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The map label for this gene is kdtA [H]

Identifier: 126208602

GI number: 126208602

Start: 1309230

End: 1310510

Strand: Direct

Name: kdtA [H]

Synonym: APL_1132

Alternate gene names: 126208602

Gene position: 1309230-1310510 (Clockwise)

Preceding gene: 126208601

Following gene: 126208603

Centisome position: 57.56

GC content: 42.31

Gene sequence:

>1281_bases
ATGTTACGTATTTTCTATACCGTTATCAGTTACATTATCCAACCGTTTATTTTACTGATGATGTGGAAACGCGGTTATAA
ACAACCGGCTTATCGTCATCGTTTATTTGAACGTTACGGTTGTTATCATGAATTGGCAAAGCCCGTAGCGGGTGGTATTA
TCGTGCATGCCGCCTCAGTGGGAGAGGTTATCGCCGCAACACCGTTAATTAGGGAAATTCAAACCGCCTATCCCGAGTTG
CCGATTACGGTTACAACTGTTACGCCGACGGGATCCGCGCGAGTCAAATCCGCTTTCGGCAATAGCGTGTCACATTTTTA
TTTGCCTTATGATTTACCCGATGCCATTTTACGTTTTCTAAACTTTATCAATCCTAAATTGATGATTGTAATTGAAACCG
AATTATGGCCGAATCTTATTCATCAGGTTCATAAGAAAGGCATAGCCTTTATCATTGCTAATGCTCGACTTTCGCCTCGT
TCCGCCAAACGCTACGGTTGGATTAAGCCTAGCGTCGAACATATGTTAAATAAAATCTCATTAATTATGGCGCAAGATGC
GGTCAGTGCCGAACGCTATTTAGCATTAGGTTTTTCTCCCGAAAAATTGGTCAATACCGGTAACCTGAAATTTGATTTGG
AAATTACCGATACGTTACGTCATAAAGTGGATAATACGAAACAAGAGTTGAATTTGGCTAAACGCTCGGTTTGGATCGCC
GGCAGTACGCATGAAGGCGAAGAAAAACTGATCCTAGACGCACATAGACAACTTCTCTCGCAGTGGCCGGATTTAGTACT
GATTCTAGTGCCTCGCCACCCCGAGCGATTCGGAACGGTGGAGGAATTATTAGTCAAATCCAATCTCAATTATATAAAAC
GTACCGATAAACATCCGTTAAAACCCAATACTCAGGTTCTACTCGGCGATACCATGGGAGAAATGATGCAATTATACGGG
TTAGCTAAAATTGCTTTTGTCGGCGGAAGTTTAGTCAAACACGGCGGACATAACCCGTTAGAACCGATTGCTTTTGAACT
TCCGGTTATTTCCGGTGTACATACATTTAATTTTCTGGAAATTTTTGAAAAATTGCGTTATGTGAAAGGGGTGGTGGAAG
TGAAATCCGATGCGCAAGACATCGCACAAGCGGTACACTTTTTACTCAGCAATGCGGATGTTTGTCAAAAAATCAGCCAA
GCAGGGTTCGATGTTTTACAAGAAAATCAAGGCGCTCTCAAACGCCATATGGCACTTATCGCCCCTTACTTAGAGAAATA
A

Upstream 100 bases:

>100_bases
TATCGCATAATTCCGGCGTAATGTTTTATTTTACCGTTACGCTTATTTTCCTAGGATTACAAAAAACCGCACAAAATCAA
CCGCTTGTAGGAACTCAATA

Downstream 100 bases:

>100_bases
AATGAGCTATACCGTTATTTATGCAGGGACTTTTGATCCCATGACCAACGGACATTTAGATATTATCGAACGAGCGTCCG
AGCTGTTCGGACAAGTGATT

Product: 3-deoxy-D-manno-octulosonic-acid transferase

Products: NA

Alternate protein names: KDO transferase [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MLRIFYTVISYIIQPFILLMMWKRGYKQPAYRHRLFERYGCYHELAKPVAGGIIVHAASVGEVIAATPLIREIQTAYPEL
PITVTTVTPTGSARVKSAFGNSVSHFYLPYDLPDAILRFLNFINPKLMIVIETELWPNLIHQVHKKGIAFIIANARLSPR
SAKRYGWIKPSVEHMLNKISLIMAQDAVSAERYLALGFSPEKLVNTGNLKFDLEITDTLRHKVDNTKQELNLAKRSVWIA
GSTHEGEEKLILDAHRQLLSQWPDLVLILVPRHPERFGTVEELLVKSNLNYIKRTDKHPLKPNTQVLLGDTMGEMMQLYG
LAKIAFVGGSLVKHGGHNPLEPIAFELPVISGVHTFNFLEIFEKLRYVKGVVEVKSDAQDIAQAVHFLLSNADVCQKISQ
AGFDVLQENQGALKRHMALIAPYLEK

Sequences:

>Translated_426_residues
MLRIFYTVISYIIQPFILLMMWKRGYKQPAYRHRLFERYGCYHELAKPVAGGIIVHAASVGEVIAATPLIREIQTAYPEL
PITVTTVTPTGSARVKSAFGNSVSHFYLPYDLPDAILRFLNFINPKLMIVIETELWPNLIHQVHKKGIAFIIANARLSPR
SAKRYGWIKPSVEHMLNKISLIMAQDAVSAERYLALGFSPEKLVNTGNLKFDLEITDTLRHKVDNTKQELNLAKRSVWIA
GSTHEGEEKLILDAHRQLLSQWPDLVLILVPRHPERFGTVEELLVKSNLNYIKRTDKHPLKPNTQVLLGDTMGEMMQLYG
LAKIAFVGGSLVKHGGHNPLEPIAFELPVISGVHTFNFLEIFEKLRYVKGVVEVKSDAQDIAQAVHFLLSNADVCQKISQ
AGFDVLQENQGALKRHMALIAPYLEK
>Mature_426_residues
MLRIFYTVISYIIQPFILLMMWKRGYKQPAYRHRLFERYGCYHELAKPVAGGIIVHAASVGEVIAATPLIREIQTAYPEL
PITVTTVTPTGSARVKSAFGNSVSHFYLPYDLPDAILRFLNFINPKLMIVIETELWPNLIHQVHKKGIAFIIANARLSPR
SAKRYGWIKPSVEHMLNKISLIMAQDAVSAERYLALGFSPEKLVNTGNLKFDLEITDTLRHKVDNTKQELNLAKRSVWIA
GSTHEGEEKLILDAHRQLLSQWPDLVLILVPRHPERFGTVEELLVKSNLNYIKRTDKHPLKPNTQVLLGDTMGEMMQLYG
LAKIAFVGGSLVKHGGHNPLEPIAFELPVISGVHTFNFLEIFEKLRYVKGVVEVKSDAQDIAQAVHFLLSNADVCQKISQ
AGFDVLQENQGALKRHMALIAPYLEK

Specific function: Essential step in lipopolysaccharides biosynthesis. Acts at transfer of 3-deoxy-D-mono octulonic acid (KDO) from CMP-KDO to a tetraacyldisaccharide 1,4'-bisphosphate precursor of lipid A (lipid IVA). Transfers a single molecule of KDO to lipid IVA [H]

COG id: COG1519

COG function: function code M; 3-deoxy-D-manno-octulosonic-acid transferase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 1 family [H]

Homologues:

Organism=Escherichia coli, GI1790064, Length=424, Percent_Identity=50.9433962264151, Blast_Score=428, Evalue=1e-121,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001296
- InterPro:   IPR007507 [H]

Pfam domain/function: PF00534 Glycos_transf_1; PF04413 Glycos_transf_N [H]

EC number: 2.-.-.-

Molecular weight: Translated: 48113; Mature: 48113

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: PS00435 PEROXIDASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRIFYTVISYIIQPFILLMMWKRGYKQPAYRHRLFERYGCYHELAKPVAGGIIVHAASV
CEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHCCEEEEECHH
GEVIAATPLIREIQTAYPELPITVTTVTPTGSARVKSAFGNSVSHFYLPYDLPDAILRFL
HHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHCCCCCEEEECCCCHHHHHHHH
NFINPKLMIVIETELWPNLIHQVHKKGIAFIIANARLSPRSAKRYGWIKPSVEHMLNKIS
HHCCCEEEEEEECHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHCCCCCHHHHHHHHHHH
LIMAQDAVSAERYLALGFSPEKLVNTGNLKFDLEITDTLRHKVDNTKQELNLAKRSVWIA
HHHHHHHHCCCCEEEECCCHHHHHCCCCEEEEEEEHHHHHHHHCCHHHHHHHHHHEEEEE
GSTHEGEEKLILDAHRQLLSQWPDLVLILVPRHPERFGTVEELLVKSNLNYIKRTDKHPL
CCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHCHHHHHHHHHCCHHHHCCCCCCC
KPNTQVLLGDTMGEMMQLYGLAKIAFVGGSLVKHGGHNPLEPIAFELPVISGVHTFNFLE
CCCCEEEECCHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCEEECCHHCCCHHHHHHH
IFEKLRYVKGVVEVKSDAQDIAQAVHFLLSNADVCQKISQAGFDVLQENQGALKRHMALI
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
APYLEK
HHHHCC
>Mature Secondary Structure
MLRIFYTVISYIIQPFILLMMWKRGYKQPAYRHRLFERYGCYHELAKPVAGGIIVHAASV
CEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHCCEEEEECHH
GEVIAATPLIREIQTAYPELPITVTTVTPTGSARVKSAFGNSVSHFYLPYDLPDAILRFL
HHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHCCCCCEEEECCCCHHHHHHHH
NFINPKLMIVIETELWPNLIHQVHKKGIAFIIANARLSPRSAKRYGWIKPSVEHMLNKIS
HHCCCEEEEEEECHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHCCCCCHHHHHHHHHHH
LIMAQDAVSAERYLALGFSPEKLVNTGNLKFDLEITDTLRHKVDNTKQELNLAKRSVWIA
HHHHHHHHCCCCEEEECCCHHHHHCCCCEEEEEEEHHHHHHHHCCHHHHHHHHHHEEEEE
GSTHEGEEKLILDAHRQLLSQWPDLVLILVPRHPERFGTVEELLVKSNLNYIKRTDKHPL
CCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHCHHHHHHHHHCCHHHHCCCCCCC
KPNTQVLLGDTMGEMMQLYGLAKIAFVGGSLVKHGGHNPLEPIAFELPVISGVHTFNFLE
CCCCEEEECCHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCEEECCHHCCCHHHHHHH
IFEKLRYVKGVVEVKSDAQDIAQAVHFLLSNADVCQKISQAGFDVLQENQGALKRHMALI
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
APYLEK
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring phosphorus-containing groups [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952982; 7542800 [H]