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The map label for this gene is adk [H]

Identifier: 126208764

GI number: 126208764

Start: 1486517

End: 1487161

Strand: Reverse

Name: adk [H]

Synonym: APL_1298

Alternate gene names: 126208764

Gene position: 1487161-1486517 (Counterclockwise)

Preceding gene: 126208765

Following gene: 126208761

Centisome position: 65.38

GC content: 44.34

Gene sequence:

>645_bases
ATGAAAATTATTCTTTTAGGTGCGCCGGGTGCAGGTAAAGGCACGCAAGCACAATTTATGATGAACAAATTCGGTATTCC
GCAAATCTCAACCGGCGATATGTTCCGTGCGGCAATTAAAGAAGGCACGGAGCTTGGTAAACAAGCAAAAGCGTTAATGG
ACGAAGGTAAATTAGTACCGGACGAATTAACCGTTGCATTAGTTAAAGATCGTATCGCACAACCGGATTGCGCAAACGGC
TTCTTATTAGACGGTTTCCCTCGCACGATTCCGCAAGCGGACGCATTAAAAGATTCGGGTGTGAAAATTGATTTAGTCTT
AGAGTTTGATGTCGCGGACGAAGTGATTGTTGAACGTATGAGCGGTCGTCGTGTACACCAGCCTTCCGGTCGTACTTATC
ACGTGGTTTACAACCCGCCGAAAGTGGAAGGCAAAGATGATGTAACCGGTGAAGATTTAATTATTCGCCAAGATGATAAA
CCTGAAACCGTATTAGAACGTTTAGCGATTTATCACAAACAAACCAAGCCGTTAATTGCTTACTATACGGCGGAAGCGGA
AGCGGGTAATACGCGTTACGAGCGTTTAGACGGTACAAAACCGGTTGAAGAAGTGAGTGCGGAATTAGCGAAAATTTTAG
GTTAA

Upstream 100 bases:

>100_bases
TTATTTTTCATAAAAAATTTGCAATTTCAGGCAGTAATCGGTAAGGTTACTGCCTTAGCTTTTTTATTCGTTATATTTTC
ATTTTTTAGAGGTTTTCCCT

Downstream 100 bases:

>100_bases
TCTTCCTAAATAAATATGAAAAAGCGGTTGATTTTTTATTAAAATCAACCGCTTGTTTTTTTATATCTTAGTAGGAATGA
TGGCGAGAAATAATTTGTTT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MKIILLGAPGAGKGTQAQFMMNKFGIPQISTGDMFRAAIKEGTELGKQAKALMDEGKLVPDELTVALVKDRIAQPDCANG
FLLDGFPRTIPQADALKDSGVKIDLVLEFDVADEVIVERMSGRRVHQPSGRTYHVVYNPPKVEGKDDVTGEDLIIRQDDK
PETVLERLAIYHKQTKPLIAYYTAEAEAGNTRYERLDGTKPVEEVSAELAKILG

Sequences:

>Translated_214_residues
MKIILLGAPGAGKGTQAQFMMNKFGIPQISTGDMFRAAIKEGTELGKQAKALMDEGKLVPDELTVALVKDRIAQPDCANG
FLLDGFPRTIPQADALKDSGVKIDLVLEFDVADEVIVERMSGRRVHQPSGRTYHVVYNPPKVEGKDDVTGEDLIIRQDDK
PETVLERLAIYHKQTKPLIAYYTAEAEAGNTRYERLDGTKPVEEVSAELAKILG
>Mature_214_residues
MKIILLGAPGAGKGTQAQFMMNKFGIPQISTGDMFRAAIKEGTELGKQAKALMDEGKLVPDELTVALVKDRIAQPDCANG
FLLDGFPRTIPQADALKDSGVKIDLVLEFDVADEVIVERMSGRRVHQPSGRTYHVVYNPPKVEGKDDVTGEDLIIRQDDK
PETVLERLAIYHKQTKPLIAYYTAEAEAGNTRYERLDGTKPVEEVSAELAKILG

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=186, Percent_Identity=50.5376344086022, Blast_Score=195, Evalue=3e-50,
Organism=Homo sapiens, GI4502013, Length=186, Percent_Identity=50.5376344086022, Blast_Score=194, Evalue=4e-50,
Organism=Homo sapiens, GI19923437, Length=186, Percent_Identity=46.7741935483871, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI310110345, Length=184, Percent_Identity=41.8478260869565, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI53832003, Length=184, Percent_Identity=41.8478260869565, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI8051579, Length=184, Percent_Identity=41.8478260869565, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI53832001, Length=184, Percent_Identity=41.8478260869565, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI4502011, Length=181, Percent_Identity=31.4917127071823, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI7706497, Length=219, Percent_Identity=30.5936073059361, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI22749187, Length=140, Percent_Identity=30.7142857142857, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI28144897, Length=186, Percent_Identity=27.4193548387097, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI28144899, Length=186, Percent_Identity=27.4193548387097, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI21450759, Length=139, Percent_Identity=24.4604316546763, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI237858799, Length=139, Percent_Identity=24.4604316546763, Blast_Score=68, Evalue=5e-12,
Organism=Escherichia coli, GI1786680, Length=214, Percent_Identity=73.3644859813084, Blast_Score=332, Evalue=1e-92,
Organism=Caenorhabditis elegans, GI17552384, Length=218, Percent_Identity=42.2018348623853, Blast_Score=187, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17537943, Length=186, Percent_Identity=36.5591397849462, Blast_Score=120, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17567503, Length=187, Percent_Identity=32.620320855615, Blast_Score=103, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17550688, Length=215, Percent_Identity=27.906976744186, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17533833, Length=215, Percent_Identity=26.5116279069767, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320432, Length=219, Percent_Identity=43.8356164383562, Blast_Score=198, Evalue=6e-52,
Organism=Saccharomyces cerevisiae, GI6321018, Length=203, Percent_Identity=43.3497536945813, Blast_Score=151, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6322828, Length=196, Percent_Identity=29.5918367346939, Blast_Score=97, Evalue=1e-21,
Organism=Drosophila melanogaster, GI22026816, Length=183, Percent_Identity=52.4590163934426, Blast_Score=194, Evalue=3e-50,
Organism=Drosophila melanogaster, GI17737899, Length=182, Percent_Identity=45.6043956043956, Blast_Score=164, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24645822, Length=182, Percent_Identity=45.6043956043956, Blast_Score=164, Evalue=3e-41,
Organism=Drosophila melanogaster, GI221459597, Length=215, Percent_Identity=29.3023255813954, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21356893, Length=215, Percent_Identity=29.3023255813954, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17647141, Length=181, Percent_Identity=27.6243093922652, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24663208, Length=181, Percent_Identity=27.6243093922652, Blast_Score=90, Evalue=1e-18,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 23480; Mature: 23480

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIILLGAPGAGKGTQAQFMMNKFGIPQISTGDMFRAAIKEGTELGKQAKALMDEGKLVP
CEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCH
DELTVALVKDRIAQPDCANGFLLDGFPRTIPQADALKDSGVKIDLVLEFDVADEVIVERM
HHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCCHHHCCCCCEEEEEEEECCHHHHHHHHH
SGRRVHQPSGRTYHVVYNPPKVEGKDDVTGEDLIIRQDDKPETVLERLAIYHKQTKPLIA
CCCEEECCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEE
YYTAEAEAGNTRYERLDGTKPVEEVSAELAKILG
EEEECCCCCCCHHHHCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKIILLGAPGAGKGTQAQFMMNKFGIPQISTGDMFRAAIKEGTELGKQAKALMDEGKLVP
CEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCH
DELTVALVKDRIAQPDCANGFLLDGFPRTIPQADALKDSGVKIDLVLEFDVADEVIVERM
HHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCCHHHCCCCCEEEEEEEECCHHHHHHHHH
SGRRVHQPSGRTYHVVYNPPKVEGKDDVTGEDLIIRQDDKPETVLERLAIYHKQTKPLIA
CCCEEECCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEE
YYTAEAEAGNTRYERLDGTKPVEEVSAELAKILG
EEEECCCCCCCHHHHCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA