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The map label for this gene is seqA [H]

Identifier: 126208230

GI number: 126208230

Start: 862740

End: 863300

Strand: Reverse

Name: seqA [H]

Synonym: APL_0752

Alternate gene names: 126208230

Gene position: 863300-862740 (Counterclockwise)

Preceding gene: 126208239

Following gene: 126208229

Centisome position: 37.96

GC content: 40.82

Gene sequence:

>561_bases
ATGAAAACGATCGAAGTCGATGATGAATTATATCATTACATTGCCAGCAGAACCCAAGCAATTGGTGAAAGTGCGTCGGA
TATTTTACGTCGTTTGTTACGTTTACCTTCATCGCCACAGCCTTTTGTATTGGTTCAGCAAAATACGATTGATGAACTGA
AAGAACTGGCAAAGCCGAAAGCAAAAGCTAAAAAAGAAGATCTGATTGAAAAAGCGGTACAAAAAGTTGAAAAGGTATTG
AAATCCGATGTCTTTATAAACGAAAGCAAAAATGTCGCACGTTTTTTAATGTTGCTTTCTGCATTGCACCATGCAAATGC
TCAGGGTTTTGAACAGGCGACGGAAGTGGTGACCGGCACGGAGCGCACCTATTTTTCTAAAAGTGAGGAAGCTTTATTAA
GTCACGGTAGTAGCGTGAAAGCGAAACAAATTCCGGATTCGCCGTTTTGGGTGGTCACCAATAATAATACCGCTCGTAAG
GGCTTGATTCTTACCGGCGTAATGGAATCAATGGAACTTCCTCAACATATCATTGAGCGTGTTCGCACTATTTTTGCTTA
A

Upstream 100 bases:

>100_bases
GTTTGGTTAAGATCCTGTAAAAAGATCTTGAATCTGTATTATAATGCCTAGAATTTTTTTCTAATCAAGTAAATCAAAAC
AAAAATATCAAGAGGTTAAG

Downstream 100 bases:

>100_bases
TTAATTTCTATCTGCTTATGGTAAATTTTTCCCTTTTTCCGACCGCCTATTGGGCGCAACATTTTGCACAACAACCGGCT
ATTATCTGGGAAAAAGGGAA

Product: replication initiation regulator SeqA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 186; Mature: 186

Protein sequence:

>186_residues
MKTIEVDDELYHYIASRTQAIGESASDILRRLLRLPSSPQPFVLVQQNTIDELKELAKPKAKAKKEDLIEKAVQKVEKVL
KSDVFINESKNVARFLMLLSALHHANAQGFEQATEVVTGTERTYFSKSEEALLSHGSSVKAKQIPDSPFWVVTNNNTARK
GLILTGVMESMELPQHIIERVRTIFA

Sequences:

>Translated_186_residues
MKTIEVDDELYHYIASRTQAIGESASDILRRLLRLPSSPQPFVLVQQNTIDELKELAKPKAKAKKEDLIEKAVQKVEKVL
KSDVFINESKNVARFLMLLSALHHANAQGFEQATEVVTGTERTYFSKSEEALLSHGSSVKAKQIPDSPFWVVTNNNTARK
GLILTGVMESMELPQHIIERVRTIFA
>Mature_186_residues
MKTIEVDDELYHYIASRTQAIGESASDILRRLLRLPSSPQPFVLVQQNTIDELKELAKPKAKAKKEDLIEKAVQKVEKVL
KSDVFINESKNVARFLMLLSALHHANAQGFEQATEVVTGTERTYFSKSEEALLSHGSSVKAKQIPDSPFWVVTNNNTARK
GLILTGVMESMELPQHIIERVRTIFA

Specific function: Negative regulator of replication initiation. Required for sequestration, a process that blocks secondary initiation events. Could block the allosteric transition of dnaA from an inactive form to an active form [H]

COG id: COG3057

COG function: function code L; Negative regulator of replication initiationR

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786903, Length=181, Percent_Identity=43.646408839779, Blast_Score=159, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005621
- InterPro:   IPR010985 [H]

Pfam domain/function: PF03925 SeqA [H]

EC number: NA

Molecular weight: Translated: 20916; Mature: 20916

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTIEVDDELYHYIASRTQAIGESASDILRRLLRLPSSPQPFVLVQQNTIDELKELAKPK
CCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHCCH
AKAKKEDLIEKAVQKVEKVLKSDVFINESKNVARFLMLLSALHHANAQGFEQATEVVTGT
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
ERTYFSKSEEALLSHGSSVKAKQIPDSPFWVVTNNNTARKGLILTGVMESMELPQHIIER
CHHHHCCHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
VRTIFA
HHHHCC
>Mature Secondary Structure
MKTIEVDDELYHYIASRTQAIGESASDILRRLLRLPSSPQPFVLVQQNTIDELKELAKPK
CCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHCCH
AKAKKEDLIEKAVQKVEKVLKSDVFINESKNVARFLMLLSALHHANAQGFEQATEVVTGT
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
ERTYFSKSEEALLSHGSSVKAKQIPDSPFWVVTNNNTARKGLILTGVMESMELPQHIIER
CHHHHCCHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
VRTIFA
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]