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The map label for this gene is thiD [H]

Identifier: 126208021

GI number: 126208021

Start: 609992

End: 610450

Strand: Direct

Name: thiD [H]

Synonym: APL_0539

Alternate gene names: 126208021

Gene position: 609992-610450 (Clockwise)

Preceding gene: 126208020

Following gene: 126208022

Centisome position: 26.82

GC content: 43.79

Gene sequence:

>459_bases
TTGGGCGTTTTTGATATTCATAGCGTGCCGCTCAGTACGATTGAATCGCAACTTAAAGCAATCGCAGCAGACTTTCAGAT
CTCCGCTTTTAAAATCGGTATGTTAGGCACGGCGGAAGTGATTGAATGTGTGGCAAATGCGTTACGTCAGTATAATTTCG
GTAAATTAGTACTTGATCCGGTAATGATCGCCAAAGGCGGTGCGCCGTTATTACAACAAAATGCGATTAACGCCTTAAAG
ACGCATTTATTACCGCTCGCAGATGTGATTACGCTGAATTTACCCGAAGCGGAAGCCTTAACCGGTGTGAAAATTATTGA
TGATATGACCGCTTATCAGGCGGCAAAAAAATTGCAAGATTTAGGTGTTAAGACGGTAGTGATTAAGGGCGGGCATTTGG
CGGATTCGCAAAGTGCGCATTGCCGTGATTGGGTATTTACACCAATGCCGTCTATATAA

Upstream 100 bases:

>100_bases
TAGCGGTGGCGGAGCGGGGATTCAGGCGGATTTCAAAACCTTCCAAATGCGAGGCGTTTTCGGCACATCGGTACTGACCG
CAATTACCGCGTAAAATACG

Downstream 100 bases:

>100_bases
CGTTCCGTTTATTGTGGACGATAACGTGGCATTAGCGATTGAGATTGATGCGGACGGCGTACATGTCGGACAAAAAGATA
TGTCACCGATAATGATTCGT

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 152; Mature: 151

Protein sequence:

>152_residues
MGVFDIHSVPLSTIESQLKAIAADFQISAFKIGMLGTAEVIECVANALRQYNFGKLVLDPVMIAKGGAPLLQQNAINALK
THLLPLADVITLNLPEAEALTGVKIIDDMTAYQAAKKLQDLGVKTVVIKGGHLADSQSAHCRDWVFTPMPSI

Sequences:

>Translated_152_residues
MGVFDIHSVPLSTIESQLKAIAADFQISAFKIGMLGTAEVIECVANALRQYNFGKLVLDPVMIAKGGAPLLQQNAINALK
THLLPLADVITLNLPEAEALTGVKIIDDMTAYQAAKKLQDLGVKTVVIKGGHLADSQSAHCRDWVFTPMPSI
>Mature_151_residues
GVFDIHSVPLSTIESQLKAIAADFQISAFKIGMLGTAEVIECVANALRQYNFGKLVLDPVMIAKGGAPLLQQNAINALKT
HLLPLADVITLNLPEAEALTGVKIIDDMTAYQAAKKLQDLGVKTVVIKGGHLADSQSAHCRDWVFTPMPSI

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=147, Percent_Identity=38.0952380952381, Blast_Score=100, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6324517, Length=151, Percent_Identity=30.4635761589404, Blast_Score=65, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6324997, Length=136, Percent_Identity=31.6176470588235, Blast_Score=60, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 16265; Mature: 16134

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVFDIHSVPLSTIESQLKAIAADFQISAFKIGMLGTAEVIECVANALRQYNFGKLVLDP
CCCCCCCCCCHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHH
VMIAKGGAPLLQQNAINALKTHLLPLADVITLNLPEAEALTGVKIIDDMTAYQAAKKLQD
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHCCHHHHHHHHHHHHHHHHHH
LGVKTVVIKGGHLADSQSAHCRDWVFTPMPSI
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GVFDIHSVPLSTIESQLKAIAADFQISAFKIGMLGTAEVIECVANALRQYNFGKLVLDP
CCCCCCCCCHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHH
VMIAKGGAPLLQQNAINALKTHLLPLADVITLNLPEAEALTGVKIIDDMTAYQAAKKLQD
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHCCHHHHHHHHHHHHHHHHHH
LGVKTVVIKGGHLADSQSAHCRDWVFTPMPSI
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]