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The map label for this gene is coaD

Identifier: 126208603

GI number: 126208603

Start: 1310512

End: 1310988

Strand: Direct

Name: coaD

Synonym: APL_1133

Alternate gene names: 126208603

Gene position: 1310512-1310988 (Clockwise)

Preceding gene: 126208602

Following gene: 126208604

Centisome position: 57.62

GC content: 45.49

Gene sequence:

>477_bases
ATGAGCTATACCGTTATTTATGCAGGGACTTTTGATCCCATGACCAACGGACATTTAGATATTATCGAACGAGCGTCCGA
GCTGTTCGGACAAGTGATTGTCGCCGTTGCGAAAAACCCGAGTAAACAACCGTTATTCTCATTTGAAGAACGAACCGCTT
TGGTGCGACAAAGTTGCGCTCATTTAGCTAACGTACAAGCGGTCGGATTTAGCGGATTACTTGCGGATTTTGCCAAACAA
CACCAAGCGAAAGCATTAGTCCGAGGGATCCGTGGCAGTGATGATATTGAGTATGAAATTCAGCTTGCTCAACTGAACGA
TAAATTATCCGGACGACTGGACACCGTGTTTTTACCGCCGTCCGTCACCTGGCGTTATTTATCCTCGACAATGGTACGTG
AAATTTATCGCCATCAAGGCGATGTGGCGCAATTTGTGCCTAATGCGGTACTTTGCGCCTTAAAAGAAAAGGAATAA

Upstream 100 bases:

>100_bases
TGTCAAAAAATCAGCCAAGCAGGGTTCGATGTTTTACAAGAAAATCAAGGCGCTCTCAAACGCCATATGGCACTTATCGC
CCCTTACTTAGAGAAATAAA

Downstream 100 bases:

>100_bases
ATATGAGTAAATTAGATAACCAAAATCTTATATGGATTGATTTGGAAATGACCGGACTTGATCCGGAAAAAGAGCGTATT
ATCGAAGTTGCGACGATTGT

Product: phosphopantetheine adenylyltransferase

Products: NA

Alternate protein names: Dephospho-CoA pyrophosphorylase; Pantetheine-phosphate adenylyltransferase; PPAT

Number of amino acids: Translated: 158; Mature: 157

Protein sequence:

>158_residues
MSYTVIYAGTFDPMTNGHLDIIERASELFGQVIVAVAKNPSKQPLFSFEERTALVRQSCAHLANVQAVGFSGLLADFAKQ
HQAKALVRGIRGSDDIEYEIQLAQLNDKLSGRLDTVFLPPSVTWRYLSSTMVREIYRHQGDVAQFVPNAVLCALKEKE

Sequences:

>Translated_158_residues
MSYTVIYAGTFDPMTNGHLDIIERASELFGQVIVAVAKNPSKQPLFSFEERTALVRQSCAHLANVQAVGFSGLLADFAKQ
HQAKALVRGIRGSDDIEYEIQLAQLNDKLSGRLDTVFLPPSVTWRYLSSTMVREIYRHQGDVAQFVPNAVLCALKEKE
>Mature_157_residues
SYTVIYAGTFDPMTNGHLDIIERASELFGQVIVAVAKNPSKQPLFSFEERTALVRQSCAHLANVQAVGFSGLLADFAKQH
QAKALVRGIRGSDDIEYEIQLAQLNDKLSGRLDTVFLPPSVTWRYLSSTMVREIYRHQGDVAQFVPNAVLCALKEKE

Specific function: Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate

COG id: COG0669

COG function: function code H; Phosphopantetheine adenylyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial CoaD family

Homologues:

Organism=Escherichia coli, GI1790065, Length=157, Percent_Identity=52.2292993630573, Blast_Score=185, Evalue=9e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAD_ACTP2 (A3N1D7)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001053828.1
- ProteinModelPortal:   A3N1D7
- SMR:   A3N1D7
- STRING:   A3N1D7
- GeneID:   4849508
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_1133
- eggNOG:   COG0669
- HOGENOM:   HBG288308
- OMA:   VRQIAAM
- PhylomeDB:   A3N1D7
- ProtClustDB:   PRK00168
- BioCyc:   APLE416269:APL_1133-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00151
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR001980
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR01020
- TIGRFAMs:   TIGR01510
- TIGRFAMs:   TIGR00125

Pfam domain/function: PF01467 CTP_transf_2

EC number: =2.7.7.3

Molecular weight: Translated: 17586; Mature: 17455

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYTVIYAGTFDPMTNGHLDIIERASELFGQVIVAVAKNPSKQPLFSFEERTALVRQSCA
CCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
HLANVQAVGFSGLLADFAKQHQAKALVRGIRGSDDIEYEIQLAQLNDKLSGRLDTVFLPP
HHHCCHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCHHHCCCEEEEEECC
SVTWRYLSSTMVREIYRHQGDVAQFVPNAVLCALKEKE
CHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHCCCCC
>Mature Secondary Structure 
SYTVIYAGTFDPMTNGHLDIIERASELFGQVIVAVAKNPSKQPLFSFEERTALVRQSCA
CEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
HLANVQAVGFSGLLADFAKQHQAKALVRGIRGSDDIEYEIQLAQLNDKLSGRLDTVFLPP
HHHCCHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCHHHCCCEEEEEECC
SVTWRYLSSTMVREIYRHQGDVAQFVPNAVLCALKEKE
CHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA