAVILEASEEQGIISTHLH
HHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCEEEEEEC
SSSDTEYMLALPAQKRGDEKSGFIQMQGNATFKLAVGQLSSVVEETLEANNLQKSDLDWL
CCCCCEEEEEECCHHCCCCCCCEEEECCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCEE
VPHQANIRIIAATAKKLEMDMSQVVLTVEKYGNNSAATVPVALDEAVRDGRIQRGQLLLL
CCCCCCEEEEEEEHHHHHHCHHHHEEEEECCCCCCCEEEEEEHHHHHHCCCCCCCCEEEE
EAFGGGWTWGSALVRF
EECCCCEEHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA