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The map label for this gene is purK [H]

Identifier: 126208141

GI number: 126208141

Start: 754466

End: 755554

Strand: Direct

Name: purK [H]

Synonym: APL_0661

Alternate gene names: 126208141

Gene position: 754466-755554 (Clockwise)

Preceding gene: 126208140

Following gene: 126208142

Centisome position: 33.17

GC content: 43.89

Gene sequence:

>1089_bases
ATGCAAAAAAGTGCCATTTATCCCCCAATTTATGTGCTTGGTAACGGTCAGCTCGGCAGAATGTTACGCTATGCCGGCGC
ACCGCTTGATATTGAAGTAAAACCGCTTGCGTTTGATGCGCCGGTTTTTGAGCTTGAACAAAACAGTATCATTACCGCAG
AAATCGAACGTTGGGCAGAAACGCCGCTCACACAATTACTCGGCAATCATAAAAACTTTGTCAATTTAAACGTATTCGGC
ACAACGGCGGATCGTTTCACCCAAAAATCCTTATTAGACAAGCTCCAACTTTCCACTTCGCCATGGCAATTATTAGAATC
TGCCGAACAATGGCAAAGCGTATTTAGCAATGTCGGCGAAAAAGTGGTGGTAAAACGTCGTACCGGCGGTTATGACGGCA
GAGGTCAATGGATTGTGACACAAGACAGCATTGACCAAATCACACCGGATCTGTTCGGTGAAGTGATTGCGGAAAAGTTT
ATTCCGTTTGACGGTGAGATCTCGATTGTCGGCGCCCGTTTCCGTGACGGTTCTACCCGCTTCTATCCGATTAGCCATAA
CTTACAGCAAAACGGCATCTTGCGTTACTCCGTTTGTGATGAGAATTTACCGAATCAACAAACTTACCAAACTCAAGCAG
AACAAATGCTCGGCACGATTATGCAAGATTTAGAATATGTCGGCGTAATGGCAATGGAATGTTTTGTAGTGGGCGATAAA
TTATTAATTAATGAACTTGCTCCGCGTGTACATAACAGCGGACATTGGACCCAATTAGGATGTTCAATCAGCCAGTTTGA
ATTGCATTTACGTGCATTGCTTGATTTACCGACACCGCAACTCAGACAAATTGCACCGAGCGTAATGGTGAATCTGATTG
GTATTGAACACAATAATGCGTGGTTGGAAGTCCCGTTCTCACAACTACATTGGTATGGCAAAGAAGTTCGTGCAGGGCGT
AAAGTCGGACATATCAATTTATGCCATCCGGAACAAGCTCAGTTGATCCAATTACTCGAACAACTTCGTCCGCATTTAAC
CGATGATTTCCATTCAGGGTTAGATTGGGCGATTAATAAACTCAAATAA

Upstream 100 bases:

>100_bases
AACACAGAAAGTTTGAGGTTTCCGAGCCGTACAAGCGGTCAAATTTACCCCAAAAATTGCAAATCGAGCCTCAAACTTTC
CGCAAACGGAATCATAAAAA

Downstream 100 bases:

>100_bases
GTACAGGCGGTCTATTTTCTTGTGAAATTTGCAAAAAATTTTCAAAAATAGACCGCTTTTCTATTGCTAAAATAGCTAAT
GGGTTGTATAAATATTTCTA

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MQKSAIYPPIYVLGNGQLGRMLRYAGAPLDIEVKPLAFDAPVFELEQNSIITAEIERWAETPLTQLLGNHKNFVNLNVFG
TTADRFTQKSLLDKLQLSTSPWQLLESAEQWQSVFSNVGEKVVVKRRTGGYDGRGQWIVTQDSIDQITPDLFGEVIAEKF
IPFDGEISIVGARFRDGSTRFYPISHNLQQNGILRYSVCDENLPNQQTYQTQAEQMLGTIMQDLEYVGVMAMECFVVGDK
LLINELAPRVHNSGHWTQLGCSISQFELHLRALLDLPTPQLRQIAPSVMVNLIGIEHNNAWLEVPFSQLHWYGKEVRAGR
KVGHINLCHPEQAQLIQLLEQLRPHLTDDFHSGLDWAINKLK

Sequences:

>Translated_362_residues
MQKSAIYPPIYVLGNGQLGRMLRYAGAPLDIEVKPLAFDAPVFELEQNSIITAEIERWAETPLTQLLGNHKNFVNLNVFG
TTADRFTQKSLLDKLQLSTSPWQLLESAEQWQSVFSNVGEKVVVKRRTGGYDGRGQWIVTQDSIDQITPDLFGEVIAEKF
IPFDGEISIVGARFRDGSTRFYPISHNLQQNGILRYSVCDENLPNQQTYQTQAEQMLGTIMQDLEYVGVMAMECFVVGDK
LLINELAPRVHNSGHWTQLGCSISQFELHLRALLDLPTPQLRQIAPSVMVNLIGIEHNNAWLEVPFSQLHWYGKEVRAGR
KVGHINLCHPEQAQLIQLLEQLRPHLTDDFHSGLDWAINKLK
>Mature_362_residues
MQKSAIYPPIYVLGNGQLGRMLRYAGAPLDIEVKPLAFDAPVFELEQNSIITAEIERWAETPLTQLLGNHKNFVNLNVFG
TTADRFTQKSLLDKLQLSTSPWQLLESAEQWQSVFSNVGEKVVVKRRTGGYDGRGQWIVTQDSIDQITPDLFGEVIAEKF
IPFDGEISIVGARFRDGSTRFYPISHNLQQNGILRYSVCDENLPNQQTYQTQAEQMLGTIMQDLEYVGVMAMECFVVGDK
LLINELAPRVHNSGHWTQLGCSISQFELHLRALLDLPTPQLRQIAPSVMVNLIGIEHNNAWLEVPFSQLHWYGKEVRAGR
KVGHINLCHPEQAQLIQLLEQLRPHLTDDFHSGLDWAINKLK

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=353, Percent_Identity=58.0736543909348, Blast_Score=390, Evalue=1e-110,
Organism=Escherichia coli, GI1788155, Length=357, Percent_Identity=26.3305322128852, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324702, Length=375, Percent_Identity=30.1333333333333, Blast_Score=141, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 41028; Mature: 41028

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKSAIYPPIYVLGNGQLGRMLRYAGAPLDIEVKPLAFDAPVFELEQNSIITAEIERWAE
CCCCCCCCCEEEEECCCHHHHHHHCCCCCEEEEECEEECCCEEEECCCCEEHHHHHHHHC
TPLTQLLGNHKNFVNLNVFGTTADRFTQKSLLDKLQLSTSPWQLLESAEQWQSVFSNVGE
CHHHHHHCCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
KVVVKRRTGGYDGRGQWIVTQDSIDQITPDLFGEVIAEKFIPFDGEISIVGARFRDGSTR
EEEEEECCCCCCCCCCEEEECCCHHHCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCE
FYPISHNLQQNGILRYSVCDENLPNQQTYQTQAEQMLGTIMQDLEYVGVMAMECFVVGDK
EEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
LLINELAPRVHNSGHWTQLGCSISQFELHLRALLDLPTPQLRQIAPSVMVNLIGIEHNNA
HHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEECCCC
WLEVPFSQLHWYGKEVRAGRKVGHINLCHPEQAQLIQLLEQLRPHLTDDFHSGLDWAINK
EEECCHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHCCHHHHCCHHHHHHC
LK
CC
>Mature Secondary Structure
MQKSAIYPPIYVLGNGQLGRMLRYAGAPLDIEVKPLAFDAPVFELEQNSIITAEIERWAE
CCCCCCCCCEEEEECCCHHHHHHHCCCCCEEEEECEEECCCEEEECCCCEEHHHHHHHHC
TPLTQLLGNHKNFVNLNVFGTTADRFTQKSLLDKLQLSTSPWQLLESAEQWQSVFSNVGE
CHHHHHHCCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
KVVVKRRTGGYDGRGQWIVTQDSIDQITPDLFGEVIAEKFIPFDGEISIVGARFRDGSTR
EEEEEECCCCCCCCCCEEEECCCHHHCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCE
FYPISHNLQQNGILRYSVCDENLPNQQTYQTQAEQMLGTIMQDLEYVGVMAMECFVVGDK
EEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
LLINELAPRVHNSGHWTQLGCSISQFELHLRALLDLPTPQLRQIAPSVMVNLIGIEHNNA
HHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEECCCC
WLEVPFSQLHWYGKEVRAGRKVGHINLCHPEQAQLIQLLEQLRPHLTDDFHSGLDWAINK
EEECCHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHCCHHHHCCHHHHHHC
LK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]