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The map label for this gene is bioA [H]

Identifier: 126208418

GI number: 126208418

Start: 1082841

End: 1084139

Strand: Reverse

Name: bioA [H]

Synonym: APL_0942

Alternate gene names: 126208418

Gene position: 1084139-1082841 (Counterclockwise)

Preceding gene: 126208420

Following gene: 126208417

Centisome position: 47.67

GC content: 42.34

Gene sequence:

>1299_bases
ATGAGAACGACCGAGCTTATCGAACTAGACCAAAAGCATATTTGGCATCCTTATTCTTCCATTACTCATCCTATTCCCAC
TTATCCGGTAGAACGTGCTGACGGTGTAATAATTACACTTAAAGACGGTAAAAAATTGATTGATGGAATGTCTTCATGGT
GGGCTGCATTACACGGCTATAACCATCCTCGATTAAATCAGGCGGCAACCGAACAATTAAGCAAAATGAGCCATATCATG
TTTGGTGGCTTGACTCACGAGCCGGCGGCTAAACTTTCGCAAAAATTATTGGAAATCTTACCGCCTGAGCTGAATAAAAT
TTTCTTTGCTGATAGCGGCTCGGTAGCAGTTGAAGTCGCTATGAAGATGGCATTGCAATATGCGCAAGCAAGCGGTCAAA
AAAATGCTAAAAAACGCACTAAATTTGCCACTATTCGTTCCGGTTATCATGGCGATACTTGGCATGCGATGTCAGTTTGT
GATCCCGTTACTGGGATGCACGGTTTATTCAATTCCAGTTTACCGGTGCAATATTTTCTGCCGCAACCGAGTGTGAAATT
TGGTGAAGCATGGCGAGATGAAGCGATTTTGCCACTACAAGATTTATTTGAACAACATGGCGATGAGATTGCCGCATTAA
TTCTCGAACCTGTTGTACAGGGCGCAGGTGGGATGTATTTCTATTCGCCGGTTTATTTACAAAAAGCAAGAGAATTATGT
GATCGTTTCGGGATTCTGTTAATTTTCGATGAAATTGCAACCGGCTTCGGGCGGACTGGCAAATTATTTGCGTTGCAACA
CGCTGAGGTGGTGCCGGATATTATTTGTTTGGGCAAAGCACTCACCGGCGGTTATTTGACTTTATCTGCAACCGTTACTA
CAGAAAAAGTTGCAACGGTCATTTGCGAAGGAGAAGCAAAATGTTTTATGCACGGCCCGACATTTATGGCGAATCCGCTT
GCCTGTGCGATTGCTTATGAATCGATTAATTTATTATTAGAAAGTGATTGGCAAGCCAATATTCAACGTATTGAACGGCA
ATTACTTGAGGAACTCGCACCGGCAAAACACTTTAAATCGGTAGCGGAAGTACGAGTATTAGGCGCAATCGGTGTATTAG
AAATGCAACAGCCGGTTGATTTGGTACCACTACAAAAATTATTTGTCGAACACGGCATTTGGGTTCGCCCTTTCGGCAAA
CTGGTTTATATTATGCCGCCGTTTATTATTAGTCAGGCGGAATTAACCCAACTCACTAGCGCATTATTGCAAGTATTAAA
AATAGCTTATAACGAATAA

Upstream 100 bases:

>100_bases
GTTCAAACATAGTTGTCCCTTTTATATAAGTTAAAGCAGGCTTATTCTATACCGATATGCTTTTTTGCGCTAGAATTCCG
CAAAATTAAAGGAAATAAAA

Downstream 100 bases:

>100_bases
AACGTAATACATTTTACGGAGGTTTTATGAATGTATTCGAACAAAAGTTAGCGGAATTAACGCAAGCCGGTTTAAAGCGA
GCGTTACCGCCGATTCAACA

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MRTTELIELDQKHIWHPYSSITHPIPTYPVERADGVIITLKDGKKLIDGMSSWWAALHGYNHPRLNQAATEQLSKMSHIM
FGGLTHEPAAKLSQKLLEILPPELNKIFFADSGSVAVEVAMKMALQYAQASGQKNAKKRTKFATIRSGYHGDTWHAMSVC
DPVTGMHGLFNSSLPVQYFLPQPSVKFGEAWRDEAILPLQDLFEQHGDEIAALILEPVVQGAGGMYFYSPVYLQKARELC
DRFGILLIFDEIATGFGRTGKLFALQHAEVVPDIICLGKALTGGYLTLSATVTTEKVATVICEGEAKCFMHGPTFMANPL
ACAIAYESINLLLESDWQANIQRIERQLLEELAPAKHFKSVAEVRVLGAIGVLEMQQPVDLVPLQKLFVEHGIWVRPFGK
LVYIMPPFIISQAELTQLTSALLQVLKIAYNE

Sequences:

>Translated_432_residues
MRTTELIELDQKHIWHPYSSITHPIPTYPVERADGVIITLKDGKKLIDGMSSWWAALHGYNHPRLNQAATEQLSKMSHIM
FGGLTHEPAAKLSQKLLEILPPELNKIFFADSGSVAVEVAMKMALQYAQASGQKNAKKRTKFATIRSGYHGDTWHAMSVC
DPVTGMHGLFNSSLPVQYFLPQPSVKFGEAWRDEAILPLQDLFEQHGDEIAALILEPVVQGAGGMYFYSPVYLQKARELC
DRFGILLIFDEIATGFGRTGKLFALQHAEVVPDIICLGKALTGGYLTLSATVTTEKVATVICEGEAKCFMHGPTFMANPL
ACAIAYESINLLLESDWQANIQRIERQLLEELAPAKHFKSVAEVRVLGAIGVLEMQQPVDLVPLQKLFVEHGIWVRPFGK
LVYIMPPFIISQAELTQLTSALLQVLKIAYNE
>Mature_432_residues
MRTTELIELDQKHIWHPYSSITHPIPTYPVERADGVIITLKDGKKLIDGMSSWWAALHGYNHPRLNQAATEQLSKMSHIM
FGGLTHEPAAKLSQKLLEILPPELNKIFFADSGSVAVEVAMKMALQYAQASGQKNAKKRTKFATIRSGYHGDTWHAMSVC
DPVTGMHGLFNSSLPVQYFLPQPSVKFGEAWRDEAILPLQDLFEQHGDEIAALILEPVVQGAGGMYFYSPVYLQKARELC
DRFGILLIFDEIATGFGRTGKLFALQHAEVVPDIICLGKALTGGYLTLSATVTTEKVATVICEGEAKCFMHGPTFMANPL
ACAIAYESINLLLESDWQANIQRIERQLLEELAPAKHFKSVAEVRVLGAIGVLEMQQPVDLVPLQKLFVEHGIWVRPFGK
LVYIMPPFIISQAELTQLTSALLQVLKIAYNE

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=426, Percent_Identity=28.169014084507, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI13994255, Length=374, Percent_Identity=28.0748663101604, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI284507298, Length=315, Percent_Identity=30.1587301587302, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI37574042, Length=451, Percent_Identity=23.5033259423503, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI226442709, Length=397, Percent_Identity=24.1813602015113, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI226442705, Length=370, Percent_Identity=24.3243243243243, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI24119277, Length=367, Percent_Identity=26.9754768392371, Blast_Score=89, Evalue=7e-18,
Organism=Escherichia coli, GI1786991, Length=425, Percent_Identity=57.6470588235294, Blast_Score=511, Evalue=1e-146,
Organism=Escherichia coli, GI145693181, Length=352, Percent_Identity=34.9431818181818, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1788044, Length=397, Percent_Identity=31.7380352644836, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI1789016, Length=413, Percent_Identity=29.0556900726392, Blast_Score=151, Evalue=6e-38,
Organism=Escherichia coli, GI1789759, Length=352, Percent_Identity=31.8181818181818, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1787560, Length=410, Percent_Identity=27.5609756097561, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1786349, Length=325, Percent_Identity=29.5384615384615, Blast_Score=110, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI25144271, Length=433, Percent_Identity=25.635103926097, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI32564660, Length=412, Percent_Identity=27.6699029126214, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI25144274, Length=219, Percent_Identity=30.5936073059361, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71992977, Length=464, Percent_Identity=22.8448275862069, Blast_Score=91, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324386, Length=463, Percent_Identity=44.9244060475162, Blast_Score=413, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6323470, Length=435, Percent_Identity=27.3563218390805, Blast_Score=139, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6324432, Length=401, Percent_Identity=26.4339152119701, Blast_Score=111, Evalue=3e-25,
Organism=Drosophila melanogaster, GI21357415, Length=421, Percent_Identity=26.8408551068884, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI28574759, Length=417, Percent_Identity=27.5779376498801, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI161085790, Length=363, Percent_Identity=28.6501377410468, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI21356575, Length=401, Percent_Identity=25.6857855361596, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI281366494, Length=289, Percent_Identity=27.681660899654, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24667139, Length=289, Percent_Identity=27.681660899654, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24667143, Length=289, Percent_Identity=27.681660899654, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 47998; Mature: 47998

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTTELIELDQKHIWHPYSSITHPIPTYPVERADGVIITLKDGKKLIDGMSSWWAALHGY
CCCCHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCC
NHPRLNQAATEQLSKMSHIMFGGLTHEPAAKLSQKLLEILPPELNKIFFADSGSVAVEVA
CCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHH
MKMALQYAQASGQKNAKKRTKFATIRSGYHGDTWHAMSVCDPVTGMHGLFNSSLPVQYFL
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHCHHHHHHHHHCCCCCEEEEC
PQPSVKFGEAWRDEAILPLQDLFEQHGDEIAALILEPVVQGAGGMYFYSPVYLQKARELC
CCCCCCCCHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHH
DRFGILLIFDEIATGFGRTGKLFALQHAEVVPDIICLGKALTGGYLTLSATVTTEKVATV
HHCCCEEEEHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCEEEEEEEEEHHHHEEE
ICEGEAKCFMHGPTFMANPLACAIAYESINLLLESDWQANIQRIERQLLEELAPAKHFKS
EECCCCEEEEECCCHHCCCHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHCCHHHHHH
VAEVRVLGAIGVLEMQQPVDLVPLQKLFVEHGIWVRPFGKLVYIMPPFIISQAELTQLTS
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEECCCCEEEECCCHHHCHHHHHHHHH
ALLQVLKIAYNE
HHHHHHHHHCCC
>Mature Secondary Structure
MRTTELIELDQKHIWHPYSSITHPIPTYPVERADGVIITLKDGKKLIDGMSSWWAALHGY
CCCCHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCC
NHPRLNQAATEQLSKMSHIMFGGLTHEPAAKLSQKLLEILPPELNKIFFADSGSVAVEVA
CCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHH
MKMALQYAQASGQKNAKKRTKFATIRSGYHGDTWHAMSVCDPVTGMHGLFNSSLPVQYFL
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHCHHHHHHHHHCCCCCEEEEC
PQPSVKFGEAWRDEAILPLQDLFEQHGDEIAALILEPVVQGAGGMYFYSPVYLQKARELC
CCCCCCCCHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHH
DRFGILLIFDEIATGFGRTGKLFALQHAEVVPDIICLGKALTGGYLTLSATVTTEKVATV
HHCCCEEEEHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCEEEEEEEEEHHHHEEE
ICEGEAKCFMHGPTFMANPLACAIAYESINLLLESDWQANIQRIERQLLEELAPAKHFKS
EECCCCEEEEECCCHHCCCHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHCCHHHHHH
VAEVRVLGAIGVLEMQQPVDLVPLQKLFVEHGIWVRPFGKLVYIMPPFIISQAELTQLTS
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEECCCCEEEECCCHHHCHHHHHHHHH
ALLQVLKIAYNE
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]