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The map label for this gene is ppiB [H]

Identifier: 126208390

GI number: 126208390

Start: 1055847

End: 1056356

Strand: Direct

Name: ppiB [H]

Synonym: APL_0914

Alternate gene names: 126208390

Gene position: 1055847-1056356 (Clockwise)

Preceding gene: 126208384

Following gene: 126208391

Centisome position: 46.42

GC content: 41.76

Gene sequence:

>510_bases
ATGATTACATTACATACGAATTTCGGTGACATTAAAATCGAACTTAACTTTGAAAAAGCACCGGTAACCGCAAAAAACTT
TGAAGATTACTGCAAAGAAGGCTTCTATAACGGCACAATTTTCCACCGTGTTATCGATGGTTTTATGATTCAAGGCGGCG
GTATGACTTCAGGCTTAATTGAAAAAGCAACCAAAGCGCCGATTCAAAACGAAGCGAACAACCGTTTAAGCAACAAACGC
GGCACACTTGCCATGGCACGTACTTCTGATCCGCATTCAGCAAGCTCACAATTCTTTATCAACGTAGCGGACAACACTTT
CTTAGATTATCGTTCAAAAGAAATGTTTGGTCGTGAAGTGGTTCAAGAATGGGGCTATGCGGTATTTGGTGAAGTAGTTG
AAGGCATGGACGTGGTTGATAAAATCAAAGGCGTGAAAACCGGCAACAAAGGCTTCCACCAAGACGTACCTGTTGAAGAT
GTAGTAATTGAATCGGTTACCGTTGCCTAA

Upstream 100 bases:

>100_bases
GCGAATAAGCGGTCTAATTTTGAGATTTTTTTGCAATTTCCCGTAAACTTTTTAATAATAACGCACCAAACTTCCCTTTC
TCTTTTATAAGGAAATCTAA

Downstream 100 bases:

>100_bases
TCGCAAAATCCATTAGAAATTTGACCGCTTGCACTCAACACAAGCGGTCAAATTTTTTATCATTCTGCAAAATGGAATCC
TCTTTCATAAAAGTAACAAA

Product: peptidyl-prolyl cis-trans isomerase B

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 169; Mature: 169

Protein sequence:

>169_residues
MITLHTNFGDIKIELNFEKAPVTAKNFEDYCKEGFYNGTIFHRVIDGFMIQGGGMTSGLIEKATKAPIQNEANNRLSNKR
GTLAMARTSDPHSASSQFFINVADNTFLDYRSKEMFGREVVQEWGYAVFGEVVEGMDVVDKIKGVKTGNKGFHQDVPVED
VVIESVTVA

Sequences:

>Translated_169_residues
MITLHTNFGDIKIELNFEKAPVTAKNFEDYCKEGFYNGTIFHRVIDGFMIQGGGMTSGLIEKATKAPIQNEANNRLSNKR
GTLAMARTSDPHSASSQFFINVADNTFLDYRSKEMFGREVVQEWGYAVFGEVVEGMDVVDKIKGVKTGNKGFHQDVPVED
VVIESVTVA
>Mature_169_residues
MITLHTNFGDIKIELNFEKAPVTAKNFEDYCKEGFYNGTIFHRVIDGFMIQGGGMTSGLIEKATKAPIQNEANNRLSNKR
GTLAMARTSDPHSASSQFFINVADNTFLDYRSKEMFGREVVQEWGYAVFGEVVEGMDVVDKIKGVKTGNKGFHQDVPVED
VVIESVTVA

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=170, Percent_Identity=34.7058823529412, Blast_Score=93, Evalue=1e-19,
Organism=Homo sapiens, GI22547212, Length=170, Percent_Identity=35.8823529411765, Blast_Score=91, Evalue=6e-19,
Organism=Homo sapiens, GI7657473, Length=170, Percent_Identity=35.8823529411765, Blast_Score=91, Evalue=6e-19,
Organism=Homo sapiens, GI22547215, Length=170, Percent_Identity=35.8823529411765, Blast_Score=91, Evalue=6e-19,
Organism=Homo sapiens, GI24308049, Length=168, Percent_Identity=36.3095238095238, Blast_Score=87, Evalue=7e-18,
Organism=Homo sapiens, GI7706339, Length=165, Percent_Identity=35.1515151515151, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI64276486, Length=105, Percent_Identity=43.8095238095238, Blast_Score=77, Evalue=7e-15,
Organism=Homo sapiens, GI5454154, Length=151, Percent_Identity=33.112582781457, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI310110104, Length=142, Percent_Identity=35.9154929577465, Blast_Score=67, Evalue=6e-12,
Organism=Homo sapiens, GI5031987, Length=151, Percent_Identity=35.0993377483444, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI310129267, Length=142, Percent_Identity=34.5070422535211, Blast_Score=64, Evalue=5e-11,
Organism=Homo sapiens, GI310120620, Length=142, Percent_Identity=34.5070422535211, Blast_Score=64, Evalue=5e-11,
Organism=Escherichia coli, GI1786736, Length=169, Percent_Identity=68.0473372781065, Blast_Score=232, Evalue=1e-62,
Organism=Escherichia coli, GI1789763, Length=167, Percent_Identity=55.0898203592814, Blast_Score=182, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI71980594, Length=152, Percent_Identity=37.5, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71980590, Length=152, Percent_Identity=37.5, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17539496, Length=151, Percent_Identity=35.7615894039735, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17506311, Length=169, Percent_Identity=34.3195266272189, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71997782, Length=106, Percent_Identity=38.6792452830189, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17532641, Length=165, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17552780, Length=162, Percent_Identity=36.4197530864198, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17551282, Length=155, Percent_Identity=32.258064516129, Blast_Score=66, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17551284, Length=155, Percent_Identity=32.258064516129, Blast_Score=66, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17539498, Length=141, Percent_Identity=35.4609929078014, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323562, Length=165, Percent_Identity=33.9393939393939, Blast_Score=69, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6320359, Length=145, Percent_Identity=32.4137931034483, Blast_Score=65, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6320510, Length=152, Percent_Identity=35.5263157894737, Blast_Score=63, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19922376, Length=172, Percent_Identity=34.8837209302326, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17986117, Length=165, Percent_Identity=34.5454545454545, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI19922912, Length=171, Percent_Identity=35.0877192982456, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24652460, Length=175, Percent_Identity=29.1428571428571, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45549139, Length=142, Percent_Identity=38.0281690140845, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17136360, Length=167, Percent_Identity=31.7365269461078, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24664125, Length=162, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21357783, Length=162, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21357249, Length=122, Percent_Identity=36.0655737704918, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18763; Mature: 18763

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITLHTNFGDIKIELNFEKAPVTAKNFEDYCKEGFYNGTIFHRVIDGFMIQGGGMTSGLI
CEEEECCCCEEEEEEECCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHEEECCCCCHHHH
EKATKAPIQNEANNRLSNKRGTLAMARTSDPHSASSQFFINVADNTFLDYRSKEMFGREV
HHHHCCCCCCCHHHHHCCCCCCEEEEECCCCCCCCCEEEEEECCCCEEHHHHHHHHHHHH
VQEWGYAVFGEVVEGMDVVDKIKGVKTGNKGFHQDVPVEDVVIESVTVA
HHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHEEECC
>Mature Secondary Structure
MITLHTNFGDIKIELNFEKAPVTAKNFEDYCKEGFYNGTIFHRVIDGFMIQGGGMTSGLI
CEEEECCCCEEEEEEECCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHEEECCCCCHHHH
EKATKAPIQNEANNRLSNKRGTLAMARTSDPHSASSQFFINVADNTFLDYRSKEMFGREV
HHHHCCCCCCCHHHHHCCCCCCEEEEECCCCCCCCCEEEEEECCCCEEHHHHHHHHHHHH
VQEWGYAVFGEVVEGMDVVDKIKGVKTGNKGFHQDVPVEDVVIESVTVA
HHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]