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The map label for this gene is hisC [H]

Identifier: 126208180

GI number: 126208180

Start: 802505

End: 803599

Strand: Reverse

Name: hisC [H]

Synonym: APL_0700

Alternate gene names: 126208180

Gene position: 803599-802505 (Counterclockwise)

Preceding gene: 126208181

Following gene: 126208179

Centisome position: 35.33

GC content: 42.01

Gene sequence:

>1095_bases
ATGCAATTTCTCAACATCGCTAATGAGGGTGTAAAATCCCTTTCTCCTTACCAAGCGGGCAAACCGATCGAAGAATTAGA
ACGTGAGCTGGGTATCAGTAATATCATTAAACTCGCTTCCAATGAAAACCCGTTCGGTTTCCCTGAAAGTGCAAAACAAG
CGATTATTAATCAACTCAATGATCTCACTCGTTATCCGGATGCAAACGGTTTTGAATTAAAAGCGGCAATTTCAAAAAAA
TTCGGCGTACAAGCGAATCAAATTACTTTAGGTAACGGTTCAAACGATTTATTGGAATTATTTGCGCATACTTTTGCCGG
CGAGCAAGATGAAATTATCTATTCGCAATATGCCTTTATCGTGTATCCGTTAGTGACTAAAGCGATTAATGCGGTGGCTC
GTGAGATTCCGGCGAAAAATTGGGGACACGATTTAGAGGCGTTTCTTGCCGCAATCAATGAAAAAACCAAATTGATTTTT
ATCGCCAATCCGAACAACCCGACCGGTAACTTTTTAACCGAAGCGGAAATTGACACTTTCTTAGCGAAAGTGCCGGCAAA
TGTGCTTGTGGTGTTAGATGAAGCCTATACCGAGTTTACAGAGGTTTGCGAGCGTGTCGATTCATTCGGTTTATTAGCAA
AATATCCGAATTTAATTGTTTCTCGTTCACTTTCAAAAGCTTACGGACTTGCCGGACTGCGTATCGGTTATGCGGTATCT
AACGCTGAAATCGCCGATTTACTCAATCGTGTACGTCAGCCGTTTAACTGTAACAGCCTTGCGTTGGTTTCAGCGATTGC
GGTGATGAATGACGATGCTTTTGTAGAAAAAGTTGCGGAAAATAATCGCCGAGAAATGCAACGTTATGAAGCATTCTGCC
AAGCACAAGGTTTGGACTATATTCCTTCCAAAGGCAACTTTATTACGATTGATTTCAAACGTCCTGCCGCACCGATTTAC
GAAGCCTTATTACGTGAAGGCGTGATTGTTCGTCCGATTGCAGGTTACGGTATGCCGAATCATTTACGTATCAGTATCGG
TTTACCGCAAGAAAATGACCGCTTGTTTGCCGCATTAGTAAAAGTGTTGGGATAA

Upstream 100 bases:

>100_bases
AATTTCTTTCCATCTGTAACATATTTTTTACTGGCAAAGATTGGGATTCTCTAATACAATCCGAACATTACTCAATAAAA
ATAATGTTACAGAGGTAAAA

Downstream 100 bases:

>100_bases
TTTAGAGAATAAAATGGAAAAAATTACATTAGCACCGATCAGCCGTGTTGAGGGCGAGATTAATTTACCCGGCTCAAAAA
GCCTTTCAAACCGTGCGTTA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 2 [H]

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MQFLNIANEGVKSLSPYQAGKPIEELERELGISNIIKLASNENPFGFPESAKQAIINQLNDLTRYPDANGFELKAAISKK
FGVQANQITLGNGSNDLLELFAHTFAGEQDEIIYSQYAFIVYPLVTKAINAVAREIPAKNWGHDLEAFLAAINEKTKLIF
IANPNNPTGNFLTEAEIDTFLAKVPANVLVVLDEAYTEFTEVCERVDSFGLLAKYPNLIVSRSLSKAYGLAGLRIGYAVS
NAEIADLLNRVRQPFNCNSLALVSAIAVMNDDAFVEKVAENNRREMQRYEAFCQAQGLDYIPSKGNFITIDFKRPAAPIY
EALLREGVIVRPIAGYGMPNHLRISIGLPQENDRLFAALVKVLG

Sequences:

>Translated_364_residues
MQFLNIANEGVKSLSPYQAGKPIEELERELGISNIIKLASNENPFGFPESAKQAIINQLNDLTRYPDANGFELKAAISKK
FGVQANQITLGNGSNDLLELFAHTFAGEQDEIIYSQYAFIVYPLVTKAINAVAREIPAKNWGHDLEAFLAAINEKTKLIF
IANPNNPTGNFLTEAEIDTFLAKVPANVLVVLDEAYTEFTEVCERVDSFGLLAKYPNLIVSRSLSKAYGLAGLRIGYAVS
NAEIADLLNRVRQPFNCNSLALVSAIAVMNDDAFVEKVAENNRREMQRYEAFCQAQGLDYIPSKGNFITIDFKRPAAPIY
EALLREGVIVRPIAGYGMPNHLRISIGLPQENDRLFAALVKVLG
>Mature_364_residues
MQFLNIANEGVKSLSPYQAGKPIEELERELGISNIIKLASNENPFGFPESAKQAIINQLNDLTRYPDANGFELKAAISKK
FGVQANQITLGNGSNDLLELFAHTFAGEQDEIIYSQYAFIVYPLVTKAINAVAREIPAKNWGHDLEAFLAAINEKTKLIF
IANPNNPTGNFLTEAEIDTFLAKVPANVLVVLDEAYTEFTEVCERVDSFGLLAKYPNLIVSRSLSKAYGLAGLRIGYAVS
NAEIADLLNRVRQPFNCNSLALVSAIAVMNDDAFVEKVAENNRREMQRYEAFCQAQGLDYIPSKGNFITIDFKRPAAPIY
EALLREGVIVRPIAGYGMPNHLRISIGLPQENDRLFAALVKVLG

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=365, Percent_Identity=29.041095890411, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1788627, Length=366, Percent_Identity=25.9562841530055, Blast_Score=66, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322075, Length=359, Percent_Identity=28.4122562674095, Blast_Score=107, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 40164; Mature: 40164

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFLNIANEGVKSLSPYQAGKPIEELERELGISNIIKLASNENPFGFPESAKQAIINQLN
CCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
DLTRYPDANGFELKAAISKKFGVQANQITLGNGSNDLLELFAHTFAGEQDEIIYSQYAFI
HHHCCCCCCCCEEHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHH
VYPLVTKAINAVAREIPAKNWGHDLEAFLAAINEKTKLIFIANPNNPTGNFLTEAEIDTF
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEHHHHHHH
LAKVPANVLVVLDEAYTEFTEVCERVDSFGLLAKYPNLIVSRSLSKAYGLAGLRIGYAVS
HHHCCCCEEEEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEC
NAEIADLLNRVRQPFNCNSLALVSAIAVMNDDAFVEKVAENNRREMQRYEAFCQAQGLDY
CHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
IPSKGNFITIDFKRPAAPIYEALLREGVIVRPIAGYGMPNHLRISIGLPQENDRLFAALV
CCCCCCEEEEEECCCCHHHHHHHHHCCEEEEEHHCCCCCCEEEEEEECCCCCCHHHHHHH
KVLG
HHHC
>Mature Secondary Structure
MQFLNIANEGVKSLSPYQAGKPIEELERELGISNIIKLASNENPFGFPESAKQAIINQLN
CCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
DLTRYPDANGFELKAAISKKFGVQANQITLGNGSNDLLELFAHTFAGEQDEIIYSQYAFI
HHHCCCCCCCCEEHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHH
VYPLVTKAINAVAREIPAKNWGHDLEAFLAAINEKTKLIFIANPNNPTGNFLTEAEIDTF
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEHHHHHHH
LAKVPANVLVVLDEAYTEFTEVCERVDSFGLLAKYPNLIVSRSLSKAYGLAGLRIGYAVS
HHHCCCCEEEEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEC
NAEIADLLNRVRQPFNCNSLALVSAIAVMNDDAFVEKVAENNRREMQRYEAFCQAQGLDY
CHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
IPSKGNFITIDFKRPAAPIYEALLREGVIVRPIAGYGMPNHLRISIGLPQENDRLFAALV
CCCCCCEEEEEECCCCHHHHHHHHHCCEEEEEHHCCCCCCEEEEEEECCCCCCHHHHHHH
KVLG
HHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA