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The map label for this gene is serS

Identifier: 126208344

GI number: 126208344

Start: 1007146

End: 1008453

Strand: Direct

Name: serS

Synonym: APL_0868

Alternate gene names: 126208344

Gene position: 1007146-1008453 (Clockwise)

Preceding gene: 126208343

Following gene: 126208348

Centisome position: 44.28

GC content: 43.27

Gene sequence:

>1308_bases
ATGATCGACCAAAATCTTCTTCGTACTAATTTAGACGATGTTGCAAATGCACTTAAAGTTAAACGTGGTTTTACCCTTGA
TGTAGAGAGTGTAAAAGCATTGGAAGAAAAACGTAAAGCACTTCAAGTTAAAACAGAAACCTTACAAGCGGAACGTAACG
CCCGTTCGAAAAATATCGGTGCGGCAAAAGCTCGCGGCGAAGATATTTCTGCGTTATTAGCGGAAGTAGATAATATGGGT
AACGAATTAAACGAAGCGAAAGTCGCTTTAGACCAAGTTCAAGCGGAAATTCGTGAATTACTCTTATCTGTGCCGAACTT
ACCGGCTGACGAAGTACCGTTAGGTAAAGACGACACGGAAAACTTAGAAGTGTCACGTTGGGGCGAGCCTCGTCAATTTG
ACTTTGAAGTAAAAGATCACGTGGCATTAGGTGAGGCGTTAAACGGTTTAGATTTTGCTGCCGGCGTAAAATTAACCGCT
AGCCGTTTTGTGGTCATGAAAGGTAAACTTGCTCGTTTACACCGTGCTTTATCGCAATTTATGTTAGATCTTCATACCGA
ACAACACGGTTATGTGGAAACAAATGTACCGTTCTTAGTGAACCACGACACGCTGTTCGGTACCGGTCAATTACCGAAAT
TCGGTGAAGATTTATTCCATACTCAACCATTAACCGGTCAAGATCCTAACGAAACGCAACGTCCGTTCAGCTTAATTCCA
ACGGCGGAAGTACCGGTAACAAACTTAGTGCGTGACGAAATTATTGATGAAAACAGCTTACCGCTACGCTATACGGCACA
TACGCCGTGTTTCCGTTCTGAAGCAGGTTCTTACGGTCGTGACACACGCGGTTTAATTCGTATGCACCAATTCGAAAAAG
TGGAAATGGTACAGATCGTTGCACCGGAAAAATCAATGGAAGCGTTAGAAGAATTAACCGGTCACGCTGAAAAAGTATTA
CAACTTTTAGGCTTACCATACCGTAAAGTTTTACTTTGTACCGGCGATATGGGCTTCGGTTCAGCAAAAACTTATGACTT
AGAAGTTTGGTTACCGGCACAAAATACTTACCGTGAGATTTCTTCTTGCTCAAATATGTGGGATTTCCAAGCTCGCCGTA
TGTCTGCACGTTGCAAAGCGAAAGGCGACAAGAAAACTCGCTTAGTCCACACCTTAAACGGCTCAGGTTTAGCGGTGGGT
CGTACGTTAGTTGCGGTACTTGAAAACTATCAAAACGCTGACGGTTCAATCACTGTTCCGGAAGTATTACGTCCATATAT
GGGCGGTGTGGAAGTGATTACCGCTTAA

Upstream 100 bases:

>100_bases
AACAGCAAGCACGGAACAAGCGGTCAAATTTGACCCGTTTTTTGCCTCTCCGTGTTGCCTGTGCCGTCCGTGGTCACAAT
TAAAAATTAAGGAATAAAAA

Downstream 100 bases:

>100_bases
CGAAATATTCTTATCAAGTAGAAAAGCCAACTCAAATTTGCCGAGTTGGCTTTTATTTTTTCAAATATTCCTAATTCAAT
AATCTCTGAATTAATGTAGT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MIDQNLLRTNLDDVANALKVKRGFTLDVESVKALEEKRKALQVKTETLQAERNARSKNIGAAKARGEDISALLAEVDNMG
NELNEAKVALDQVQAEIRELLLSVPNLPADEVPLGKDDTENLEVSRWGEPRQFDFEVKDHVALGEALNGLDFAAGVKLTA
SRFVVMKGKLARLHRALSQFMLDLHTEQHGYVETNVPFLVNHDTLFGTGQLPKFGEDLFHTQPLTGQDPNETQRPFSLIP
TAEVPVTNLVRDEIIDENSLPLRYTAHTPCFRSEAGSYGRDTRGLIRMHQFEKVEMVQIVAPEKSMEALEELTGHAEKVL
QLLGLPYRKVLLCTGDMGFGSAKTYDLEVWLPAQNTYREISSCSNMWDFQARRMSARCKAKGDKKTRLVHTLNGSGLAVG
RTLVAVLENYQNADGSITVPEVLRPYMGGVEVITA

Sequences:

>Translated_435_residues
MIDQNLLRTNLDDVANALKVKRGFTLDVESVKALEEKRKALQVKTETLQAERNARSKNIGAAKARGEDISALLAEVDNMG
NELNEAKVALDQVQAEIRELLLSVPNLPADEVPLGKDDTENLEVSRWGEPRQFDFEVKDHVALGEALNGLDFAAGVKLTA
SRFVVMKGKLARLHRALSQFMLDLHTEQHGYVETNVPFLVNHDTLFGTGQLPKFGEDLFHTQPLTGQDPNETQRPFSLIP
TAEVPVTNLVRDEIIDENSLPLRYTAHTPCFRSEAGSYGRDTRGLIRMHQFEKVEMVQIVAPEKSMEALEELTGHAEKVL
QLLGLPYRKVLLCTGDMGFGSAKTYDLEVWLPAQNTYREISSCSNMWDFQARRMSARCKAKGDKKTRLVHTLNGSGLAVG
RTLVAVLENYQNADGSITVPEVLRPYMGGVEVITA
>Mature_435_residues
MIDQNLLRTNLDDVANALKVKRGFTLDVESVKALEEKRKALQVKTETLQAERNARSKNIGAAKARGEDISALLAEVDNMG
NELNEAKVALDQVQAEIRELLLSVPNLPADEVPLGKDDTENLEVSRWGEPRQFDFEVKDHVALGEALNGLDFAAGVKLTA
SRFVVMKGKLARLHRALSQFMLDLHTEQHGYVETNVPFLVNHDTLFGTGQLPKFGEDLFHTQPLTGQDPNETQRPFSLIP
TAEVPVTNLVRDEIIDENSLPLRYTAHTPCFRSEAGSYGRDTRGLIRMHQFEKVEMVQIVAPEKSMEALEELTGHAEKVL
QLLGLPYRKVLLCTGDMGFGSAKTYDLEVWLPAQNTYREISSCSNMWDFQARRMSARCKAKGDKKTRLVHTLNGSGLAVG
RTLVAVLENYQNADGSITVPEVLRPYMGGVEVITA

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=359, Percent_Identity=36.4902506963788, Blast_Score=208, Evalue=7e-54,
Organism=Homo sapiens, GI8923421, Length=447, Percent_Identity=27.5167785234899, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI225579074, Length=439, Percent_Identity=26.879271070615, Blast_Score=157, Evalue=1e-38,
Organism=Escherichia coli, GI1787120, Length=433, Percent_Identity=74.8267898383372, Blast_Score=682, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539260, Length=435, Percent_Identity=31.4942528735632, Blast_Score=200, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17542084, Length=339, Percent_Identity=30.3834808259587, Blast_Score=147, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6320226, Length=401, Percent_Identity=32.9177057356608, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6321799, Length=392, Percent_Identity=30.1020408163265, Blast_Score=175, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24581334, Length=436, Percent_Identity=31.651376146789, Blast_Score=195, Evalue=6e-50,
Organism=Drosophila melanogaster, GI17737985, Length=344, Percent_Identity=31.9767441860465, Blast_Score=151, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_ACTP2 (A3N0M8)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001053569.1
- ProteinModelPortal:   A3N0M8
- SMR:   A3N0M8
- STRING:   A3N0M8
- GeneID:   4850467
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_0868
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   AHWDLGP
- PhylomeDB:   A3N0M8
- ProtClustDB:   PRK05431
- BioCyc:   APLE416269:APL_0868-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48366; Mature: 48366

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 295-295 BINDING 395-395

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDQNLLRTNLDDVANALKVKRGFTLDVESVKALEEKRKALQVKTETLQAERNARSKNIG
CCCHHHHHCCHHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
AAKARGEDISALLAEVDNMGNELNEAKVALDQVQAEIRELLLSVPNLPADEVPLGKDDTE
CHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NLEVSRWGEPRQFDFEVKDHVALGEALNGLDFAAGVKLTASRFVVMKGKLARLHRALSQF
CCCCCCCCCCCEECCCHHHHHHHHHHHCCCCHHCCCEEECCEEEEECCHHHHHHHHHHHH
MLDLHTEQHGYVETNVPFLVNHDTLFGTGQLPKFGEDLFHTQPLTGQDPNETQRPFSLIP
HHHHHCCCCCEEECCCCEEEECCEEECCCCCCHHHHHHHCCCCCCCCCCCCCCCCCEECC
TAEVPVTNLVRDEIIDENSLPLRYTAHTPCFRSEAGSYGRDTRGLIRMHQFEKVEMVQIV
CCCCCHHHHHHHHHCCCCCCCEEEECCCCCHHHCCCCCCCCHHHHHHHHHHCCEEEEEEE
APEKSMEALEELTGHAEKVLQLLGLPYRKVLLCTGDMGFGSAKTYDLEVWLPAQNTYREI
CCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEEEECCCHHHHHH
SSCSNMWDFQARRMSARCKAKGDKKTRLVHTLNGSGLAVGRTLVAVLENYQNADGSITVP
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEHH
EVLRPYMGGVEVITA
HHHHHHCCCEEEEEC
>Mature Secondary Structure
MIDQNLLRTNLDDVANALKVKRGFTLDVESVKALEEKRKALQVKTETLQAERNARSKNIG
CCCHHHHHCCHHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
AAKARGEDISALLAEVDNMGNELNEAKVALDQVQAEIRELLLSVPNLPADEVPLGKDDTE
CHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NLEVSRWGEPRQFDFEVKDHVALGEALNGLDFAAGVKLTASRFVVMKGKLARLHRALSQF
CCCCCCCCCCCEECCCHHHHHHHHHHHCCCCHHCCCEEECCEEEEECCHHHHHHHHHHHH
MLDLHTEQHGYVETNVPFLVNHDTLFGTGQLPKFGEDLFHTQPLTGQDPNETQRPFSLIP
HHHHHCCCCCEEECCCCEEEECCEEECCCCCCHHHHHHHCCCCCCCCCCCCCCCCCEECC
TAEVPVTNLVRDEIIDENSLPLRYTAHTPCFRSEAGSYGRDTRGLIRMHQFEKVEMVQIV
CCCCCHHHHHHHHHCCCCCCCEEEECCCCCHHHCCCCCCCCHHHHHHHHHHCCEEEEEEE
APEKSMEALEELTGHAEKVLQLLGLPYRKVLLCTGDMGFGSAKTYDLEVWLPAQNTYREI
CCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEEEECCCHHHHHH
SSCSNMWDFQARRMSARCKAKGDKKTRLVHTLNGSGLAVGRTLVAVLENYQNADGSITVP
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEHH
EVLRPYMGGVEVITA
HHHHHHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA