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The map label for this gene is yedX [H]

Identifier: 126208294

GI number: 126208294

Start: 945527

End: 945940

Strand: Reverse

Name: yedX [H]

Synonym: APL_0818

Alternate gene names: 126208294

Gene position: 945940-945527 (Counterclockwise)

Preceding gene: 126208297

Following gene: 126208292

Centisome position: 41.59

GC content: 36.96

Gene sequence:

>414_bases
ATGAATTTAAATCGTTATATTATCGGAGGGATTGCAATGTTTACCGCTTCCGTTTGTGCTGCTAGCCCTTATCAATTAAG
TACTCATATTTTGGATATTAACAAAGGAAAGCCTGCTGCGGATGTCCAAGTTGAACTTTACAAACTTAATAACGAAAACG
GGAACTGGCAACAAATTGCGAAAGAAGTTACCGATGCAAACGGGCGAATTACAGCATTTCTACCGACTCGAGAAGGTTTA
AATAACAAGGGTGTTTATAAGCTGAAATTTCAGGTAAAAGATTATTTTAATCGTCTGCAGGAACAAAGTTTTTACCCTTT
TGTTGAAGTCTCATTTGAATTGAACGATAGTTCGCATTACCATGTTCCGATCACTTTATCGCCTTATGGTTACTCGACTT
ATAGAGGAAGTTAA

Upstream 100 bases:

>100_bases
GAGATTAAAGATAAGACAAGCAACTGTAGGCAGAATAAATGAAAGTTAATTTATTAGTATAAGTCTAATGAAACGATGAA
TTTCATTATCAGGAGGAAAA

Downstream 100 bases:

>100_bases
TATGCTAAGATTAATGAATATCGAATAAGAAAAGTTTTAATGGTGCCAGTGGTCGGACTCGAACCGACACGTTTATTCAA
CGGCGGATTTTGAATCCGCT

Product: transthyretin-like periplasmic protein

Products: NA

Alternate protein names: HIU hydrolase; HIUHase; Transthyretin-like protein; TLP [H]

Number of amino acids: Translated: 137; Mature: 137

Protein sequence:

>137_residues
MNLNRYIIGGIAMFTASVCAASPYQLSTHILDINKGKPAADVQVELYKLNNENGNWQQIAKEVTDANGRITAFLPTREGL
NNKGVYKLKFQVKDYFNRLQEQSFYPFVEVSFELNDSSHYHVPITLSPYGYSTYRGS

Sequences:

>Translated_137_residues
MNLNRYIIGGIAMFTASVCAASPYQLSTHILDINKGKPAADVQVELYKLNNENGNWQQIAKEVTDANGRITAFLPTREGL
NNKGVYKLKFQVKDYFNRLQEQSFYPFVEVSFELNDSSHYHVPITLSPYGYSTYRGS
>Mature_137_residues
MNLNRYIIGGIAMFTASVCAASPYQLSTHILDINKGKPAADVQVELYKLNNENGNWQQIAKEVTDANGRITAFLPTREGL
NNKGVYKLKFQVKDYFNRLQEQSFYPFVEVSFELNDSSHYHVPITLSPYGYSTYRGS

Specific function: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) [H]

COG id: COG2351

COG function: function code R; Transthyretin-like protein

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788281, Length=140, Percent_Identity=45, Blast_Score=102, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI115532920, Length=126, Percent_Identity=41.2698412698413, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI115532922, Length=125, Percent_Identity=41.6, Blast_Score=99, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI115534555, Length=114, Percent_Identity=43.859649122807, Blast_Score=95, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24652571, Length=113, Percent_Identity=38.0530973451327, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014306
- InterPro:   IPR000895 [H]

Pfam domain/function: PF00576 Transthyretin [H]

EC number: =3.5.2.17 [H]

Molecular weight: Translated: 15552; Mature: 15552

Theoretical pI: Translated: 8.39; Mature: 8.39

Prosite motif: PS00768 TRANSTHYRETIN_1 ; PS00769 TRANSTHYRETIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLNRYIIGGIAMFTASVCAASPYQLSTHILDINKGKPAADVQVELYKLNNENGNWQQIA
CCCCEEEEHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCEEEEEEEEECCCCCHHHHH
KEVTDANGRITAFLPTREGLNNKGVYKLKFQVKDYFNRLQEQSFYPFVEVSFELNDSSHY
HHHCCCCCEEEEEEECCCCCCCCCEEEEEEEHHHHHHHHHHCCCCCEEEEEEEECCCCEE
HVPITLSPYGYSTYRGS
EEEEEECCCCCCCCCCC
>Mature Secondary Structure
MNLNRYIIGGIAMFTASVCAASPYQLSTHILDINKGKPAADVQVELYKLNNENGNWQQIA
CCCCEEEEHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCEEEEEEEEECCCCCHHHHH
KEVTDANGRITAFLPTREGLNNKGVYKLKFQVKDYFNRLQEQSFYPFVEVSFELNDSSHY
HHHCCCCCEEEEEEECCCCCCCCCEEEEEEEHHHHHHHHHHCCCCCEEEEEEEECCCCEE
HVPITLSPYGYSTYRGS
EEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]