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The map label for this gene is prsA [H]

Identifier: 126208253

GI number: 126208253

Start: 891522

End: 892472

Strand: Reverse

Name: prsA [H]

Synonym: APL_0775

Alternate gene names: 126208253

Gene position: 892472-891522 (Counterclockwise)

Preceding gene: 126208254

Following gene: 126208252

Centisome position: 39.24

GC content: 46.06

Gene sequence:

>951_bases
ATGCCAGATATTAAATTGTTTGCAGGTAATGCAACGCCTGAACTTGCAAAACGTATTGCAGAACGTCTTTATACATCTCT
CGGAGATGCAACCGTCGGTCGTTTTAGTGACGGTGAGATCCAAGTTCAAATTAATGAAAATGTACGTGGCGGCGATATTT
TTATCGTGCAATCGACTTGCGCGCCGACAAATGATAACTTGATGGAATTAATTGTAATGGTCGATGCGCTACGTCGTGCG
TCAGCCGGTCGTATTACCGCAGTTATTCCTTATTTCGGTTATGCGCGCCAAGACCGTCGCGTACGTTCTGCACGTGTGCC
GATTACGGCTAAAGTGGTAGCGGATTTCCTTTCTAGCGTGGGTGTGGATCGCGTTTTAACTTGTGATTTACACGCGGAAC
AAATTCAAGGTTTCTTTGACGTACCGGTAGATAACGTATTCGGTTCACCGGTATTAATTGACGATATTTTGAAAAAATCG
GATTTAGTGAATCCTATCGTCGTTTCTCCGGATATCGGCGGTGTGGTGCGCGCTCGTGCGGTAGCCAAATTATTAAACGA
TACGGATATGGCGATTATCGATAAACGCCGCCCGAAAGCGAACGTATCGCAAGTGATGCATATTATCGGTGATGTAACCG
ACCGCGATTGTATCTTAGTGGACGATATGATTGATACCGGCGGTACATTGGTTAAAGCGGCGGAAGCGTTAAAAGAACGC
GGTGCGCGTCGCGTATTCGCTTATGCAACGCATGCGGTATTCTCCGGTACGGCGGCAAGTAATTTAGCGAATCCGGCATT
GGACGAAGTGGTGGTAACCGATACCATTCCGTTATCCGATGAGATTAAAGCGTTAAATAAAGTTCGCGTACTCACGTTAT
CAAGCATGTTAGCGGAAGCGATTCGTCGTATCAGTAACGAAGAATCCATCTCTGCAATGTTCGATGCATAA

Upstream 100 bases:

>100_bases
AACCGCACAATATTTTCGGTTTTATTGCAAAAGGACAAAATCGCTCTCCTTTACATCAAATGCTCAATTTAACCACTTCC
CCACAATAGGATTCATTCCA

Downstream 100 bases:

>100_bases
TATCCAGTAAGGGCGGGTTTGATACCCGCCCTTAATTTATCCGTTTCTTTCTAACTATATCCAAGAGTTCACCATGTATT
CTCTGATTCGTAAATGTCTT

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MPDIKLFAGNATPELAKRIAERLYTSLGDATVGRFSDGEIQVQINENVRGGDIFIVQSTCAPTNDNLMELIVMVDALRRA
SAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSVGVDRVLTCDLHAEQIQGFFDVPVDNVFGSPVLIDDILKKS
DLVNPIVVSPDIGGVVRARAVAKLLNDTDMAIIDKRRPKANVSQVMHIIGDVTDRDCILVDDMIDTGGTLVKAAEALKER
GARRVFAYATHAVFSGTAASNLANPALDEVVVTDTIPLSDEIKALNKVRVLTLSSMLAEAIRRISNEESISAMFDA

Sequences:

>Translated_316_residues
MPDIKLFAGNATPELAKRIAERLYTSLGDATVGRFSDGEIQVQINENVRGGDIFIVQSTCAPTNDNLMELIVMVDALRRA
SAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSVGVDRVLTCDLHAEQIQGFFDVPVDNVFGSPVLIDDILKKS
DLVNPIVVSPDIGGVVRARAVAKLLNDTDMAIIDKRRPKANVSQVMHIIGDVTDRDCILVDDMIDTGGTLVKAAEALKER
GARRVFAYATHAVFSGTAASNLANPALDEVVVTDTIPLSDEIKALNKVRVLTLSSMLAEAIRRISNEESISAMFDA
>Mature_315_residues
PDIKLFAGNATPELAKRIAERLYTSLGDATVGRFSDGEIQVQINENVRGGDIFIVQSTCAPTNDNLMELIVMVDALRRAS
AGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSVGVDRVLTCDLHAEQIQGFFDVPVDNVFGSPVLIDDILKKSD
LVNPIVVSPDIGGVVRARAVAKLLNDTDMAIIDKRRPKANVSQVMHIIGDVTDRDCILVDDMIDTGGTLVKAAEALKERG
ARRVFAYATHAVFSGTAASNLANPALDEVVVTDTIPLSDEIKALNKVRVLTLSSMLAEAIRRISNEESISAMFDA

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=315, Percent_Identity=50.1587301587302, Blast_Score=309, Evalue=2e-84,
Organism=Homo sapiens, GI4506129, Length=315, Percent_Identity=49.2063492063492, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI84875539, Length=317, Percent_Identity=48.8958990536278, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI28557709, Length=315, Percent_Identity=48.8888888888889, Blast_Score=299, Evalue=2e-81,
Organism=Homo sapiens, GI4506133, Length=343, Percent_Identity=36.4431486880466, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI194018537, Length=345, Percent_Identity=36.8115942028986, Blast_Score=189, Evalue=2e-48,
Organism=Homo sapiens, GI310128524, Length=145, Percent_Identity=28.9655172413793, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI310115209, Length=145, Percent_Identity=28.9655172413793, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI310118259, Length=145, Percent_Identity=28.9655172413793, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI310119946, Length=145, Percent_Identity=28.9655172413793, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1787458, Length=315, Percent_Identity=87.3015873015873, Blast_Score=557, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI17554702, Length=315, Percent_Identity=45.7142857142857, Blast_Score=290, Evalue=9e-79,
Organism=Caenorhabditis elegans, GI25149168, Length=316, Percent_Identity=46.2025316455696, Blast_Score=290, Evalue=9e-79,
Organism=Caenorhabditis elegans, GI71989924, Length=315, Percent_Identity=45.7142857142857, Blast_Score=288, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI17554704, Length=311, Percent_Identity=45.6591639871383, Blast_Score=280, Evalue=5e-76,
Organism=Caenorhabditis elegans, GI17570245, Length=336, Percent_Identity=35.1190476190476, Blast_Score=199, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6321776, Length=317, Percent_Identity=48.5804416403785, Blast_Score=278, Evalue=1e-75,
Organism=Saccharomyces cerevisiae, GI6320946, Length=313, Percent_Identity=46.0063897763578, Blast_Score=274, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6319403, Length=314, Percent_Identity=46.1783439490446, Blast_Score=272, Evalue=6e-74,
Organism=Saccharomyces cerevisiae, GI6322667, Length=206, Percent_Identity=41.2621359223301, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6324511, Length=114, Percent_Identity=40.3508771929825, Blast_Score=98, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21355239, Length=315, Percent_Identity=48.8888888888889, Blast_Score=298, Evalue=3e-81,
Organism=Drosophila melanogaster, GI45551540, Length=337, Percent_Identity=45.6973293768546, Blast_Score=289, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24651458, Length=355, Percent_Identity=34.9295774647887, Blast_Score=201, Evalue=5e-52,
Organism=Drosophila melanogaster, GI24651456, Length=355, Percent_Identity=34.9295774647887, Blast_Score=201, Evalue=5e-52,
Organism=Drosophila melanogaster, GI281362873, Length=355, Percent_Identity=34.9295774647887, Blast_Score=201, Evalue=6e-52,
Organism=Drosophila melanogaster, GI24651454, Length=355, Percent_Identity=34.9295774647887, Blast_Score=201, Evalue=6e-52,
Organism=Drosophila melanogaster, GI24651462, Length=374, Percent_Identity=33.1550802139037, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24651464, Length=374, Percent_Identity=33.1550802139037, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI45552010, Length=374, Percent_Identity=33.1550802139037, Blast_Score=192, Evalue=2e-49,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34208; Mature: 34077

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDIKLFAGNATPELAKRIAERLYTSLGDATVGRFSDGEIQVQINENVRGGDIFIVQSTC
CCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCEEEEEECCC
APTNDNLMELIVMVDALRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSV
CCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHC
GVDRVLTCDLHAEQIQGFFDVPVDNVFGSPVLIDDILKKSDLVNPIVVSPDIGGVVRARA
CCCEEEEECCCHHHCCCEECCCHHHHCCCCHHHHHHHHHHCCCCCEEECCCCCHHHHHHH
VAKLLNDTDMAIIDKRRPKANVSQVMHIIGDVTDRDCILVDDMIDTGGTLVKAAEALKER
HHHHHCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEECHHCCCCHHHHHHHHHHHC
GARRVFAYATHAVFSGTAASNLANPALDEVVVTDTIPLSDEIKALNKVRVLTLSSMLAEA
CCCEEHHHHHHHHHCCCHHHHCCCCCHHCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
IRRISNEESISAMFDA
HHHHCCCCHHHHHCCC
>Mature Secondary Structure 
PDIKLFAGNATPELAKRIAERLYTSLGDATVGRFSDGEIQVQINENVRGGDIFIVQSTC
CCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCEEEEEECCC
APTNDNLMELIVMVDALRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSV
CCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHC
GVDRVLTCDLHAEQIQGFFDVPVDNVFGSPVLIDDILKKSDLVNPIVVSPDIGGVVRARA
CCCEEEEECCCHHHCCCEECCCHHHHCCCCHHHHHHHHHHCCCCCEEECCCCCHHHHHHH
VAKLLNDTDMAIIDKRRPKANVSQVMHIIGDVTDRDCILVDDMIDTGGTLVKAAEALKER
HHHHHCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEECHHCCCCHHHHHHHHHHHC
GARRVFAYATHAVFSGTAASNLANPALDEVVVTDTIPLSDEIKALNKVRVLTLSSMLAEA
CCCEEHHHHHHHHHCCCHHHHCCCCCHHCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
IRRISNEESISAMFDA
HHHHCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA