Click here to switch to the map view.

The map label for this gene is uppS [H]

Identifier: 126207898

GI number: 126207898

Start: 472284

End: 472997

Strand: Reverse

Name: uppS [H]

Synonym: APL_0414

Alternate gene names: 126207898

Gene position: 472997-472284 (Counterclockwise)

Preceding gene: 126207899

Following gene: 126207897

Centisome position: 20.8

GC content: 42.44

Gene sequence:

>714_bases
GTGAATTTTGATCCTCAAAAGATGCCTCAACATGTTGCGATTATCATGGACGGTAACGGTCGTTGGGCTAAACAACAAGG
GAAATTACGTGTTTTCGGTCATCAAAACGGTGTGAAAGCGGTACGTTCCGCGGTAAGTTTTGCTGCCAAACACGGGATTA
AAGTTTTAACGCTTTACGCTTTCAGTAGTGAAAATTGGAGCCGCCCCGAAGCGGAAGTTTCCGCACTGATGGCTTTGTTT
ATGCGGGCATTGGATTCCGAAGTAAAAAAGCTGCATAAAAATAATATTCGTTTGAATATTATCGGTAATAAGAGTGCTTT
TAGTGAAAGTTTACAGAAACGTATCGCCGAATCGGAAAAACTTACGGAAAATAATACGGGACTGATTCTCAATATCGCCG
CCAACTACGGTAGCCATTGGGATATCACGCAAGCCGCTCAACAACTTGCTATAAAAGTAAAATTAGGCGAAATAACAGTT
TCGGACATCACGCCGGAACGTTTACAAAATGCATTGGTAACAGGCACGCAACCTCTGGTCGATTTATTAATCAGAACCAG
CGGAGAGCAACGTATCAGCAACTTTTTATTATGGCAAATCGCTTATGCGGAGTTGGTTTTCAGCCCCGTATTATGGCCGG
ATTTTAATGATGACTCTTTTAGTGAAGCCATCATTGCTTATCAACAACGTGATCGTCGTTTCGGCGGTTGTTAA

Upstream 100 bases:

>100_bases
TCAATTCCTCCTGTATCTATCTTAGAATCTTATCCTATGATATAGTTATCTTCATTTGTATTAATGATTAATTTACTATC
TAACTAAAGCGAGAACTCCT

Downstream 100 bases:

>100_bases
TAAAATAATTATAAGGATTTTTTAATGCTTAAAGAACGAGTACTTTCTGCGATTGTGATGGTTATTGCCGTCTTAGCAGG
TATCTTCTTACTTTCTCCGC

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MNFDPQKMPQHVAIIMDGNGRWAKQQGKLRVFGHQNGVKAVRSAVSFAAKHGIKVLTLYAFSSENWSRPEAEVSALMALF
MRALDSEVKKLHKNNIRLNIIGNKSAFSESLQKRIAESEKLTENNTGLILNIAANYGSHWDITQAAQQLAIKVKLGEITV
SDITPERLQNALVTGTQPLVDLLIRTSGEQRISNFLLWQIAYAELVFSPVLWPDFNDDSFSEAIIAYQQRDRRFGGC

Sequences:

>Translated_237_residues
MNFDPQKMPQHVAIIMDGNGRWAKQQGKLRVFGHQNGVKAVRSAVSFAAKHGIKVLTLYAFSSENWSRPEAEVSALMALF
MRALDSEVKKLHKNNIRLNIIGNKSAFSESLQKRIAESEKLTENNTGLILNIAANYGSHWDITQAAQQLAIKVKLGEITV
SDITPERLQNALVTGTQPLVDLLIRTSGEQRISNFLLWQIAYAELVFSPVLWPDFNDDSFSEAIIAYQQRDRRFGGC
>Mature_237_residues
MNFDPQKMPQHVAIIMDGNGRWAKQQGKLRVFGHQNGVKAVRSAVSFAAKHGIKVLTLYAFSSENWSRPEAEVSALMALF
MRALDSEVKKLHKNNIRLNIIGNKSAFSESLQKRIAESEKLTENNTGLILNIAANYGSHWDITQAAQQLAIKVKLGEITV
SDITPERLQNALVTGTQPLVDLLIRTSGEQRISNFLLWQIAYAELVFSPVLWPDFNDDSFSEAIIAYQQRDRRFGGC

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=225, Percent_Identity=38.6666666666667, Blast_Score=157, Evalue=5e-39,
Organism=Homo sapiens, GI45580742, Length=225, Percent_Identity=38.6666666666667, Blast_Score=157, Evalue=6e-39,
Organism=Escherichia coli, GI1786371, Length=232, Percent_Identity=62.0689655172414, Blast_Score=293, Evalue=9e-81,
Organism=Caenorhabditis elegans, GI71993029, Length=230, Percent_Identity=39.1304347826087, Blast_Score=147, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6323748, Length=218, Percent_Identity=33.4862385321101, Blast_Score=113, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6319474, Length=213, Percent_Identity=32.3943661971831, Blast_Score=105, Evalue=7e-24,
Organism=Drosophila melanogaster, GI18857969, Length=229, Percent_Identity=37.5545851528384, Blast_Score=148, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 26572; Mature: 26572

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFDPQKMPQHVAIIMDGNGRWAKQQGKLRVFGHQNGVKAVRSAVSFAAKHGIKVLTLYA
CCCCHHCCCCEEEEEECCCCCEECCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEE
FSSENWSRPEAEVSALMALFMRALDSEVKKLHKNNIRLNIIGNKSAFSESLQKRIAESEK
ECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECHHHHHHHHHHHHHHHHH
LTENNTGLILNIAANYGSHWDITQAAQQLAIKVKLGEITVSDITPERLQNALVTGTQPLV
CCCCCCCEEEEEECCCCCCCCHHHHHHHHEEEEEECEEEECCCCHHHHHHHHHCCCHHHH
DLLIRTSGEQRISNFLLWQIAYAELVFSPVLWPDFNDDSFSEAIIAYQQRDRRFGGC
HHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNFDPQKMPQHVAIIMDGNGRWAKQQGKLRVFGHQNGVKAVRSAVSFAAKHGIKVLTLYA
CCCCHHCCCCEEEEEECCCCCEECCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEE
FSSENWSRPEAEVSALMALFMRALDSEVKKLHKNNIRLNIIGNKSAFSESLQKRIAESEK
ECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECHHHHHHHHHHHHHHHHH
LTENNTGLILNIAANYGSHWDITQAAQQLAIKVKLGEITVSDITPERLQNALVTGTQPLV
CCCCCCCEEEEEECCCCCCCCHHHHHHHHEEEEEECEEEECCCCHHHHHHHHHCCCHHHH
DLLIRTSGEQRISNFLLWQIAYAELVFSPVLWPDFNDDSFSEAIIAYQQRDRRFGGC
HHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA