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The map label for this gene is tyrR [H]

Identifier: 126208273

GI number: 126208273

Start: 918871

End: 920019

Strand: Reverse

Name: tyrR [H]

Synonym: APL_0797

Alternate gene names: 126208273

Gene position: 920019-918871 (Counterclockwise)

Preceding gene: 126208276

Following gene: 126208272

Centisome position: 40.45

GC content: 42.38

Gene sequence:

>1149_bases
ATGCTGTTATCAATTAAATGTACGGAAAAATTCACAGTTGCAGAACAAGCGCTACATTTATTAGGTGTGCAAAAGCAGCC
TGTTCGCCATATTGAATTTACCGAATTAGGTCTTCAAATAGCGTTTTCACCGTTAAATATCGTCCAACAATCGCAAATTC
TTGAACAAATTCGACCGCTTGAAGGTGTTGAGTATGCGGAATTCAGCGATTCTTCCCAAAACTGTTTTGATCATATTATT
GCCGAAAGCCCCAAAATGCGGGCGGTTGTCGAGCAAGCTAAAAAATTTGCGATGTTAAGTGCTCCGTTATTGATTCAAGG
GGAAACAGGGACGGGAAAAGATGTTTTTGCTAAGGCTTGTCATGAACTTAGTACGCGTCGAGAGCATAAATTTATTGCGG
TAAATTGTGCGGGGTTGCCTGCTGATGAGGCGGAATCGGAAATGTTCGGGCATCGCGGTAACGGTAAAGAGAATATCGGT
TTCTTTGAATATGCTAACGGCGGTACGGTATTATTGGATTCGATTGCGGAACTTTCGCTTGAAATGCAGGCGAAACTGTT
ACGTTTCTTAAATGACGGTTGTTTTCGTCGTGTCGGTGAAGATCAAGAAATTAAAGTGGATGTACGCGTTATTTGTACCT
CTCAAAAACCGTTGGCGTTATTGGTCTCGGAAGGAAAAGTTCGGGAAGATCTCTACCACCGTTTAAACGTACTTAGCTTA
GAATTACCGCCGTTACGAGAACGTCACGGTGATTTACCGTTATTGGCGGATCATTTTATTACGCGTATCAGTCAGCAGTT
AGGTATCAGTAAATTGGAATATGACGATGAGTTTTTACAGGCGTTGCAAGCGTATCGCTGGCCGGGTAATTTGCGAGAGT
TATATAATGCCGTTTATCGCGCTTGTACGCTTTCTCATAGTTATCGCCTAGCGGTAAAAGATCTGAACTTACCGGATCAA
GTCGGCCAATCGGATGATTTTCAAGTCGATGAGAATGTGACGTTAGACGAGTTGGTTAATCGCTTTGAGGCTTCATTGTT
ACGTAAATTATATAATGAATACCCGAGTACGAGAAAATTGGCCCAACGTTTAGGCGTTTCTCATACGGCGGTTGCAAATA
AGTTACGTGCATACGGCATTGGGAAATAA

Upstream 100 bases:

>100_bases
AATAATATTTACATTAACGAATGTAAACAAAAGTTTCCAAAAAGATGTTTTCAGAGTATGATGAAGCAAAATTTATCATC
TTGAATTAAGGTAAAAGATC

Downstream 100 bases:

>100_bases
GGAAAGACTATGGTTTCTTGTATGCGACAAGCGGTCGGTTTTATCCGCTTTTTTGCAATTTTAGCGATGATTCCGACCGC
TTATAGTGCGCCTCGTATTC

Product: transcriptional regulatory protein TyrR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MLLSIKCTEKFTVAEQALHLLGVQKQPVRHIEFTELGLQIAFSPLNIVQQSQILEQIRPLEGVEYAEFSDSSQNCFDHII
AESPKMRAVVEQAKKFAMLSAPLLIQGETGTGKDVFAKACHELSTRREHKFIAVNCAGLPADEAESEMFGHRGNGKENIG
FFEYANGGTVLLDSIAELSLEMQAKLLRFLNDGCFRRVGEDQEIKVDVRVICTSQKPLALLVSEGKVREDLYHRLNVLSL
ELPPLRERHGDLPLLADHFITRISQQLGISKLEYDDEFLQALQAYRWPGNLRELYNAVYRACTLSHSYRLAVKDLNLPDQ
VGQSDDFQVDENVTLDELVNRFEASLLRKLYNEYPSTRKLAQRLGVSHTAVANKLRAYGIGK

Sequences:

>Translated_382_residues
MLLSIKCTEKFTVAEQALHLLGVQKQPVRHIEFTELGLQIAFSPLNIVQQSQILEQIRPLEGVEYAEFSDSSQNCFDHII
AESPKMRAVVEQAKKFAMLSAPLLIQGETGTGKDVFAKACHELSTRREHKFIAVNCAGLPADEAESEMFGHRGNGKENIG
FFEYANGGTVLLDSIAELSLEMQAKLLRFLNDGCFRRVGEDQEIKVDVRVICTSQKPLALLVSEGKVREDLYHRLNVLSL
ELPPLRERHGDLPLLADHFITRISQQLGISKLEYDDEFLQALQAYRWPGNLRELYNAVYRACTLSHSYRLAVKDLNLPDQ
VGQSDDFQVDENVTLDELVNRFEASLLRKLYNEYPSTRKLAQRLGVSHTAVANKLRAYGIGK
>Mature_382_residues
MLLSIKCTEKFTVAEQALHLLGVQKQPVRHIEFTELGLQIAFSPLNIVQQSQILEQIRPLEGVEYAEFSDSSQNCFDHII
AESPKMRAVVEQAKKFAMLSAPLLIQGETGTGKDVFAKACHELSTRREHKFIAVNCAGLPADEAESEMFGHRGNGKENIG
FFEYANGGTVLLDSIAELSLEMQAKLLRFLNDGCFRRVGEDQEIKVDVRVICTSQKPLALLVSEGKVREDLYHRLNVLSL
ELPPLRERHGDLPLLADHFITRISQQLGISKLEYDDEFLQALQAYRWPGNLRELYNAVYRACTLSHSYRLAVKDLNLPDQ
VGQSDDFQVDENVTLDELVNRFEASLLRKLYNEYPSTRKLAQRLGVSHTAVANKLRAYGIGK

Specific function: Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport [H]

COG id: COG3283

COG function: function code KE; Transcriptional regulator of aromatic amino acids metabolism

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1787583, Length=312, Percent_Identity=55.7692307692308, Blast_Score=343, Evalue=1e-95,
Organism=Escherichia coli, GI1788550, Length=323, Percent_Identity=39.6284829721362, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI1789087, Length=314, Percent_Identity=36.9426751592357, Blast_Score=201, Evalue=5e-53,
Organism=Escherichia coli, GI87082117, Length=322, Percent_Identity=36.6459627329193, Blast_Score=194, Evalue=5e-51,
Organism=Escherichia coli, GI1790299, Length=242, Percent_Identity=42.9752066115703, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI1790437, Length=307, Percent_Identity=36.4820846905537, Blast_Score=187, Evalue=8e-49,
Organism=Escherichia coli, GI1789233, Length=321, Percent_Identity=33.9563862928349, Blast_Score=185, Evalue=4e-48,
Organism=Escherichia coli, GI87082152, Length=237, Percent_Identity=43.0379746835443, Blast_Score=182, Evalue=4e-47,
Organism=Escherichia coli, GI1788905, Length=277, Percent_Identity=36.4620938628159, Blast_Score=181, Evalue=7e-47,
Organism=Escherichia coli, GI87081872, Length=251, Percent_Identity=38.2470119521912, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1786524, Length=245, Percent_Identity=38.3673469387755, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI87081858, Length=374, Percent_Identity=28.0748663101604, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1789828, Length=266, Percent_Identity=34.2105263157895, Blast_Score=139, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR002078 [H]

Pfam domain/function: PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 43102; Mature: 43102

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLSIKCTEKFTVAEQALHLLGVQKQPVRHIEFTELGLQIAFSPLNIVQQSQILEQIRPL
CEEEEECCCHHHHHHHHHHHHCCCCCCCCHHHHHHHCHHEEECHHHHHHHHHHHHHHCCC
EGVEYAEFSDSSQNCFDHIIAESPKMRAVVEQAKKFAMLSAPLLIQGETGTGKDVFAKAC
CCCCCHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHH
HELSTRREHKFIAVNCAGLPADEAESEMFGHRGNGKENIGFFEYANGGTVLLDSIAELSL
HHHHHHCCCEEEEEEECCCCCCHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHH
EMQAKLLRFLNDGCFRRVGEDQEIKVDVRVICTSQKPLALLVSEGKVREDLYHRLNVLSL
HHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCEEEEECCCCHHHHHHHHHHHEEE
ELPPLRERHGDLPLLADHFITRISQQLGISKLEYDDEFLQALQAYRWPGNLRELYNAVYR
CCCCHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHH
ACTLSHSYRLAVKDLNLPDQVGQSDDFQVDENVTLDELVNRFEASLLRKLYNEYPSTRKL
HHHCCCCEEEEEECCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHH
AQRLGVSHTAVANKLRAYGIGK
HHHHCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLLSIKCTEKFTVAEQALHLLGVQKQPVRHIEFTELGLQIAFSPLNIVQQSQILEQIRPL
CEEEEECCCHHHHHHHHHHHHCCCCCCCCHHHHHHHCHHEEECHHHHHHHHHHHHHHCCC
EGVEYAEFSDSSQNCFDHIIAESPKMRAVVEQAKKFAMLSAPLLIQGETGTGKDVFAKAC
CCCCCHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHH
HELSTRREHKFIAVNCAGLPADEAESEMFGHRGNGKENIGFFEYANGGTVLLDSIAELSL
HHHHHHCCCEEEEEEECCCCCCHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHH
EMQAKLLRFLNDGCFRRVGEDQEIKVDVRVICTSQKPLALLVSEGKVREDLYHRLNVLSL
HHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCEEEEECCCCHHHHHHHHHHHEEE
ELPPLRERHGDLPLLADHFITRISQQLGISKLEYDDEFLQALQAYRWPGNLRELYNAVYR
CCCCHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHH
ACTLSHSYRLAVKDLNLPDQVGQSDDFQVDENVTLDELVNRFEASLLRKLYNEYPSTRKL
HHHCCCCEEEEEECCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHH
AQRLGVSHTAVANKLRAYGIGK
HHHHCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]