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The map label for this gene is parC [H]

Identifier: 126208060

GI number: 126208060

Start: 652954

End: 655200

Strand: Direct

Name: parC [H]

Synonym: APL_0578

Alternate gene names: 126208060

Gene position: 652954-655200 (Clockwise)

Preceding gene: 126208055

Following gene: 126208061

Centisome position: 28.71

GC content: 44.95

Gene sequence:

>2247_bases
ATGAGTATAGAAATCAATTACGAAGGCGTTGAACAGATGCCGATTAAGCGTTTTACCGAAGACGCTTACCTCAACTATTC
GATGTACGTCATTATGGATCGTGCATTGCCGTTTATCGGTGACGGGTTAAAACCGGTACAACGCCGTATTATTTATGCCA
TGTCCGAATTAGGCTTAAATGCTTCGGCAAAATATAAAAAATCCGCACGTACCGTCGGGGACGTGTTAGGTAAATTCCAT
CCGCATGGCGATAGTGCTTGTTATGAAGCAATGGTGCTCATGGCGCAGCCGTTTTCTTACCGCTATCCATTGATTGACGG
ACAAGGAAACTGGGGGGCACCTGACGATCCGAAATCTTTTGCGGCAATGCGTTATACCGAATCAAAGCTGTCAAAAATGG
CAGAGGTATTATTGGGCGAATTAGGGCAAGGTACGGTTGATTACCAGCCGAATTTTGACGGCTCGCTTGAAGAACCGAAA
TATTTACCGGCACGTTTACCGCATATTTTGCTGAACGGCACTATGGGGATTGCAGTCGGTATGGCAACCGATATTCCGCC
GCACAATATCAACGAATTAGCCGAAGCAAGCGTGATGTTATTGGAAAATCCGAAAGCAAGTCTTGCCGAGTTAATGACGG
TGGTGCAAGGTCCGGATTACCCGACTGAGGCAGAAATCATTACCCCTAAAGCCGATATTGCCAAAATGTATGAGCAAGGC
AAAGGCTCAATCAAAATGCGTGCGGTGTGGAAAAAAGAAGACGGAGAAATTGTGATTTCGGCATTGCCGCATCAAGCTTC
ACCGTCAAAAGTGATTGAGCAAATCGCAACGCAAATGCGGAATAAAAAATTGCCGATGGTGGATGATATTCGTGATGAAT
CGGATCACGAAAATCCAATTCGCATCGTGATTGTGCCTCGTTCAAATCGTATTGATTTTGAAGCGTTAATGGATCATTTG
TTTGCCACGACTGACCTCGAGAAAAGTTATCGAGTCAATATGAATATGATCGGGCTAGACGGCAAACCGGCGGTGAAAAA
TCTGCAAACGATTTTAACCGAATGGCTAACATTCCGCCGTACTACGGTAACGCGCCGTTTAAATTACCGTTTAGATAAAA
TTTTAAACCGCTTGCATATTTTAGACGGTTTGATGATCGCTTTTCTGAATATTGATGAAGTGATTGAAATTATCCGTAAT
GAAGACGAGCCGAAAACGGCATTAATGGCTCGCTTTAATTTGAGCGAAGCACAAGCAGAAGCGATTTTAAATTTACGCTT
ACGTCATTTAGCAAAATTAGAAGAACACGAATTGCAAGCGGAAAAATCGCAGCTTGAAAAAGAGCGTGATGAATTGCAAT
TAACGCTTGGCTCGGAGCGCCGTTTAAATACGTTGATCAAAAAAGAAATTCAAGCGGATGCAAAAGCGTTTGCCAGCCCG
CGCCGTTCACCGCTTGTTGAGCGTGCCGAAGCGAAAGCGATTTCTGAAAGTGATTTAACCCCAACCGAAGATGTGACAGT
TATTCTATCGGAAAAAGGCTGGGTACGTTGTGCGAAAGGGCATGATATTGACGTGCAAGGCTTAAGTTATCGTGCCGGTG
ACGGCTATCTTGCCCATGCTTATGGCAGAAGTAATCAGCCGGTCGTGTTCCTAGATAGCACCGGGCGAGCTTATGCGCTT
GATCCGACTTCGCTACCATCGGCACGTTCTCAAGGCGAACCGCTCACCGGTAAGATTACTTTGCCGGAAGGTGCAACCGT
TCAGCAAGTGTTAATGGCGAACTCGGACACTAAAGTCCTGATGGCGTCGGATTCCGGTTATGGTTTCATTTGTAGCTTCG
AAGATTTGGTTTCTCGCAATAAGGCGGGTAAAGCGGTCATTTCTTTAACCGAAAATGCCAAAGTGCTGCCGCCGCAATTA
ATTGATAACGAAGCTGAACTTTCGCTTGTCGCAATGAGTAGTGTCGGACGAATGTTAGTATTCCCGATCACCGAATTACC
ACAGCTTTCGAAAGGTAAAGGGAATAAGATTATCAATATTTCCGCACAGGCGGCAAAAGAAGGTAATGAATTGCTTGCCC
GTTTATTACTGGTTAAACCGACACAGTCGTTAGTGTTTGTTTCCGGCAAACGCAAAATCACGCTTAAACCGAGCGATATT
GATAATTATCGTGGCGAACGAGCAAGAAAAGGATCTCAACTTGTACGAGGCCTAAGTGCCACTTCGACTGTGGAAATTGT
AGACTAA

Upstream 100 bases:

>100_bases
TAAGATTTTTACAAAATCGGACCGCTTACCTTTTTACGGTGGACAGCGATCCGTAAATCATAGAAAATAAGCGGTCTTTT
TTACTAAATTATTTGCAAAA

Downstream 100 bases:

>100_bases
TTATTTTCTCATCAGACAAGCGGTCAAATTTCGTAAAAACTTTGCGGAATTTGACCGCTTCTTTTTTTGATTTCGTTCCT
ATTTGATTCACATTCCTGTA

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 748; Mature: 747

Protein sequence:

>748_residues
MSIEINYEGVEQMPIKRFTEDAYLNYSMYVIMDRALPFIGDGLKPVQRRIIYAMSELGLNASAKYKKSARTVGDVLGKFH
PHGDSACYEAMVLMAQPFSYRYPLIDGQGNWGAPDDPKSFAAMRYTESKLSKMAEVLLGELGQGTVDYQPNFDGSLEEPK
YLPARLPHILLNGTMGIAVGMATDIPPHNINELAEASVMLLENPKASLAELMTVVQGPDYPTEAEIITPKADIAKMYEQG
KGSIKMRAVWKKEDGEIVISALPHQASPSKVIEQIATQMRNKKLPMVDDIRDESDHENPIRIVIVPRSNRIDFEALMDHL
FATTDLEKSYRVNMNMIGLDGKPAVKNLQTILTEWLTFRRTTVTRRLNYRLDKILNRLHILDGLMIAFLNIDEVIEIIRN
EDEPKTALMARFNLSEAQAEAILNLRLRHLAKLEEHELQAEKSQLEKERDELQLTLGSERRLNTLIKKEIQADAKAFASP
RRSPLVERAEAKAISESDLTPTEDVTVILSEKGWVRCAKGHDIDVQGLSYRAGDGYLAHAYGRSNQPVVFLDSTGRAYAL
DPTSLPSARSQGEPLTGKITLPEGATVQQVLMANSDTKVLMASDSGYGFICSFEDLVSRNKAGKAVISLTENAKVLPPQL
IDNEAELSLVAMSSVGRMLVFPITELPQLSKGKGNKIINISAQAAKEGNELLARLLLVKPTQSLVFVSGKRKITLKPSDI
DNYRGERARKGSQLVRGLSATSTVEIVD

Sequences:

>Translated_748_residues
MSIEINYEGVEQMPIKRFTEDAYLNYSMYVIMDRALPFIGDGLKPVQRRIIYAMSELGLNASAKYKKSARTVGDVLGKFH
PHGDSACYEAMVLMAQPFSYRYPLIDGQGNWGAPDDPKSFAAMRYTESKLSKMAEVLLGELGQGTVDYQPNFDGSLEEPK
YLPARLPHILLNGTMGIAVGMATDIPPHNINELAEASVMLLENPKASLAELMTVVQGPDYPTEAEIITPKADIAKMYEQG
KGSIKMRAVWKKEDGEIVISALPHQASPSKVIEQIATQMRNKKLPMVDDIRDESDHENPIRIVIVPRSNRIDFEALMDHL
FATTDLEKSYRVNMNMIGLDGKPAVKNLQTILTEWLTFRRTTVTRRLNYRLDKILNRLHILDGLMIAFLNIDEVIEIIRN
EDEPKTALMARFNLSEAQAEAILNLRLRHLAKLEEHELQAEKSQLEKERDELQLTLGSERRLNTLIKKEIQADAKAFASP
RRSPLVERAEAKAISESDLTPTEDVTVILSEKGWVRCAKGHDIDVQGLSYRAGDGYLAHAYGRSNQPVVFLDSTGRAYAL
DPTSLPSARSQGEPLTGKITLPEGATVQQVLMANSDTKVLMASDSGYGFICSFEDLVSRNKAGKAVISLTENAKVLPPQL
IDNEAELSLVAMSSVGRMLVFPITELPQLSKGKGNKIINISAQAAKEGNELLARLLLVKPTQSLVFVSGKRKITLKPSDI
DNYRGERARKGSQLVRGLSATSTVEIVD
>Mature_747_residues
SIEINYEGVEQMPIKRFTEDAYLNYSMYVIMDRALPFIGDGLKPVQRRIIYAMSELGLNASAKYKKSARTVGDVLGKFHP
HGDSACYEAMVLMAQPFSYRYPLIDGQGNWGAPDDPKSFAAMRYTESKLSKMAEVLLGELGQGTVDYQPNFDGSLEEPKY
LPARLPHILLNGTMGIAVGMATDIPPHNINELAEASVMLLENPKASLAELMTVVQGPDYPTEAEIITPKADIAKMYEQGK
GSIKMRAVWKKEDGEIVISALPHQASPSKVIEQIATQMRNKKLPMVDDIRDESDHENPIRIVIVPRSNRIDFEALMDHLF
ATTDLEKSYRVNMNMIGLDGKPAVKNLQTILTEWLTFRRTTVTRRLNYRLDKILNRLHILDGLMIAFLNIDEVIEIIRNE
DEPKTALMARFNLSEAQAEAILNLRLRHLAKLEEHELQAEKSQLEKERDELQLTLGSERRLNTLIKKEIQADAKAFASPR
RSPLVERAEAKAISESDLTPTEDVTVILSEKGWVRCAKGHDIDVQGLSYRAGDGYLAHAYGRSNQPVVFLDSTGRAYALD
PTSLPSARSQGEPLTGKITLPEGATVQQVLMANSDTKVLMASDSGYGFICSFEDLVSRNKAGKAVISLTENAKVLPPQLI
DNEAELSLVAMSSVGRMLVFPITELPQLSKGKGNKIINISAQAAKEGNELLARLLLVKPTQSLVFVSGKRKITLKPSDID
NYRGERARKGSQLVRGLSATSTVEIVD

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Escherichia coli, GI1789396, Length=736, Percent_Identity=70.2445652173913, Blast_Score=1114, Evalue=0.0,
Organism=Escherichia coli, GI1788562, Length=728, Percent_Identity=34.478021978022, Blast_Score=390, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI212645845, Length=189, Percent_Identity=27.5132275132275, Blast_Score=66, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=385, Percent_Identity=24.1558441558442, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 83033; Mature: 82901

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIEINYEGVEQMPIKRFTEDAYLNYSMYVIMDRALPFIGDGLKPVQRRIIYAMSELGLN
CEEEEECCCCHHCCHHHHCHHHHCCEEEEEEEECCCHHHCCCHHHHHHHHHHHHHHHCCC
ASAKYKKSARTVGDVLGKFHPHGDSACYEAMVLMAQPFSYRYPLIDGQGNWGAPDDPKSF
CCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCHHH
AAMRYTESKLSKMAEVLLGELGQGTVDYQPNFDGSLEEPKYLPARLPHILLNGTMGIAVG
HHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCHHHCCEEEECCCCCEEEE
MATDIPPHNINELAEASVMLLENPKASLAELMTVVQGPDYPTEAEIITPKADIAKMYEQG
EECCCCCCCHHHHHHHEEEEEECCCHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHCC
KGSIKMRAVWKKEDGEIVISALPHQASPSKVIEQIATQMRNKKLPMVDDIRDESDHENPI
CCCEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCE
RIVIVPRSNRIDFEALMDHLFATTDLEKSYRVNMNMIGLDGKPAVKNLQTILTEWLTFRR
EEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHH
TTVTRRLNYRLDKILNRLHILDGLMIAFLNIDEVIEIIRNEDEPKTALMARFNLSEAQAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCHHHHHEECCCCHHHHH
AILNLRLRHLAKLEEHELQAEKSQLEKERDELQLTLGSERRLNTLIKKEIQADAKAFASP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHCCC
RRSPLVERAEAKAISESDLTPTEDVTVILSEKGWVRCAKGHDIDVQGLSYRAGDGYLAHA
CCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCEEEECCCCCCCCCCCEEECCCCEEEEE
YGRSNQPVVFLDSTGRAYALDPTSLPSARSQGEPLTGKITLPEGATVQQVLMANSDTKVL
CCCCCCCEEEEECCCCEEEECCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHCCCCCEEE
MASDSGYGFICSFEDLVSRNKAGKAVISLTENAKVLPPQLIDNEAELSLVAMSSVGRMLV
EECCCCCEEEEEHHHHHCCCCCCCEEEEEECCCCCCCHHHCCCCCCEEEEEHHCCCCEEE
FPITELPQLSKGKGNKIINISAQAAKEGNELLARLLLVKPTQSLVFVSGKRKITLKPSDI
EECCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCEEEEECCEEEEECCCCC
DNYRGERARKGSQLVRGLSATSTVEIVD
CCCCCHHHHHHHHHHHCCCCCCEEEEEC
>Mature Secondary Structure 
SIEINYEGVEQMPIKRFTEDAYLNYSMYVIMDRALPFIGDGLKPVQRRIIYAMSELGLN
EEEEECCCCHHCCHHHHCHHHHCCEEEEEEEECCCHHHCCCHHHHHHHHHHHHHHHCCC
ASAKYKKSARTVGDVLGKFHPHGDSACYEAMVLMAQPFSYRYPLIDGQGNWGAPDDPKSF
CCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCHHH
AAMRYTESKLSKMAEVLLGELGQGTVDYQPNFDGSLEEPKYLPARLPHILLNGTMGIAVG
HHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCHHHCCEEEECCCCCEEEE
MATDIPPHNINELAEASVMLLENPKASLAELMTVVQGPDYPTEAEIITPKADIAKMYEQG
EECCCCCCCHHHHHHHEEEEEECCCHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHCC
KGSIKMRAVWKKEDGEIVISALPHQASPSKVIEQIATQMRNKKLPMVDDIRDESDHENPI
CCCEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCE
RIVIVPRSNRIDFEALMDHLFATTDLEKSYRVNMNMIGLDGKPAVKNLQTILTEWLTFRR
EEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHH
TTVTRRLNYRLDKILNRLHILDGLMIAFLNIDEVIEIIRNEDEPKTALMARFNLSEAQAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCHHHHHEECCCCHHHHH
AILNLRLRHLAKLEEHELQAEKSQLEKERDELQLTLGSERRLNTLIKKEIQADAKAFASP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHCCC
RRSPLVERAEAKAISESDLTPTEDVTVILSEKGWVRCAKGHDIDVQGLSYRAGDGYLAHA
CCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCEEEECCCCCCCCCCCEEECCCCEEEEE
YGRSNQPVVFLDSTGRAYALDPTSLPSARSQGEPLTGKITLPEGATVQQVLMANSDTKVL
CCCCCCCEEEEECCCCEEEECCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHCCCCCEEE
MASDSGYGFICSFEDLVSRNKAGKAVISLTENAKVLPPQLIDNEAELSLVAMSSVGRMLV
EECCCCCEEEEEHHHHHCCCCCCCEEEEEECCCCCCCHHHCCCCCCEEEEEHHCCCCEEE
FPITELPQLSKGKGNKIINISAQAAKEGNELLARLLLVKPTQSLVFVSGKRKITLKPSDI
EECCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCEEEEECCEEEEECCCCC
DNYRGERARKGSQLVRGLSATSTVEIVD
CCCCCHHHHHHHHHHHCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]