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The map label for this gene is prlC [H]

Identifier: 126208508

GI number: 126208508

Start: 1199892

End: 1201925

Strand: Reverse

Name: prlC [H]

Synonym: APL_1034

Alternate gene names: 126208508

Gene position: 1201925-1199892 (Counterclockwise)

Preceding gene: 126208509

Following gene: 126208507

Centisome position: 52.84

GC content: 43.41

Gene sequence:

>2034_bases
ATGTCTAATCCTCTTTTAAATTACACCGGTTTACCTGCATTTTCACAAATTAAACCGGAACATATCCAGCCTGCGGTAGA
AGCAGTAATCAAAGAATGTCGTGATACCATTGAACAAGTTGCCCGAATTGAAAACCCGACTTGGGAAAATTTCTATATGC
CGCAAGCGATTGCCGGCGATAAATTTGCGCGTGCGTGGTCGCCTGTCGGTCATTTAAACGGCGTGAAAAACTCACCGGAA
TTGCGTGAAGCATACCAAGCCTGCTTGCCGCTACTTTCTGAATACAGCACTTGGGCGGGACAACACCAAGGTTTGTATCA
AGGTTATGTAAAACTGAAAAACTCACCGGAATTCGAGAGCTATTCGCTTGCACAGAAAAAAGCGATTGAAAACAGCCTAC
GTGATTTTGAGCTTTCGGGGATTTCATTACCGGCAGATAAACAAAAACGCTATGGCGAAGTGTCCGCTCGTTTATCGGAA
CTCAGCTCGCAATTCAGTAACAATGTATTGGATGCGACCATGGGTTGGGATATCGTGATCACAGACGAAGCACAGCTTAA
AGGCTTACCTGAATCCGCTTTAGAAGCGGCAAAACTTTCTGCGGAAAGCAAAGGTCAAAAAGGCTATCGTTTTACTTTGG
AGTTCCCAAGTTACTATCCGGTACTCACTTACTGCGAAAACCGTGAATTACGTGCGGCAATTTATAAAGAATATGCAACA
CGTGCTTCTGACCAAGGCTCAAATGCAGGAAAATGGGATAACTCGGCAAATATTGATGAAAAACTCAAATTACGCTTAGA
AATGGCGCAGTTATTAGGGTTTGAAACTTACGCTGATCTTTCTCTTGCTACGAAAATGGCGGAAAACCCGCAGCAAGTGG
TGGATTTCTTAGAAGATTTAGCCAAACGATCAAAAGCACAAGGCGAAAAAGAATTAGCGGAATTACACGCTTTTGTGGAA
CAAGAATACGGCGTAACCGAACTTCAACCGTGGGATATTGCATTCTATAGCGAAAAGCAAAAACAAGCGTTATATGCGAT
CAATGATGAAGAACTTCGCCCTTATTTCCCGGAAGATCGTGTACTTTCAGGCTTATTTGAATTAATGAAACGTATTTTCG
GCTTACGTATCGAAGAAAAATTCGGTATTGATACTTGGCACGAAGACGTGCGTTTCTTCCAAATTTACGATGAGCAAAAC
GAAGAACGCGGTGCATTCTATTTAGATTTATACGCACGTGAAAATAAACGTGGCGGTGCATGGATGGACGATTGTATCAA
CCAAAAACGTTTAGCGGACGGTTCGTTACAAAAACCGGTAGCATACTTAACTTGTAACTTTAATAAACCGATTGGTGATA
AGCCGGCACTCTTTACGCATGACGAAGTCACTACCTTATTCCATGAGTTTGGTCACGGTATCCACCATATGCTCACTCAA
ATTGATGTCGGTGATGTTGCGGGTATCAACGGTGTACCGTGGGATGCAGTGGAATTACCGAGCCAATTCTTAGAAAACTG
GTGTTGGGAAGCGGAAGCGCTTGAATTTATCTCGGGACATTATCAAACCGGTGAATCGTTACCGAAGGATAAATTAACTC
AGTTACTCAAGGCGAAAAACTTCCAAGCCGCCATGTTTGTACTAAGACAATTAGAATTCGGTTTATTCGATTTCCGTTTG
CATTTGGCACAGCCTCGTGAAGGTTTGGTATTAGATACGTTAAAAGTGGTAAAAGCGGATGTTGCGGTGGTACGCACACC
TGAATGGGTACGCACGCCACATAGCTTTAGCCATATTTTTGCCGGCGGTTATGCAGCAGGTTATTACAGCTACTTATGGG
CGGAAGTATTATCGGCGGATGCCTTTGCTAAATTTGAAGAAGATGGCATTTTCAACCGAGCGACCGGTCAATCTTATTTA
GATAATATTCTGACTCGCGGCGGTTCGGAAGAACCGATGGTATTGTTTGAACGCTTCCGCGGTCGCAAGCCAACCTTAGA
CGCTTTATTACGCCATAAAGGTATTGCGAGCTAA

Upstream 100 bases:

>100_bases
GGCTGAATTCGACCGCTTTTTACTTGAAAGACTTGATCTTTTCCTTCCTTAACCCAATCATAAGAGAACTTTTTGACTAA
ACAAAAGGAATTAATAAACA

Downstream 100 bases:

>100_bases
CCCCTTTCTATTCTTACAAGCGGTCAAATTTGCAAAAAATCTTGCAAATTCGACCGCTTATCTTTTTTTTATCGACTAAA
TCGCTATAATCTTGATAAAT

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 677; Mature: 676

Protein sequence:

>677_residues
MSNPLLNYTGLPAFSQIKPEHIQPAVEAVIKECRDTIEQVARIENPTWENFYMPQAIAGDKFARAWSPVGHLNGVKNSPE
LREAYQACLPLLSEYSTWAGQHQGLYQGYVKLKNSPEFESYSLAQKKAIENSLRDFELSGISLPADKQKRYGEVSARLSE
LSSQFSNNVLDATMGWDIVITDEAQLKGLPESALEAAKLSAESKGQKGYRFTLEFPSYYPVLTYCENRELRAAIYKEYAT
RASDQGSNAGKWDNSANIDEKLKLRLEMAQLLGFETYADLSLATKMAENPQQVVDFLEDLAKRSKAQGEKELAELHAFVE
QEYGVTELQPWDIAFYSEKQKQALYAINDEELRPYFPEDRVLSGLFELMKRIFGLRIEEKFGIDTWHEDVRFFQIYDEQN
EERGAFYLDLYARENKRGGAWMDDCINQKRLADGSLQKPVAYLTCNFNKPIGDKPALFTHDEVTTLFHEFGHGIHHMLTQ
IDVGDVAGINGVPWDAVELPSQFLENWCWEAEALEFISGHYQTGESLPKDKLTQLLKAKNFQAAMFVLRQLEFGLFDFRL
HLAQPREGLVLDTLKVVKADVAVVRTPEWVRTPHSFSHIFAGGYAAGYYSYLWAEVLSADAFAKFEEDGIFNRATGQSYL
DNILTRGGSEEPMVLFERFRGRKPTLDALLRHKGIAS

Sequences:

>Translated_677_residues
MSNPLLNYTGLPAFSQIKPEHIQPAVEAVIKECRDTIEQVARIENPTWENFYMPQAIAGDKFARAWSPVGHLNGVKNSPE
LREAYQACLPLLSEYSTWAGQHQGLYQGYVKLKNSPEFESYSLAQKKAIENSLRDFELSGISLPADKQKRYGEVSARLSE
LSSQFSNNVLDATMGWDIVITDEAQLKGLPESALEAAKLSAESKGQKGYRFTLEFPSYYPVLTYCENRELRAAIYKEYAT
RASDQGSNAGKWDNSANIDEKLKLRLEMAQLLGFETYADLSLATKMAENPQQVVDFLEDLAKRSKAQGEKELAELHAFVE
QEYGVTELQPWDIAFYSEKQKQALYAINDEELRPYFPEDRVLSGLFELMKRIFGLRIEEKFGIDTWHEDVRFFQIYDEQN
EERGAFYLDLYARENKRGGAWMDDCINQKRLADGSLQKPVAYLTCNFNKPIGDKPALFTHDEVTTLFHEFGHGIHHMLTQ
IDVGDVAGINGVPWDAVELPSQFLENWCWEAEALEFISGHYQTGESLPKDKLTQLLKAKNFQAAMFVLRQLEFGLFDFRL
HLAQPREGLVLDTLKVVKADVAVVRTPEWVRTPHSFSHIFAGGYAAGYYSYLWAEVLSADAFAKFEEDGIFNRATGQSYL
DNILTRGGSEEPMVLFERFRGRKPTLDALLRHKGIAS
>Mature_676_residues
SNPLLNYTGLPAFSQIKPEHIQPAVEAVIKECRDTIEQVARIENPTWENFYMPQAIAGDKFARAWSPVGHLNGVKNSPEL
REAYQACLPLLSEYSTWAGQHQGLYQGYVKLKNSPEFESYSLAQKKAIENSLRDFELSGISLPADKQKRYGEVSARLSEL
SSQFSNNVLDATMGWDIVITDEAQLKGLPESALEAAKLSAESKGQKGYRFTLEFPSYYPVLTYCENRELRAAIYKEYATR
ASDQGSNAGKWDNSANIDEKLKLRLEMAQLLGFETYADLSLATKMAENPQQVVDFLEDLAKRSKAQGEKELAELHAFVEQ
EYGVTELQPWDIAFYSEKQKQALYAINDEELRPYFPEDRVLSGLFELMKRIFGLRIEEKFGIDTWHEDVRFFQIYDEQNE
ERGAFYLDLYARENKRGGAWMDDCINQKRLADGSLQKPVAYLTCNFNKPIGDKPALFTHDEVTTLFHEFGHGIHHMLTQI
DVGDVAGINGVPWDAVELPSQFLENWCWEAEALEFISGHYQTGESLPKDKLTQLLKAKNFQAAMFVLRQLEFGLFDFRLH
LAQPREGLVLDTLKVVKADVAVVRTPEWVRTPHSFSHIFAGGYAAGYYSYLWAEVLSADAFAKFEEDGIFNRATGQSYLD
NILTRGGSEEPMVLFERFRGRKPTLDALLRHKGIAS

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=616, Percent_Identity=33.6038961038961, Blast_Score=319, Evalue=6e-87,
Organism=Homo sapiens, GI14149738, Length=669, Percent_Identity=29.745889387145, Blast_Score=281, Evalue=1e-75,
Organism=Homo sapiens, GI156105687, Length=600, Percent_Identity=27.5, Blast_Score=184, Evalue=3e-46,
Organism=Escherichia coli, GI1789913, Length=678, Percent_Identity=67.4041297935103, Blast_Score=957, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=687, Percent_Identity=29.6943231441048, Blast_Score=294, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI71999758, Length=561, Percent_Identity=26.0249554367201, Blast_Score=162, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI32565901, Length=619, Percent_Identity=24.7172859450727, Blast_Score=139, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6319793, Length=700, Percent_Identity=29.7142857142857, Blast_Score=305, Evalue=1e-83,
Organism=Saccharomyces cerevisiae, GI6322715, Length=692, Percent_Identity=25.1445086705202, Blast_Score=150, Evalue=9e-37,
Organism=Drosophila melanogaster, GI21356111, Length=554, Percent_Identity=29.9638989169675, Blast_Score=246, Evalue=6e-65,
Organism=Drosophila melanogaster, GI20129717, Length=595, Percent_Identity=25.2100840336134, Blast_Score=173, Evalue=3e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 76989; Mature: 76857

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPLLNYTGLPAFSQIKPEHIQPAVEAVIKECRDTIEQVARIENPTWENFYMPQAIAGD
CCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCC
KFARAWSPVGHLNGVKNSPELREAYQACLPLLSEYSTWAGQHQGLYQGYVKLKNSPEFES
HHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCH
YSLAQKKAIENSLRDFELSGISLPADKQKRYGEVSARLSELSSQFSNNVLDATMGWDIVI
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEHCCCCEEEE
TDEAQLKGLPESALEAAKLSAESKGQKGYRFTLEFPSYYPVLTYCENRELRAAIYKEYAT
ECCHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHEECCCHHHHHHHHHHHH
RASDQGSNAGKWDNSANIDEKLKLRLEMAQLLGFETYADLSLATKMAENPQQVVDFLEDL
HCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHH
AKRSKAQGEKELAELHAFVEQEYGVTELQPWDIAFYSEKQKQALYAINDEELRPYFPEDR
HHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHCEEEEECCCCCCCCCCHHH
VLSGLFELMKRIFGLRIEEKFGIDTWHEDVRFFQIYDEQNEERGAFYLDLYARENKRGGA
HHHHHHHHHHHHHCCEEHHHCCCCHHHHCCEEEEEECCCCCCCCCEEEEEEECCCCCCCC
WMDDCINQKRLADGSLQKPVAYLTCNFNKPIGDKPALFTHDEVTTLFHEFGHGIHHMLTQ
HHHHHCCHHHCCCCCCCCCEEEEEEECCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHH
IDVGDVAGINGVPWDAVELPSQFLENWCWEAEALEFISGHYQTGESLPKDKLTQLLKAKN
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCC
FQAAMFVLRQLEFGLFDFRLHLAQPREGLVLDTLKVVKADVAVVRTPEWVRTPHSFSHIF
HHHHHHHHHHHHHCHHHHHHEECCCCCCCHHHHHHHHHHHHHEEECCHHHCCCCHHHHHH
AGGYAAGYYSYLWAEVLSADAFAKFEEDGIFNRATGQSYLDNILTRGGSEEPMVLFERFR
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHC
GRKPTLDALLRHKGIAS
CCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
SNPLLNYTGLPAFSQIKPEHIQPAVEAVIKECRDTIEQVARIENPTWENFYMPQAIAGD
CCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCC
KFARAWSPVGHLNGVKNSPELREAYQACLPLLSEYSTWAGQHQGLYQGYVKLKNSPEFES
HHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCH
YSLAQKKAIENSLRDFELSGISLPADKQKRYGEVSARLSELSSQFSNNVLDATMGWDIVI
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEHCCCCEEEE
TDEAQLKGLPESALEAAKLSAESKGQKGYRFTLEFPSYYPVLTYCENRELRAAIYKEYAT
ECCHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHEECCCHHHHHHHHHHHH
RASDQGSNAGKWDNSANIDEKLKLRLEMAQLLGFETYADLSLATKMAENPQQVVDFLEDL
HCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHH
AKRSKAQGEKELAELHAFVEQEYGVTELQPWDIAFYSEKQKQALYAINDEELRPYFPEDR
HHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHCEEEEECCCCCCCCCCHHH
VLSGLFELMKRIFGLRIEEKFGIDTWHEDVRFFQIYDEQNEERGAFYLDLYARENKRGGA
HHHHHHHHHHHHHCCEEHHHCCCCHHHHCCEEEEEECCCCCCCCCEEEEEEECCCCCCCC
WMDDCINQKRLADGSLQKPVAYLTCNFNKPIGDKPALFTHDEVTTLFHEFGHGIHHMLTQ
HHHHHCCHHHCCCCCCCCCEEEEEEECCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHH
IDVGDVAGINGVPWDAVELPSQFLENWCWEAEALEFISGHYQTGESLPKDKLTQLLKAKN
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCC
FQAAMFVLRQLEFGLFDFRLHLAQPREGLVLDTLKVVKADVAVVRTPEWVRTPHSFSHIF
HHHHHHHHHHHHHCHHHHHHEECCCCCCCHHHHHHHHHHHHHEEECCHHHCCCCHHHHHH
AGGYAAGYYSYLWAEVLSADAFAKFEEDGIFNRATGQSYLDNILTRGGSEEPMVLFERFR
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHC
GRKPTLDALLRHKGIAS
CCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]